KR20140037868A - 폐동맥 고혈압의 치료에서 마이크로rna를 조절하는 방법 - Google Patents

폐동맥 고혈압의 치료에서 마이크로rna를 조절하는 방법 Download PDF

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KR20140037868A
KR20140037868A KR1020137032530A KR20137032530A KR20140037868A KR 20140037868 A KR20140037868 A KR 20140037868A KR 1020137032530 A KR1020137032530 A KR 1020137032530A KR 20137032530 A KR20137032530 A KR 20137032530A KR 20140037868 A KR20140037868 A KR 20140037868A
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South Korea
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mir
inhibitor
sequence
antisense oligonucleotide
modification
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Korean (ko)
Inventor
앤드류 베이커
마가렛 맥클린
니콜라스 모렐
Original Assignee
더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우
캠브리지 엔터프라이즈 리미티드
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Application filed by 더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우, 캠브리지 엔터프라이즈 리미티드 filed Critical 더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우
Publication of KR20140037868A publication Critical patent/KR20140037868A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020137032530A 2011-05-09 2012-05-09 폐동맥 고혈압의 치료에서 마이크로rna를 조절하는 방법 Withdrawn KR20140037868A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161484091P 2011-05-09 2011-05-09
US61/484,091 2011-05-09
US201261605376P 2012-03-01 2012-03-01
US61/605,376 2012-03-01
PCT/GB2012/051018 WO2012153135A1 (en) 2011-05-09 2012-05-09 Methods of modulating micrornas in the treatment of pulmonary arterial hypertension

Publications (1)

Publication Number Publication Date
KR20140037868A true KR20140037868A (ko) 2014-03-27

Family

ID=46178572

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137032530A Withdrawn KR20140037868A (ko) 2011-05-09 2012-05-09 폐동맥 고혈압의 치료에서 마이크로rna를 조절하는 방법

Country Status (11)

Country Link
US (1) US9267134B2 (enExample)
EP (1) EP2707485B1 (enExample)
JP (1) JP6049700B2 (enExample)
KR (1) KR20140037868A (enExample)
CN (1) CN103814131A (enExample)
AU (1) AU2012252165A1 (enExample)
BR (1) BR112013029016A2 (enExample)
CA (1) CA2835568A1 (enExample)
CO (1) CO6870004A2 (enExample)
SG (1) SG194901A1 (enExample)
WO (1) WO2012153135A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022154636A1 (ko) * 2021-01-18 2022-07-21 (주)스템메디텍 Mir 145 억제제를 유효성분으로 포함하는 심근경색증의 치료용 조성물

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EP2970968B1 (en) 2013-03-15 2018-01-10 Miragen Therapeutics, Inc. Bridged bicyclic nucleosides
US9752143B2 (en) 2013-03-15 2017-09-05 MiRagen Therapeutics, Inc. Locked nucleic acid inhibitor of miR-145 and uses thereof
WO2015082896A1 (en) * 2013-12-02 2015-06-11 The University Court Of The University Of Glasgow Materials and methods for treatment of pulmonary arterial hypertension
CA2956256A1 (en) * 2014-08-01 2016-02-04 The Brigham And Women's Hospital, Inc. Methods and compositions relating to treatment of pulmonary arterial hypertension
BR112017014914B1 (pt) * 2015-01-13 2023-11-14 Vivus, Inc Uso de uma combinação de tacrolimus e um segundo agente ativo eficaz no tratamento ou prevenção da hipertensão pulmonar
CN110088278B (zh) * 2016-10-31 2023-08-11 e-NA生物科技公司 双链核酸分子及其用途
CN115175685B (zh) * 2019-12-09 2024-12-13 艾姆皮瑞克公司 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸
CN113332306A (zh) * 2021-04-28 2021-09-03 武汉华纪元生物技术开发有限公司 用于治疗肺动脉高血压的microRNA-30a抑制剂及其应用
GB202215974D0 (en) * 2022-10-28 2022-12-14 Imperial College Innovations Ltd Microrna panels for pulmonary hypertension

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SE9600216D0 (sv) 1996-01-18 1996-01-18 Hans Arne Hansson Styrning av läkningsprocesser
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022154636A1 (ko) * 2021-01-18 2022-07-21 (주)스템메디텍 Mir 145 억제제를 유효성분으로 포함하는 심근경색증의 치료용 조성물
EP4279091A4 (en) * 2021-01-18 2024-12-11 Regen Innopharm Inc. Composition comprising mir 145 inhibitor as active ingredient for treatment of myocardial infarction

Also Published As

Publication number Publication date
BR112013029016A2 (pt) 2017-01-17
EP2707485A1 (en) 2014-03-19
WO2012153135A1 (en) 2012-11-15
SG194901A1 (en) 2013-12-30
JP6049700B2 (ja) 2016-12-21
CO6870004A2 (es) 2014-02-20
US9267134B2 (en) 2016-02-23
JP2014516027A (ja) 2014-07-07
CA2835568A1 (en) 2012-11-15
CN103814131A (zh) 2014-05-21
EP2707485B1 (en) 2016-12-14
US20140163086A1 (en) 2014-06-12
AU2012252165A1 (en) 2013-03-21

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PA0105 International application

Patent event date: 20131206

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid