KR20140103985A - 인슐린 아미노산 서열을 포함하는 치료제 - Google Patents
인슐린 아미노산 서열을 포함하는 치료제 Download PDFInfo
- Publication number
- KR20140103985A KR20140103985A KR1020147017232A KR20147017232A KR20140103985A KR 20140103985 A KR20140103985 A KR 20140103985A KR 1020147017232 A KR1020147017232 A KR 1020147017232A KR 20147017232 A KR20147017232 A KR 20147017232A KR 20140103985 A KR20140103985 A KR 20140103985A
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- South Korea
- Prior art keywords
- val pro
- gly
- gly val
- pro gly
- pharmaceutical composition
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 247
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 5
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Landscapes
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017078439A1 (ko) * | 2015-11-03 | 2017-05-11 | 재단법인대구경북과학기술원 | 췌장소도세포 및 엘라스틴 유사 인공 세포외 기질을 포함하는 당뇨병 치료용 약학적 조성물 |
| KR20200131721A (ko) * | 2019-05-14 | 2020-11-24 | 강원대학교산학협력단 | 당뇨병성 합병증의 예방 또는 치료용 약제학적 조성물 |
| US11607445B2 (en) | 2019-05-14 | 2023-03-21 | Amolifescience Co., Ltd. | Pharmaceutical composition for preventing or treating diabetic complications |
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| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
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| CN105727261A (zh) | 2008-06-27 | 2016-07-06 | 杜克大学 | 包含弹性蛋白样肽的治疗剂 |
| ES2669190T3 (es) | 2011-06-06 | 2018-05-24 | Phasebio Pharmaceuticals, Inc. | Uso de péptidos intestinales vasoactivos modificados en el tratamiento de la hipertensión |
| US20150290328A1 (en) | 2012-11-20 | 2015-10-15 | Phasebio Pharmaceuticals, Inc. | Formulations of active agents for sustained release |
| EP2945643A4 (en) * | 2013-01-15 | 2017-04-26 | Phasebio Pharmaceuticals, Inc. | Therapeutic agents, compositions, and methods for glycemic control |
| EP3139949B1 (en) | 2014-05-08 | 2020-07-29 | Phasebio Pharmaceuticals, Inc. | Compositions comprising a vip-elp fusion protein for use in treating cystic fibrosis |
| JPWO2015178466A1 (ja) * | 2014-05-21 | 2017-04-20 | 味の素株式会社 | フィブロイン様タンパク質の製造法 |
| EP3220936A4 (en) * | 2014-11-21 | 2018-08-22 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins for controlled and sustained release |
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| TW201718627A (zh) * | 2015-06-11 | 2017-06-01 | 梅茲製藥有限兩合公司 | 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞 |
| EP3124495A1 (en) * | 2015-07-31 | 2017-02-01 | Centre National de la Recherche Scientifique (C.N.R.S.) | Derivatives of elastin-like polypeptides and uses thereof |
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| WO2017189860A1 (en) | 2016-04-27 | 2017-11-02 | The Regents Of The University Of California | Preparation of functional homocysteine residues in polypeptides and peptides |
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| US12435116B2 (en) | 2019-10-16 | 2025-10-07 | Clarence Hurt | Compounds, compositions, methods, and uses for treating insulin resistance, type 2 diabetes and metabolic syndrome |
| JPWO2021112249A1 (enExample) * | 2019-12-06 | 2021-06-10 | ||
| WO2026015937A1 (en) * | 2024-07-15 | 2026-01-22 | The University Of Melbourne | Novel treatment for diabetes and obesity |
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| CA2309955A1 (en) * | 1997-11-12 | 1999-05-20 | Alza Corporation | Method for decreasing self-association of polypeptides |
| US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| EP1971355B1 (en) * | 2005-12-20 | 2020-03-11 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| WO2007095337A2 (en) * | 2006-02-15 | 2007-08-23 | Imclone Systems Incorporated | Antibody formulation |
| CN101438158A (zh) * | 2006-03-06 | 2009-05-20 | 阿穆尼克斯股份有限公司 | 遗传包和其应用 |
| CN105727261A (zh) * | 2008-06-27 | 2016-07-06 | 杜克大学 | 包含弹性蛋白样肽的治疗剂 |
| WO2010014689A1 (en) * | 2008-07-29 | 2010-02-04 | Phasebio Pharmaceuticals, Inc. | Pharmaceutical formulations comprising elastin-like proteins |
| DK2459171T3 (en) * | 2009-07-31 | 2017-09-25 | Sanofi Aventis Deutschland | Long-acting insulin composition |
| IN2012DN02120A (enExample) * | 2009-08-14 | 2015-08-21 | Phasebio Pharmaceuticals Inc |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017078439A1 (ko) * | 2015-11-03 | 2017-05-11 | 재단법인대구경북과학기술원 | 췌장소도세포 및 엘라스틴 유사 인공 세포외 기질을 포함하는 당뇨병 치료용 약학적 조성물 |
| US10813954B2 (en) | 2015-11-03 | 2020-10-27 | Daegu Gyeongbuk Institute Of Science And Technology | Pharmaceutical composition for treating diabetes, comprising pancreatic islet cells and elastin-like artificial extracellular matrix |
| KR20200131721A (ko) * | 2019-05-14 | 2020-11-24 | 강원대학교산학협력단 | 당뇨병성 합병증의 예방 또는 치료용 약제학적 조성물 |
| US11607445B2 (en) | 2019-05-14 | 2023-03-21 | Amolifescience Co., Ltd. | Pharmaceutical composition for preventing or treating diabetic complications |
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| CA2856967A1 (en) | 2013-06-06 |
| AU2012346058A1 (en) | 2014-06-12 |
| WO2013082116A1 (en) | 2013-06-06 |
| BR112014012789A2 (pt) | 2019-09-24 |
| HK1202067A1 (en) | 2015-09-18 |
| US20130150291A1 (en) | 2013-06-13 |
| JP2014534265A (ja) | 2014-12-18 |
| IL232781A0 (en) | 2014-07-31 |
| CN104080473A (zh) | 2014-10-01 |
| RU2014126244A (ru) | 2016-01-27 |
| EP2785367A4 (en) | 2015-06-17 |
| SG11201402661TA (en) | 2014-08-28 |
| MX2014006391A (es) | 2014-09-22 |
| EP2785367A1 (en) | 2014-10-08 |
| US20140364362A1 (en) | 2014-12-11 |
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