KR20130119453A - 암에 대한 면역요법의 효과를 예측하는 생체지표 - Google Patents

암에 대한 면역요법의 효과를 예측하는 생체지표 Download PDF

Info

Publication number
KR20130119453A
KR20130119453A KR1020137015847A KR20137015847A KR20130119453A KR 20130119453 A KR20130119453 A KR 20130119453A KR 1020137015847 A KR1020137015847 A KR 1020137015847A KR 20137015847 A KR20137015847 A KR 20137015847A KR 20130119453 A KR20130119453 A KR 20130119453A
Authority
KR
South Korea
Prior art keywords
cancer
patient
patients
immunotherapy
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020137015847A
Other languages
English (en)
Korean (ko)
Inventor
토니 바인쉔크
하르프리트 싱
옌스 프리췌
안드레아 마르
Original Assignee
이매틱스 바이오테크놀로지스 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이매틱스 바이오테크놀로지스 게엠베하 filed Critical 이매틱스 바이오테크놀로지스 게엠베하
Publication of KR20130119453A publication Critical patent/KR20130119453A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/521Chemokines
    • G01N2333/523Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775Apolipopeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
KR1020137015847A 2010-11-24 2011-11-22 암에 대한 면역요법의 효과를 예측하는 생체지표 Ceased KR20130119453A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41698110P 2010-11-24 2010-11-24
US61/416,981 2010-11-24
GBGB1021289.2A GB201021289D0 (en) 2010-12-15 2010-12-15 Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer
GB1021289.2 2010-12-15
US42365210P 2010-12-16 2010-12-16
US61/423,652 2010-12-16
PCT/EP2011/070661 WO2012069462A1 (en) 2010-11-24 2011-11-22 Biomarkers for predicting the efficacy of an immunotherapy against cancer

Publications (1)

Publication Number Publication Date
KR20130119453A true KR20130119453A (ko) 2013-10-31

Family

ID=43567254

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137015847A Ceased KR20130119453A (ko) 2010-11-24 2011-11-22 암에 대한 면역요법의 효과를 예측하는 생체지표

Country Status (17)

Country Link
US (2) US8669063B2 (enExample)
EP (1) EP2643698B1 (enExample)
JP (1) JP6005051B2 (enExample)
KR (1) KR20130119453A (enExample)
CN (1) CN103384827B (enExample)
AU (1) AU2011333819A1 (enExample)
BR (1) BR112013012820A2 (enExample)
CA (1) CA2818738A1 (enExample)
EA (1) EA201390762A1 (enExample)
ES (1) ES2592957T3 (enExample)
GB (1) GB201021289D0 (enExample)
HU (1) HUE030005T2 (enExample)
MX (1) MX341734B (enExample)
NZ (1) NZ609712A (enExample)
PL (1) PL2643698T3 (enExample)
SG (1) SG190698A1 (enExample)
WO (1) WO2012069462A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190088403A (ko) * 2017-06-02 2019-07-26 이종균 대장 직장암 환자와 정상인의 말초혈액 내 면역세포의 분포 차이를 이용하여 면역력을 평가하고 암 발병 유무에 대한 정보를 제공하는 방법 및 이를 이용한 진단키트

