KR20140123922A - Composition from natural material for hair loss or hair growth effect - Google Patents

Abstract

The present invention relates to a composition having an alopecia preventing function or a hair growing function using natural materials. According to the present invention, provided are a composition with an alopecia preventing function or a hair growing function comprising fermented solution obtained by fermenting a mixture of eoseongcho, perilla frutescens, green tea leaves, a method for preparing the same, and a pharmaceutical composition with an alopecia preventing function or a hair growing function comprising the composition as an active ingredient. Therefore, the composition can be used in various medicines and functional health products having an alopecia preventing function or a hair growing function and has the excellent alopecia preventing function or the hair growing function with no side effects using natural materials.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition having a hair loss prevention function or a hair growth prevention function using a natural material,

The present invention relates to a composition having a function of preventing hair loss or having a hair growth function by using a natural material, and more particularly, to a composition having a hair loss preventing or hair growth function, comprising a fermentation liquid obtained by fermenting a mixture And a method for producing the same, and a pharmaceutical composition having an anti-hair loss or hair growth function, which comprises the composition as an active ingredient.

Hair is one of the major parts of the body derived from the outer cell layer of the skin and is considered to be a sub-structure of the envelope, along with sebaceous glands, sweat glands and nails. Hair is also known as an envelope derivative since it originates from the envelope during embryological growth. Hair is important for the overall appearance of the human body, and despite the development of several medical therapies, many people suffer from hair loss or hair loss.

The cause of hair loss is discussed in terms of male hormone hyperactivity, excessive sebaceous secretion, poor blood circulation, peroxidation, hypofunction of the bacterium, lowering of collagen production in the papilla, genetic factors, aging and stress come. However, the cause of hair loss has not been clarified to date. Recently, the number of hair loss is increasing due to changes in diet and stress due to social environment, age is lowered, and female hair loss population is increasing.

Conventionally, in order to treat or prevent hair loss, there are blood circulation promotion, hair follicle enhancement, scalp moisturizing and the like. Commercially available medicines include female hormone-based preparations for suppressing male hormone and hypertensive drugs for controlling blood pressure, , Which is based on the side effect of hair growth, is sold. However, there is a side effect problem such as a decrease in strength, and when the use is stopped, the effect is not sustained and it returns to the state before use. It is true.

Therefore, it is urgent to develop a therapeutic method and a pharmaceutical composition for prevention of hair loss, hair growth and hair growth using a component derived from natural materials and having no side effects.

Korean Patent No. 10-0800359 (a composition showing hair loss prevention and hair growth promoting effect), Korean Patent No. 10-0773457 (a composition having a hair growth promoting effect and a method of using the composition) .

The object of the present invention is to solve the problems of the prior art described above and provide a composition having a hair loss prevention or hair growth function including a fermentation broth obtained by fermenting a mixture of natural and synthetic leaves, have.

Another object of the present invention is to provide a pharmaceutical composition having a hair-loss preventing or hair-removing function, which comprises the composition having the hair-loss preventing or hair-growing function as an active ingredient.

In order to achieve the above object, the inventors of the present invention have studied extensively on a composition derived from a natural material having a function of preventing hair loss or having hair growth function, and as a result, found that the three kinds of the above- It has been confirmed that the composition containing the triple complex enzyme fermentation liquid obtained after the administration of the present invention has an effect on prevention of hair loss or on the hair growth function and that it has been experimentally confirmed that there is an excellent effect of alleviating the side effects of the conventional commercial minoxidil Thereby completing the invention.

In the case of alopecia areata, which has a strong antibacterial and anti-inflammatory effect, malachseida is caused by yeast and staphylococci, and decaffeinated alopecia, the decanoyl acetaldehyde component of alopecia are remarkably inhibited by these two bacteria The above lobular lobes contain not only minerals but also vitamins B1, B2, B6, vitamin C, vitamin E, vitamin K and niacin in large quantities and contain alpha-linolenes such as calcium, potassium, iron, magnesium, Zinc and so on, so that almost all of the coenzyme components required for the human body are contained. In addition, perilla aldehyde and beta-carotene contained in the baby leaf are effective not only in a strong antimicrobial activity and antioxidant activity, but also in the prevention of activation of phyto-cells and prevention of aging, thereby alleviating seborrhoeic alopecia and alopecia areata Thereby achieving optimum synergy. Finally, the green tea leaf contains a polypolyol component, which forms a triple combination of phase oxidation, antiinflammation and anti-DHT effect together with the above-mentioned mesophyll and mesophyll.

Meanwhile, the present invention provides a composition having a hair loss prevention function or a hair growth function, comprising a fermentation broth obtained by fermenting a mixture obtained by mixing a green tea leaf, a green leaf and a green tea leaf.

The mixture is characterized in that the green tea leaf, green leaf, and green tea leaf are mixed at a weight ratio of 5: 6: 1.5 to 3: 1.5: 2, respectively.

The fermentation broth is characterized in that it is fermented using yeast and alcohol as an fermentation agent.

