KR20190047750A - A composition comprising a herbal fermentation extract having excellent skin stability and preventing and improving acne lesion - Google Patents

Abstract

The present invention relates to a composition having an effect of preventing and ameliorating symptoms of skin troubles such as acne with an optimal combination of an antibacterial, antioxidant, detoxifying effects, skin regeneration, blood circulation, capillary dilation, supply of nutrients such as vitamins and minerals, and various bacterial elimination effects of an herbal fermentation extract, and components having an excellent effect on skin care.

Description

[0001] The present invention relates to a composition containing a herbal fermentation extract having excellent skin stability and preventing and improving acne lesion,

The present invention relates to an antibacterial, antioxidant, detoxifying, skin regeneration, blood circulation, capillary expansion, supply of nutrients such as vitamins and minerals, It contains an herbal extract which has excellent effect of preventing and improving the symptom of skin troubles such as acne, and which is excellent in skin stability with few side effects due to long-term use, ≪ / RTI >

Acne refers to a chronic, intractable, inflammatory skin disease that occurs in hair follicles and sebaceous glands. Such acne is generally caused by excess sebum secretion and anaerobic skin bacteria, such as Propionibacterium Acnes is known to be responsible for the inflammatory response of various low molecular weight substances, such as free fatty acids, produced by lipase.

Most of the acne that occurs after puberty is caused by the excessive secretion of sebum due to the increase of sex hormone estrogen, which induces stenosis of the hair follicle.

In other words, sebum is different from skin epidermis because its lipid composition is oxidized well and it is mainly used as an energy source of acne bacterium. Therefore, it becomes the first factor to cause acne when it is increased.

In addition, acne is an anaerobic bacterium that does not multiply when the hair follicle is open. As the sebum increases and the hair keratinization progresses, the hair follicle entrance becomes clogged, causing comedones, an early lesion of acne, and overgrowth of acne bacteria.

Increased acne bacteria metabolize sebaceous lipids to produce various fatty acids which are stimulating sources. Acne bacteria are recognized as antigens and stimulate the immune response in the body to cause an inflammatory reaction.

When the papules and inflammatory acne lesions deteriorate, the hair follicles are destroyed and the tissues are damaged, resulting in cysts and pustules.

As a result, medicines in the form of oral or topical agents are currently being used to treat such acne.

That is, anti-androgens that inhibit sebum production, nonsteroidal anti-inflammatory agents that act as anti-inflammatory agents, antibiotics such as resorcinol, sulfur, benzoyl peroxide, isotretinoin, and antimicrobials such as keratolytic agents, tetracycline, erythromycin, A method for inhibiting the activity of propionibacterium acnes by the above-mentioned method is used.

However, although these methods have achieved some success in the treatment of acne, they have some problems in terms of side effects.

In other words, the use of hormones has been reported to inhibit the growth of the epidermis and other side effects of hormone abuse. Retinoic acid and benzoyl peroxide, such as keratolytic agents, There is a concern about contact dermatitis. Antibiotics such as tetracycline have been known to exhibit resistance and photosensitizing function.

Therefore, there is a growing interest in the development of a product that is safe and effective for the human body since it has no side effects on acne skin.

Korean Patent Publication No. 10-2017-0061805 (published Jul. Korean Patent Laid-Open No. 10-2015-0035276 (published on April 26, 2015) Korean Patent Laid-Open No. 10-2011-0130555 (Published Dec. 2011)

The object of the present invention is to solve the above-mentioned problems, and an object of the present invention is to provide an antimicrobial, antioxidant, detoxification, skin regeneration, blood circulation, capillary vasodilation, Nutrients such as minerals and various bacterium-removing effects in the skin are optimally combined to improve the symptoms of skin troubles such as acne, which are superior to those of conventional products, and chemicals harmful to human body such as retinoic acid and benzoyl peroxide The present invention provides a composition comprising a herbal fermentation extract having excellent skin stability with little side effects due to long-term use and having an effect of preventing and improving acne lesions.

In order to accomplish the above object, the present invention provides a method for producing a fermented soybean oil comprising 54.5 to 71.2 wt% of purified water, 3.6 to 4.5 wt% of butylene glycol, 8.1 to 10.0 wt% 2.0 to 3.0 wt% of cyclopentasiloxane, 2.0 to 2.5 wt% of glycerin, 1.8 to 2.5 wt% of glyceryl stearate PEG-100 stearate, 1.6 to 2.2 wt% of hyaluronic acid, 1.5 to 2.2 wt% of polyglyceryl-3 methylglucose distearate, PEG-20 glyceryl stearate 1.2 - 1.8 wt%, cyclohexasiloxane 1.0 - 1.4 wt%, stearic acid 1.0 - 1.4 wt%, dimethicone / vinyl dimethicone crosspolymer 0.9 - 1.3 wt% , Macadamia ternifolia seed oil 0.5 - 1.4 wt%, glyceryl stearate 0.5-1.4 wt% of glyceryl stearate, 0.5-1.4 wt% of betaine, 0.5-1.4 wt% of panthenol, 0.5-1.4 wt% of helianthus annuus seed oil, dimethicone 0.1 to 0.8 wt%, jojoba seed oil 0.2 to 0.7 wt%, caffeine 0.3 to 0.8 wt%, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer (ammonium 0.1 to 0.5 wt% of acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, 0.1 to 0.5 wt% of tocopheryl acetate, 0.1 to 0.3 wt% of allantoin, 0.1 to 0.3 wt% of potassium cetyl phosphate, 0.1 to 0.4 wt% of salicylic acid, 0.1 to 0.4 wt% of shea butter, 0.1 to 0.4 wt% of phenoxy ethanol, 0.1 to 0.3 of dipotassium glycyrrhizate, 0.02 to 0.1 wt% of caprylic / capric triglyceride, 0.03 to 0.1 wt% of camphor and fragrance nce) of 0.06 - 0.4 wt%.

Herein, the herbal fermentation extract may be selected from any one or two selected from Aloe vera leaf extract, Aloe vera extract, Chamomile extract, Indomarbe tree extract, Lavender flower extract, Citron extract, Eucalyptus leaf extract, Grapefruit extract, Clove flower extract, And the fermentation is carried out by inoculating each of the above extracts with a culture solution of lactic acid bacteria.

The lactic acid bacteria culture solution may include lactobacillus lactic acid bacteria, hydrolyzed collagen and glucose, and the lactobacillus lactic acid bacteria may be selected from the group consisting of Lactobacillus acidophilus , Lactobacillus casei Lactobacillus casei , Lactobacillus plantarum , Lactobacillus fermentum , Lactobacillus bulgaricus , Lactobacillus gasseri , and Lactobacillus thermophilus . And at least one selected from the group consisting of

Meanwhile, the herbal fermentation extract is extracted using any one of solvent extraction, hydrodistillation, and steam distillation. The solvent for the solvent extraction is water, methanol methanol, ethanol, propanol, isopropanol, butanol, acetone, glycerin, propylene glycol, 1,3-butylene glycol (1, 3-butylene glycol, methyl acetate, ethyl acetate, hexane, diethylether, dichloromethane, and sorbitol. In addition, do.

On the other hand, the composition may be at least one selected from serums, nutritional creams, massage creams, eye creams, cleansing creams, supple cosmetics, astringent cosmetics, nutritional lotions, cleansing foams, cleansing waters, packs, sprays, natural soaps, essences and powders . ≪ / RTI >

The composition of the present invention, which is excellent in skin stability and has an effect of preventing and ameliorating acne lesion, is free from side effects due to long-term use due to the addition of chemicals harmful to human body such as retinoic acid and benzoyl peroxide, Antioxidants, antioxidants, detoxification, skin regeneration, blood circulation, capillary vasodilation, nutrient supply such as vitamins and minerals, and various bacterium eliminating effects of the herbal fermentation extract are combined in an optimal combination as a whole The effect of preventing and improving symptoms of skin troubles such as acne is excellent.

FIG. 1 is a microscope photograph showing the antimicrobial activity of a composition comprising a herbal fermented extract having excellent skin stability and preventing and treating acne lesions according to a preferred embodiment of the present invention.

The composition of the present invention, which has excellent skin stability and has an effect of preventing and improving acne lesion,

The composition of the present invention is characterized by containing 54.5 to 71.2 wt% of purified water, 3.6 to 4.5 wt% of butylene glycol, 8.1 to 10.0 wt% of herbal fermented extract, 2.0 to 3.0 wt% of cyclopentasiloxane, 2.5 to 2.5 wt% of glyceryl stearate, 1.8 to 2.5 wt% of glyceryl stearate PEG-100 stearate, 1.6 to 2.2 wt% of hyaluronic acid, polyglyceryl- 1.5 to 2.2 wt% of polyglyceryl-3 methylglucose distearate, 1.2 to 1.8 wt% of PEG-20 glyceryl stearate, 1.0 to 1.4 wt% of cyclohexasiloxane, 0.9-1.3 wt% of dimethicone / vinyl dimethicone crosspolymer, 0.5-1.4 wt% of macadamia ternifolia seed oil, 1.0-1.4 wt% of stearic acid, 0.5 - 1.2 wt% glyceryl stearate, 0.5 - 1.4 wt% betaine, panthenol 0.5 to 1.4 wt% of sunflower seed oil, 0.5 to 1.4 wt% of helianthus annuus seed oil, 0.19 to 0.8 wt% of dimethicone, 0.2 to 0.7 wt% of jojoba seed oil, 0.1 to 0.5 wt% of ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, 0.1 to 0.5 wt% of tocopheryl acetate, 0.3 to 0.8 wt% of ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, 0.1 to 0.3 wt% of allantoin, 0.1 to 0.3 wt% of potassium cetyl phosphate, 0.1 to 0.3 wt% of salicylic acid, 0.1 to 0.4 wt% of shea butter, 0.1 to 0.4 wt% of phenoxy ethanol, 0.1 to 0.3 wt% of dipotassium glycyrrhizate, 0.02 to 0.1 wt% of caprylic / capric triglyceride, 0.03 to 0.1 wt% of camphor and 0.06 to 0.4 wt% of fragrance.

First, the role and effect of each ingredient contained in the composition containing the herbal fermentation extract having excellent skin stability and preventing and improving acne lesion according to the present invention will be described below.

1) Butylene glycol: It is used as a skin conditioning agent and a solvent as well as being used as a strong moisturizing agent component because it is attracted moisture with a large amount of alcohol and is highly absorbent.

2) Cyclopentasiloxane: It is a non-viscous, colorless and odorless fluid liquid with low surface tension. It has good spreading and spreading properties. It has good lubricity. It helps to give conditioning to skin and hair. It helps to soften and soften the skin.

3) Glycerin: It is a component contained in the fat of plants and animals. It is strong in viscosity, has wettability and unique dissolving power and is used as viscosifier, moisturizer, booster, and solvent.

4) Glyceryl stearate (PEG-100 stearate): A surfactant, a stearic acid used as a detergent, a polyethylene glycol ester, It acts as an active substance which adsorbs at the interface of each substance and mixes well, and helps to give detergency.

5) Hyaluronic acid: It helps moisturizing the skin by forming a moisturizing film that supplies moisture to the skin and attracts moisture from the outside to fix the moisture. It also has excellent absorbency to attract water molecules, prevents water evaporation between the fibers of the skin, and provides moisture and nutrition.

6) Polyglyceryl-3 methyl glucose distearate: It is a compound of methylglucose and polyglycerin-3 condensation reaction and stearic acid compound. There is a very high skin stability.

7) PEG-20 glyceryl stearate: Polyethylene glycol etheral ingredient of glyceryl stearate, which gives conditioning to the skin and helps smooth and soften the texture of the skin.

8) Cyclohexasiloxane: It facilitates the spreading of cosmetics. It also has softness and softness. It softens and softens the texture of the skin. It gives conditioning to the skin and helps healthy and energetic skin care. .

9) Stearic acid: It is a natural derived fatty acid. It helps balance the oil content after cleansing, helping to make the skin shiny and make the skin smoother. Usually this ingredient is contained in a lot of cream formulations with oily or cleanser that can be cleaned without drying feeling.

10) Dimethicone / vinyl dimethicone crosspolymer: It is a type of elastomer which is elastic polymer material. It is used to adsorb sebum and regulate sebum to help manage oily skin, It also helps to improve skin luster and gently manage skin texture.

11) Macadamia ternifolia seed oil: It is an oil component obtained from macadamia seeds. It has a characteristic that it is similar to the composition of human skin. Therefore, it has excellent barrier function to prevent moisture evaporation of skin, It not only helps to moisturize skin, it also gives soft touch, it is involved in softening and softening skin texture, it helps to improve tired skin due to aging and give young energy.

12) Glyceryl stearate: It is mainly composed of glyceryl stearate and contains glyceryl distearate, glyceryl tristearate, unreacted glycerin, etc., and is mainly used in flavoring agents and skin conditioners .

13) Betaine: As an amino acid with three methyl groups, it facilitates the synthesis of mesiononin through methylation donation, and acts as anti-interferon, hypotensive, anti-glycemic, detoxifying, and cell replication.

14) Panthenol: Alcohol derivative of pantothenic acid, a persistent pantothenic acid. It is oxidized in vivo, and it has acetylcholine production promoting activity in this agent.

15) Sunflower seed oil (helianthus annuus seed oil): Contains natural skin barrier ingredients, which helps to moisturize and protect the hips that are dry and damaged.

16) Dimethicone: A type of polymerized siloxane, which is a type of silicone oil, belonging to the silicone-based high molecular organochemical series. It is visually transparent, generally inert, non-toxic and nonflammable. It is mainly used as an emollient for skin moisturizing.

17) Jojoba seed oil: It is a liquid ester oil obtained from jojoba seeds. It is excellent in stability and feeling, and is widely used as an oil-based raw material mainly in basic cosmetics. The above-mentioned jojoba oil is less oil-repellent than other vegetable oils and has a structure of wax ester which is one component of sebum, so it is easy to be familiar with the skin. Therefore, it is used as an oil component in make-up products such as skin care products such as emulsion, cream, body oil, hand lotion, lipstick and foundation.

18) Caffeine: It is white and has a bitter taste. It is contained in seeds of coffee, tea leaves, cacao and cola fruit, maté trey and ura lina.

19) Ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer: It is stable in ultraviolet (UV) and exerts its function in a wide pH range, is soluble in water It is a high molecular weight gelling agent component with good dispersing ability, mainly controlling the viscosity of cosmetics or forming a film. It also helps to give a soft skin texture.

20) Tocopheryl acetate: It is mainly used as a raw material for skin-related products such as skin and cream. It is known to protect skin from harmful oxygen. It is used as an alternative to pure tocopherol and has antioxidative effects such as inhibiting the oxidation of unsaturated fatty acids constituting the cell membrane.

21) Allantoin: A ureide compound of glyoxylic acid, used mainly as a component of cosmetics and medicine.

22) Potassium cetyl phosphate: A potassium salt component of a complex mixture of phospholipid and cetyl alcohol, which adsorbs at the interface of the constituents of the cosmetic composition to reduce the surface tension, thereby dispersing and emulsifying the incompatible components It is used as a raw material to help.

23) Salicylic acid: It is a colorless solid which is one of aromatic oxycarboxylic acids. It is also used as a medicinal drug or to synthesize mordant azo dyes or direct dyes.

24) Shea butter: refers to a product that is extracted and purified with a hexane-based chemical, and is mainly added to cosmetics for moisturizing effects.

25) phenoxy ethanol: One of the ingredients in almost all cosmetics, it acts as a preservative and a preservative, and is also included in common cosmetics like lotions and skins.

26) Dipotassium glycyrrhizate: Used mainly as a skin conditioning agent, it protects the skin from harmful oxygen and protects the skin tone. It helps to maintain vitality and clean skin.

Caprylic / capric triglyceride: A type of natural fat obtained from plants and animals. Caprylic / capric triglycerides, capric acids and capric acids synthesized from fatty acids, and glycerin is a mixed fatty acid of a triester of glycerin. It does not contain unsaturated fatty acids, so it has excellent oxidation stability and excellent stability.

28) Camphor: Apply alcohol solution to the neuralgia / urticaria with stimulant, analgesia and preservative, and use the solid as antifungal and insecticide. It is also marketed as a fragrance product, an insect repellent for clothes, and the like.

29) Fragrance: A fragrance which is added to add flavor to daily necessities such as cosmetics. They are highly volatile at room temperature, and they are divided into natural fragrance and artificial fragrance.

