CN110327276B - Traditional Chinese medicine toothpaste and preparation method thereof - Google Patents
Traditional Chinese medicine toothpaste and preparation method thereof Download PDFInfo
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to the technical field of daily chemical industry, and particularly relates to traditional Chinese medicine toothpaste and a preparation method thereof. The traditional Chinese medicine toothpaste disclosed by the invention comprises a traditional Chinese medicine extract prepared from south African leaves, liquorice and bletilla striata, can effectively relieve gingival inflammation, gingival bleeding and gingival swelling and pain, maintains gingiva, has no toxic or side effect on a human body, is safe and reliable to use, has no stimulation to oral mucosa, does not generate drug resistance, and is suitable for long-term use.
Description
Technical Field
The invention belongs to the technical field of daily chemical industry, and particularly relates to traditional Chinese medicine toothpaste and a preparation method thereof.
Background
Periodontal disease is a common oral disease with symptoms of bleeding, swelling, and pain of the gums. Statistics show that periodontal disease is the leading cause of tooth loss in people over 35 years of age, and the severity of periodontal disease is seen. However, most people do not know that they suffer from the disease because the patient is not aware of it, and many people mistakenly think that they will suffer from periodontal disease only by the elderly, and in fact, children aged 5 may suffer from periodontal disease.
Periodontal disease affects not only the health of the teeth but also the general health. The effects of periodontal disease on general health have attracted attention in recent years. The bacterial components and bacterial products are easy to diffuse to nearby or distant organs through the ulcer surface of the periodontal pocket, which causes or aggravates the occurrence and development of certain systemic diseases, such as coronary heart disease, low birth weight infants, diabetes, lung infection and the like, and seriously harms the human health. The requirement of improving oral health level cannot be met by oral hospitals and drug therapy alone, and the periodontal disease can be effectively prevented and controlled gradually by matching with the oral care health product for preventing and treating the periodontal disease.
In order to better prevent and treat periodontal diseases and reduce gingival bleeding, tranexamic acid is generally selected to be added into toothpaste, but the addition of the tranexamic acid can cause antibodies to gingiva, and the tranexamic acid belongs to prescription drugs. This necessarily increases the production cost of the toothpaste and the risk of using raw materials. At present, researchers are more inclined to develop traditional Chinese medicine toothpaste with the function of treating periodontal diseases to solve the above problems.
CN101380285B discloses a bletilla striata Chinese herbal medicine toothpaste, which comprises a toothpaste matrix containing paeonol and bletilla striata or bletilla striata polysaccharide. The invention contains bletilla striata which is a traditional Chinese medicine with the functions of detumescence, granulation promotion, wound healing and hemostasis and paeonol with the functions of antibiosis, antiphlogosis and antianaphylaxis. The toothpaste has antibacterial, antiinflammatory, sore healing and hemostatic effects, and can be used for preventing and treating oral and dental diseases such as oral ulcer, sore throat, periodontitis, gingivitis, dental caries, and halitosis, and provides a new oral health toothpaste.
CN108522758A discloses a tea drink for nursing oral cavity, belonging to the technical field of health-care functional drink. The material is mainly prepared from the following raw materials: 10-16 parts of oil tea leaves, 10-16 parts of south Africa leaves, 4-6 parts of green tea powder, 3-6 parts of ginger, 2-5 parts of stevia rebaudiana, 2-3 parts of baking soda and 600 parts of water. The oral care tea beverage prepared by the invention can relieve the oral problems of toothache, gingival bleeding, oral ulcer, gingivitis, periodontitis and the like.
The leaf of south Africa is leaf of Vernonia amygdalina Del of Vernonia of Compositae, and is bitter and cold in nature, can enter liver, gallbladder, lung and large intestine channels, is primarily determined to have the effects of clearing heat and removing toxicity, eliminating dampness and killing insects, and is suitable for dialectical use in application, according to clinical experience of Chinese medicine and herbal pharmacist in origin.
The traditional Chinese medicine toothpaste containing south African leaves, bletilla striata and liquorice provided by the invention can effectively relieve gingival inflammation and gingival bleeding, maintain gingiva, effectively remove oral peculiar smell, and keep oral health and breath fresh for a long time.
Disclosure of Invention
In order to solve the problems in the prior art, the traditional Chinese medicine toothpaste provided by the invention adopts the following technical scheme: the traditional Chinese medicine toothpaste comprises traditional Chinese medicine extracts prepared from south African leaves, liquorice and bletilla striata.
Preferably, the weight ratio of the south African leaves, the liquorice and the bletilla striata in the raw materials for preparing the traditional Chinese medicine extract is 5:3: 2.
Further, the traditional Chinese medicine toothpaste also comprises the following components: trichlorogalactose, sodium benzoate, sorbitol, polyethylene glycol-400, titanium dioxide, carrageenan, carboxymethyl cellulose, xanthan gum, silica H type, silica MIV type, silica MIG type, sodium dodecyl sulfate, essence and water.
Further, the traditional Chinese medicine toothpaste comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 0.05-0.3 part of trichlorogalactose, 1-2 parts of sodium benzoate, 180-220 parts of sorbitol, 8-10 parts of polyethylene glycol-4008 parts of titanium dioxide, 1-2 parts of carrageenan, 3-7 parts of carboxymethyl cellulose, 0.5-2 parts of xanthan gum, 30-45 parts of silica H type, 25-40 parts of silica MIV type, 30-50 parts of silica MIG type, 5-12 parts of sodium dodecyl sulfate, 5-8 parts of essence and 100-140 parts of water.
Preferably, the traditional Chinese medicine toothpaste comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 0.05-0.2 part of trichlorogalactose, 1-2 parts of sodium benzoate, 190-220 parts of sorbitol, 9-10 parts of polyethylene glycol-4009 parts of titanium dioxide, 1.5-2 parts of carrageenan, 4-6 parts of carboxymethyl cellulose, 0.5-1 part of xanthan gum, 33-40 parts of silica H type, 30-40 parts of silica MIV type, 35-45 parts of silica MIG type, 7-12 parts of sodium dodecyl sulfate, 5-7 parts of essence and 110-130 parts of water.
Preferably, the traditional Chinese medicine toothpaste comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 0.05-0.1 part of trichlorogalactose, 1-2 parts of sodium benzoate, 210-220 parts of sorbitol, 9-10 parts of polyethylene glycol-4009 parts of titanium dioxide, 1.8-2 parts of carrageenan, 4-5 parts of carboxymethyl cellulose, 0.5-0.7 part of xanthan gum, 34-36 parts of silica H type, 33-37 parts of silica MIG type, 38-42 parts of sodium dodecyl sulfate, 5-6 parts of essence and 120-130 parts of water.
Preferably, the traditional Chinese medicine toothpaste comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 10 parts of south African leaves, liquorice and bletilla striata, 0.05 part of trichlorogalactose, 1.5 parts of sodium benzoate, 215 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts of titanium dioxide, 2 parts of carrageenan, 1 part of carboxymethyl cellulose 5 parts of xanthan gum, 0.5 part of silica H type 35 parts of silica MIV type 35 parts of silica MIG type 40 parts of silica MIG type, 10 parts of sodium dodecyl sulfate, 6 parts of essence and 128.95 parts of water.
Further, the traditional Chinese medicine extract is prepared by the following method: washing, draining, crushing and grinding the south African leaves, the liquorice and the bletilla striata in corresponding weight parts, wrapping the mixture with gauze, putting the mixture into a container, adding ethanol with the concentration of 70% for extraction, and mixing the materials and the solution in a ratio of 1: 9; refluxing at 60 deg.C for 4 hr, filtering, removing residue, pouring the filtrate into a distillation flask, distilling off ethanol and recovering, and filtering the liquid to obtain Chinese medicinal extract.
