KR20110130555A - Cream manufacturing process for the prevention of atopic dermatitis and improve - Google Patents

Abstract

PURPOSE: A method for manufacturing a cream containing extract of bamboo leaf and Glycyrrhizae radix is provided to ensure antibactiral, antifungal, and anti-inflammatory effect and to relieve skin dryness and eczema without side effect. CONSTITUTION: A method for manufacturing a cream for preventing and treating atopic dermatitis comprises: a step of mixing 200g of bamboo leaves, 200g of Lithospermum erythrohizon S. et Z., 200g of Japanese elm, and 400g of Glycyrrhizae radix with purified water, ethanol, propanol, and butanol; a step of extracting the mixture at room temperature to 100°C for three hours to isolated crude drug ingredients; a step of pressing, filtering, heating, and vacuum-concentrating; a step of adding 0.1-5wt% of methylsulfonylmethane(MSM) to the solution at room temperature. The cream is manufactured in the form of liquid, spray, lotion, cream, and ointment.

Description

Cream manufacturing process for the prevention of atopic dermatitis and improve}

The present invention relates to a method for preparing a cream for preventing and improving atopic skin.

The present invention relates to a method for producing and preventing atopic dermatitis creams by adding methylsulfonylmethane as an active ingredient to extracts of bamboo leaves, ferns, elm, and licorice. The cream of the present invention is antibacterial, antifungal, free radical It has scavenging, anti-inflammatory and moisturizing effects, improves skin dryness and eczema that is characteristic of atopic skin, treats and prevents secondary infections including atopic dermatitis without side effects, and effectively relieves itching.

Atopy, a word from the Latin Atopia, has an odd meaning (Odd) and is a constitution that is prone to hypersensitivity. Atopy causes a series of allergic symptoms in the skin and respiratory mucosa, eye mucosa and intestinal mucosa in individuals with atopic inducers. People with atopic inducers often have urticaria reactions in skin tests for protein substances commonly encountered in the outside environment, such as house dust, mites, animal hair, food, pollen, and mold. Symptoms include itching, skin attacks, hives, angioedema, sneezing, runny nose, stuffy nose, conjunctival hyperemia and tearing. These atopy triggers are inherited and appear to be family. Allergic diseases caused by atopic inducers include atopic dermatitis, allergic rhinitis, asthma, allergic conjunctivitis, allergic enteritis, and atopic urticaria. These diseases are caused by genetic factors, environment, and age of each patient. It may appear alone or in combination. Among them, atopic dermatitis is a representative allergic skin disease in people with atopic allergy.

In the mechanism of allergy to atopy, when allergens invade through the stratum corneum and reach the epidermal cells, macrophage (macrophage), a type of white blood cell, eats it and breaks it down. If the macrophages cannot handle all of the large amounts of allergens that have invaded them, they send information about the presence of allergens that could not be processed to T cells, a kind of white blood cells. T cells transmit the information back to eosinophils, a type of white blood cells, which bring eosinophils, which are widely distributed in the blood, to the place where allergens invade. At this time, the eosinophils accumulated in the affected area cause inflammation due to excessive release of chemical transport material.

Usually, atopic dermatitis begins with infant eczema, commonly referred to as febrile fever, and itchy skin during the acute phase, with reddening, swelling, millet-like growth, small blisters, moist scabs, and itching in the chronic phase, The skin may become hard, thick, thin, or may have scales such as rice powder sitting or darkening or whitening.

Among the currently used therapeutic drugs, steroids have excellent effects on anti-inflammatory and immunosuppressive effects. However, one thing to watch out for is the side effects of steroids. Long-term application can cause hair to shine on the skin, shrink the skin, reduce skin pigments, cause bacterial infections, acne, thin skin, and uneven skin. In severe cases, hormonal systemic symptoms may occur and stop using the drug, and the symptoms may explode again. Also, systemic administration of the adrenal cortex is not recommended because the development of atopic dermatitis is common in infants before the age of five. Therefore, steroid ointments with very low hormone levels should be used only when necessary for a short period of time, and should be applied frequently instead of applying large amounts at once.

Antihistamines can be used as a temporary measure to relieve itching by preventing histamine from being released from mast cells.