On the other hand, 54.5 wt% to 71.2 wt% of water is added to the total composition ratio. When the amount of the purified water is more than 71.2 wt%, the properties of the final product become poor. When the amount of the purified water is less than 54.5 wt%, solidification proceeds in the form of the final product, And is unsuitable for use.

The butylene glycol serves as a humectant, and 3.6 wt% to 4.5 wt% of the total composition ratio is added. When the butylene glycol is added in an amount exceeding 4.5 wt%, the water absorbency becomes strong and problems in formulation occur. When the butylene glycol is added in an amount less than 3.6 wt%, the effect of dissolving the constituents decreases.

The cyclopentasiloxane is a component that moisturizes and softens the skin, and 2.0 wt% to 3.0 wt% of the total composition ratio is added. When the cyclopentasiloxane is added in an amount of more than 3.0 wt%, the lubricity characteristics may be strong, and when the cyclopentasiloxane is added in an amount of less than 2.0 wt%, the effect is not exhibited.

The glycerin is a component having high viscosity and wettability and solubility, and it is added in an amount of 2.0 wt% to 2.5 wt% of the total composition ratio. When the glycerin is added in an amount of more than 2.5 wt%, a problem arises in formulation due to an increase in the amount of the fat-soluble component. When the glycerin is added in an amount of less than 2.0 wt%, dryness of the final product tends to be accelerated.

The glyceryl stearate (PEG-100 stearate) is surfactant, that is, an emulsifier component, 1.8 wt% to 2.5 wt% of the total composition ratio is added. When the glyceryl stearate · phage-100 stearate is added in an amount exceeding 2.5 wt%, it is uneconomical because it is added more than necessary, and when it is added in an amount less than 1.8 wt%, it does not exhibit the function of surface activity.

The hyaluronic acid is a natural moisturizing factor (NMF), which plays an important role in accumulating and retaining moisture in the dermal layer of the skin, and 1.6 wt% to 2.2 wt% of the total composition ratio is added . When the hyaluronic acid is added in an amount of more than 2.2 wt%, the other components are self-absorbed. As a result, it is difficult to achieve the object of the present invention. When the hyaluronic acid is added in an amount less than 1.6 wt% .

The polyglyceryl-3 methylglucose distearate is a component for skin moisturization and skin protection, and 1.5 wt% to 2.2 wt% of the total composition ratio is added. When the polyglyceryl-3 methylglucoside distearate is added in an amount exceeding 2.2 wt%, the stability to the skin is drastically deteriorated due to excessive addition, and when it is added in an amount less than 1.5 wt%, skin moisturization and skin protection The function becomes insignificant.

The above-mentioned PEG-20 glyceryl stearate is a component which imparts conditioning to the skin, and from 1.2 wt% to 1.8 wt% of the total composition ratio is added. When the above-mentioned glyceryl stearate is added in an amount of more than 1.8 wt%, the stability of the final composition is deteriorated. If it is added in an amount of less than 1.2 wt%, the effect of conditioning is not exhibited.

The cyclohexasiloxane is a component that moisturizes and softens the skin, and 1.0 wt% to 1.4 wt% of the total composition ratio is added. When the cyclohexasiloxane is added in an amount exceeding 1.4 wt%, there is a problem in formulation in the final product. When the cyclohexasiloxane is added in an amount less than 1.0 wt%, it is difficult to exert the above effect.

The stearic acid is a naturally occurring fatty acid and 1.0 wt.% To 1.4 wt.% Of the total composition ratio is added. If the stearic acid is out of the above-mentioned composition range, the viscosity is not maintained and the phase separation phenomenon .

The dimethicone / vinyl dimethicone crosspolymer is a component which imparts luster to the skin and softens the texture of the skin, and 0.9 wt% to 1.3 wt% of the total composition ratio is added, If the composition is out of the above-mentioned range, the above-mentioned effect can not be exhibited, and stability of the composition of the final composition is caused.

The macadamia ternifolia seed oil is a component for softening the skin as well as softening the skin due to the similar composition composition with the sebum secreted from the skin. The content of the macadamia ternifolia seed oil is 0.5 wt% to 1.4 wt%. When the Macadamia seed oil is added in an amount exceeding 1.4 wt%, the oil component becomes excessive and the stability of the final formulation is deteriorated. When the added amount is less than 0.5 wt%, the functionality is insignificant.

The glyceryl stearate is a component which imparts conditioning to the skin by containing unreacted glycerin or the like, and 0.5 wt% to 1.2 wt% of the total composition ratio is added. When the glyceryl stearate is added in an amount exceeding 1.2 wt%, the stability of the final composition is deteriorated. When the glyceryl stearate is added in an amount less than 0.5 wt%, it is difficult to exert the effect of conditioning.

The betaine is for moisturizing and irritation-relieving, and 0.5 wt% to 1.4 wt% of the total composition ratio is added. When the betaine is added in an amount exceeding 1.4 wt%, moisture is excessively increased in the skin. When the betaine is added in an amount less than 0.5 wt%, the effect of moisturizing and irritation alleviation is insignificant.

The panthenol acts to promote acetylcholine formation, and 0.5 wt% to 1.4 wt% of the total composition ratio is added. When the panthenol is added in an amount exceeding 1.4 wt%, phase separation easily occurs and the stability of the final formulation is deteriorated. When the panthenol is added in an amount of less than 0.5 wt%, the effect of promoting acetylcholine formation is insignificant.

The above-mentioned sunflower seed oil (helianthus annuus seed oil) imparts moisturization to the dried skin, and 0.5 wt% to 1.4 wt% of the total composition ratio is added. When the sunflower seed oil is added in an amount exceeding 1.4 wt%, the oil component becomes excessive and a problem arises in formulation of the final composition. When the sunflower seed oil is added in an amount of less than 0.5 wt%, the above- Is difficult.

The dimethicone is for moisturizing the skin, and 0.19 wt% to 0.8 wt% of the total composition ratio is added. When the dimethicone is added in an amount exceeding 0.8 wt%, phase separation easily occurs and the stability of the final formulation is deteriorated. When the dimethicone is added in an amount of less than 0.19 wt%, the function of the emollient as well as the stability of the final formulation deteriorate.

The jojoba seed oil is a component having a structure of wax ester which is a component of sebum, and 0.2 wt% to 0.7 wt% of the total composition ratio is added. When the jojoba seed oil is added in an amount exceeding 0.7 wt%, the oil component becomes excessive and a problem occurs in formulation. When the jojoba seed oil is added in an amount less than 0.2 wt%, it is difficult to exhibit the functionality of jojoba seed oil.

It has been reported in the academic world that the caffeine can prevent skin cancer when it is applied to the skin in the form of a skin or a lotion, and it is a component having a characteristic that it selectively kills abnormal cells when exposed to ultraviolet rays (UV) 0.3 wt% to 0.8 wt% of the content of the composition ratio is added. When the caffeine is added in an amount exceeding 0.8 wt%, it shows a harmful action mechanism to the skin due to excessive addition of caffeine, and when it is added in an amount less than 0.3 wt%, it is difficult to exhibit the caffeine characteristic as described above.

The ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer is used as a component for controlling the viscosity, and the content of the ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer is 0.1 wt% to 0.5 wt% . When the ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer is out of the above-mentioned composition range, it is difficult to exert its viscosity control function.

The tocopheryl acetate is a component for imparting an antioxidative function, and 0.1 wt% to 0.5 wt% of the total composition ratio is added. When the above-mentioned tocopherol acetate is added in an amount exceeding 0.5 wt%, it is unnecessarily added and unnoticeable. When the tocopherol acetate is added in an amount of less than 0.1 wt%, the addition amount is insufficient and it is difficult to exert an antioxidant function.

The above-mentioned allantoin is added to impart keratinolytic action and anti-inflammatory action, and 0.1 wt% to 0.3 wt% of the total composition ratio is added. When the allantoin is added in an amount exceeding 0.3 wt%, it is unnecessarily added and unnecessarily added. When the allantoin is added in an amount less than 0.1 wt%, the added amount is insufficient and it is difficult to exert a keratinolytic and anti-inflammatory function.

The potassium cetyl phosphate is a component for inducing the surface activity, and 0.1 wt% to 0.3 wt% of the total composition ratio is added. When the composition is out of the above range, it is difficult to exhibit the surface active function However, problems arise in the formulation of the composition to be finally produced.

The salicylic acid is added to improve the fine wrinkles associated with intrinsic aging and to treat acne through topical application, and 0.1 wt% to 0.3 wt% of the total composition ratio is added. When the salicylic acid is added in an amount exceeding 0.3 wt%, it is uneconomical because it is added more than necessary, and when it is added in an amount less than 0.1 wt%, the action mechanism related to acne treatment does not actively progress.

The shea butter is a component that imparts skin moisturizing and soothing effect, and 0.1 wt% to 0.4 wt% of the total composition ratio is added. When the shea butter is added in an amount exceeding 0.4 wt%, the effect is not increased more than the content increase. When the shea butter is added in an amount less than 0.1 wt%, the skin moisturizing and soothing effect is insignificant.

The above phenoxy ethanol has a sterilizing action against Gram-negative bacteria such as P. aeruginosa and the like. In the present invention, it is added to perform a role as a solvent, and 0.1 wt% to 0.4 wt% of the total composition ratio is added . When the phenoxyethanol is added in an amount exceeding 0.4 wt%, the stability of the final formulation is deteriorated. When the phenoxyethanol is added in an amount of less than 0.1 wt%, the function as a solvent is markedly decreased and the physical properties of the phenoxyethanol rapidly change.

The dipotassium glycyrrhizate is a component which imparts conditioning to the skin, and 0.1 wt% to 0.3 wt% of the total composition ratio is added. When the dipotassium glycyrrhizate is added in an amount of more than 0.3 wt%, the stability against the formulation of the final composition is lowered, and when it is added in an amount of less than 0.1 wt%, it is difficult to exert the effect of conditioning Do.

The caprylic / capric triglyceride is added for oxidation stability, and 0.02 wt% to 0.1 wt% of the total composition ratio is added. When the caprylic / capric triglyceride is added in an amount exceeding 0.1 wt%, it is added unnecessarily and unexpectedly, and when it is added in an amount of less than 0.02 wt%, the oxidation stability is significantly reduced.

The camphor is a component for imparting antioxidative and anti-inflammatory functions, and 0.03 wt% to 0.1 wt% of the total composition ratio is added. When the camphor is added in an amount exceeding 0.1 wt%, it is unnecessarily added and unnecessarily added. When the camphor is added in an amount less than 0.03 wt%, the addition amount is insufficient and it is difficult to exhibit functionalities such as anti-inflammation.

The fragrance is added to add a perfume to enhance the taste of the composition according to the present invention, and 0.06 wt% to 0.4 wt% of the total composition ratio is added. When the fragrance is added in an amount exceeding 0.4 wt%, the fragrance is too strong and the quality is deteriorated. When the fragrance is added in an amount less than 0.06 wt%, a sufficient fragrance can not be emitted.

