KR20140035967A - 세포 및 유전자에 기반한 심장 기능을 개선하는 방법 - Google Patents

세포 및 유전자에 기반한 심장 기능을 개선하는 방법 Download PDF

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KR20140035967A
KR20140035967A KR1020137034630A KR20137034630A KR20140035967A KR 20140035967 A KR20140035967 A KR 20140035967A KR 1020137034630 A KR1020137034630 A KR 1020137034630A KR 20137034630 A KR20137034630 A KR 20137034630A KR 20140035967 A KR20140035967 A KR 20140035967A
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nucleic acid
acid sequence
cardiac
ctnc
vector
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미셸 레그니어
미셸 라플레임
찰스 머리
에프. 스티븐 코르테
스코트 룬디
스테펜 데니슨 호쉬카
제프리 에스. 챔버레인
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유니버시티 오브 워싱톤
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KR1020137034630A 2011-05-26 2012-05-29 세포 및 유전자에 기반한 심장 기능을 개선하는 방법 Ceased KR20140035967A (ko)

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Application Number Priority Date Filing Date Title
US201161490450P 2011-05-26 2011-05-26
US61/490,450 2011-05-26
PCT/US2012/039897 WO2012162705A2 (en) 2011-05-26 2012-05-29 Cell and gene based methods to improve cardiac function

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KR20140035967A true KR20140035967A (ko) 2014-03-24

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US (1) US9868937B2 (enExample)
EP (1) EP2714709B1 (enExample)
JP (1) JP6162104B2 (enExample)
KR (1) KR20140035967A (enExample)
CN (1) CN103946230B (enExample)
AU (1) AU2012258525B2 (enExample)
BR (1) BR112013030209A2 (enExample)
CA (1) CA2837322C (enExample)
RU (1) RU2608957C2 (enExample)
WO (1) WO2012162705A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2837322C (en) 2011-05-26 2023-03-21 University Of Washington Cell and gene based methods to improve cardiac function
EP2792742A1 (en) 2013-04-17 2014-10-22 Universitätsklinikum Hamburg-Eppendorf (UKE) Gene-therapy vectors for treating cardiomyopathy
WO2015153357A1 (en) * 2014-03-29 2015-10-08 Beat Biotherapeutics Corp. Compositions and methods for improving cardiac function
WO2016115543A2 (en) * 2015-01-16 2016-07-21 University Of Washington Novel micro-dystrophins and related methods of use
CA2979229A1 (en) 2015-03-11 2016-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rp2 vectors for treating x-linked retinitis pigmentosa
EP3337892A2 (en) 2015-08-18 2018-06-27 Boston Scientific Scimed Inc. Methods for producing cardiomyocyte cells
JP6940920B2 (ja) 2017-02-04 2021-09-29 アナバイオス コーポレーション 医薬誘発性の変力作用および不整脈誘発のリスクを予測するためのシステムおよび方法
CN108913655B (zh) * 2018-07-16 2022-07-15 浙江大学 基于多能干细胞技术建立“人源性”心肌肥大模型的方法
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
KR20210102870A (ko) 2018-08-30 2021-08-20 테나야 테라퓨틱스, 인코포레이티드 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍
US20200405824A1 (en) * 2019-06-26 2020-12-31 University Of Washington Use of ribonucleotide reductase alone or in combination with micro-dystrophin to treat duchenne muscular dystrophy striated muscle disease
CN110384800B (zh) * 2019-07-19 2021-06-08 广东省实验动物监测所 LncRNA XLOC_075168在制备促进血管新生的药物中的应用
FI4103214T3 (fi) 2020-02-13 2026-07-03 Tenaya Therapeutics Inc Geeniterapian vektorit sydänsairauden hoitoon
US20240189481A1 (en) * 2021-04-06 2024-06-13 University Of Washington Non-contractile cardiomyocytes for cardiac repair
CA3240616A1 (en) * 2021-12-10 2023-06-15 Christopher Dean HERZOG Troponin c (tnnc1) gene therapy using aav vector
WO2025207745A1 (en) * 2024-03-27 2025-10-02 The Board Of Trustees Of The Leland Stanford Junior University Methods of inducing dilated cardiomyopathy phenotype in cardiomyocytes and applications thereof
CN120758566B (zh) * 2025-09-10 2025-11-21 瓯江实验室 一种在心肌细胞中特异性过表达zer1的病毒载体的构建及在心衰治疗中的应用

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
JPH02240440A (ja) 1989-03-14 1990-09-25 Shiigeru:Kk 慣性ダンパ
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
US6151525A (en) 1997-11-07 2000-11-21 Medtronic, Inc. Method and system for myocardial identifier repair
EP1085910A2 (en) 1998-05-30 2001-03-28 Collateral Therapeutics, Inc. Methods of altering cardiac cell phenotype
CN1159445C (zh) 1998-09-11 2004-07-28 加利福尼亚大学董事会 能在心脏中组织特异性表达的重组腺病毒
EP1139751A4 (en) * 1998-12-28 2003-03-19 Arch Dev Corp EFFICIENT AND STABLE -I (IN VIVO) GENE TRANSFER TO CARDIOMYCETS USING RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS
AU2002230999A1 (en) 2000-12-21 2002-07-01 Medtronic, Inc. Electrically responsive promoter system
EP1509252A4 (en) * 2002-05-08 2006-08-16 Univ California METHOD AND COMPOSITIONS FOR CORRECTING HEART TRANSFER FAULTS
WO2004024867A2 (en) 2002-09-11 2004-03-25 University Of Florida Vigilant vector system
EP1654365A1 (en) 2003-08-11 2006-05-10 University Of South Florida Vigilant cells
BRPI0416732A (pt) 2003-11-21 2007-01-16 Daiichi Asubio Pharma Co Ltd métodos para a proliferação de cardiomiócitos, e para tratar um distúrbio cardìaco, vetor, composição farmacêutica, e, cardiomiócito
US20050260637A1 (en) 2004-03-25 2005-11-24 Yun Yen Drug screening
DE102011018586A1 (de) 2011-04-26 2012-10-31 Oliver Müller Vektorsystem zur spezifischen Genexpression im Herzmuskel
CA2837322C (en) 2011-05-26 2023-03-21 University Of Washington Cell and gene based methods to improve cardiac function

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WO2012162705A3 (en) 2013-02-28
RU2608957C2 (ru) 2017-01-27
US20160186139A1 (en) 2016-06-30
US9868937B2 (en) 2018-01-16
RU2013157590A (ru) 2015-07-10
CA2837322A1 (en) 2012-11-29
EP2714709B1 (en) 2018-04-18
CN103946230A (zh) 2014-07-23
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EP2714709A2 (en) 2014-04-09
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AU2012258525B2 (en) 2017-02-23
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