KR20140082699A - 플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제 - Google Patents
플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제 Download PDFInfo
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- KR20140082699A KR20140082699A KR1020147009783A KR20147009783A KR20140082699A KR 20140082699 A KR20140082699 A KR 20140082699A KR 1020147009783 A KR1020147009783 A KR 1020147009783A KR 20147009783 A KR20147009783 A KR 20147009783A KR 20140082699 A KR20140082699 A KR 20140082699A
- Authority
- KR
- South Korea
- Prior art keywords
- corneal epithelial
- cell death
- epithelial cell
- salt
- adenine dinucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 235000019162 flavin adenine dinucleotide Nutrition 0.000 title claims abstract description 73
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- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical compound C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229940069265 ophthalmic ointment Drugs 0.000 description 1
- 229940023490 ophthalmic product Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP-P-2011-210875 | 2011-09-27 | ||
| JP2011210875 | 2011-09-27 | ||
| PCT/JP2012/074662 WO2013047567A1 (ja) | 2011-09-27 | 2012-09-26 | フラビンアデニンジヌクレオチドまたはその塩を有効成分として含有する角膜上皮細胞死の抑制剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140082699A true KR20140082699A (ko) | 2014-07-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147009783A Withdrawn KR20140082699A (ko) | 2011-09-27 | 2012-09-26 | 플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제 |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP5969872B2 (enExample) |
| KR (1) | KR20140082699A (enExample) |
| CN (1) | CN103826642B (enExample) |
| IN (1) | IN2014DN03350A (enExample) |
| MY (1) | MY185239A (enExample) |
| PH (1) | PH12014500660A1 (enExample) |
| SG (2) | SG11201400947XA (enExample) |
| TW (1) | TWI561238B (enExample) |
| WO (1) | WO2013047567A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016046734A2 (en) * | 2014-09-22 | 2016-03-31 | University Of The Western Cape | Compounds and compositions for treatment of tuberculosis |
| EP4512395A1 (en) | 2023-08-21 | 2025-02-26 | Bio Even | Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773076B1 (fr) * | 1997-12-29 | 2000-05-19 | Chauvin Lab Sa | Utilisation de la flavine-adenine-dinucleotide pour la preparation de compositions ophtalmiques utiles pour le traitement de l'oeil sec |
| JP4836401B2 (ja) * | 2002-04-01 | 2011-12-14 | ロート製薬株式会社 | 眼科用組成物 |
| JP2004203836A (ja) * | 2002-12-26 | 2004-07-22 | Rohto Pharmaceut Co Ltd | 眼科用局所適用製剤 |
| JP2005239622A (ja) * | 2004-02-26 | 2005-09-08 | Rohto Pharmaceut Co Ltd | 角膜障害治療剤 |
| JP4999304B2 (ja) * | 2004-09-27 | 2012-08-15 | ロート製薬株式会社 | ヒアルロン酸又はその塩を含有する粘膜適用組成物 |
| JP4969052B2 (ja) * | 2005-03-31 | 2012-07-04 | 小林製薬株式会社 | 眼科用組成物 |
| CN101301305A (zh) * | 2008-05-14 | 2008-11-12 | 北京润德康医药技术有限公司 | 一种黄素腺嘌呤二核苷酸二钠冻干粉针制剂及其制备方法 |
| JP5506357B2 (ja) * | 2009-12-02 | 2014-05-28 | ロート製薬株式会社 | シリコーンハイドロゲルコンタクトレンズ用眼科組成物 |
| EP2735303A1 (en) * | 2012-11-23 | 2014-05-28 | Pilosciences | Hair growth compositions and methods |
-
2012
- 2012-09-26 CN CN201280046826.0A patent/CN103826642B/zh not_active Expired - Fee Related
- 2012-09-26 JP JP2012212575A patent/JP5969872B2/ja active Active
- 2012-09-26 WO PCT/JP2012/074662 patent/WO2013047567A1/ja not_active Ceased
- 2012-09-26 SG SG11201400947XA patent/SG11201400947XA/en unknown
- 2012-09-26 MY MYPI2014000895A patent/MY185239A/en unknown
- 2012-09-26 PH PH1/2014/500660A patent/PH12014500660A1/en unknown
- 2012-09-26 KR KR1020147009783A patent/KR20140082699A/ko not_active Withdrawn
- 2012-09-26 SG SG10201602401PA patent/SG10201602401PA/en unknown
- 2012-09-26 TW TW101135280A patent/TWI561238B/zh not_active IP Right Cessation
-
2014
- 2014-04-25 IN IN3350DEN2014 patent/IN2014DN03350A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12014500660A1 (en) | 2014-05-05 |
| MY185239A (en) | 2021-04-30 |
| JP5969872B2 (ja) | 2016-08-17 |
| CN103826642B (zh) | 2016-02-17 |
| SG10201602401PA (en) | 2016-04-28 |
| SG11201400947XA (en) | 2014-07-30 |
| JP2013082696A (ja) | 2013-05-09 |
| TWI561238B (en) | 2016-12-11 |
| WO2013047567A1 (ja) | 2013-04-04 |
| IN2014DN03350A (enExample) | 2015-06-05 |
| CN103826642A (zh) | 2014-05-28 |
| TW201318628A (zh) | 2013-05-16 |
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