TWI561238B - Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredient - Google Patents

Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredient

Info

Publication number
TWI561238B
TWI561238B TW101135280A TW101135280A TWI561238B TW I561238 B TWI561238 B TW I561238B TW 101135280 A TW101135280 A TW 101135280A TW 101135280 A TW101135280 A TW 101135280A TW I561238 B TWI561238 B TW I561238B
Authority
TW
Taiwan
Prior art keywords
inhibitor
salts
active ingredient
cell death
adenine dinucleotide
Prior art date
Application number
TW101135280A
Other languages
English (en)
Chinese (zh)
Other versions
TW201318628A (zh
Inventor
Asuka Sakamoto
Masatsugu Nakamura
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of TW201318628A publication Critical patent/TW201318628A/zh
Application granted granted Critical
Publication of TWI561238B publication Critical patent/TWI561238B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW101135280A 2011-09-27 2012-09-26 Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredient TWI561238B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011210875 2011-09-27

Publications (2)

Publication Number Publication Date
TW201318628A TW201318628A (zh) 2013-05-16
TWI561238B true TWI561238B (en) 2016-12-11

Family

ID=47995597

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101135280A TWI561238B (en) 2011-09-27 2012-09-26 Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredient

Country Status (9)

Country Link
JP (1) JP5969872B2 (enExample)
KR (1) KR20140082699A (enExample)
CN (1) CN103826642B (enExample)
IN (1) IN2014DN03350A (enExample)
MY (1) MY185239A (enExample)
PH (1) PH12014500660A1 (enExample)
SG (2) SG11201400947XA (enExample)
TW (1) TWI561238B (enExample)
WO (1) WO2013047567A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016046734A2 (en) * 2014-09-22 2016-03-31 University Of The Western Cape Compounds and compositions for treatment of tuberculosis
EP4512395A1 (en) 2023-08-21 2025-02-26 Bio Even Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014080015A2 (en) * 2012-11-23 2014-05-30 Pilosciences Hair growth compositions and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773076B1 (fr) * 1997-12-29 2000-05-19 Chauvin Lab Sa Utilisation de la flavine-adenine-dinucleotide pour la preparation de compositions ophtalmiques utiles pour le traitement de l'oeil sec
JP4836401B2 (ja) * 2002-04-01 2011-12-14 ロート製薬株式会社 眼科用組成物
JP2004203836A (ja) * 2002-12-26 2004-07-22 Rohto Pharmaceut Co Ltd 眼科用局所適用製剤
JP2005239622A (ja) * 2004-02-26 2005-09-08 Rohto Pharmaceut Co Ltd 角膜障害治療剤
JP4999304B2 (ja) * 2004-09-27 2012-08-15 ロート製薬株式会社 ヒアルロン酸又はその塩を含有する粘膜適用組成物
JP4969052B2 (ja) * 2005-03-31 2012-07-04 小林製薬株式会社 眼科用組成物
CN101301305A (zh) * 2008-05-14 2008-11-12 北京润德康医药技术有限公司 一种黄素腺嘌呤二核苷酸二钠冻干粉针制剂及其制备方法
JP5506357B2 (ja) * 2009-12-02 2014-05-28 ロート製薬株式会社 シリコーンハイドロゲルコンタクトレンズ用眼科組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014080015A2 (en) * 2012-11-23 2014-05-30 Pilosciences Hair growth compositions and methods

Also Published As

Publication number Publication date
PH12014500660A1 (en) 2014-05-05
KR20140082699A (ko) 2014-07-02
MY185239A (en) 2021-04-30
JP5969872B2 (ja) 2016-08-17
CN103826642B (zh) 2016-02-17
SG10201602401PA (en) 2016-04-28
SG11201400947XA (en) 2014-07-30
JP2013082696A (ja) 2013-05-09
WO2013047567A1 (ja) 2013-04-04
IN2014DN03350A (enExample) 2015-06-05
CN103826642A (zh) 2014-05-28
TW201318628A (zh) 2013-05-16

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees