KR20140019585A - Cosmetic composition comprising yeonwoojuanbang and yeonbang for skin whitening - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin whitening comprising an extract of Yeonwoojuanbang (lotus flower, lotus root, and lotus seed) and Yeonbang and Korean herbal medicine cosmetics for skin whitening prepared by using the same. For the water or ethanol extract of the Yeonwoojuanbang (lotus flower, lotus root, and lotus seed) and Yeonbang, the Yeonwoojuanbang (lotus flower, lotus root, and lotus seed) and Yeonbang are dried, and hot-water extraction is repeated three times for three hours at an extraction temperature of 80-100°C using water containing purified water having 10 times the dry weight of the dried materials or reflux cooling extraction is repeated three times for three hours at an extraction temperature of 60-80°C using an ethanol solvent, to obtain an extract, followed by filtering under reduced pressure and freeze-drying, thereby obtaining the final extract. The cosmetic for skin whitening according to the present invention has effects in improving skin darkness and preventing skin aging and the loss of skin elasticity. [Reference numerals] (AA) Yeonwoojuanbang; (BB) Yeonwoo M/F; (CC) Yeonwoogagambang; (DD) Kojic

Description

Cosmetic composition for improving whitening containing Yeonwoobangbang and the Federation and herbal cosmetics including the same {Cosmetic composition comprising YeonWooJuanbang and Yeonbang for skin whitening}

The present invention relates to a cosmetic composition for improving whitening and anti-aging, and in particular, soft-woongbang (softening, lotus root, softening) that can inhibit the growth of melanocytes or inhibit the activity of tyrosinase and inhibit the synthesis of melanin; The present invention relates to a cosmetic composition for improving whitening and anti-aging and a herbal cosmetic including the same, which are prepared by using a fed-in-or-rhea softening chamber containing federal.

In recent years, as interest in the LOHAS (Lifestyles of Health and Sustainablity) has become more comprehensive and wider than the concept of well-being, the desire to pursue healthy beauty is expanding all over society. The development and marketability of the cosmetic industry that can care for beautiful skin is expanding rapidly.

In addition, the body care beauty products of herbal materials are expected to impart a mysterious power to their skin, and also due to the desire for skin stability is increasing interest in natural materials. Advantages of natural materials include antimicrobial activity, antioxidation and mild side effects, and after-use, environmentally friendly by-products.

As the demand flows, many researches are currently being made in the Korean medicine, medicine, and cosmetics industries to develop skin whitening agents from natural products in consideration of safety, and some of them have been commercialized as products. The whitening agent has the effect of inhibiting the growth of melanocytes or inhibiting the activity of tyrosinase and inhibiting the synthesis of melanin.

Melanin is a major factor that determines the color tone of skin. It is a complex of black pigment and protein. It exists mainly in the skin of human body. It protects skin against UV rays and removes cytotoxic substances such as amines, free radicals and metal ions . Melanin is generally divided into alkaline-soluble black melanin and soluble red and yellow melanin.

Despite the beneficial effects of melanocytes on the human body, melanocytes produced by ultraviolet light, especially UV-A, which is 95% of ultraviolet light, cause skin pigmentation and skin aging resulting in wrinkles, loss of elasticity, And the like. In order to prevent this, the growth of melanocytes is suppressed or the activity of tyrosinase is inhibited to inhibit the synthesis of melanin, thereby preventing the blackening phenomenon and aging appearing on human skin.

In the present invention, in the composition of the kite as a cosmetic composition that produces such an effect, a kite-woobang room including the soft-woongbang room and the Union was used.

The lotus (Nelumbo nucifera Gaertner) is a perennial aquatic plant that is a perennial plant of water lily. It is a kind of aquatic plant which has soft leaves of lotus leaves (or lower leaves) It is said that the root of the kite is called the lotus root. The chemical composition of the lotus leaf is roemerine, nuciferine, nornuciferine, armepavine, pronuciferine, N-nornuciferine, The compounds of the present invention may be used in combination with other therapeutic agents such as luteolin, anonaine, asimilobine, N-methylasimilobine, N-norarmepavine, lirinidine, quercetin, isoquercitrin, leucocyanidin, leucodelphinidin, gluconicacid, 10-nonacosanol,?-sitosterol, Dehydroroemerine, dehydronuciferine, kaempferol, kaempferol-3-galactoglucoside, campperol-3-dichlorosidase, kaempferol-3-diglucoside, dehydroanonaine, N-methylisobutyric acid ococlaurine, N-methylcoclaurine and the like are known.

In addition, in the present invention, in order to confirm the anti-whitening and anti-aging effects of soft space dust (softening, lotus root, softening) and federal whitening, tyrosinase activity inhibitory effect, melanin biosynthesis inhibitory effect, antioxidant (DPPH) radical scavenging effect, dopa (DOPA) The present invention was completed by confirming the antioxidant inhibitory effect.

The present invention has been made to solve the above problems, an object of the present invention is to inhibit the growth of melanocytes or inhibit the activity of tyrosinase to inhibit the synthesis of melanin, blackening phenomenon and / or aging appearing on the skin of the human body It is to provide a cosmetic composition for improving the whitening and / or anti-aging herbal composition containing a soft-woongbang and the Union that can prevent the natural ingredients, and herbal cosmetics prepared using the same as a component.

In order to achieve the object according to the present invention, the present invention provides a cosmetic composition for improving oriental herbal whitening (softening, lotus root, softening) and federal water or ethanol extract having an effect of improving whitening and anti-aging It is characteristic to provide.

In addition, in the cosmetic composition for improving whitening according to the present invention,

The blended weight ratio of the soft-wool milkweed (softening, lotus root, soft-lead) and federal is soft-wool milkweed: federal = 24:12, and the mixed weight ratio of each component of the soft-wool milkweed is softening: lotus root: softwood = 7: 8: 9 It is characterized by that.

In addition, in the cosmetic composition for improving herbal whitening according to the present invention,

The soft milk room (softening, lotus root, lotus) and federal water or ethanol extract,

After drying the soft milk oven (softening, lotus root, soft) and the federal, repeated three times for 3 hours at an extraction temperature of 80 to 100 ℃ with water containing 10 times the dry weight of purified water, or 60 times with ethanol solvent After reflux cooling extraction three times for three hours at an extraction temperature of ~ 80 ℃ to obtain an extract, it is characterized in that it is produced by the method of filtration under reduced pressure and lyophilized to obtain the final extract.

In addition, using the cosmetic composition for improving whitening according to the invention is characterized in that the herbal cosmetic for improving whitening is produced.

The composition containing the soft-shell milk oven and federal extract according to the present invention inhibits the growth of melanocytes or inhibits the activity of tyrosinase, inhibits melanin synthesis, shows an antioxidant effect, cosmetics for improving whitening and anti-aging effect It can be used as a composition.

1 is a comparative view showing the tyrosinase inhibitory activity of the water extracts of Yeonwoobangbang and Yeonwoobangbang Gagambang,
Figure 2 is a comparative view showing the tyrosinase inhibitory activity of the ethanol extracts of Yeonwoo master room and Yeonwoo master room Gagambang,
3 is a diagram showing the melanin cell survival rate of the combination of the soft and milk room room and the soft and dry room room gagambang,
Figure 4 is a view showing the melanin biosynthesis inhibitory effect of the soft and warm room room gaobang
5 is a view showing the DPPH radical scavenging effect of the water extract of Yeonwoobangbang and Yeonwoobangbang Gagambang,
6 is a diagram showing the DPPH radical scavenging effect of the ethanol extract of Yeonwoobang room and Yeonwoobang room gagambang,
Figure 7 shows the DOPA oxidation inhibitory activity of the water extract of Yeonwoo master room and Gaobang room of Yeonwoo master room,
8 is a diagram showing DOPA oxidation inhibitory activity of ethanol extracts of Yeonwoobang room and Yeonwoobang room gagabang.

Hereinafter, the method for obtaining the extract of the present invention will be described in detail.

The present invention is produced by using the soft rain room (softening, lotus root, soft) and the federal of the components of the kite, the extract of the present invention is dried by the soft rain room (softening, lotus root, soft) and the federal, the weight of about 10 Hot water extraction was repeated three times for about 3 hours at an extraction temperature of 80 to 100 ° C., preferably 95 ° C., with water containing pear purified water, or at an extraction temperature of 60 to 80 ° C., preferably 70 ° C. with an ethanol solvent. Repeated 3 times for 3 hours to extract the reflux cooling to obtain an extract, and then filtered under reduced pressure and lyophilized to obtain the soft milk oven (softening, lotus root, soft) and the federal extract of the present invention.