Correspondingly, the invention also provides a preparation method of the traditional Chinese medicine toothpaste, which comprises the following steps:
s1, preparing traditional Chinese medicine extracts from traditional Chinese medicines according to the formula amount;
s2, blending the sodium benzoate and the trichlorogalactose into 1/5 of water according to the formula amount, and slowly stirring for 3-5 minutes; dissolving completely to obtain preservative solution for later use;
s3, dissolving the sorbitol, the traditional Chinese medicine extract and the preservative solution in the formula amount in the rest water to obtain a solution A;
s4, dissolving the carrageenan, the carboxymethyl cellulose and the xanthan gum in the formula amount in polyethylene glycol-400, uniformly stirring, pouring into the solution A, and quickly stirring for 5-10 minutes to obtain glue;
s5, putting titanium dioxide, silicon dioxide H type, silicon dioxide MIV type, silicon dioxide MIG type, sodium dodecyl sulfate and glue water according to the formula amount into a paste making pot, stirring for 30-40 minutes, adding essence according to the formula amount, and stirring for 8-12 minutes to obtain paste;
s6, subpackaging to obtain the traditional Chinese medicine toothpaste for relieving gingival inflammation and gingival bleeding.
Compared with the prior art, the invention has the following advantages:
the traditional Chinese medicine toothpaste provided by the invention can effectively relieve gingival inflammation and gingival bleeding, maintain gingiva, effectively remove oral peculiar smell, and keep oral health and breath fresh for a long time.
(1) The traditional Chinese medicine toothpaste provided by the invention contains the south African leaf extract, the licorice extract and the bletilla striata extract, helps to improve gingival bleeding and gingival swelling and pain, helps to repair red and swollen parts of gingival inflammation, can effectively solve multiple oral problems of oral cavity excessive internal heat, gingival swelling and pain, oral ulcer and the like, comprehensively maintains the oral cavity, relieves trouble of tooth and gingival pain, and makes the oral environment healthier.
(2) The traditional Chinese medicine toothpaste provided by the invention has no toxic or side effect on a human body, is safe and reliable to use, has no stimulation to oral mucosa, does not generate drug resistance, and is suitable for long-term use.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Other embodiments, which can be derived by one of ordinary skill in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Materials, reagents and the like used in the following examples are commercially available unless otherwise specified; unless otherwise indicated, the examples were run according to routine experimental conditions or according to manufacturer's instructions.
Example 1
The formula is as follows: 5 parts of south African leaves, 3 parts of liquorice, 2 parts of bletilla striata, 0.05 part of trichlorogalactose, 1.5 parts of sodium benzoate, 215 parts of sorbitol, 10 parts of polyethylene glycol-400, 2 parts of titanium pigment, 1 part of carrageenan, 5 parts of carboxymethyl cellulose, 0.5 part of xanthan gum, 35 parts of silicon dioxide H type, 35 parts of silicon dioxide MIV type, 40 parts of silicon dioxide MIG type, 10 parts of sodium dodecyl sulfate, 6 parts of essence and 128.95 parts of water.
The preparation method comprises the following steps:
s1, washing, draining, crushing and grinding the south Africa leaves, the liquorice and the bletilla striata, wrapping the mixture with gauze, putting the mixture into a container, adding ethanol with the concentration of 70% for leaching, and mixing the materials and the solution at a ratio of 1: 9; refluxing at 60 deg.C for 4 hr, filtering, removing residue, pouring the filtrate into a distillation flask, distilling off ethanol, recovering ethanol, and filtering to obtain Chinese medicinal extract;
s2, adding sodium benzoate and trichlorogalactose into 1/5 of water, and slowly stirring for 3-5 minutes; dissolving completely to obtain preservative solution for later use;
s3, dissolving sorbitol, the traditional Chinese medicine extract and the preservative solution into the rest water to obtain a solution A;
s4, dissolving carrageenan, carboxymethyl cellulose and xanthan gum in polyethylene glycol-400, uniformly stirring, pouring into the solution A, and rapidly stirring for 5-10min to obtain glue;
s5, putting titanium dioxide, silicon dioxide H type, silicon dioxide MIV type, silicon dioxide MIG type, sodium dodecyl sulfate and glue into a paste making pot, stirring for 30-40min, adding formula amount of essence, and stirring for 8-12min to obtain paste;
and S6, subpackaging.