Meanwhile, 8.1 wt% to 10.0 wt% of the total composition ratio of the herbal fermentation extract is added. As a raw material for extracting the herbal fermentation extract, aloe vera leaves, oriental herb, chamomile, indian marbles, lavender flowers, Citron, Eucalyptus leaf, Cucumber, Clove flower, and Cichlid flower can be used. When the above-mentioned one-body fermentation extract is added in an amount exceeding 10.0 wt%, it is uneconomical because it is added more than necessary, and when it is added in an amount less than 8.1 wt%, antibacterial activity, Antioxidant, detoxification, skin regeneration, blood circulation, capillary vasodilation, supply of nutrients such as vitamins and minerals, and the function of removing various bacteria in the skin become insignificant.

Characteristics and efficacy of the herbal medicines listed above are shown in Table 1 below.

division main ingredient Features and Benefits Aloe Vera Vitamins A, C, D, E, fatty acids, amino acids, selenium, potassium and allantoin, aloe, etc. · Immune function enhancement
· Facilitate local regeneration of skin and relieve pain
· Excellent for treating skin ulcers, burns, sunburned skin, etc. Sophora Decanoyl, etc. · Antibacterial and anti-inflammatory effect → Treatment and prevention of acne and atopy
· Suppress DHT, a component of hair loss
· Suppression of germs and folliculitis in skin → Treatment and prevention of acne and atopy
· Acne skin and atopy improvement
· Detoxification and diuretic action Chamomile Beta-carotene, calcium, vitamin A, C, phosphorus, etc. · Insect repellent, soothing, perspiration, analgesic, sweating, promoting digestion, and restoring fatigue. Indian marbled wood Azadirachtin, vitamin E, essential amino acids, etc. · Excellent poisoning and detoxification
· The effect of making skin smooth and improving acne lavender Vitamin A, C, E, potassium, folic acid, etc. · It is mainly used as cosmetics, and it is effective for headache and nervous stability Citron Vitamin B, C, Carbohydrates, Protein, Hesperidin, etc. · Skin cosmetic and waste effect Eucalyptus Citnerol, etc. · Cleanses the skin and is effective for skin disorders
· Cooling effect on sun-exposed skin grapefruit Vitamin C, etc. · Vomiting, nausea, digestion, etc. Clove Sodium, beta-carotene, vitamin A, folic acid, phosphorus, lipid, iron, potassium, calcium, etc. · Antioxidant and antibacterial efficacy Bedspread Methacaric acid, etc. · Skin wound healing

Each herbal medicine can be fermented by inoculating a culture solution of lactic acid bacteria. The lactic acid bacteria culture solution may include Lactobacillus sp. Lactis bacteria, hydrolyzed collagen and glucose. The Lactobacillus sp. Lactic acid bacteria may be Lactobacillus acidophilus , Lactobacillus acidophilus , Casey (Lactobacillus casei), Lactobacillus Planta Room (Lactobacillus plantarum), Lactobacillus flops momentum (Lactobacillus fermentum), Lactobacillus Bulgaria Syracuse (Lactobacillus bulgaricus), Lactobacillus joined Lee (Lactobacillus gasseri) and Lactobacillus Summer pillar's (Lactobacillus thermophilus ) may be used.

The hydrolyzed collagen (CAS No. 73049-73-7) is a hydrolyzed collagen. Collagen is the most abundant protein present in the human body, accounting for about 65% of the total protein. Generally, collagen is made up of more than 1,500 amino acid chains and gives skin elasticity.

In one embodiment, the herbal medicine culture liquid may be inoculated to the herbal medicine at a ratio of 1: 0.01-5 (herbal medicine: lactic acid bacteria culture) in a weight ratio. At this time, if the ratio is out of the above range, the lactic acid bacteria may be inoculated at a ratio within the above-mentioned range, because the fermentation process may be overcooked due to excessive content of lactic acid bacteria or the fermentation mechanism may not be performed due to a small amount of added lactic acid bacteria.

Each herbal medicine having been inoculated with the culture solution of lactic acid bacteria can be sufficiently fermented for 2 to 4 days at a temperature of 32 to 40 캜 to form a one-body fermented product.

In order to maximize the expression of the active ingredient, the herbal fermented extract may be obtained by a known extraction method. As an example, the herbal fermentation product can be extracted using any one of solvent extraction, hydrodistillation, and steam distillation. Here, it is most preferable to extract by applying a solvent extraction that can maximize the extraction efficiency while preventing the active ingredient from being destroyed during the extraction process.

In the solvent extraction, the solvent may be water, methanol, ethanol, propanol, isopropanol, butanol, acetone, glycerin, propylene Propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, hexane, diethylether, dichloromethane, and the like. ), And sorbitol may be used.

In one embodiment, the fermented herb is added to low-temperature hot water at 60 to 80 ° C for 10 to 15 hours to remove the extract from the fermented oriental fermentation product. Extract to obtain an extract from each oriental fermented product. At this time, it is preferable that each herbal fermentation product and water are mixed in a ratio of 20-40: 60: 80 (fermentation product: water) by weight, and after the extraction process is performed, only the liquid extract is separated do. In addition, a sterilization treatment may be further applied to the liquid extract obtained above.

The above-mentioned composition can be used as a raw material which is expected to improve the skin troubles such as skin care, especially acne in the production of cosmetics.

At this time, the composition may be at least one selected from the group consisting of serum, nutritional cream, massage cream, eye cream, cleansing cream, supple cosmetics, convergent cosmetics, nutrition lotion, cleansing foam, cleansing water, pack, spray, natural soap, essence and powder But the present invention is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples.

EXAMPLES Preparation of a composition comprising a herbal fermented extract having an excellent skin stability and an effect of preventing and improving acne lesion according to the present invention

A lot of herbal medicines such as Aloe vera, Persimmon, Camomile, Indian marbled bean, Lavender, Citron, Eucalyptus, Grapefruit, Clove and Clove were washed in water to remove foreign matter.

The herbal medicine was mixed with water at a weight ratio of 1:10, and the mixture was heated at an average temperature of 70 ° C for about 72 hours to obtain an extract. The cooled extract was cooled, and then the cooled material was allowed to stand for about 24 hours Aged. The fermented herbal medicine fermented product was prepared by putting 1wt% of the culture liquid of lactic acid bacteria of the total weight of the aged herbal medicine aged material in a cool place for 3 days and then sealed and packed in a film bag and refrigerated at an average temperature of 3 ° C Respectively.

Next, a mixture of 65.0 wt% of purified water, 4.2 wt% of butylene glycol, 10.0 wt% of refrigerated herbal fermented extract, 2.5 wt% of cyclopentasiloxane, 2.2 wt% of glycerin, 2.0 wt% of glyceryl stearate PEG-100 stearate, 2.2 wt% of hyaluronic acid, polyglyceryl-3 methylglucose (distearate) distearate, 1.2 wt% of PEG-20 glyceryl stearate, 1.2 wt% of cyclohexasiloxane, 1.0 wt% of stearic acid, dimethicone / vinyl 1.0 wt% of dimethicone / vinyl dimethicone crosspolymer, 0.5 wt% of macadamia ternifolia seed oil, 0.5 wt% of glyceryl stearate, 0.5 wt% of betaine, 1.0 wt% of panthenol, 0.5 wt% of sunflower seed oil (helianthus annuus seed oil) , Dimethicone 0.2 wt%, jojoba seed oil 0.4 wt%, caffeine 0.5 wt%, ammonium acryloyldimethyltaurate / behenes-25 methacrylate crosspolymer (ammonium acryloyldi methyltaurate / beheneth-25 methacrylate crosspolymer, 0.25 wt% of tocopheryl acetate, 0.1 wt% of allantoin, 0.1 wt% of potassium cetyl phosphate, 0.2 wt% of salicylic acid %, Shea butter 0.3 wt.%, Phenoxy ethanol 0.1 wt.%, Dipotassium glycyrrhizate 0.1 wt.%, Caprylic / capric triglyceride ), Camphor (0.1 wt%) and fragrance (0.1 wt%) were mixed by using a conventional mixer to prepare a composition for preventing and improving acne according to the present invention.

The composition and content of the composition prepared in the above examples are shown in Table 2 below.

Constituent Content (wt%) Purified water 65.0 Butylene glycol 4.2 Fermented herbal extract 10.0 Cyclopentasiloxane < RTI ID = 0.0 > 2.5 Glycerin 2.2 Glyceryl stearate < RTI ID = 0.0 >
(glyceryl stearate · PEG-100 stearate) 2.0 Hyaluronic acid < RTI ID = 0.0 > 2.2 Polyglyceryl-3 methyl glucoside distearate
(polyglyceryl-3 methylgucose distearate) 1.7 Phage-20 glyceryl stearate
(PEG-20 glyceryl stearate) 1.2 Cyclohexasiloxane < RTI ID = 0.0 > 1.2 Stearic acid 1.0 Dimethicone / Vinyl Dimethicone Crosspolymer
(dimethicone / vinyl dimethicone crosspolymer) 1.0 Macadamia ternifolia seed oil 0.5 Glyceryl stearate < RTI ID = 0.0 > 0.5 Betaine 0.5 Panthenol 1.0 Sunflower seed oil (helianthus annuus seed oil) 0.5 Dimethicone 0.2 Jojoba seed oil 0.4 Caffeine 0.5 Ammonium acryloyldimethyltaurate /
Behennes-25 methacrylate crosspolymer
(ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer) 0.3 Tocopheryl acetate 0.25 Allantoin 0.1 Potassium cetyl phosphate < RTI ID = 0.0 > 0.1 Salicylic acid 0.2 Shea butter 0.3 Phenoxy ethanol 0.1 Dipotassium glycyrrhizate (dipotassium glycyrrhizate) 0.1 Caprylic / capric triglyceride
(caprylic / capric triglyceride) 0.05 Camphor 0.1 Fragrance 0.1

[Experimental Example 1] Antibacterial experiment against acne bacterium ( P. acnes )

Propionibacterium , known as the cause of acne acnes (ATCC 6919) was cultured in a fluid thioglycollate medium (DIFCO) and used for the experiment. The bacterium Propionibacterium acnes (ATCC 6919) was inoculated on a prepared agar plate agar (DIFCO) (PH 8.0) was placed in the center of the culture medium, and 50 mg of the composition prepared in Example was applied. The mixture was then anaerobically incubated at 35 ± 1 ° C in an anaerobic jar under anaerobic conditions The diameter of the inhibition zone formed after incubation for 72 hours was measured, and 50 μl of alcohol (70%) was inoculated on a sterilization disk (Φ8.0) and incubated under the same conditions for comparative experiments.

W is the width of the low zone in mm, T is the total diameter (mm) of the sample and the low zone, D is the diameter of the sample disk (mm) (mm). The results are shown in Table 3 below.

division unit Width of the lowlands Example mm 6.9 Comparative Example
(70% alcohol) mm 0.2

From the results of Table 3, it can be seen that the width of the inhibition zones of the Examples is significantly wider than that of the Comparative Examples, and Propionibacterium acnes (ATCC 6919) were found to have excellent antimicrobial activity.

Meanwhile, Propionibacterium To determine the antimicrobial activity of the test substance against acnes (hereinafter referred to as P. acnes ), 100 μl of the microorganism diluted with 10 ⁷ CFU / ml of P. acnes in the GAM drug medium was dropped into the GAM solid medium 15 μl of the control group (alcohol) and the test group (Example) were placed on a sterilized 6 mm paper disc and dried for 5 to 10 minutes, and then 15 μl After the drip, it was dried for 5 minutes, and the experimental strain was placed on the smoothed GAM solid medium. After the addition of the gas pack, the clear zone formed around the paper disc was observed while incubating in a shaking incubator at 37 ° C for 72 hours. Observation results are shown in Fig.

As a result of the above experiment, a transparent ring was observed around the paper disc according to the composition of the present invention, thereby confirming the antimicrobial effect against acne causing bacteria.

[Experimental Example 2] Skin Trouble Improvement Evaluation

In order to evaluate the improvement effect on skin troubles (acne, atopy, etc.), 18 male and female subjects (7 male, 11 female, 12 female, 20 male, 5 female, A lotion containing the composition prepared through the examples was applied to the skin around the trouble where the trouble occurred, and the degree of satisfaction, acne improvement, atopy improvement , Satisfaction of moisturizing power, degree of wound, improvement of circle circle, and flavor. The evaluation criterion was 100 points, and the average value of the subjects was evaluated. The results are shown in Table 4 below.

division Evaluation results Acne atopy use satisfaction 98 Acne improvement 99 Degree of atopy improvement 90 Satisfaction with Essence Moisture 98 Improvement of wound, circle circle 87 Flavor 63

As shown in Table 4, the lotion containing the composition according to the present invention produced excellent results in the evaluation of overall satisfaction, acne improvement, atopic improvement, moisturizing satisfaction, wound, and improvement of the circles. .

Claims (5)

The composition of the present invention is characterized by containing 54.5 to 71.2 wt% of purified water, 3.6 to 4.5 wt% of butylene glycol, 8.1 to 10.0 wt% of herbal fermented extract, 2.0 to 3.0 wt% of cyclopentasiloxane, 2.5 to 2.5 wt% of glyceryl stearate, 1.8 to 2.5 wt% of glyceryl stearate PEG-100 stearate, 1.6 to 2.2 wt% of hyaluronic acid, polyglyceryl- 1.5 to 2.2 wt% of polyglyceryl-3 methylglucose distearate, 1.2 to 1.8 wt% of PEG-20 glyceryl stearate, 1.0 to 1.4 wt% of cyclohexasiloxane, 0.9-1.3 wt% of dimethicone / vinyl dimethicone crosspolymer, 0.5-1.4 wt% of macadamia ternifolia seed oil, 1.0-1.4 wt% of stearic acid, 0.5 - 1.2 wt% glyceryl stearate, 0.5 - 1.4 wt% betaine, panthenol 0.5 to 1.4 wt% of sunflower seed oil, 0.5 to 1.4 wt% of helianthus annuus seed oil, 0.19 to 0.8 wt% of dimethicone, 0.2 to 0.7 wt% of jojoba seed oil, 0.1 to 0.5 wt% of ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, 0.1 to 0.5 wt% of tocopheryl acetate, 0.3 to 0.8 wt% of ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, 0.1 to 0.3 wt% of allantoin, 0.1 to 0.3 wt% of potassium cetyl phosphate, 0.1 to 0.3 wt% of salicylic acid, 0.1 to 0.4 wt% of shea butter, 0.1 to 0.4 wt% of phenoxy ethanol, 0.1 to 0.3 wt% of dipotassium glycyrrhizate, 0.02 to 0.1 wt% of caprylic / capric triglyceride, 0.03 - 0.1 wt.% of camphor and 0.06 - 0.4 wt.% of fragrance. A composition comprising a herbal extract which is fermented with acne lesions is excellent prevention and improvement effect. The method according to claim 1,
The herbal fermentation extract may be one or more selected from the group consisting of Aloe vera leaf extract, Aloe vera extract, Camomile extract, Indomarbe tree extract, Lavender flower extract, Citron extract, Eucalyptus leaf extract, Grapefruit extract, Clove flower extract, Wherein the extract is prepared by inoculating a culture solution of a lactic acid bacterium to each of the extracts and fermenting the same. 3. The method of claim 2,
The culture medium for lactic acid bacteria includes lactobacillus lactic acid bacteria, hydrolyzed collagen and glucose,
The Lactobacillus genus Lactobacillus is Lactobacillus ash is also necessary Ruth (Lactobacillus acidophilus), Lactobacillus Kasei (Lactobacillus casei), Lactobacillus Planta Room (Lactobacillus plantarum), Lactobacillus flops momentum (Lactobacillus fermentum), Lactobacillus Bulgaria Syracuse (Lactobacillus The present invention relates to a herbal composition comprising at least one selected from the group consisting of bulgaricus , Lactobacillus gasseri , and Lactobacillus thermophilus . A composition comprising a fermented extract. The method according to claim 1,
The herbal fermentation extract is extracted using any one of solvent extraction, hydrodistillation, and steam distillation,
The solvent for the solvent extraction may be water, methanol, ethanol, propanol, isopropanol, butanol, acetone, glycerin, propylene glycol glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, hexane, diethylether, dichloromethane, and the like. And sorbitol, wherein the composition has excellent skin stability and is effective in preventing and improving acne lesion. The method according to claim 1,
Characterized in that the composition is formulated with at least one selected from the group consisting of serum, nutritional cream, massage cream, eye cream, cleansing cream, supple cosmetics, astringent cosmetics, nutritional lotion, cleansing foam, cleansing water, pack, spray and powder A composition comprising a herbal fermentation extract having excellent skin stability and preventing and treating acne lesions.

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