CN103826642B - 含有黄素腺嘌呤二核苷酸或其盐作为有效成分的角膜上皮细胞死亡的抑制剂 - Google Patents

含有黄素腺嘌呤二核苷酸或其盐作为有效成分的角膜上皮细胞死亡的抑制剂 Download PDF

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Publication number
CN103826642B
CN103826642B CN201280046826.0A CN201280046826A CN103826642B CN 103826642 B CN103826642 B CN 103826642B CN 201280046826 A CN201280046826 A CN 201280046826A CN 103826642 B CN103826642 B CN 103826642B
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China
Prior art keywords
present
fad
corneal epithelial
cell death
epithelial cell
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Expired - Fee Related
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CN201280046826.0A
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English (en)
Chinese (zh)
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CN103826642A (zh
Inventor
阪元明日香
中村雅胤
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201280046826.0A 2011-09-27 2012-09-26 含有黄素腺嘌呤二核苷酸或其盐作为有效成分的角膜上皮细胞死亡的抑制剂 Expired - Fee Related CN103826642B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011210875 2011-09-27
JP2011-210875 2011-09-27
PCT/JP2012/074662 WO2013047567A1 (ja) 2011-09-27 2012-09-26 フラビンアデニンジヌクレオチドまたはその塩を有効成分として含有する角膜上皮細胞死の抑制剤

Publications (2)

Publication Number Publication Date
CN103826642A CN103826642A (zh) 2014-05-28
CN103826642B true CN103826642B (zh) 2016-02-17

Family

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Family Applications (1)

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CN201280046826.0A Expired - Fee Related CN103826642B (zh) 2011-09-27 2012-09-26 含有黄素腺嘌呤二核苷酸或其盐作为有效成分的角膜上皮细胞死亡的抑制剂

Country Status (9)

Country Link
JP (1) JP5969872B2 (enExample)
KR (1) KR20140082699A (enExample)
CN (1) CN103826642B (enExample)
IN (1) IN2014DN03350A (enExample)
MY (1) MY185239A (enExample)
PH (1) PH12014500660A1 (enExample)
SG (2) SG11201400947XA (enExample)
TW (1) TWI561238B (enExample)
WO (1) WO2013047567A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016046734A2 (en) * 2014-09-22 2016-03-31 University Of The Western Cape Compounds and compositions for treatment of tuberculosis
EP4512395A1 (en) 2023-08-21 2025-02-26 Bio Even Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773076B1 (fr) * 1997-12-29 2000-05-19 Chauvin Lab Sa Utilisation de la flavine-adenine-dinucleotide pour la preparation de compositions ophtalmiques utiles pour le traitement de l'oeil sec
JP4836401B2 (ja) * 2002-04-01 2011-12-14 ロート製薬株式会社 眼科用組成物
JP2004203836A (ja) * 2002-12-26 2004-07-22 Rohto Pharmaceut Co Ltd 眼科用局所適用製剤
JP2005239622A (ja) * 2004-02-26 2005-09-08 Rohto Pharmaceut Co Ltd 角膜障害治療剤
JP4999304B2 (ja) * 2004-09-27 2012-08-15 ロート製薬株式会社 ヒアルロン酸又はその塩を含有する粘膜適用組成物
JP4969052B2 (ja) * 2005-03-31 2012-07-04 小林製薬株式会社 眼科用組成物
CN101301305A (zh) * 2008-05-14 2008-11-12 北京润德康医药技术有限公司 一种黄素腺嘌呤二核苷酸二钠冻干粉针制剂及其制备方法
JP5506357B2 (ja) * 2009-12-02 2014-05-28 ロート製薬株式会社 シリコーンハイドロゲルコンタクトレンズ用眼科組成物
EP2735303A1 (en) * 2012-11-23 2014-05-28 Pilosciences Hair growth compositions and methods

Also Published As

Publication number Publication date
PH12014500660A1 (en) 2014-05-05
KR20140082699A (ko) 2014-07-02
MY185239A (en) 2021-04-30
JP5969872B2 (ja) 2016-08-17
SG10201602401PA (en) 2016-04-28
SG11201400947XA (en) 2014-07-30
JP2013082696A (ja) 2013-05-09
TWI561238B (en) 2016-12-11
WO2013047567A1 (ja) 2013-04-04
IN2014DN03350A (enExample) 2015-06-05
CN103826642A (zh) 2014-05-28
TW201318628A (zh) 2013-05-16

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