The extract is characterized by containing 1 to 10% by weight, preferably 1 to 5% by weight, more preferably 3 to 4% by weight based on the total weight of the composition.

The extract showed a melanin production inhibitory effect, tyrosinase activity inhibitory effect, melanin synthesis inhibitory effect, antioxidant effect was confirmed as an excellent effect, and also confirmed that there is no problem in safety when applied to the skin.

The present invention provides a skin external pharmaceutical composition for improving whitening containing gagambang [yeonwoonbangbangbang (softening, lotus root, softwood) and federal extract] obtained as the active ingredient.

The skin care composition for improving skin whitening of the present invention comprises 1 to 3% by weight of the extract, based on the total weight of the composition.

The external dermal pharmaceutical composition comprising the extract of the present invention may further comprise suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.

The pharmaceutical composition containing the extract according to the present invention can be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, external preparations such as syrups and aerosols, and sterilized injection solutions according to a conventional method, , Preferably a cream, a gel, a patch, a spray, an ointment, a warning agent, a lotion, a liniment, a pasta or a cataplasma. Carriers, excipients and diluents that may be included in the composition comprising the extract include lactose, dextrose, sucrose, oligosaccharides, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, Calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations may include at least one excipient such as starch, calcium carbonate, sucrose in the extract. ) Or lactose, gelatin and the like are mixed. In addition to simple excipients, lubricants such as magnesium stearate talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.

The cosmetic composition for improving whitening containing the soft milk oven and federal extract of the present invention is a skin external preparation formulation that can be applied to the skin such as cream, gel, patch, spray, ointment, warning agent, lotion agent, linen agent, pasta agent Or it can be prepared and used as a pharmaceutical composition in the form of an external preparation for skin of cataplasmase, but is not limited thereto.

Hereinafter, the present invention will be described in detail with reference to the following examples and experimental examples. The following Examples and Experimental Examples are merely illustrative of the present invention, and the present invention is not limited to the following Examples and Experimental Examples.

Example 1 . Yeonwoo Space  Preparation of extract

1-1. Yeonwoo Juanbang Water Extract Manufacturing

100 g of softening, lotus root, and soft water, which are soft rain spaces, are mixed at a weight ratio of 7: 8: 9, and 1,000 ml of 10 times purified water are added.Then, a cooler is attached and heated at 95 ° C. for 3 hours. After extracting repeatedly, the filtrate filtered under reduced pressure with a filter paper was concentrated under reduced pressure with a rotary vacuum concentrator, and dried using a lyophilizer to obtain a concentrated amount of 14.21 g (yield 14.2).

1-2. Yeonwoo Zhubang Ethanol Extract Preparation

100 g of softening, lotus root, and soft water, which are soft rain spaces, are mixed at a weight ratio of 7: 8: 9, and 1,000 ml of 10-fold ethanol is added, and a cooler is attached and heated at a temperature of 70 ° C. for 3 hours. After extracting repeatedly, the filtrate filtered under reduced pressure with a filter paper was concentrated under reduced pressure with a rotary vacuum concentrator and dried using a lyophilizer to obtain a concentrated amount of 10.08 g (yield 10.1).

Example 2 . Preparation of Federal Extracts

1-1. Federal water extract manufacturer

100 g of fed federal water was added 1,000 ml of purified water 10 times, and then attached with a cooler, heated at 95 ° C. for 3 hours, extracted three times, and the filtrate was filtered under reduced pressure with a filter paper. The resultant was dried using a lyophilizer to obtain a concentrated amount of 5.4 g (yield 5.4).

1-2. Federal Ethanol Extract Manufacturer

100 g of fed federal ethanol was added 1,000 ml of 10 times the ethanol, attached with a cooler, heated at 70 ° C. for 3 hours, extracted three times, and the filtrate filtered under reduced pressure with a filter paper was concentrated under reduced pressure with a rotary vacuum concentrator. It dried with the lyophilizer and obtained the concentrated amount 5.01g (yield 5.01).

Example 3 . Yeonwoo Space Inmate  Produce

Yeonwoobangbangbang extract and federal extract prepared by mixing in a ratio of 24:12 by weight ratio to prepare Yeonwoobangbang gagambang water extract and Yeonwoobangbang gagambang ethanol extract.

Of course, the softening, lotus root, softening, and fed fed in a ratio of weight ratio of 7: 8: 9: 12, and then the extract may be prepared by the above-described water extract preparation or ethanol extract manufacturing method.

Experimental Example 1 . Tyrosinase  Measurement of inhibition of activity

To determine the inhibitory effect of tyrosinase activity, 1.5 ~ 2 ml of 0.1M phosphate buffer solution (pH 6.8) was added to 3-4 mg of each extract and completely dissolved. After that, 100, 250, 500, 1000, 2000 μg / ml ) Samples. Phosphate buffer (pH 6.8) was completely dissolved at a concentration of 0.3 mg / ml of L-tyrosine (100 units, Sigma, U.S.A) as a substrate, and tyrosinase was prepared at a concentration of 125 unit / ml.

To a 96-well plate, add 220 μl of 0.1 M phosphate buffer (pH 6.8), 20 μl of sample solution and 20 μl of tyrosinase (150 units / ml to 200 unit / ml) 40 μl of 1.5 mM tyrosin was added and reacted at 37 ° C for 10 to 15 minutes. The absorbance was measured at 490 nm using a microplate reader.

A 0.1M phosphate buffer solution (pH 6.8) was added to the test solution instead of the sample solution, and kojic acid, a tyrosinase inhibitor, was used as a positive control. In addition, as a comparison group, a soft milk house extract, a microfluidizer treated soft water house extract was also used. Experimental group is Yeonwoobangbang gagambang.

As a result, the water extract and ethanol extract of kojic acid used as a control as shown in Figures 1 and 2 significantly inhibited tyrosinase activity as the concentration increases. As the concentration of kojic acid increased to 100 μg / ml, 250 μg / ml, 500 μg / ml, 1000 μg / ml, and 2000 μg / ml, it can be seen that tyrosinase activity was rapidly suppressed.

In the figure, Myeon-myeon M / F refers to a microfluidizer (M / F) -treated Yeonwoo milkweed extract, Yeonwoo gagambang is a term that refers to Yeonwoo milkweed gagambang extract.

As shown in FIG. 1, the Yeonwoobangbang water extract of Comparative Group 1 had tyrosinase activity at 100% approximately as the concentration increased to 100 μg / ml, 250 μg / ml, 500 μg / ml, 1000 μg / ml, and 2000 μg / ml. It was found that the activity inhibition rate was low as it was reduced to 92%.

As shown in FIG. 2, Yinwoobang ethanol extract of Comparative Group 1 had tyrosinase activity of approximately 107% at about 100 μg / ml, 250 μg / ml, 500 μg / ml, 1000 μg / ml, and 2000 μg / ml. As it is reduced to 90%, it can be seen that the activity inhibition rate is low.

The microfluidizer (M / F) treated Yeonwoojubang water extract was shown in Figure 1, the concentration is 100μg / ml, 250μg / ml, 500μg / ml, 1000μg / ml, 2000μg / ml As tyrosinase activity decreases from 110% to approximately 93%, the activity inhibition rate is low.

As shown in FIG. 2, the ethanol extract of Yeonwoojubang, a microfluidizer of Comparative Group 2, was tyrosinase as the concentration was increased to 100 μg / ml, 250 μg / ml, 500 μg / ml, 1000 μg / ml, and 2000 μg / ml. As the activity is reduced from 110% to approximately 94%, it can be seen that the activity inhibition rate is low.

As shown in FIG. 1, the experimental group of Yeonwoo ovary gagabang water extract, the tyrosinase activity increased from 105% to about 105 μg / ml, 250 μg / ml, 500 μg / ml, 1000 μg / ml, and 2000 μg / ml It was found that the activity inhibition rate was low as it was reduced to 92%.

As shown in FIG. 2, the experimental group of Yeonwoo ovary gagabang ethanol extract, the tyrosinase activity was increased from 93% to 93 μg / ml as concentration increased to 100 μg / ml, 250 μg / ml, 500 μg / ml, 1000 μg / ml, and 2000 μg / ml. It was seen that the activity was significantly inhibited by a reduction of up to 52%.

Therefore, the ethanol extract of Yeonwoojubang Mogabang mixed with softening, lotus root, soft potato, and federation at 7: 8: 9: 12 had the best tyrosinase inhibitory effect.