Example 2
The formula is as follows: 3.75 parts of south African leaves, 2.25 parts of liquorice, 1.5 parts of bletilla striata, 0.05 part of trichlorogalactose, 1.5 parts of sodium benzoate, 215 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts of titanium dioxide, 2 parts of carrageenan, 5 parts of carboxymethyl cellulose, 0.5 part of xanthan gum, 35 parts of silicon dioxide H type, 35 parts of silicon dioxide MIV type, 40 parts of silicon dioxide MIG type, 10 parts of sodium dodecyl sulfate, 6 parts of essence and 131.45 parts of water.
The preparation method comprises the following steps:
the same as in example 1.
Example 3
The formula is as follows: 6.25 parts of south African leaves, 3.75 parts of liquorice, 2.5 parts of bletilla striata, 0.05 part of trichlorogalactose, 1.5 parts of sodium benzoate, 215 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts of titanium dioxide, 2 parts of carrageenan, 5 parts of carboxymethyl cellulose, 0.5 part of xanthan gum, 35 parts of silicon dioxide H type, 35 parts of silicon dioxide MIV type, 40 parts of silicon dioxide MIG type, 10 parts of sodium dodecyl sulfate, 6 parts of essence and 126.45 parts of water.
The preparation method comprises the following steps:
the same as in example 1.
Comparative example 1
The comparative example differs from example 1 only in that: no Chinese medicinal extract is added.
Comparative example 2
The comparative example differs from example 1 only in that: 6 parts of south African leaves, 2 parts of liquorice and 2 parts of bletilla striata.
Test example 1
1. The test contents are as follows:
a. and (3) placing the toothpaste samples in the examples 1-3 into a 50 ℃ oven for storage, taking out after 3 months, splitting the toothpaste, and observing the change condition of the toothpaste.
b. And (3) shelf-trial storing the toothpaste samples in the examples 1-3 at normal temperature, taking out after 12 months, splitting the toothpaste, and observing the change condition of the toothpaste.
c. The microbial indicators were tested according to the technical Specification for cosmetic safety.
2. And (3) test results:
the toothpaste of examples 1-3 is stored at 50 ℃ for 3 months and at normal temperature for 12 months, the paste is stable, the fragrance and color are normal, and abnormal conditions such as paste overflowing out of the toothpaste tube mouth and liquid separation do not occur. The microbial indexes all accord with the national standard GB/T8372-2018, which shows that the traditional Chinese medicine toothpaste has good stability and the compatibility of the traditional Chinese medicine and the paste is good.
Test example 2
1. Test materials: example 1, example 2, example 3, comparative example 1 and comparative example 2.
2. Test subjects: selecting 100 subjects to participate in the test, wherein each subject accounts for half of the total number of the male subjects and the female subjects; photographing oral gums of a subject; the average was divided into example 1 group, example 2 group, example 3 group, comparative example 1 group, and comparative example 2 group, each of which was 20 persons.
3. The test method comprises the following steps: the subjects brushed their teeth 1 time each day in the morning and evening for 3 minutes each time for 1 week. All the subjects in each group can not use other oral cleaning products in the test period, the oral gum of the subjects is photographed after 1 week, and the effects before and after use are compared.
The test results are shown in table 1:
TABLE 1 comparison of improvement in oral gingival inflammation before and after the test
As can be seen from table 1, the oral gingival inflammation of the subjects of example 1, example 2, example 3 and comparative example 2 is obviously faster than the recovery of comparative example 1, and the recovery effect is significant, which indicates that the toothpaste added with the traditional Chinese medicine has the effect of significantly improving gingivitis; wherein, the traditional Chinese medicine toothpaste prepared in the embodiment 1 and the embodiment 2 of the invention has more remarkable effect.
Test example 3
1. Test materials: example 1, example 2, example 3, comparative example 1 and comparative example 2.
2. Test subjects: selecting 100 subjects to participate in the test, wherein each subject accounts for half of the total number of the male subjects and the female subjects; the average values were divided into example 1 group, example 2 group, example 3 group, comparative example 1 group and comparative example 2 group.