Further, the present invention provides a pharmaceutical composition having a hair-loss preventing or hair-growing function comprising the composition as an active ingredient.

In addition, the present invention provides a method for producing a fermented soybean milk, comprising the steps of: (1) adding and leaving an fermentation agent in a mixture of a green tea leaf, a green leaf and a green tea leaf, and (2) And (3) fermenting and aging at a temperature of 15 to 25 ° C after the alcohol is added by the step (2); And (4) filtering the fermentation broth obtained after the fermentation and aging in the step (3), thereby producing a composition having a hair loss preventing function or a hair growth function.

In the step (1), the mixture is prepared by mixing the green tea leaf, green leaf, and green tea leaf at a weight ratio of 5 to 6: 1.5 to 3: 1.5 to 2, respectively.

The step (1) is characterized in that the fermentation agent is yeast.

And the fermentation and aging are carried out in the step (3) at a temperature of 15 to 25 ° C and a relative humidity of 50 to 60%.

Further, the present invention provides a pharmaceutical composition having a hair loss preventing function or a hair growth function, which comprises the composition prepared by the above-mentioned method as an active ingredient.

According to the present invention, there is provided a composition comprising a fermentation broth obtained by fermenting a mixture of natural and synthetic leaves, natural leaves, and green tea leaves, a method for producing the same, and a pharmaceutical composition comprising the composition as an active ingredient, There is no side effect, and there is an excellent effect of preventing hair loss or promoting hair growth.

FIG. 1 is a photograph showing an increase in density of hair after the development of new hair follicles after using the pharmaceutical composition according to the present invention. FIG.
FIG. 2 is a photograph showing a state in which the scalp inflammation is relieved after using the pharmaceutical composition according to the present invention. FIG.
FIG. 3 is a photograph showing that a neonatal hair is expressed from a hair follicle after using the pharmaceutical composition according to the present invention. FIG.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are merely illustrative of the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

Example 1.

A fermentation aging vessel of 10 liters size was cleaned with purified water and sterilized. Here, the herbal medicine materials for fermentation were treated as follows. After the slices were cleaned, the slices were cut to a width of about 1 cm in the transverse direction of the persimmon, and when the slices were pressed with a finger, they were sufficiently waited until a transparent mucilage liquid came out and then put into a fermentation vessel. On the other hand, Japanese leaf and green tea leaf were dried and finely chopped. A total of 500 g of 250 g, 150 g, and 100 g of a total of 500 g of yeast extract, yeast leaf and green tea leaf were added to the fermentation vessel at a ratio of 5: 3: 2, Mixed well with the kind of herbal ingredients, and sealed with a plug. This was allowed to continue for 2 days, then the cap of the fermentation vessel was opened, and 8.0 liters of a 30% alcohol was carefully poured. The fermentation vessel was shaken slowly with each ingredient mixed well and then sealed with a stopper. The fermented containers filled with all the materials and sealed were fermented and aged for 6 months in a room free of direct sunlight where the storage temperature was maintained at about 20 ° C and the relative humidity was about 55%. During the fermentation period, the sealed fermentation vessel was rolled for about 10 minutes once a week, so that the yeast and the herbal materials and the alcohol were sliced together. After 6 months, the fermentation vessel was opened, and the remnants of the herbal material and the liquid were filtered to obtain a fermentation broth, which was then filtered with a sliver membrane filter (Maker: Cole-Parmer, USA). Finally, 7.8 L of the fermented broth was obtained by fermentation and aging with a mixture of Lentinus edulis, Liliaceae and Green tea leaves.

Example 2.

In Example 1, the total weight of the herb medicine was 800 g and the amount of the fermentation period was set to 4 months using the total dosage of 800 g of the herbal medicine and 7.5 liters of the 30% alcohol, with the weighing ratio of 7: 1.5: 1.5, , 7.2 liters of a triple-complexed fermentation broth of a mixture of fish, cotyledon and green tea leaves was finally obtained.

Example 3.

In Example 1, 8.0 liters of a solution obtained by mixing 400 g of a total weight ratio of 6: 2: 2, which is the weight ratio of the seedlings, lobsters and green tea leaves, and 15.0 v / v% of ethanol to purified water was fermented , And 7.8 L of a triple complex fermentation broth of a mixture of Horseshoe cherry, Mulberry leaf and Green tea leaf was finally obtained in the same manner as in Example 1, except that the fermentation period was changed to 3 months. The mixture was distilled under reduced pressure at an evaporator temperature of 60 ° C and a pressure of 30 mmHg at 20 ° C in a 20 L rotary evaporator (manufactured by Dae Young Hitech, Korea), and the residue was taken to obtain 4.0 liters of a triple complex enzyme fermentation concentrate .

Example 4.

A liquid type pharmaceutical composition containing the triple-complexed compound liquid of the whorl, young lobule and green tea leaf mixture obtained in Example 1 was prepared as shown in Table 1 below. The preparation method was as follows. The raw material No. 3 in Table 1 was put into 1 part of purified water and sufficiently stirred to dissolve. Then, the triple complex enzyme fermentation solution obtained in Example 1 was gradually added while stirring. Finally, a light brown liquid pharmaceutical composition was obtained.