Experimental Example 2 . Measurement of Melanin Biosynthesis Inhibitory Effect

2-1. Cell culture

The cell lines used for the experiment were wells in a 6-well plate with DMEM medium containing murine melanoma (B-16 F1) or similar cells in an appropriate amount of FBS (fetal bovine serum) The cells were inoculated at 1 × 10 ⁵ per well and cultured at 5% CO _{2 at} 37 ° C. until cells were attached to the bottom of the wells at about 80% or more.

2-2. Melanin production inhibition experiment and cell viability measurement

After the culture, the medium was removed, and the medium was replaced with a medium diluted to the appropriate concentration. The medium was incubated at 37 ° C in 5% CO _{2 for a} certain period of time. The concentration range of the sample was determined by a crystal violet assay .

Cells from which the medium was removed were washed with PBS (phosphatized buffer saline), and treated with trypsin to recover the cells. The recovered cells were counted using a hematocytometer and then cultured at 5,000 to 10,000 rpm After centrifugation for 10 minutes, the supernatant was removed to obtain a pellet.

The cell pellet was dried at 60 ° C., and 100 μl of 1 M sodium hydroxide solution containing 10% DMSO or an appropriate amount of cell lysis buffer was added to obtain intracellular melanin in a 60 ° C. thermostat.

Using this solution, the absorbance at 490 nm was measured with a microplate reader to determine the amount of melanin per cell number.

As a result, as shown in Figure 3, the concentration of 0.1 mg / ml or less in the comparison group 1 and 2 and the experimental group was not significant for the cell viability, the experimental group Yeonwoo ovary gagabang ethanol extract at the concentration of 1 mg / ml It can be seen that the cell viability was lowered to approximately 55%.

In addition, as shown in FIG. 4, the higher the concentration of soft-bang inner room gagambang, the higher the melanin biosynthesis inhibitory effect. This is due to the inhibitory activity of TRP-1,2 gene expression of quercetin galactopyranose (quercetin-3-O-β-D-galactopyranose) contained in about 0.4% of federal and soft space extracts.

The term 'con' used in FIG. 4 is a term representing a control group, and 'addition and decrement' is a term indicating a soft space chamber.

Experimental Example 3 . Antioxidant ( DPPH ) Radical  Measure erasure effect

In the control group, 100 μl of the extract solution was added to the experimental group (10, 25, 50, 100, 250 μg / ml), and the control and experimental groups were supplemented with 60 μM DPPH , Ethanol was added to the blank instead of 60 μM DPPH, the mixture was shaken for about 3 seconds, left at room temperature for 30 minutes, and absorbance was measured at 540 nm using a microplate reader.

Vitamin C extract as a control group, lotus milk room extract as a comparative group, and lotus milk extract treated with a microfluidizer was used.

As a result, as shown in Figures 5 and 6, the higher the concentration of all the samples, the higher the antioxidant radical scavenging effect.

Experimental Example 4 . Waveguide ( DOPA ) Measurement of oxidation inhibitory activity

The effect of tyrosine inhibiting the oxidation of DOPA produced by tyrosinase to DOPA quinone and DOPA chrome was measured.

Vitamin C extract as a control group, lotus milk room extract as a comparative group, and lotus milk extract treated with a microfluidizer was used.

As a result of the experiment, as shown in Figures 7 and 8, the inhibitory activity effect of the ethanol extract of Yeonwoobangbang gagambang increased as the concentration increased.

The composition comprising the soft milk extract of the present invention can be used in a variety of cosmetics and cleansing agents for the skin whitening and / or anti-aging effect. Examples of products to which the present composition can be added include cosmetics such as various creams, lotions, skins, essences, and the like, cleansing agents, face washes, soaps, treatments, and essences.

In Tables 1 to 5 below, A, B, C, and D of the table sequentially indicate the control, whitening cream (containing arbutin), containing 1% of soft-woongbang gagambang, and 3% of soft-bangbang gabang gagambang.

Yeonwoobangbang Gagambang is an extract of softening, lotus root, lotus root, and federation mixed at 7: 8: 9: 12 weight ratio.

