JP2018039766A - Composition having hair loss prevention function or hair growth function using natural materials - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide compositions which have hair loss prevention function or hair growth function and contains a fermented solution obtained by fermenting a mixture of Houttuynia cordata, Perilla frutescens leaf, and green tea leaf which are natural materials, and to provide production methods thereof.SOLUTION: The present invention relates to a composition having hair loss prevention function or hair growth function using natural materials. According to the invention, by providing a composition which has hair loss prevention function or hair growth function and which contains a fermented solution obtained by fermenting a mixture in which Houttuynia cordata, Perilla frutescens leaf, and green tea leaf are mixed, and a production method thereof, as well as a pharmaceutical composition which has hair loss prevention function or hair growth function and which contains the composition as an active ingredient, this can be utilized for various pharmaceuticals and health functional foods which have hair loss prevention function or hair growth function, and has no side effects because of using natural materials, having excellent effect on hair loss prevention function or hair growth function.SELECTED DRAWING: Figure 1

Description

The present invention relates to a composition having a hair loss prevention or hair growth function using a natural material, and more specifically, hair removal comprising a fermentation liquid obtained by fermenting a mixture of fish salmon grass, shiso leaves and green tea leaves. The present invention relates to a composition having a prevention or hair growth function, a method for producing the same, and a pharmaceutical composition having a hair loss prevention or hair growth function comprising the composition as an active ingredient.

Hair is one of the main body parts derived from the cell layer outside the skin and is treated as an accessory structure of the outer skin along with sebaceous glands, sweat glands and nails. Hair is also known as a husk derivative because it is derived from the husk during developmental growth. Hair is important in the overall appearance of the human body, and despite the development of several medical therapies, many people are currently struggling with hair loss or hair weakening.

Causes of hair loss include male hormone overactivity theory, excessive sebum secretion theory, poor blood circulation theory, hypothesis of hyposcalp function due to peroxides and bacteria, hypothesis of collagen production in hair papilla, genetic factors, aging and stress Etc. have been discussed. However, the clear cause for hair loss has not been clarified until now, and recently, the hair loss population has increased due to changes in dietary habits and increased stress due to social environment, etc., and the age has also decreased. It is a fact that the hair loss population of women is also increasing.

Conventionally, in order to treat or prevent hair loss, there are blood circulation promotion, hair root function enhancement, scalp moisturizing methods, etc., and commercialized drugs include preparations and blood pressure based on female hormones for male hormone suppression Although it is a hypertension drug that regulates the skin, minoxidil, which was developed with a focus on the side effects of hair growth in patients taking it, is sold, but there are side effects such as loss of vigor and it is effective when discontinued However, there is a disadvantage that it does not last and returns to the state before use, and there is no obvious effect.

Accordingly, there is a need for development of therapeutic methods and pharmaceutical compositions for preventing hair loss, hair growth and hair growth, utilizing ingredients derived from natural materials and having no side effects.

As related prior art, Korean Patent No. 10-0800359 (Composition showing hair loss prevention and hair growth promoting effect) of Patent Document 1 and Korean Registered Patent No. 10-0773457 (Growth Promotion) of Patent Document 2 Effective compositions and methods for using the same).

Korean Registered Patent No. 10-0800359 Korean Registered Patent No. 10-0773457

An object of the present invention is to solve the above-mentioned problems of the prior art, and is intended to prevent or prevent hair loss including a fermented liquor obtained by fermenting a mixture of natural fish stocks, shiso leaves and green tea leaves. It is providing the composition which has a hair function, and its manufacturing method.

Another object of the present invention is to provide a pharmaceutical composition having a hair loss prevention or hair growth function comprising the composition having the hair loss prevention or hair growth function as an active ingredient.

In order to achieve the above object, the present inventor conducted extensive research on a composition derived from a natural material having hair loss prevention or hair growth function. It is confirmed that the composition containing the fermented solution of the triple complex enzyme obtained after secondary fermentation with alcohol is effective in preventing hair loss or the hair growth function. It has been experimentally confirmed that there is an excellent effect of relaxing, and the present invention has been completed.

In the seborrheic alopecia, which has a strong antibacterial and anti-inflammatory effect, and is caused by malassezia yeast and staphylococci, the symptoms are exacerbated. There is an effect to remarkably suppress two fungi, and Shiso leaves contain not only minerals but also vitamins B1, B2, B6, vitamin C, vitamin E, vitamin K, niacin, and cholesterol in the body. It is rich in calcium, potassium, iron, magnesium, zinc and the like containing α-linolene that decomposes, and contains almost all coenzyme components necessary for the human body. In addition, perylaldehyde and β-carotene contained in Shiso leaves are not only useful for strong antibacterial and antioxidant effects, but also pitochemical simultaneously activates hair follicle cells and prevents aging. Optimal synergies can be achieved in alleviating seborrheic alopecia and male pattern alopecia. Finally, the green tea leaves contain a component called polyphenols and achieve a triple combination of antioxidant, anti-flame and anti-DHT effects with the fish licorice and shiso leaves.

In addition, this invention provides the composition which has the hair loss prevention or hair growth function containing the fermented liquor obtained by fermenting the mixture which mixed the fish salmon grass, Shiso leaves, and green tea leaves.

The mixture is prepared by mixing fish licorice, shiso leaves and green tea leaves in a weight ratio of 5 to 6: 1.5 to 3: 1.5 to 2, respectively.

The fermented liquid is fermented using koji and sake as fermenting agents.

Moreover, the pharmaceutical composition which has the hair loss prevention or hair growth function which contains the said composition as an active ingredient is provided.

In addition, the present invention includes (1) a step of adding a fermenting agent to a mixture of fish licorice, shiso leaves and green tea leaves, and leaving the mixture; (2) after proceeding the fermentation process according to step (1), A step of adding alcohol; (3) a step of fermenting and aging at a temperature of 15 to 25 ° C. after the alcohol is added in step (2); and (4) fermentation and aging in step (3). And a step of filtering the fermentation broth obtained later.

In the step (1), a fish mixture, a shiso leaf, and a green tea leaf are mixed at a weight ratio of 5-6: 1.5-3: 1.5-2, respectively, to produce a mixture.

In the step (1), the fermenting agent is koji.

In the step (3), fermentation and aging are performed under a temperature condition of 15 to 25 ° C. and a relative humidity condition of 50 to 60%.

Moreover, the pharmaceutical composition which has the hair loss prevention or hair growth function which contains the composition manufactured by the said manufacturing method as an active ingredient is provided.

According to the present invention, a composition comprising a fermented liquor obtained by fermenting a mixture of natural fish stocks, shiso leaves and green tea leaves, a method for producing the same, and a pharmaceutical composition comprising the composition as an active ingredient It uses natural materials and has not only side effects, but also has an excellent effect of preventing hair loss or promoting hair growth.

FIG. 1 is a photograph showing the appearance of new hair and increased density of scalp hair after using a pharmaceutical composition according to the present invention. FIG. 2 is a photograph showing how the scalp inflammation was resolved after using the pharmaceutical composition according to the present invention. FIG. 3 is a photograph showing that new hair is expressed from the hair follicle after using the pharmaceutical composition according to the present invention.

Hereinafter, the present invention will be described in more detail through examples. These examples are intended to illustrate the present invention, and it is obvious to those skilled in the art that the scope of the present invention is not construed as being limited by these examples.

Example 1
A 10 L ripening container for fermentation was washed with purified water and prepared by sterilization. The medicinal material for fermentation was put into this as follows. Fish carp grass should be carefully cared for fresh leaves that are not dried, then cut to a length of about 1 cm in the length direction of the leaves, and when the cut surface is pressed with a finger, it is sufficient until a clear mucous liquid is produced. After waiting, it was put into a fermentation vessel. On the other hand, Shiso leaves and green tea leaves were used after being dried finely. The weight ratio of fish cucumber grass, shiso leaves and green tea leaves is set to a ratio of 5: 3: 2 in the fermentation vessel, and a total of 500 g of 250 g, 150 g, and 100 g is added, and 10.0 g of koji is added to the fermentation vessel. The mixture was mixed together with 3 kinds of herbal materials and mixed well, and then sealed with a stopper. This was left as it was for 2 days, then the fermentation vessel was opened, and 8.0 L of 30% alcohol was gradually poured into it. The fermentation vessel was shaken slowly so that each material was well mixed, and then sealed with a stopper. Thus, the fermentation vessel filled with all the materials was sealed and fermented for 6 months in a room where the storage temperature was maintained at 20 ° C. and outside and the relative humidity was maintained at 55% inside and outside, and where there was no direct sunlight. The fermentation vessel, which was sealed about once a week during the fermentation period, was rolled for 10 minutes so that the cut koji and herbal material and alcohol could mix well with each other. Six months later, the fermentation vessel was opened, and the residue and liquid of the crude drug material were sieved to obtain a fermentation broth, which was filtered with a membrane filter made of silver (Sliver membrane filter, Maker: Cole-Parmer, USA). did. Finally, it was fermented and matured with a mixture of fish licorice, shiso leaves and green tea leaves to obtain 7.8 L of a fermentation broth.

