CN103946230B - 改善心脏功能的基于细胞和基因的方法 - Google Patents

改善心脏功能的基于细胞和基因的方法 Download PDF

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CN103946230B
CN103946230B CN201280034527.5A CN201280034527A CN103946230B CN 103946230 B CN103946230 B CN 103946230B CN 201280034527 A CN201280034527 A CN 201280034527A CN 103946230 B CN103946230 B CN 103946230B
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ctnc
cardiac
cardiomyocytes
relaxation
heart
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CN103946230A (zh
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M·雷尼尔
M·拉弗拉梅
C·默里
F·S·科尔特
S·伦迪
S·D·豪施卡
J·S·张伯伦
G·奥多姆
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University of Washington
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CN201280034527.5A 2011-05-26 2012-05-29 改善心脏功能的基于细胞和基因的方法 Expired - Fee Related CN103946230B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9868937B2 (en) 2011-05-26 2018-01-16 University Of Washington Cell and gene based methods to improve cardiac function

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2792742A1 (en) * 2013-04-17 2014-10-22 Universitätsklinikum Hamburg-Eppendorf (UKE) Gene-therapy vectors for treating cardiomyopathy
WO2015153357A1 (en) * 2014-03-29 2015-10-08 Beat Biotherapeutics Corp. Compositions and methods for improving cardiac function
CA2972811A1 (en) * 2015-01-16 2016-07-21 University Of Washington Novel micro-dystrophins and related methods of use
CA2979229A1 (en) 2015-03-11 2016-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rp2 vectors for treating x-linked retinitis pigmentosa
WO2017031238A2 (en) * 2015-08-18 2017-02-23 Boston Scientific Scimed Inc. Methods for producing cardiomyocyte cells
CA3089957C (en) 2017-02-04 2024-01-23 AnaBios Corporation System and methods for predicting drug-induced inotropic and pro-arrhythmia risk
CN108913655B (zh) * 2018-07-16 2022-07-15 浙江大学 基于多能干细胞技术建立“人源性”心肌肥大模型的方法
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
SG11202102058UA (en) 2018-08-30 2021-03-30 Tenaya Therapeutics Inc Cardiac cell reprogramming with myocardin and ascl1
US20200405824A1 (en) * 2019-06-26 2020-12-31 University Of Washington Use of ribonucleotide reductase alone or in combination with micro-dystrophin to treat duchenne muscular dystrophy striated muscle disease
CN110384800B (zh) * 2019-07-19 2021-06-08 广东省实验动物监测所 LncRNA XLOC_075168在制备促进血管新生的药物中的应用
CN116096394A (zh) 2020-02-13 2023-05-09 特纳亚治疗股份有限公司 用于治疗心脏病的基因疗法载体
WO2022216800A1 (en) * 2021-04-06 2022-10-13 University Of Washington Non-contractile cardiomyocytes for cardiac repair
CN120758566B (zh) * 2025-09-10 2025-11-21 瓯江实验室 一种在心肌细胞中特异性过表达zer1的病毒载体的构建及在心衰治疗中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02240440A (ja) 1989-03-14 1990-09-25 Shiigeru:Kk 慣性ダンパ
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
US6151525A (en) * 1997-11-07 2000-11-21 Medtronic, Inc. Method and system for myocardial identifier repair
AU770384B2 (en) 1998-05-30 2004-02-19 Collateral Therapeutics, Inc. Methods of altering cardiac cell phenotype
ATE294874T1 (de) * 1998-09-11 2005-05-15 Univ California Rekombinante adenovirus für gewebespezifische genexpression ins herz
CA2356551A1 (en) * 1998-12-28 2000-07-06 Arch Development Corporation Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors
AU2002230999A1 (en) * 2000-12-21 2002-07-01 Medtronic, Inc. Electrically responsive promoter system
AU2003234520A1 (en) 2002-05-08 2003-11-11 The Regents Of The University Of California Methods and compositions for correction of cardiac conduction disturbances
AU2003270544A1 (en) 2002-09-11 2004-04-30 University Of Florida Vigilant vector system
EP1654365A1 (en) 2003-08-11 2006-05-10 University Of South Florida Vigilant cells
EP1693451B1 (en) 2003-11-21 2011-11-09 Daiichi Sankyo Company, Limited Method of growing myocardial cells
WO2005094485A2 (en) 2004-03-25 2005-10-13 Yun Yen Drug screening
DE102011018586A1 (de) 2011-04-26 2012-10-31 Oliver Müller Vektorsystem zur spezifischen Genexpression im Herzmuskel
CN103946230B (zh) 2011-05-26 2017-02-08 华盛顿大学 改善心脏功能的基于细胞和基因的方法

Cited By (1)

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US9868937B2 (en) 2011-05-26 2018-01-16 University Of Washington Cell and gene based methods to improve cardiac function

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WO2012162705A3 (en) 2013-02-28
EP2714709B1 (en) 2018-04-18
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EP2714709A2 (en) 2014-04-09
CN103946230A (zh) 2014-07-23
AU2012258525A1 (en) 2013-12-12
JP2014517694A (ja) 2014-07-24
KR20140035967A (ko) 2014-03-24
RU2608957C2 (ru) 2017-01-27
BR112013030209A2 (pt) 2017-06-13
RU2013157590A (ru) 2015-07-10
US9868937B2 (en) 2018-01-16
US20160186139A1 (en) 2016-06-30
CA2837322A1 (en) 2012-11-29
JP6162104B2 (ja) 2017-07-12

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