<Skin production>

Skin preparation, as shown in Table 1 below, put a preservative and a moisturizing agent in the aqueous phase dissolving unit to dissolve in advance by heating and melting at 45 ~ 50 ℃ temperature, and then put the solubilized image into the aqueous phase dissolving unit (Agi Mixer) After solubilizing slowly using, add the remaining additives and cool by mixing and stirring.

INCI persons Usage content A B C D Water Solvent To 100 To 100 To 100 To 100 Disodium EDTA Chelating Agent 0.02 0.02 0.02 0.02 Allantoin Skin-Conditioning Agent 0.10 0.10 0.10 0.10 Methylparaben Preservative 0.10 0.10 0.10 0.15 Butylene glycol Humectant 1.00 1.00 1.00 1.00 Sodium Hyaluronate Humectant 1.00 1.00 1.00 1.00 Panthenol Skin-Conditioning Agent 0.50 0.50 0.50 0.50 Alcohol Denat. Solvent 1.00 1.00 1.00 1.00 Portulaca oleacea extract Skin-Conditioning Agent 0.30 0.30 0.30 0.30 Phyllostachis Bambusoides Juice Skin-Conditioning Agent 0.20 0.20 0.20 0.20 Betula Platyphylla Japonica Juice Skin-Conditioning Agent 0.30 0.30 0.30 0.30 Chamaecyparis Obtusa Water Skin-Conditioning Agent 0.20 0.20 0.20 0.20 Trehalose Humectant 0.50 0.50 0.50 0.50 Skin whitening agent PEG-60 Hydrogenated Castor Oil Surfactant 0.20 0.20 0.20 0.20

<Lotion manufacturing>

In lotion manufacturing, as shown in [Table 2], emulsifiers, oils, antioxidants, and preservatives were melted by heating to 80-82 ° C. in an oil phase dissolving unit, and some additives and solvents were heated and dissolved at 78-80 ° C. After the addition, the mixture is cooled to 40 ° C after emulsification using a homo mixer (HOMO MIXER), the remaining additives are added, mixed, stirred and cooled.

INCI name Usage content A B C D Disodium EDTA Chelating Agent 0.02 0.02 0.02 0.02 Allantoin Skin-Conditioning Agent 0.10 0.10 0.10 0.10 Methylparaben Preservative 0.20 0.20 0.20 0.20 Butylene glycol Humectant 5.00 5.00 5.00 5.00 Water & Butylene Glycol & Beta-Glucan Skin-Conditioning Agent 2.00 2.00 2.00 2.00 Polyglyceryl-10 Stearate Surfactant 0.50 0.50 0.50 0.50 Glycerine Humectant 5.00 5.00 5.00 5.00 Xanthan Gum Viscosity Increasing Agent 0.10 0.10 0.10 0.10 Polyacrylate-13 & Polyisobutene & Polysorbate-20 Viscosity Increasing Agent 0.30 0.30 0.30 0.30 Sodium Polyacrylate Viscosity Increasing Agent 0.20 0.20 0.20 0.20 Cetearyl Alcohol Emulsion Stabilizer 1.20 1.20 1.20 1.20 Glyceryl Stearate & PEG-100 Stearate Surfactant 0.20 0.20 0.20 0.20 Stearic Acid Emulsion Stabilizer 0.70 0.70 0.70 0.70 Caprylic / Capric Triglyceride Skin-Conditioning Agent 8.00 8.00 8.00 8.00 Camellia Japonica Seed Oil Skin-Conditioning Agent 1.00 1.00 1.00 1.00 Dimethicone Skin-Conditioning Agent 0.30 0.30 0.30 0.30 Tocopheryl Acetate Antioxidant 0.10 0.10 0.10 0.10 Propylparaben Preservative 0.10 0.10 0.10 0.10 Butyrospermum parkii Skin-Conditioning Agent 0.50 0.50 0.50 0.50 Phenoxyethanol Preservative 0.50 0.50 0.50 0.50 Butylene Glycol & Water & Camellia Japonica Flower Extract Skin-Conditioning Agent 0.50 0.50 0.50 0.50 Skin whitening agent Polyquaternium-51 Skin-Conditioning Agent 0.50 0.50 0.50 0.50 Superoxide Dismutase Skin-Conditioning Agent 0.10 0.10 0.10 0.10 Water & Butylene Glycol & Taraxacum Officinale (Dandelion) Extract & Perilla Ocymoides Leaf Extract Skin-Conditioning Agent 0.50 0.50 0.50 0.50 Water & Butylene Glycol & Dextran & Palmitoyl Tripeptide 8 Skin-Conditioning Agent 0.10 0.10 0.10 0.10 WATER Solvent To 100 To 100 To 100 To 100

