KR20140066783A - 종양 또는 종양 세포에서의 상피 또는 중간엽 표현형 및 egfr 키나제 억제제에 대한 반응의 진단 메틸화 마커 - Google Patents

종양 또는 종양 세포에서의 상피 또는 중간엽 표현형 및 egfr 키나제 억제제에 대한 반응의 진단 메틸화 마커 Download PDF

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KR20140066783A
KR20140066783A KR1020147011145A KR20147011145A KR20140066783A KR 20140066783 A KR20140066783 A KR 20140066783A KR 1020147011145 A KR1020147011145 A KR 1020147011145A KR 20147011145 A KR20147011145 A KR 20147011145A KR 20140066783 A KR20140066783 A KR 20140066783A
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methylation
dna
egfr
tumor
cancer
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데이빗 셰임스
토마스 엠. 홀콤브
킴벌리 월터
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제넨테크, 인크.
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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KR1020147011145A 2011-09-30 2012-09-28 종양 또는 종양 세포에서의 상피 또는 중간엽 표현형 및 egfr 키나제 억제제에 대한 반응의 진단 메틸화 마커 Ceased KR20140066783A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161542141P 2011-09-30 2011-09-30
US61/542,141 2011-09-30
PCT/US2012/057777 WO2013055530A1 (en) 2011-09-30 2012-09-28 Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells

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KR20140066783A true KR20140066783A (ko) 2014-06-02

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KR1020147011145A Ceased KR20140066783A (ko) 2011-09-30 2012-09-28 종양 또는 종양 세포에서의 상피 또는 중간엽 표현형 및 egfr 키나제 억제제에 대한 반응의 진단 메틸화 마커

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US (1) US20130084287A1 (https=)
EP (1) EP2761025A1 (https=)
JP (1) JP2014531213A (https=)
KR (1) KR20140066783A (https=)
CN (1) CN104066851A (https=)
AU (1) AU2012321248A1 (https=)
BR (1) BR112014007569A2 (https=)
CA (1) CA2849120A1 (https=)
IL (1) IL231590A0 (https=)
MX (1) MX2014003698A (https=)
RU (1) RU2014110228A (https=)
SG (1) SG11201400996SA (https=)
WO (1) WO2013055530A1 (https=)
ZA (1) ZA201401968B (https=)

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JP6779858B2 (ja) * 2014-07-29 2020-11-04 ウェルマーカー バイオ カンパニー リミテッド Ｅｇｆｒ−標的製剤に対する感受性予測用の新規なバイオマーカー及びその用途
JP6709541B2 (ja) * 2014-10-17 2020-06-17 国立大学法人東北大学 大腸癌に対する薬物療法の感受性を予測する方法
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CN118086498A (zh) 2018-01-18 2024-05-28 纽克莱克斯有限公司 用于诊断肺癌的方法
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BR112021009795A2 (pt) * 2018-11-27 2021-08-17 Exact Sciences Development Company, Llc métodos de caracterização e para caracterizar uma amostra, kit e composição
CN111521810B (zh) * 2019-02-02 2024-06-21 中国科学院上海药物研究所 癌症患者根据脾酪氨酸激酶进行分层
IL265451B (en) 2019-03-18 2020-01-30 Frumkin Dan Methods and systems for the detection of methylation changes in DNA samples
CN110283910B (zh) * 2019-06-21 2021-04-20 浙江大学 目标基因dna甲基化作为分子标志物在制备判别结直肠组织癌变进展试剂盒中的应用
CN111304305B (zh) * 2020-03-30 2023-05-30 陕西科技大学 一种用于检测egfr基因甲基化的试剂盒及方法
CN111676286B (zh) * 2020-05-29 2023-04-14 武汉爱基百客生物科技有限公司 肺癌血浆游离dna甲基化检测用的多重pcr引物系统、检测方法及应用
CN114354927B (zh) * 2021-03-18 2025-04-22 中国人民解放军陆军特色医学中心 唾液酸转移酶st3gal4作为egfr-tki耐药标志物的新应用
CN115772565B (zh) * 2021-09-08 2023-09-05 广州市基准医疗有限责任公司 用于辅助检测肺癌体细胞egfr基因突变的甲基化位点及其应用
CN114525281B (zh) * 2022-03-14 2024-03-12 右江民族医学院 Esrp1启动子报告基因转录活性可视化及在去甲基化抗癌药物筛选中的应用
CN115651984B (zh) * 2022-10-20 2023-04-14 山东大学 一种生物标志物在评价肿瘤紫杉类化疗耐药性的应用

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BR112014007569A2 (pt) 2017-04-18
RU2014110228A (ru) 2015-11-10
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