KR20140094539A - 덱스메데토미딘을 사용한 소아과 환자 치료 방법 - Google Patents

덱스메데토미딘을 사용한 소아과 환자 치료 방법 Download PDF

Info

Publication number
KR20140094539A
KR20140094539A KR1020147012837A KR20147012837A KR20140094539A KR 20140094539 A KR20140094539 A KR 20140094539A KR 1020147012837 A KR1020147012837 A KR 1020147012837A KR 20147012837 A KR20147012837 A KR 20147012837A KR 20140094539 A KR20140094539 A KR 20140094539A
Authority
KR
South Korea
Prior art keywords
dexmedetomidine
dose
group
age
subjects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020147012837A
Other languages
English (en)
Korean (ko)
Inventor
마르셀로 가르시아 데 로차
웨인 와이스만들
데니스 제이. 스토커
에드워드 쿠우
Original Assignee
호스피라 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47226666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20140094539(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 호스피라 인코포레이티드 filed Critical 호스피라 인코포레이티드
Publication of KR20140094539A publication Critical patent/KR20140094539A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147012837A 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아과 환자 치료 방법 Ceased KR20140094539A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161547626P 2011-10-14 2011-10-14
US61/547,626 2011-10-14
US13/343,693 US20130096170A1 (en) 2011-10-14 2012-01-04 Methods of treating pediatric patients using dexmedetomidine
US13/343,693 2012-01-04
US13/471,403 US8324260B1 (en) 2011-10-14 2012-05-14 Methods of treating pediatric patients using dexmedetomidine
US13/471,403 2012-05-14
PCT/US2012/057652 WO2013055528A1 (en) 2011-10-14 2012-09-27 Methods of treating pediatric patients using dexmedetomidine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197007143A Division KR20190029775A (ko) 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아 환자 치료 방법

Publications (1)

Publication Number Publication Date
KR20140094539A true KR20140094539A (ko) 2014-07-30

Family

ID=47226666

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020147012837A Ceased KR20140094539A (ko) 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아과 환자 치료 방법
KR1020197007143A Ceased KR20190029775A (ko) 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아 환자 치료 방법
KR1020207004550A Ceased KR20200019791A (ko) 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아 환자 치료 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020197007143A Ceased KR20190029775A (ko) 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아 환자 치료 방법
KR1020207004550A Ceased KR20200019791A (ko) 2011-10-14 2012-09-27 덱스메데토미딘을 사용한 소아 환자 치료 방법

Country Status (23)

Country Link
US (8) US20130096170A1 (enExample)
EP (2) EP3446691A1 (enExample)
JP (5) JP6270727B2 (enExample)
KR (3) KR20140094539A (enExample)
CN (2) CN109700806A (enExample)
AU (3) AU2012321246C1 (enExample)
BR (1) BR112014008983A2 (enExample)
CA (2) CA2851780C (enExample)
CY (1) CY1121041T1 (enExample)
DK (1) DK2766014T3 (enExample)
ES (1) ES2685814T3 (enExample)
HK (1) HK1200333A1 (enExample)
HR (1) HRP20181378T1 (enExample)
HU (1) HUE039671T2 (enExample)
IL (2) IL232070A0 (enExample)
IN (1) IN2014KN00996A (enExample)
LT (1) LT2766014T (enExample)
MX (1) MX362626B (enExample)
PL (1) PL2766014T3 (enExample)
PT (1) PT2766014T (enExample)
RS (1) RS57660B1 (enExample)
SI (1) SI2766014T1 (enExample)
WO (1) WO2013055528A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) * 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
KR101831290B1 (ko) 2013-10-07 2018-02-22 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 조성물을 사용하여 주의력 결핍 과잉행동 장애, 불안 및 불면증을 치료하기 위한 방법 및 조성물
TWI645866B (zh) 2013-10-07 2019-01-01 美商帝國製藥美國股份有限公司 右美托咪啶經皮輸送裝置及使用其之方法
EP3054931B1 (en) * 2013-10-07 2020-12-23 Teikoku Pharma USA, Inc. Transdermal delivery device for managing pain comprising dexmedetomidine transdermal compositions
BR112016006848A2 (pt) * 2013-10-07 2017-08-01 Teikoku Pharma Usa Inc métodos e composições para distribuição transdérmica de uma quantidade não sedativa de dexmedetomidina
US11017330B2 (en) * 2014-05-20 2021-05-25 Elasticsearch B.V. Method and system for analysing data
EP3182893B1 (en) 2014-08-18 2024-02-07 Electronic Pain Assessment Technologies (EPAT) Pty Ltd A pain assessment system
CN104784174A (zh) * 2015-03-06 2015-07-22 北京大学第一医院 右美托咪定的药物新用途
US9717796B1 (en) * 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
CA3038354C (en) * 2016-10-31 2021-08-17 Teikoku Pharma Usa, Inc. Methods of managing pain using dexmedetomidine transdermal delivery devices
CN106539778A (zh) * 2016-12-08 2017-03-29 武汉大学 一种小儿麻醉术前含服口腔泡腾片及其制备方法
WO2018126182A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
US11621969B2 (en) 2017-04-26 2023-04-04 Elasticsearch B.V. Clustering and outlier detection in anomaly and causation detection for computing environments
US11783046B2 (en) 2017-04-26 2023-10-10 Elasticsearch B.V. Anomaly and causation detection in computing environments
CN108042533B (zh) * 2017-12-25 2020-11-13 苏州格兰科医药科技有限公司 右美托米定在制备用于预防和/或抑制创伤性脑损伤后的神经元死亡的药物组合物中的用途
WO2020006119A1 (en) * 2018-06-27 2020-01-02 Bioxcel Therapeutics, Inc. Methods for treating agitation using dexmedetomidine hydrochloride
CN114983979A (zh) 2018-06-27 2022-09-02 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
AU2019339352B2 (en) * 2018-09-12 2025-05-22 Hough Ear Institute Methods for treating hearing loss incident to cochlear implant surgery
EP3849532A4 (en) * 2018-09-13 2022-06-08 Taiwan Liposome Company, Ltd. SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A SEDATIVE MEDICINE AND THEIR USES
US20220051802A1 (en) * 2018-12-13 2022-02-17 Dignity Health System and method for detection and monitoring of over sedation to prevent harm to patients
US10817669B2 (en) 2019-01-14 2020-10-27 International Business Machines Corporation Automatic classification of adverse event text fragments
CN109793709A (zh) * 2019-02-22 2019-05-24 青岛农业大学 一种斑海豹用复方注射剂及其制备方法
US11000488B2 (en) * 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol
KR20220049526A (ko) 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
WO2021211507A1 (en) * 2020-04-17 2021-10-21 Bioventures, Llc Methods and systems for predicting the effect of inhaled and infused anesthetics
KR102815903B1 (ko) 2021-12-21 2025-05-30 충남대학교산학협력단 감염 환자에서 반코마이신 최적 용량을 결정하는 방법
EP4386768A1 (en) * 2022-12-13 2024-06-19 Koninklijke Philips N.V. Active sleep apnea case finding and scheduling system and method of operation thereof
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2025176701A1 (en) * 2024-02-19 2025-08-28 Rigshospitalet Novel pediatric composition of nasal dexmedetomidine

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
JPS6058890A (ja) 1983-09-13 1985-04-05 Mizusawa Ind Chem Ltd 感熱記録紙用填剤
FI844786A0 (fi) 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
GB2206880B (en) 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5344840A (en) 1988-02-29 1994-09-06 Orion-Yhtyma Oy 4-substituted imidazole derivatives useful in perioperative care
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI894911A0 (fi) 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
US5304569A (en) 1989-11-13 1994-04-19 Orion-Yhtyma Oy Compositions and their use in lowering intraocular pressure
EP0585368B1 (en) 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
KR100291620B1 (ko) 1992-09-29 2001-10-24 추후제출 부갑상선호르몬의활성단편의폐를통한전달방법
GB2281206A (en) 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
CZ286714B6 (en) 1994-08-08 2000-06-14 Debiopharm Sa Pharmaceutically stable preparation based on oxaliplatinum
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19758564A1 (de) 1997-11-11 1999-08-26 Gruenenthal Gmbh Formulierung einer Kombination aus Morphin und einem alpha¶2¶-adrenergem Agonisten und deren Verwendung
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) * 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
PE20001396A1 (es) 1999-01-18 2000-12-23 Gruenenthal Chemie Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista
GB9913677D0 (en) 1999-06-11 1999-08-11 Imperial College Formulation
US6806291B1 (en) 2003-10-09 2004-10-19 The Foundation For The Lsu Health Sciences Center Analgesic compounds, their synthesis and pharmaceutical compositions containing them
US20080308444A1 (en) 2007-06-13 2008-12-18 Baxter International Inc. Packaging system and method of alerting a practitioner
US20100197694A1 (en) 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
EP2165706A1 (en) 2008-09-18 2010-03-24 BioAlliance Pharma Treating Inflammatory Pain in Mucosa of the Oral Cavity Using Mucosal Prolonged Release Bioadhesive Therapeutic Carriers.
US8100890B2 (en) * 2008-10-15 2012-01-24 Bioquiddity, Inc. Special purpose fluid dispenser with pre-filled reservoir
US7896843B2 (en) * 2008-10-15 2011-03-01 Bioquiddity, Inc. Special purpose fluid dispenser
US8603497B2 (en) 2008-10-30 2013-12-10 National University Corporation Okayama University Composition for local anesthesia
KR101859486B1 (ko) 2009-05-15 2018-06-28 레크로파마, 인코포레이티드 설하용 덱스메데토미딘 조성물과 그의 사용 방법
US8410140B2 (en) 2009-06-01 2013-04-02 The Regents Of The University Of Michigan Anesthetic methods and compositions
WO2011075621A1 (en) 2009-12-17 2011-06-23 Alpha Synergy Development, Inc. Compositions and methods for ophthalmic delivery of nasal decongestants
FR2959414B1 (fr) 2010-04-30 2016-01-08 Luc Quintin Combinaison de molecules aux fins de traitement d'hypotension survenant au cours du choc septique, cardiogenique, ou anaphylactique refractaire, ou hemorragique terminal, apres correction de la volemie et de l'etat de mal asthmatique refractaire
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation

Also Published As

Publication number Publication date
AU2019203564A1 (en) 2019-06-13
US20190269657A1 (en) 2019-09-05
IL232070A0 (en) 2014-05-28
JP6640164B2 (ja) 2020-02-05
BR112014008983A2 (pt) 2017-05-02
US9314449B2 (en) 2016-04-19
JP2014528474A (ja) 2014-10-27
MX2014004548A (es) 2015-02-12
ES2685814T3 (es) 2018-10-11
AU2012321246C1 (en) 2017-11-02
EP2766014A4 (en) 2015-06-24
HUE039671T2 (hu) 2019-01-28
EP3446691A1 (en) 2019-02-27
AU2012321246B2 (en) 2017-05-04
US8507542B2 (en) 2013-08-13
JP2022008828A (ja) 2022-01-14
KR20190029775A (ko) 2019-03-20
DK2766014T3 (en) 2018-09-24
EP2766014B1 (en) 2018-07-18
US20210137891A1 (en) 2021-05-13
JP2020073529A (ja) 2020-05-14
US20130096170A1 (en) 2013-04-18
IL249991A0 (en) 2017-03-30
LT2766014T (lt) 2018-08-27
HK1200333A1 (en) 2015-08-07
JP2018027971A (ja) 2018-02-22
AU2012321246A1 (en) 2014-05-01
CN109700806A (zh) 2019-05-03
US20160067220A1 (en) 2016-03-10
CA2851780A1 (en) 2013-04-18
US20140005243A1 (en) 2014-01-02
IN2014KN00996A (enExample) 2015-09-04
CY1121041T1 (el) 2019-12-11
JP6270727B2 (ja) 2018-01-31
MX362626B (es) 2019-01-28
AU2017206211A1 (en) 2017-08-03
EP2766014A1 (en) 2014-08-20
PT2766014T (pt) 2018-10-11
RS57660B1 (sr) 2018-11-30
PL2766014T3 (pl) 2019-02-28
CA2978258A1 (en) 2013-04-18
SI2766014T1 (sl) 2018-11-30
US20130096172A1 (en) 2013-04-18
CN103957906A (zh) 2014-07-30
AU2017206211B2 (en) 2019-02-28
KR20200019791A (ko) 2020-02-24
US20130096171A1 (en) 2013-04-18
CA2851780C (en) 2017-11-28
WO2013055528A1 (en) 2013-04-18
HRP20181378T1 (hr) 2018-10-19
US8324260B1 (en) 2012-12-04
JP2023179764A (ja) 2023-12-19

Similar Documents

Publication Publication Date Title
KR20140094539A (ko) 덱스메데토미딘을 사용한 소아과 환자 치료 방법
Amao et al. Use of sugammadex in patients with a history of pulmonary disease
Chernick et al. Clinical trial of naloxone, in birth asphyxia
Guglielminotti et al. Effects of premedication on dose requirements for propofol: comparison of clonidine and hydroxyzine.
Vaughn et al. Comparison of continuous infusion of fentanyl to bolus dosing in neonates after surgery
Zongming et al. Sidestream capnographic monitoring reduces the incidence of arterial oxygen desaturation during propofol ambulatory anesthesia for surgical abortion
Abdel‐Latif et al. Intra‐amniotic surfactant for women at risk of preterm birth for preventing respiratory distress in newborns
HK40008319A (en) Methods of treating pediatric patients using dexmedetomidine
Rajendram et al. Critical Care and Anaesthesia
HK1260448A1 (en) Methods of treating pediatric patients using dexmedetomidine
RU2848083C1 (ru) Способы лечения заболевания cln2 у детей
Makhlouf et al. Hyaluronic acid as a biomarker for liver fibrosis in chronic hepatitis “C” patients

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20140513

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20170425

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180803

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20190111

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20180803

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20190311