<Cream making>

In the cream manufacturing process, as shown in [Table 3], emulsifiers, oils, antioxidants, and preservatives were dissolved by heating to 80-82 ° C. in the oil phase dissolving unit, and some additives and solvents were dissolved in 78-80 ° C. by heating. After the addition, the mixture is cooled to 40 ° C after emulsification using a homo mixer (HOMO MIXER), the remaining additives are added, mixed, stirred and cooled.

INCI persons Usage content A B C D Water Solvent To 100 To 100 To 100 To 100 Hydrogenated Polydecene Skin-Conditioning Agent 7.00 7.00 7.00 7.00 Glycerin Humectant 7.00 7.00 7.00 7.00 Sodium Hyaluronate Skin-Conditioning Agent 5.00 5.00 5.00 5.00 Cetearyl alcohol Emulsion Stabilizer 4.00 4.00 4.00 4.00 Propanediol Solvent 4.00 4.00 4.00 4.00 Glyceryl Stearate Surfactant 3.00 3.00 3.00 3.00 Hydrogenated Vegetable Oil Skin-Conditioning Agent 3.00 3.00 3.00 3.00 Limnanthes Alba (Meadowfoam) Seed Oil Skin-Conditioning Agent 3.00 3.00 3.00 3.00 Cetyl Ethylhexanoate Skin-Conditioning Agent 2.50 2.50 2.50 2.50 Cyclopentasiloxane Skin-Conditioning Agent 2.00 2.00 2.00 2.00 Butyrospermum Parkii (Shea Butter) Skin-Conditioning Agent 2.00 2.00 2.00 2.00 Glycol Stearate SE Surfactant 1.50 1.50 1.50 1.50 Beeswax Emulsion Stabilizer 1.00 1.00 1.00 1.00 Macadamia Ternifolia Seed Oil Skin-Conditioning Agent 1.00 1.00 1.00 1.00 Dimethicone Skin-Conditioning Agent 1.00 1.00 1.00 1.00 Cyclohexasiloxane Skin-Conditioning Agent 1.00 1.00 1.00 1.00 Stearic Acid Surfactant 0.30 0.30 0.30 0.30 PEG-100 Stearate Surfactant 0.60 0.60 0.60 0.60 Hydrogenated Lecithin Skin-Conditioning Agent 0.50 0.50 0.50 0.50 Oil Soluble Licorice (Glycyrrhiza) Extract Skin-Conditioning Agent - 0.05 - - Skin whitening agent Dimethicone / Vinyl Dimethicone Crosspolymer Viscosity Increasing Agent 0.10 0.10 0.10 0.10 Polyacrylate-13 Film former 0.30 0.30 0.30 0.30 Tocopheryl Acetate Antioxidant 0.20 0.20 0.20 0.20 Methylparaben Preservative 0.20 0.20 0.20 0.20 Titanium Dioxide Colorant 0.20 0.20 0.20 0.20 Propylparaben Preservative 0.15 0.15 0.15 0.15 Chlorphenesin Preservative 0.15 0.15 0.15 0.15 Polyisobutene Film former 0.12 0.12 0.12 0.12 Butylene glycol Humectant 0.15 0.15 0.15 0.15 Polysorbate20 Surfactant 0.01 0.01 0.01 0.01 Disodium EDTA Chelating Agent 0.03 0.03 0.03 0.03 Ascorbyl Tetraisopalmitate Skin-Conditioning Agent 0.01 0.01 0.01 0.01 Glyceryl Acrylate / Acrylic Acid Copolymer Skin-Conditioning Agent 0.01 0.01 0.01 0.01 Propylene glycol Humectant 0.01 0.01 0.01 0.01 PVM / MACopolymer Binder 0.01 0.01 0.01 0.01 Pueraria Lobata Root Extract / Morus Alba Fruit Extract / Diospyros Kaki Leaf Extract / Cinnamomum Cassia Bark Extract / Artemisia Princeps Leaf Extract / ChrysanthellumIndicum Extract / Camellia Sinensis Leaf Extrac Skin-Conditioning Agent 0.1 0.1 0.1 0.1 Niacinamide Skin-Conditioning Agent 0.1 0.1 0.1 0.1

<Essence manufacturing>

Essence manufacturing, as shown in Table 4 below, by dissolving the emulsifier, oil, antioxidant, and preservative in the oil phase dissolving unit to 80 ~ 82 ℃, to some of the additives and solvent heated to 78 ~ 80 ℃ dissolution After the addition, the mixture is cooled to 40 ° C after emulsification using a homomixer (HOMO MIXER), the remaining additives are added, mixed, stirred and cooled.