Example 2
In Example 1, the total weight of herbal medicine 800 g and 30% sake spirit 7.5 L are used as 560 g, 120 g, and 120 g, where the weight ratio of fish licorice, shiso leaves and green tea leaves is 7: 1.5: 1.5. In the same manner as in Example 1, except that the fermentation period was 4 months, finally, 7.2 L of a triple complex enzyme fermentation broth of a mixture of fish licorice, shiso leaves and green tea leaves was obtained. .

Example 3
In Example 1, the input weight ratio of fish licorice to Shiso leaves and green tea leaves was 6: 2: 2 in a ratio of 300 g, 100 g, 100 g, 400 g in total, and 15.0 v / v% ethanol was mixed with purified water. Except that 8.0 L of the solution was put into a fermentation vessel and the fermentation period was 3 months, the same as in Example 1, and finally a triple complex enzyme fermentation of a mixture of fish licorice, shiso leaves and green tea leaves 7.8 L of liquid was obtained. This was put into a 20 L rotary vacuum evaporator (Rotary Evaporator, Maker: DOOYOUNG HI-TEC, Korea) and distilled under reduced pressure at an evaporator temperature of 60 ° C. and a pressure of 30 mmHg. And 4.0 L of triple complex enzyme fermentation concentrate of the mixture of green tea leaves was obtained.

Example 4
A liquid type pharmacological composition containing a triple complex enzyme fermentation broth of a mixture of fish licorice, shiso leaves and green tea leaves obtained in Example 1 was prepared as shown in Table 1 below. In the production method, the No. 3 raw material in Table 1 was put into No. 1 purified water and stirred sufficiently so as to dissolve, and then stirred while gradually adding the triple complex enzyme fermentation broth obtained in Example 1 above. . Finally, a pale brown liquid type pharmaceutical composition was obtained.

Experimental example 1
The pharmaceutical composition produced in Example 4 was stored in a 100 mL brown glass bottle with a spoid attached to the lid. After seeking prior consent from 50 patients who were hospitalized for hair loss treatment, take a certain amount of the pharmaceutical composition of Example 4 in the morning and evening (or before going to bed) every day for 3 months. It was made to apply uniformly to the entire hair loss site. However, detailed information on the pharmaceutical composition of Example 4 was not provided to the patient in advance, and was explained to all after the test evaluation. The results after applying the pharmaceutical composition of Example 4 of the present invention for 3 months are summarized in Table 2 below, and photographs showing the changes are shown in FIG. 1, FIG. 2 and FIG. In the evaluation method, the general satisfaction is evaluated by conducting an inquiry and visual observation, and the development of new hair is photographed and compared with a digital camera for the hair loss site, and the hair loss change of the scalp is measured by an endoscopic microscope (Microscope, Model). : Olympus Bx-50 / BX-40, Japan) and compared. The decrease in scalp inflammation was determined by visual observation and observation with an endoscopic microscope, and changes in the thickness and tonicity of the scalp were determined by interview and tactile sensation. Changes in symptoms associated with hair loss were evaluated in three stages (no change → slightly improved → greatly improved), and the values displayed for each applicable item responded “Yes” among the 50 patients who participated in the evaluation. The number of patients who were shown.

The results shown in Table 2 showed remarkable effects in the development of new hair and the reduction or improvement of inflammation of the scalp, and excellent effects in improving the thickness and tonicity of scalp. Therefore, the effect of improving overall hair loss symptoms was evident and all patients who participated in the study evaluation were satisfied.

1, 2, and 3 show photographs taken by a digital camera and an endoscope microscope of changes before and after the test evaluation of the participants who participated in the test evaluation. As is clear from FIG. 1, it was found that new hair was expressed in the entire brain top area of the hair loss patient, and the density of the hair was increased. FIG. 2 shows changes in scalp inflammation, which is a typical symptom of hair loss. As can be seen from the photograph, inflammation of the scalp exists in the form of a product and erythema before evaluation, but after 3 months of applying the liquid type pharmacological composition of Example 4 of the present invention, the inflammation It was confirmed that disappeared. FIG. 3 is a photograph showing that new hair is expressed from the hair follicle after applying the liquid type pharmacological composition produced in Example 4 of the present invention for 3 months. That is, the photograph in FIG. 3 shows that new hair roots are formed from the hair follicle and new hair is expressed.