Atopic dermatitis is more scary than secondary bacterial infections caused by itching and scratching. The skin of atopic patients is accompanied by bacterial infection as a result of prolonged scraping and drying. More than 90% of atopic patients are infected with Staphylococcus aureus, which is caused by scratching the patient's unbearable itching, and recent reports suggest that the toxins in these bacteria stimulate the body's immune system and cause allergies. It is said to make atopic dermatitis worse. In other words, the bacteria themselves act as allergens. Therefore, the use of appropriate antibiotics is essential for the treatment of atopy.

In addition, there are nonsteroidal ointments for drug treatment. This is a type of moisturizer, which is applied at night to moisturize and then wrap it with a wrap. Moisturizing is an important part of the management of atopic dermatitis because dry skin, which is one of the symptoms of atopic dermatitis, tends to cause itching and eczema and is a factor of recurrence and exacerbation of atopic dermatitis.

In addition, sedatives or neurostabilizers may be used to calm the patient.

In view of the characteristics of these atopy, it is understood that the development of a substance having no side effects while providing antibacterial, moisturizing, anti-inflammatory, free radical scavenging and antioxidant effects as essential items of the atopy treatment.

The present inventors have overcome the disadvantages of the raw material having a healing effect of conventional atopic skin and added methyl sulfonyl methane as an active ingredient to extracts of bamboo leaves, chichi, elm, licorice, which have excellent efficacy in improving atopic skin. Atopic skin prevention and improvement creams have excellent antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effects, which improves atopic skin and, in particular, a more appropriate ratio than using each single extract alone By confirming that the combined extract used to further increase the effect when using, to complete the present invention can effectively improve atopic skin without side effects.

As described above, the present invention relates to a method for producing and preventing atopic dermatitis creams by adding methylsulfonylmethane as an active ingredient of extracts of bamboo leaves, ferns, elm and licorice. It has the effect of free radical scavenging, anti-inflammatory and moisturizing, improves skin dryness and eczema that is characteristic of atopic skin, treats and prevents secondary infections including atopic dermatitis without side effects, and effectively improves itching.

1 is a preparation of the cream using the effective extract component completed in Example 1.
Figure 2 shows the state after 30 days of use as a cream prepared by the prescription of Example 1

The present invention relates to a method for producing and preventing atopic dermatitis creams by adding methylsulfonylmethane as an active ingredient to extracts of bamboo leaves, ferns, elm, and licorice. The cream of the present invention is antibacterial, antifungal, free radical It has scavenging, anti-inflammatory and moisturizing effects, improves skin dryness and eczema characteristic of atopic skin, treats and prevents secondary infections including atopic dermatitis without side effects, and effectively alleviates itching.

Bamboo leaves are said to have been effective in relieving, reminding, tumoring, and fevering in the ancient literature <Shin Bong Bok-Kyung>, and in <Consent Bogam>, it is said to be effective in stroke and mental and mental stability. It has been used for a long time in oriental medicine, and has been used especially for the treatment of inflammation. It has also been used as a folk remedy in China and Japan.

Bamboo leaf extract with a bamboo with such efficacy (Bamboo Grass Extract) are various amino acids by using a bamboo leaf grown in the uncontaminated area (aspartic acid, pro, etc.), vitamins (vitamin B _1, B _2, B ₆ , B ₁₂ , Vitamin C, K ₁ ) and many more minerals (calcium, potassium, magnesium, etc.).

In general, the bamboo leaf extract is known to be rich in antioxidants and contains a large amount of polyphenols and is a natural raw material that is in the spotlight as a raw material of cosmetics. It is listed in CTFA as a raw material for cosmetics.

Weary is a familiar plant with our ants because we get purple from its roots. Our ancestors have been fond of dye crops, along with safflowers, yellow and red paints, and blue paints. Tired is perennial grass called by various names such as weed, sedge, bleeding, rot, cock. It flies on sunny meadows in mountains and fields all over Korea. It was common in the fields before, but nowadays it is so rare to find it in deep mountains. The thick purple roots grow by digging into the ground like screws, the longer the older the purple is, the denser the dense hairs are, and the leaves turn to lanceolate lanceolate. Flowers bloom white from May to June and July to August, and the seeds run white after flowering.

Weary is weak. It's great for lowering heat, detoxifying, eliminating inflammation and boosting new life. It is effective in various cancers, constipation, liver disease, arteriosclerosis, coldness in women, lobster, and menstrual irregularities, and when used for a long time, the face gets better and does not get old. In China, it is used as a medicine for cancer. Tongue cancer, stomach cancer, thyroid cancer, uterine cancer, skin cancer is said to have a significant effect by taking a combination of tired and crow weight. North Korea is also tired of treating cancer and leukemia.

Strong anticoagulant action, anti-inflammatory, antiseptic action to dissolve cancer cells to get rid of new flesh. Weary is a herb that grows under the negative energy of the sky and earth, so it grows a lot like a woman's womb. A weary herb is a mystical herb like the auspicious purple color.

Tired is also excellent detoxification effect. Feeding people with various drug addictions, antibiotic addictions, heavy metal poisonings, pesticide poisonings, and alcohol poisonings will release the poison quickly.

Strong cardiac effect is excellent for people who are surprised, heart disease is also effective, and patients with pernicious anemia can be cured by drying the powder and eating it for about 6 months.

Elm peels and chews with a mouthful of sticky mucus, which is a good medicine to treat various boils and swelling. For medicine, the elm root bark is used. Peel the root bark in the early pattern and dry it in the shade. Drying usually results in yellowing of the skin. Elm has long been used as a diuretic and boil medicine.

The hungry enemy peeled the skin, ate the leaves and ate it, and soaked it with alcohol or intestines. Elm is a tree that grows under the sound of heaven and earth, so when harvesting or drying the root bark, the effect drops to less than half.

Therefore, at dawn before sunrise, the root bark should be taken and dried in the shade and used as medicine. It is also much more effective to write day than moon.

Elm is a medicine tree that has a mysterious effect on boils and swelling because it is very strong in sucking pus and raising new flesh. If you put the same amount of rosin and elm root bark on the swelling or boil, crush it together to make water.

Elm root bark has excellent effects on various ulcers such as gastric ulcer, duodenal ulcer, small intestine ulcer, and colon ulcer, and is also effective for edema or species. It is also used to treat stomach cancer and rectal cancer, and even if you eat it for a long time, there are no side effects. Stomach, duodenum, small intestine, colon ulcer mixed with elm root bark powder and Yulmu powder in a ratio of 3: 2 and made with Shiru-teok or noodles to taste and treat. Stomach cancer, kkujimi tree, elm root bark and arrow tree together to drink the water, and rectal cancer or uterine cancer is often enema with water to the elm root bark. If urine does not come out well, mix 40g each of the elm root bark and corn mustard, pour water and sweeten, squeeze the dregs away and drink the water. When there is edema, pour about 1 liter of water into 40 g of finely chopped elm bark, squeeze out the residue, and eat the water and the rice cake in an empty bowl. This is the amount you will eat per day. For sinusitis or rhinitis, mix the decoction of the elm root bark with water and bamboo salt in a 3: 1 ratio, then pour it into the cotton wool before immersion. It is painful and painful at first, but usually heals for one to two months. Soaking the elm root bark in water creates a lot of sticky gin, which is eaten or applied to the skin. When bamboo salt is mixed and applied to the skin, it has a mysterious effect in treating various skin diseases and making the skin beautiful and smooth. Elm leaves are also used as medicine. Insomnia disappears when boiling soup with young shoots sprouting in spring. Elm leaves are natural sleeping pills that have no side effects.

Licorice As the word "Licorice in the drugstore" licorice is an essential medicine among many herbs. Licorice not only sweetens bitter medicine to make it easy to eat, but also has its unique weakness. It relieves all medicines, coughs and coughs, and neutralizes all medicines. In the agreement, "Licorice controls the heat and fraud of chapter 5 and 6, normalizes the physiology of the eyes, nose, ears, and faeces, communicates all blood veins, strengthens muscles and bones, and improves nutrition. As well as detoxifying the toxicity of all medicines and 72 kinds of stone (石 藥) and 1200 kinds of herbs (草藥) harmonize with each other to make the drug appear well, so the nickname is called Kukno (國 老). " The national road means the elder of the country, and licorice means the elder in medicine.