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2172211T3 (en) 2008-10-01 2015-02-16 Immatics Biotechnologies Gmbh Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
US9026531B2 (en) * 2012-04-17 2015-05-05 Cerner Innovation, Inc. Associating multiple data sources into a web-accessible framework
EP2864792A1 (en) 2012-06-26 2015-04-29 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
CN103048453B (zh) * 2012-12-18 2014-11-26 苏州浩欧博生物医药有限公司 一种糖类抗原ca19-9的纳米磁微粒化学发光测定试剂盒及其制备方法和检测方法
RU2677742C2 (ru) 2013-11-07 2019-01-21 Медиал Рисеч Лтд. Способы и системы оценки риска развития злокачественной опухоли легкого
EP2942629A1 (en) * 2014-05-08 2015-11-11 Universität Würzburg Predictive markers for successful cancer immunotherapy
GB201505585D0 (en) * 2015-03-31 2015-05-13 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers
WO2017008046A1 (en) * 2015-07-08 2017-01-12 Children's Hospital Medical Center Loss of transcriptional fidelity leads to immunotherapy resistance in cancers
CN112710723B (zh) * 2015-07-13 2024-11-12 佰欧迪塞克斯公司 受益于pd-1抗体药物的肺癌患者的预测性测试和分类器开发方法
CN108601731A (zh) 2015-12-16 2018-09-28 磨石肿瘤生物技术公司 新抗原的鉴别、制造及使用
WO2017136139A1 (en) 2016-02-01 2017-08-10 Biodesix, Inc. Predictive test for melanoma patient benefit from interleukin-2 (il2) therapy
CN105624110A (zh) * 2016-02-29 2016-06-01 时宏珍 Hla-a0201限制性抗psa抗原特异性ctl的制备方法
GB201604490D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
CN109690314B (zh) * 2016-05-09 2022-08-02 法国国家卫生及研究医学协会 患有实体癌症的患者的分类方法
US20190177430A1 (en) * 2016-08-24 2019-06-13 The Wistar Institute Of Anatomy And Biology Methods of Treating Cancers With Chemotherapy With Reduced Toxicity
CN106198987A (zh) * 2016-08-31 2016-12-07 辽宁迈迪生物科技股份有限公司 一种用于评价肿瘤免疫细胞疗法的检测标记物及其检测方法和应用
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
EP4317432A3 (en) 2016-12-08 2024-04-17 Immatics Biotechnologies GmbH T cell receptors with improved pairing
EP3566054A4 (en) * 2017-01-05 2020-12-09 Biodesix, Inc. PROCESS FOR IDENTIFYING CANCER PATIENTS LIKELY TO BENEFIT FROM IMMUNOTHERAPY FOR LASTING SUSTAINABLE SUB-GROUPS OF PATIENTS WHO HAVE A BAD PROGNOSIS GENERALLY
US10699007B2 (en) * 2017-03-13 2020-06-30 Oracle International Corporation Hybrid univariate/multivariate prognostic-surveillance technique
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
EP3714275A4 (en) 2017-11-22 2021-10-27 Gritstone bio, Inc. REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS
EP3773691A4 (en) 2018-03-29 2022-06-15 Biodesix, Inc. Apparatus and method for identification of primary immune resistance in cancer patients
US20210263045A1 (en) * 2018-04-06 2021-08-26 The Board Of Regents Of The University Of Texas System Prediction and treatment of immunotherapeutic toxicity
CN108624650B (zh) * 2018-05-14 2022-04-29 乐普(北京)医疗器械股份有限公司 判断实体瘤是否适合免疫治疗的方法和检测试剂盒
CN110885886B (zh) * 2018-09-07 2023-04-07 华中科技大学同济医学院附属协和医院 一种胶质母细胞瘤鉴别诊断及胶质瘤生存预后的分型方法
KR102159538B1 (ko) * 2019-01-11 2020-09-24 충남대학교 산학협력단 폐암 환자의 면역항암제에 대한 치료 반응성 예측용 il-6 마커 및 이의 용도
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
CN113614537B (zh) * 2019-03-28 2025-10-17 豪夫迈·罗氏有限公司 癌症预后
CN111257563B (zh) * 2020-01-22 2022-08-23 广州泛恩生物科技有限公司 Cxcl13检测剂在制备预测免疫治疗效果的试剂盒中的用途
EP4168802A4 (en) * 2020-06-21 2025-03-19 Oncohost Ltd HOST SIGNATURES THAT PREDICTE IMMUNOTHERAPY RESPONSE
WO2022006514A1 (en) * 2020-07-02 2022-01-06 Gopath Laboratories Llc Immune profiling and methods of using same to predict responsiveness to an immunotherapy and treat cancer
US20230266337A1 (en) * 2020-07-10 2023-08-24 Sekisui Medical Co., Ltd. Composition containing tarc, and method for improving storage stability of tarc
CN113219173A (zh) * 2021-05-11 2021-08-06 中南大学湘雅医院 Sh2b1在肺癌诊断中的应用
CN113462776B (zh) * 2021-06-25 2023-03-28 复旦大学附属肿瘤医院 m6A修饰相关联合基因组在预测肾透明细胞癌患者免疫治疗疗效中的应用
CN115058440B (zh) * 2022-06-08 2023-08-15 郑州轻工业大学 催化合成天然蔗糖酯的工程菌及其构建方法和应用
CN115612737A (zh) * 2022-08-03 2023-01-17 皖南医学院第一附属医院(皖南医学院弋矶山医院) 一种胃癌免疫治疗疗效预测和预后评估的方法及其应用
CN118072954A (zh) * 2024-02-06 2024-05-24 江南大学附属医院 一种基于trp评分系统的胃癌免疫治疗反应预测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
JP3490893B2 (ja) * 1998-06-02 2004-01-26 富士レビオ株式会社 胃癌の診断方法
WO2005098446A2 (en) * 2004-03-31 2005-10-20 The Johns Hopkins University Biomarkers for ovarian cancer
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
BRPI0618564A2 (pt) * 2005-11-02 2011-09-06 Bayer Healthcare Llc métodos para predição e prognóstico de cáncer e para monitoração de terapia contra cáncer
US20090035801A1 (en) * 2005-12-27 2009-02-05 Power3 Medical Products, Inc. Twelve (12) protein biomarkers for diagnosis and early detection of breast cancer
WO2007127749A2 (en) * 2006-04-24 2007-11-08 Critical Care Diagnostics, Inc. Predicting mortality and detecting severe disease
AT504231A1 (de) * 2006-10-03 2008-04-15 Hans Dr Loibner Prädiktive parameter
WO2009015841A1 (en) * 2007-07-27 2009-02-05 Immatics Biotechnologies Gmbh Composition of tumour-associated peptides and related anti-cancer vaccine
GB0718167D0 (en) * 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
EP2080812A1 (en) * 2008-01-18 2009-07-22 Transmedi SA Compositions and methods of detecting post-stop peptides
EP2105740A1 (en) * 2008-03-28 2009-09-30 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Biomarkers for monitoring or predicting the treatment of cancer
RU2011101378A (ru) 2008-06-16 2012-07-27 Сайвидон Дайагностикс Гмбх (De) Алгоритмы предсказания исхода у пациентов с узловой формой рака молочной железы после химиотерапии
WO2010076322A1 (en) 2008-12-30 2010-07-08 Siemens Healthcare Diagnostics Inc. Prediction of response to taxane/anthracycline-containing chemotherapy in breast cancer
US20100240546A1 (en) * 2009-03-20 2010-09-23 Samuel Chun Lap Lo Use of biomarkers for the diagnosis and prognosis of lung cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190088403A (ko) * 2017-06-02 2019-07-26 이종균 대장 직장암 환자와 정상인의 말초혈액 내 면역세포의 분포 차이를 이용하여 면역력을 평가하고 암 발병 유무에 대한 정보를 제공하는 방법 및 이를 이용한 진단키트

Also Published As

Publication number Publication date
HUE030005T2 (en) 2017-04-28
JP2014500493A (ja) 2014-01-09
SG190698A1 (en) 2013-07-31
GB201021289D0 (en) 2011-01-26
US9389235B2 (en) 2016-07-12
US20120128702A1 (en) 2012-05-24
ES2592957T3 (es) 2016-12-02
CN103384827B (zh) 2016-06-08
BR112013012820A2 (pt) 2017-05-09
PL2643698T3 (pl) 2016-12-30
AU2011333819A1 (en) 2013-05-23
CA2818738A1 (en) 2012-05-31
NZ609712A (en) 2015-05-29
EA201390762A1 (ru) 2013-09-30
WO2012069462A1 (en) 2012-05-31
EP2643698A1 (en) 2013-10-02
CN103384827A (zh) 2013-11-06
US20140234347A1 (en) 2014-08-21
EP2643698B1 (en) 2016-06-22
MX341734B (es) 2016-08-31
US8669063B2 (en) 2014-03-11
MX2013005762A (es) 2013-08-12
JP6005051B2 (ja) 2016-10-12

Similar Documents

Publication Publication Date Title
KR20130119453A (ko) 암에 대한 면역요법의 효과를 예측하는 생체지표
EP2619585B1 (en) Use of myeloid cell biomarkers for the diagnosis of cancer
Vujanovic et al. CD56dim CD16− natural killer cell profiling in melanoma patients receiving a cancer vaccine and interferon-α
Yoshiyama et al. Personalized peptide vaccination in patients with refractory non-small cell lung cancer
WO2013172926A1 (en) Immune biomarkers and assays predictive of clinical response to immunotherapy for cancer
CN115785253A (zh) 原发性肝癌相关抗原的胸腺依赖性淋巴细胞抗原表位肽及其应用
JP2010520453A (ja) 前立腺癌、又は前立腺癌に対する体液性免疫応答を同定するための方法、及び組成物
EP2738557A1 (en) Organized immune response in cancer
JP2024151758A (ja) 肝臓癌を治療する方法、治療に対する応答を予測する方法、及び肝臓癌の治療中の有害作用を予測する方法
Cernera et al. Immunocytometric analysis of patients with thymic epithelial tumors revealed that COVID-19 vaccine booster strongly enhanced the immune response
JP2020524809A (ja) がんを治療するためのがん免疫
Xu et al. CD4+ CD25+ regulatory T cells in patients with advanced gastrointestinal cancer treated with chemotherapy
Zhang et al. BPIFB2 is highly expressed in “cold” lung adenocarcinoma and decreases T cell chemotaxis via activation of the STAT3 pathway
Copier et al. Biomarkers for the development of cancer vaccines: current status
HK1189939B (en) Biomarkers for predicting the efficacy of an immunotherapy against cancer
US20240066061A1 (en) A cxcr3+ cell or cell preparation for use in cancer treatment
Messner Circulating Hsp70 levels and the immunophenotype of peripheral blood lymphocytes as potential biomarkers in lung cancer and COPD patients
CN117377684A (zh) 在癌症治疗中供使用的cxcr3+细胞或细胞制剂
吉山康一 et al. Personalized peptide vaccination in patients with refractory non-small cell lung cancer
Strioga et al. patients for cancer immunotherapy
HK1183096B (en) Use of myeloid cell biomarkers for the diagnosis of cancer
HK1183096A (en) Use of myeloid cell biomarkers for the diagnosis of cancer
ITRM20130402A1 (it) Proteine immunogeniche tumorali, usi di esse e metodo per la loro identificazione

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20130619

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20161013

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180313

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20180523

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20180313

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I