3. The test method comprises the following steps: the subjects brushed their teeth 1 time and 3 minutes per time in the morning and evening for 1 week continuously, and no other oral cleaning products were used in the test period of each group of subjects, and the subjects were scored according to the degree of tooth bleeding, classified into 6 grades and scored: bleeding is not caused for 5 points, mild microhemorrhage is caused for 4 points, moderate microhemorrhage is caused for 3 points, obvious bleeding is caused for 2 points, moderate bleeding is caused for 1 point, and severe bleeding is caused for 0 point, and the gingival bleeding rate on the 2 nd day, the 4 th day, the 6 th day and the 8 th day is calculated respectively. Wherein, the calculation formula of the gingival hemostasis rate is as follows:
the gingival bleeding stopping rate is × 100 percent of the total score value/total score value of the observation score value on the same day
The test results are shown in table 2:
TABLE 2 oral gingival hemostasis rate for each group after the test
| Group of | Day 2 | Day 4 | Day 6 | Day 8 |
| Example 1 | 72％ | 83％ | 91％ | 97％ |
| Example 2 | 65％ | 96％ | 81％ | 85％ |
| Example 3 | 73％ | 85％ | 92％ | 97％ |
| Comparative example 1 | 43％ | 46％ | 44％ | 49％ |
| Comparative example 2 | 57％ | 68％ | 71％ | 76％ |
As can be seen from table 2, the oral gingival bleeding stopping rate of the subjects in the example 1 group, the example 2 group and the example 3 group is significantly more effective than that of the comparative example 1 group, which indicates that the toothpaste added with the traditional Chinese medicine has the effect of significantly improving the gingival bleeding phenomenon. The oral gingival hemostasis rates of the subjects of example 1 and example 3 are substantially the same, but example 1 has a cost advantage over example 3; meanwhile, compared with the comparative example 2, the example 1 has better gingival hemostasis effect.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages: the traditional Chinese medicine toothpaste containing south African leaves, bletilla striata and liquorice provided by the invention can effectively relieve gingival inflammation, gingival bleeding and gingival swelling and pain and maintain gingiva.
The technical solutions of the present invention are described in more detail and detail, but the technical solutions of the present invention are not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the spirit of the present invention, and these changes and modifications are within the scope of the present invention.
Claims (7)
1. A Chinese medicinal toothpaste is characterized by comprising Chinese medicinal extract prepared from folium Africae, Glycyrrhrizae radix and rhizoma Bletillae; wherein, in the raw materials for preparing the traditional Chinese medicine extract, the weight ratio of the south Africa leaves, the liquorice and the bletilla striata is 5:3: 2; the traditional Chinese medicine extract is prepared by the following method: cleaning, draining, crushing and grinding the south African leaves, the liquorice and the bletilla striata according to the formula amount, wrapping the mixture with gauze, then putting the mixture into a container, adding ethanol with the concentration of 70% for extraction, and mixing the materials and the solution in a ratio of 1: 9; refluxing at 60 deg.C for 4 hr, filtering, removing residue, pouring the filtrate into a distillation flask, distilling off ethanol, and recovering.
2. The traditional Chinese medicine toothpaste according to claim 1, further comprising the following components: trichlorogalactose, sodium benzoate, sorbitol, polyethylene glycol-400, titanium dioxide, carrageenan, carboxymethyl cellulose, xanthan gum, silica H type, silica MIV type, silica MIG type, sodium dodecyl sulfate, essence and water.
3. The traditional Chinese medicine toothpaste according to claim 2, which comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 5-15 parts of south African leaves, liquorice and bletilla striata, 0.05-0.3 part of trichlorogalactose, 1-2 parts of sodium benzoate, 180-220 parts of sorbitol, 8-10 parts of polyethylene glycol-4008, 1-2 parts of titanium dioxide, 0.5-1 part of carrageenan, 3-7 parts of carboxymethyl cellulose, 0.5-2 parts of xanthan gum, 30-45 parts of silicon dioxide H type, 25-40 parts of silicon dioxide MIV type, 30-50 parts of silicon dioxide MIG type, 5-12 parts of sodium dodecyl sulfate, 5-8 parts of essence and 100-140 parts of water.