In the present invention, methyl sulfonyl methane, which is added to the liquid extracted from the above substances, is a substance containing sulfur and has been applied to the treatment of human diseases earlier.

Methylsulfonylmethane (MSM), according to Huh Jun's agreement, "Sulfur is a lot of heat and toxic, but it helps drive the cold air in the body to help yangyang Yang (한편) and heart beat (心腹) ), And sulfur controls solstice and fraud. And, according to the Chinese classical literature, sulfur is known as the 'a great medicine' of the world. As the main ingredient of the forbidden tree, it is the predecessor of the Bul-Jong-Sang, and the old man can be said to be a 'rejuvenation potion' that the youth will be regained. In addition, it is known to be excellent in detoxification (heavy metals, pesticides, other chemical poisons, etc.) that are currently emerging as a cause of cancer and various incurable diseases.

In our country, sulfur has been used mainly as a dermatitis prescription. In Chinese intentions, there is a prescription that sulfur and alum, garlic, nostalgia, zinc oxide, vinegar, etc. are mixed at an appropriate ratio and applied to the affected area for better ringworm.

Biochemically examining the bactericidal action of sulfur, sulfur is applied to the skin to form organic pentathiate (HO-SO2-S3-SO2-OH). This substance dissolves the dead skin cells and acts as an insecticide. Therefore, sulfur is a non-toxic, odorless supply of sulfur element to reduce inflammation, and sterilization power is so strong that when taken by the surgical patient, the pain is not added, the surgical marks do not add the new life quickly.

Carriers that can be used for formulation in the atopic skin prevention and improvement cream preparation method of the present invention are conventionally pharmaceutically acceptable, for example, by adding a base, excipients, lubricants, wetting agents, preservatives, etc. It may be made into a formulation such as a lotion, cream, ointment.

The preparation according to the present invention has the advantage of very convenient in its use in the form of external preparations and is preferably applied to the skin atopic dermatitis 1 to 2 or more times, 1 to 3ml once a day.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the present invention is not limited by the embodiment.

<Example 1>

1. Extraction of herbal ingredients using purified water as solvent.

After removing the foreign matter, 200 g of dried bamboo leaves, 200 g of zigzag, 200 g of elm and 400 g of licorice were put in 3 L of purified water and extracted by heating at 100 ° C. for 5 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 15 days and finally filtered through a 0.3 μm filter to complete 1 L of herbal extract.

2. Methylsulfonylmethane (MSM) was added to the herbal extract using purified water as a solvent.

50 g of methylsulfonylmethane (MSM) is added to the 1 L solution extracted by the above method at room temperature, followed by stirring to complete the active ingredient extract of the cream for prevention and improvement of atopic skin of the present invention.

<Example 2>

1. Using the active ingredient extract completed in Example 1, a cream was prepared according to the prescription shown in FIG.

2. After heating the oily component and the aqueous component shown in Fig. 1 to a constant temperature, the emulsion was emulsified using a homogenizer mixer (homogenizer) in a cream manufacturing mixer and then degassed, filtered and cooled to prepare a cream.

(Figure 1) Preparation of Cream Preparation

<Comparative Example 1>

In order to evaluate the improvement effect on the atopic dermatitis of the cream prepared by the FIG. 1 prescription, a clinical trial was conducted on 30 children 10 years old or younger with atopic skin. As shown in FIG. 2 below, the test results of twice daily use for 30 days showed 24 out of 30 children whose symptoms of atopic dermatitis were improved in a very good or good condition. In addition, no long-term side effects were observed in the long-term use of the atopic dermatitis cream of the present invention.

(Figure 2)

Claims (2)

After removing the foreign matter, 200 g of bamboo leaves dried in the shade, 200 g of jichi, 200 g of elm and 400 g of licorice were added purified water, ethanol, propanol and butanol 2 to 5 times by weight, followed by 3 hours at room temperature to 100 ° C. Effective extraction of atopic dermatitis preventive and improvement, characterized in that after the extraction of the herbal ingredients, 0.1 to 5% by weight of methylsulfonyl methane (MSM) at room temperature was added to the extracted solution by compression filtration heating and vacuum concentration. Ingredient Extract. The cream for preventing and improving atopy skin prepared by the active ingredient extracted according to claim 1.

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