Example 5 and Comparative Example 1
In order to confirm the difference between the pharmaceutical composition containing the triple complex enzyme fermentation broth of the mixture of fish licorice, shiso leaves and green tea leaves obtained in Example 1, and a conventional composition, a shampoo was prepared. The manufacturing method is to stir while heating to a temperature of about 40 ° C. by putting raw materials from No. 3 to No. 6 and No. 9 to No. 11 into about 1/2 of the purified water of No. 1 in Table 3 in advance. Fully dissolved. Next, the remaining one of the first purified water and the remaining raw materials were added thereto and dissolved while stirring. However, the 2nd product obtained in Example 1 of the present invention was put at the end and stirred slowly to produce a shampoo.

Experimental example 2
Forty test subjects with hair loss symptoms were randomly divided into two groups of 20 people, and the shampoos produced in Example 5 and Comparative Example 1 were used for 3 months. At this time, the information about each shampoo used was provided without knowing.

Three months after using each provided shampoo, the condition of the hair and scalp of all test subjects who participated in the study was observed. The degree of alleviation of the hair loss symptoms and the degree of improvement of hair and scalp conditions were evaluated on a 5-point scale. The evaluation scale is “1 point: worse. 2 points: no change. 3 points: slightly better. 4 points: better. 5 points: very good”. The numerical value is an average value of the scores of responders. The results are shown in Table 4 below.

According to the results in Table 4 above, the majority of test subjects who used the shampoo of Example 5 of the present invention responded that there was a marked reduction or improvement in hair loss symptoms, while the comparison was a conventional shampoo. Most of the subjects who used the shampoo of Example 1 did not feel any relief or improvement of hair loss symptoms, but rather responded that it was worse or unchanged. From these results, it was found that the shampoo containing the triple complex enzyme fermentation broth of the present invention clearly has an effect of alleviating or improving hair loss symptoms.

As described above, the specific part of the contents of the present invention has been described in detail. For those who have ordinary knowledge in the art, such a specific technique is merely a preferred embodiment, and the scope of the present invention is thereby limited. Obviously, it is not limited. Accordingly, the substantial scope of the present invention is defined by the appended claims and their equivalents.

Claims (9)

A composition having a hair loss prevention or hair growth function, comprising a fermented liquid obtained by fermenting a mixture of fish salmon grass, shiso leaves and green tea leaves. The mixture according to claim 1, wherein the mixture is prepared by mixing fish salmon grass, shiso leaves, and green tea leaves in a weight ratio of 5-6: 1.5-3: 1.5-2. A composition having a hair loss prevention or hair growth function. The composition having a hair loss prevention or hair growth function according to claim 1, wherein the fermented liquid is fermented using koji and sake spirit as fermenting agents. A pharmaceutical composition having a hair loss prevention or hair growth function comprising the composition according to any one of claims 1 to 3 as an active ingredient. (1) adding a fermenting agent to a mixture of fish salmon grass, shiso leaves and green tea leaves;
(2) after the fermentation process according to the step (1) proceeds, the step of adding alcohol;
(3) after the alcohol is added in the step (2), fermenting and aging at a temperature of 15 to 25 ° C;
(4) A method for producing a composition having a hair loss prevention or hair growth function, comprising: filtering the fermentation broth obtained after fermentation and aging in the step (3). In the step (1), a mixture is prepared by mixing fish licorice, shiso leaves, and green tea leaves in a weight ratio of 5-6: 1.5-3: 1.5-2, respectively. Item 6. A method for producing a composition having hair loss prevention or hair growth function according to Item 5. The method for producing a composition having hair loss prevention or hair growth function according to claim 5, wherein in the step (1), the fermenting agent is cocoon. The composition having a hair loss prevention or hair growth function according to claim 5, wherein in the step (3), the composition is fermented and matured at a temperature of 15 to 25 ° C and a relative humidity of 50 to 60%. Production method. A pharmaceutical composition having a hair loss prevention or hair growth function, comprising as an active ingredient the composition produced by the production method according to claim 5.