4. The traditional Chinese medicine toothpaste according to claim 3, which comprises the following components in parts by weight: the traditional Chinese medicine composition comprises 7-13 parts of south African leaves, liquorice and bletilla striata, 0.05-0.2 part of trichlorogalactose, 1-2 parts of sodium benzoate, 190-220 parts of sorbitol, 9-10 parts of polyethylene glycol-4009, 1.5-2 parts of titanium dioxide, 0.8-1 part of carrageenan, 4-6 parts of carboxymethyl cellulose, 0.5-1 part of xanthan gum, 33-40 parts of silica H type, 30-40 parts of silica MIV type, 35-45 parts of silica MIG type, 7-12 parts of sodium dodecyl sulfate, 5-7 parts of essence and 110-135 parts of water.
5. The traditional Chinese medicine toothpaste according to claim 4, which comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 9-11 parts of south African leaves, liquorice and bletilla striata, 0.05-0.1 part of trichlorogalactose, 1-2 parts of sodium benzoate, 210-220 parts of sorbitol, 9-10 parts of polyethylene glycol-4009, 1.8-2 parts of titanium dioxide, 0.9-1 part of carrageenan, 4-5 parts of carboxymethyl cellulose, 0.5-0.7 part of xanthan gum, 34-36 parts of silica H type, 33-37 parts of silica MIV type, 38-42 parts of silica MIG type, 9-11 parts of sodium dodecyl sulfate, 5-6 parts of essence and 125-130 parts of water.
6. The traditional Chinese medicine toothpaste according to claim 5, which comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 10 parts of south African leaves, liquorice and bletilla striata, 0.05 part of trichlorogalactose, 1.5 parts of sodium benzoate, 215 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts of titanium dioxide, 2 parts of carrageenan, 5 parts of carboxymethyl cellulose, 0.5 part of xanthan gum, 35 parts of silica H type, 35 parts of silica MIV type, 40 parts of silica MIG type, 10 parts of sodium dodecyl sulfate, 6 parts of essence and 128.95 parts of water.
7. A method for preparing the Chinese medicinal toothpaste as claimed in any one of claims 3 to 6 for reducing gingival inflammation and gingival bleeding, comprising the steps of:
s1, preparing traditional Chinese medicine extracts from the south African leaves, the liquorice and the bletilla striata according to the formula amount;
s2, taking sodium benzoate and trichlorogalactose according to the formula amount, and dissolving in 1/5 water until complete dissolution to obtain an anti-corrosion solution;
s3, mixing the sorbitol with the traditional Chinese medicine extract obtained in S1 and the preservative solution obtained in S2, and dissolving in the rest water;
s4, dissolving the carrageenan, the carboxymethyl cellulose and the xanthan gum in the formula amount in polyethylene glycol-400, uniformly stirring, pouring into the solution obtained in the step S3, and uniformly mixing to obtain glue;
s5, mixing and stirring titanium dioxide, silicon dioxide H type, silicon dioxide MIV type, silicon dioxide MIG type and sodium dodecyl sulfate with the glue obtained in the step S4 for 30-40min, adding essence with the formula amount, continuously stirring for 8-12min, and continuously stirring to obtain paste;
and S6, subpackaging the paste obtained in the step S5.
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| CN201910740743.5A CN110327276B (en) | 2019-08-12 | 2019-08-12 | Traditional Chinese medicine toothpaste and preparation method thereof |
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| CN110327276B true CN110327276B (en) | 2020-08-07 |
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| CN110693808A (en) * | 2019-11-20 | 2020-01-17 | 高利军 | Toothpaste and preparation method thereof |
| CN112972355A (en) * | 2021-02-27 | 2021-06-18 | 厦门力嘉诚生物科技有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN115025030A (en) * | 2022-07-12 | 2022-09-09 | 苏州清馨健康科技有限公司 | Chinese herbal medicine toothpaste for treating gingival inflammation and preparation method thereof |
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| CN108522758A (en) * | 2018-05-30 | 2018-09-14 | 大连民族大学 | A kind of tea beverage in nursing oral cavity |
| CN109077981A (en) * | 2018-11-01 | 2018-12-25 | 贵州苗老藤生物养生有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108522758A (en) * | 2018-05-30 | 2018-09-14 | 大连民族大学 | A kind of tea beverage in nursing oral cavity |
| CN109077981A (en) * | 2018-11-01 | 2018-12-25 | 贵州苗老藤生物养生有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof |
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