INCI persons Usage content A B C D Water Solvent To 100 To 100 To 100 To 100 Glycerin Skin-Conditioning Agent 9.00 9.00 9.00 9.00 Butylene glycol Humectant 9.00 9.00 9.00 9.00 Cyclopentasiloxane Skin-conditioning agent 8.00 8.00 8.00 8.00 Glycereth-26 Emulsion Stabilizer 7.00 7.00 7.00 7.00 Dimethicone / Vinyl Dimethicone Crosspolymer Solvent 6.00 6.00 6.00 6.00 Dimethicone Surfactant 4.00 4.00 4.00 4.00 Cetyl Ethylhexanoate Skin-Conditioning Agent 3.00 3.00 3.00 3.00 Polyglutamic acid Skin-Conditioning Agent 3.00 3.00 3.00 3.00 Cyclohexasiloxane Skin-Conditioning Agent 2.00 2.00 2.00 2.00 Sodium Hyaluronate Skin-Conditioning Agent 2.00 2.00 2.00 2.00 PEG-240 / HDICopolymer
Bis-Decyltetradeceth-20Ether Surfactant 1.00 1.00 1.00 1.00 Propylparaben Emulsion Stabilizer 0.15 0.15 0.15 0.15 Methylparaben Skin-Conditioning Agent 0.15 0.15 0.15 0.15 Chlorphenesin Skin-Conditioning Agent 0.15 0.15 0.15 0.15 Bisabolol Skin-Conditioning Agent 0.10 0.10 0.10 0.10 Ascorbyl Tetraisopalmitate Surfactant 0.01 0.01 0.01 0.01 SodiumAcrylate /
SodiumAcryloyldimethylTaurateCopolymer Surfactant 0.30 0.30 0.30 0.30 Isohexadecane Skin-Conditioning Agent 0.20 0.20 0.20 0.20 Polysorbate 80 Skin-Conditioning Agent 0.10 0.10 0.10 0.10 Skin whitening agent Pueraria Lobata Root Extract / Morus Alba Fruit Extract / Diospyros Kaki Leaf Extract / Cinnamomum Cassia Bark Extract / Artemisia Princeps Leaf Extract / ChrysanthellumIndicum Extract / Camellia Sinensis Leaf Extract Skin-Conditioning Agent 0.1 0.1 0.1 0.1

Although the invention has been described in connection with the preferred embodiments mentioned above, other various modifications and variations will be possible without departing from the spirit and scope of the invention. It is, therefore, to be understood that the appended claims are intended to cover such modifications and changes as fall within the true scope of the invention.

Claims (4)

Whitening improvement cosmetic composition comprising as an active ingredient in soft milk room (softening, lotus root, softwood) and federal water or ethanol extract. The method of claim 1,
The blended weight ratio of the soft-wool milkweed (softening, lotus root, soft-lead) and federal is soft-wool milkweed: federal = 24:12, and the mixed weight ratio of each component of the soft-wool milkweed is softening: lotus root: softwood = 7: 8: 9 Cosmetic composition for whitening improvement, characterized in that. The method of claim 1,
The soft milk room (softening, lotus root, lotus) and federal water or ethanol extract,
After drying the soft milk oven (softening, lotus root, soft) and the federal, repeated three times for 3 hours at an extraction temperature of 80 to 100 ℃ with water containing 10 times the dry weight of purified water, or 60 times with ethanol solvent 3 to 3 hours at an extraction temperature of 80 ℃ repeatedly reflux cooling extraction to obtain the extract, and then filtered under reduced pressure and freeze-dried cosmetic composition for improving whitening, characterized in that it is prepared by a method for obtaining the final extract. Herbal cosmetics for improving whitening prepared using the cosmetic composition for improving whitening according to any one of claims 1 to 3.

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