Experimental Example 1

The pharmaceutical composition prepared in Example 4 was placed in a 100 ml brown glass bottle to which a lid was attached. 50 patients who visited the hospital for alopecia treatment were asked to obtain consent beforehand. After 3 months, the pharmaceutical composition of Example 4 was taken in a morning and evening (or before bedtime) It was straightened. However, detailed information on the pharmaceutical composition of Example 4 was not provided to the patient in advance, and was explained to all after the test evaluation. The results obtained after applying the pharmaceutical composition of Example 4 of the present invention for 3 months are summarized in the following Table 2. The photographs of the changes are shown in FIG. 1, FIG. 2 and FIG. In the evaluation method, the overall satisfaction was evaluated by a paper-based visual observation, and the expression of the new hair was compared with a digital camera with respect to the hair loss region, and the change of the hair on the scalp was observed using an echocardiography microscope (Model: Olympus Bx-50 / BX- , Japan). The reduction of inflammation of the scalp was judged by visual and endoscopic microscopy. Changes in the thickness of the hair and the stiffness of the hair were judged by the examination of the knee and touch. The change in symptom associated with hair loss was evaluated in three steps (no change → little improvement → significant improvement), and the numerical value indicated in each item indicated the number of patients answered "yes" out of the 50 patients who participated in the evaluation.

The results in Table 2 show excellent effects in alleviating or improving the expression of new hair and scalp inflammation, and the improvement of hair thickness and stiffness showed an excellent effect. Therefore, it was clear that the effect of improving overall hair loss symptoms was satisfactory, and all of the patients participating in the test evaluation were satisfied.

Figs. 1, 2 and 3 show photographs taken by a digital camera and an endoscopic microscope of the participants before and after the test evaluation. As shown in FIG. 1, it was found that the hair density was increased due to the expression of new hair on the entire crown area of hair loss patients. Figure 2 shows changes in scalp inflammation, a typical symptom of hair loss. As shown in the photograph, the inflammation of the scalp was present in the form of rash and reddish before evaluation, and it was confirmed that the inflammation disappeared after 3 months from the application of the liquid pharmaceutical composition of Example 4 of the present invention. FIG. 3 is a photograph of a neovasculous hair follicle obtained after applying the liquid pharmaceutical composition prepared in Example 4 of the present invention for 3 months. That is, the photograph of FIG. 3 shows that new hair roots are formed from hair follicles and new hair follicles are expressed.

Example 5 and Comparative Example 1.

A shampoo was prepared in order to confirm the difference between the pharmaceutical composition containing the triple-complex enzyme solution of the perilla, the green leaf and the green tea leaf mixture obtained in Example 1 and the conventional composition. For the preparation method, about one-half of the purified water of Table 3 was pre-loaded, and the raw materials 3 to 6 and 9 to 11 were added and sufficiently dissolved while being heated to about 40 ° C. Next, the remaining one of the purified water and the remaining raw materials were added thereto and dissolved with stirring. However, the product obtained in Example 1 of Example 2 of the present invention was added last and slowly stirred to prepare a shampoo.

Experimental Example 2

Forty subjects who had hair loss symptoms were randomly divided into two groups of 20 persons, and the shampoo prepared in Example 5 and Comparative Example 1 was used for 3 months. At this time, information on each used shampoo was provided unknowingly. After 3 months of using each shampoo provided, the condition of the hair and scalp of all the subjects participating in the test was observed. The degree of alleviation of hair loss symptoms and the degree of improvement of hair and scalp were evaluated on a 5 - point scale. The rating scale was' one point: worse. 2 points: No change. 3 points: It got a little better. 4 points: It got better. 5 points: very good ', and the displayed figure is the average value of the respondent's score. The results are shown in Table 4 below.

Table 4 shows that most of the subjects using the shampoo according to Example 5 of the present invention remarkably alleviated or ameliorated the symptoms of hair loss. On the other hand, when the shampoo of Comparative Example 1, Most of them answered that they did not feel alleviation or improvement of hair loss symptoms, but rather they were worse or unchanged. From these results, it was found that the shampoo formulated with the triple complex enzyme fermentation solution of the present invention was effective in alleviating or alleviating the symptoms of hair loss.

Having described specific portions of the present invention in detail, it will be apparent to those skilled in the art that this specific description is only a preferred embodiment and that the scope of the present invention is not limited thereby. It will be obvious. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (2)

And a fermentation broth obtained by fermenting a mixture obtained by mixing a green tea leaf, a green leaf, a green leaf and a green tea leaf.
(1) adding an fermentation broth to a mixture of Rhizoctonia solani, Liliaceae and Green tea leaves, and allowing to stand;
(2) adding the alcohol after fermentation by the step (1);
(3) fermenting and aging at a temperature of 15 to 25 DEG C after the alcohol is added by the step (2); And
(4) filtering the fermentation broth obtained after fermentation and aging in the step (3).

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