BR112013030209A2 - métodos baseados em célula e gene para melhorar função cardíaca - Google Patents

métodos baseados em célula e gene para melhorar função cardíaca

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Publication number
BR112013030209A2
BR112013030209A2 BR112013030209A BR112013030209A BR112013030209A2 BR 112013030209 A2 BR112013030209 A2 BR 112013030209A2 BR 112013030209 A BR112013030209 A BR 112013030209A BR 112013030209 A BR112013030209 A BR 112013030209A BR 112013030209 A2 BR112013030209 A2 BR 112013030209A2
Authority
BR
Brazil
Prior art keywords
gene
cell
based methods
heart function
improve heart
Prior art date
Application number
BR112013030209A
Other languages
English (en)
Portuguese (pt)
Inventor
Murry Charles
S Chamberlain Jeffrey
Laflamme Michael
Regnier Michael
Lundy Scott
Denison Hauschka Stephen
F Korte Steven
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of BR112013030209A2 publication Critical patent/BR112013030209A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12Y117/04—Oxidoreductases acting on CH or CH2 groups (1.17) with a disulfide as acceptor (1.17.3)
    • C12Y117/04002—Ribonucleoside-triphosphate reductase (1.17.4.2)
    • A—HUMAN NECESSITIES
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/04—Oxidoreductases acting on CH or CH2 groups (1.17) with a disulfide as acceptor (1.17.3)
    • C12Y117/04001—Ribonucleoside-diphosphate reductase (1.17.4.1)

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  • Heart & Thoracic Surgery (AREA)
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  • General Chemical & Material Sciences (AREA)
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BR112013030209A 2011-05-26 2012-05-29 métodos baseados em célula e gene para melhorar função cardíaca BR112013030209A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161490450P 2011-05-26 2011-05-26
PCT/US2012/039897 WO2012162705A2 (en) 2011-05-26 2012-05-29 Cell and gene based methods to improve cardiac function

Publications (1)

Publication Number Publication Date
BR112013030209A2 true BR112013030209A2 (pt) 2017-06-13

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BR112013030209A BR112013030209A2 (pt) 2011-05-26 2012-05-29 métodos baseados em célula e gene para melhorar função cardíaca

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US (1) US9868937B2 (enExample)
EP (1) EP2714709B1 (enExample)
JP (1) JP6162104B2 (enExample)
KR (1) KR20140035967A (enExample)
CN (1) CN103946230B (enExample)
AU (1) AU2012258525B2 (enExample)
BR (1) BR112013030209A2 (enExample)
CA (1) CA2837322C (enExample)
RU (1) RU2608957C2 (enExample)
WO (1) WO2012162705A2 (enExample)

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EP2792742A1 (en) * 2013-04-17 2014-10-22 Universitätsklinikum Hamburg-Eppendorf (UKE) Gene-therapy vectors for treating cardiomyopathy
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AU2016206518B2 (en) * 2015-01-16 2020-03-05 University Of Washington Novel micro-dystrophins and related methods of use
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CN108913655B (zh) * 2018-07-16 2022-07-15 浙江大学 基于多能干细胞技术建立“人源性”心肌肥大模型的方法
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US20200405824A1 (en) * 2019-06-26 2020-12-31 University Of Washington Use of ribonucleotide reductase alone or in combination with micro-dystrophin to treat duchenne muscular dystrophy striated muscle disease
CN110384800B (zh) * 2019-07-19 2021-06-08 广东省实验动物监测所 LncRNA XLOC_075168在制备促进血管新生的药物中的应用
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EP4319775A4 (en) * 2021-04-06 2025-03-05 University of Washington NON-CONTRACTILE CARDIOMYOCYTES FOR HEART REPAIR
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CA2837322C (en) 2023-03-21
WO2012162705A2 (en) 2012-11-29
AU2012258525B2 (en) 2017-02-23
WO2012162705A3 (en) 2013-02-28
RU2013157590A (ru) 2015-07-10
RU2608957C2 (ru) 2017-01-27
AU2012258525A1 (en) 2013-12-12
EP2714709B1 (en) 2018-04-18
US20160186139A1 (en) 2016-06-30
CA2837322A1 (en) 2012-11-29
KR20140035967A (ko) 2014-03-24
JP6162104B2 (ja) 2017-07-12
EP2714709A4 (en) 2015-05-13
EP2714709A2 (en) 2014-04-09
US9868937B2 (en) 2018-01-16
JP2014517694A (ja) 2014-07-24
CN103946230B (zh) 2017-02-08
CN103946230A (zh) 2014-07-23

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