HUE030005T2 - Biomarkers for predicting the effectiveness of immunotherapy against cancer - Google Patents

Biomarkers for predicting the effectiveness of immunotherapy against cancer Download PDF

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Publication number
HUE030005T2
HUE030005T2 HUE11788121A HUE11788121A HUE030005T2 HU E030005 T2 HUE030005 T2 HU E030005T2 HU E11788121 A HUE11788121 A HU E11788121A HU E11788121 A HUE11788121 A HU E11788121A HU E030005 T2 HUE030005 T2 HU E030005T2
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Hungary
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cancer
patients
patient
group
tumor
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HUE11788121A
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English (en)
Hungarian (hu)
Inventor
Toni Weinschenk
Harpreet Singh
Jens Fritsche
Andrea Mahr
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Immatics Biotechnologies Gmbh
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Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of HUE030005T2 publication Critical patent/HUE030005T2/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/521Chemokines
    • G01N2333/523Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775Apolipopeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
HUE11788121A 2010-11-24 2011-11-22 Biomarkers for predicting the effectiveness of immunotherapy against cancer HUE030005T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41698110P 2010-11-24 2010-11-24
GBGB1021289.2A GB201021289D0 (en) 2010-12-15 2010-12-15 Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer
US42365210P 2010-12-16 2010-12-16

Publications (1)

Publication Number Publication Date
HUE030005T2 true HUE030005T2 (en) 2017-04-28

Family

ID=43567254

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE11788121A HUE030005T2 (en) 2010-11-24 2011-11-22 Biomarkers for predicting the effectiveness of immunotherapy against cancer

Country Status (17)

Country Link
US (2) US8669063B2 (enExample)
EP (1) EP2643698B1 (enExample)
JP (1) JP6005051B2 (enExample)
KR (1) KR20130119453A (enExample)
CN (1) CN103384827B (enExample)
AU (1) AU2011333819A1 (enExample)
BR (1) BR112013012820A2 (enExample)
CA (1) CA2818738A1 (enExample)
EA (1) EA201390762A1 (enExample)
ES (1) ES2592957T3 (enExample)
GB (1) GB201021289D0 (enExample)
HU (1) HUE030005T2 (enExample)
MX (1) MX341734B (enExample)
NZ (1) NZ609712A (enExample)
PL (1) PL2643698T3 (enExample)
SG (1) SG190698A1 (enExample)
WO (1) WO2012069462A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2172211T3 (en) 2008-10-01 2015-02-16 Immatics Biotechnologies Gmbh Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
US9026531B2 (en) * 2012-04-17 2015-05-05 Cerner Innovation, Inc. Associating multiple data sources into a web-accessible framework
EP2864792A1 (en) 2012-06-26 2015-04-29 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
CN103048453B (zh) * 2012-12-18 2014-11-26 苏州浩欧博生物医药有限公司 一种糖类抗原ca19-9的纳米磁微粒化学发光测定试剂盒及其制备方法和检测方法
RU2677742C2 (ru) 2013-11-07 2019-01-21 Медиал Рисеч Лтд. Способы и системы оценки риска развития злокачественной опухоли легкого
EP2942629A1 (en) * 2014-05-08 2015-11-11 Universität Würzburg Predictive markers for successful cancer immunotherapy
GB201505585D0 (en) * 2015-03-31 2015-05-13 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers
WO2017008046A1 (en) * 2015-07-08 2017-01-12 Children's Hospital Medical Center Loss of transcriptional fidelity leads to immunotherapy resistance in cancers
CN112710723B (zh) * 2015-07-13 2024-11-12 佰欧迪塞克斯公司 受益于pd-1抗体药物的肺癌患者的预测性测试和分类器开发方法
CN108601731A (zh) 2015-12-16 2018-09-28 磨石肿瘤生物技术公司 新抗原的鉴别、制造及使用
WO2017136139A1 (en) 2016-02-01 2017-08-10 Biodesix, Inc. Predictive test for melanoma patient benefit from interleukin-2 (il2) therapy
CN105624110A (zh) * 2016-02-29 2016-06-01 时宏珍 Hla-a0201限制性抗psa抗原特异性ctl的制备方法
GB201604490D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
CN109690314B (zh) * 2016-05-09 2022-08-02 法国国家卫生及研究医学协会 患有实体癌症的患者的分类方法
US20190177430A1 (en) * 2016-08-24 2019-06-13 The Wistar Institute Of Anatomy And Biology Methods of Treating Cancers With Chemotherapy With Reduced Toxicity
CN106198987A (zh) * 2016-08-31 2016-12-07 辽宁迈迪生物科技股份有限公司 一种用于评价肿瘤免疫细胞疗法的检测标记物及其检测方法和应用
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
EP4317432A3 (en) 2016-12-08 2024-04-17 Immatics Biotechnologies GmbH T cell receptors with improved pairing
EP3566054A4 (en) * 2017-01-05 2020-12-09 Biodesix, Inc. PROCESS FOR IDENTIFYING CANCER PATIENTS LIKELY TO BENEFIT FROM IMMUNOTHERAPY FOR LASTING SUSTAINABLE SUB-GROUPS OF PATIENTS WHO HAVE A BAD PROGNOSIS GENERALLY
US10699007B2 (en) * 2017-03-13 2020-06-30 Oracle International Corporation Hybrid univariate/multivariate prognostic-surveillance technique
WO2018221820A1 (ko) * 2017-06-02 2018-12-06 이종균 대장 직장암 환자와 정상인의 말초혈액 내 면역세포의 분포 차이를 이용하여 면역력을 평가하고 암 발병 유무에 대한 정보를 제공하는 방법 및 이를 이용한 진단키트
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
EP3714275A4 (en) 2017-11-22 2021-10-27 Gritstone bio, Inc. REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS
EP3773691A4 (en) 2018-03-29 2022-06-15 Biodesix, Inc. Apparatus and method for identification of primary immune resistance in cancer patients
US20210263045A1 (en) * 2018-04-06 2021-08-26 The Board Of Regents Of The University Of Texas System Prediction and treatment of immunotherapeutic toxicity
CN108624650B (zh) * 2018-05-14 2022-04-29 乐普(北京)医疗器械股份有限公司 判断实体瘤是否适合免疫治疗的方法和检测试剂盒
CN110885886B (zh) * 2018-09-07 2023-04-07 华中科技大学同济医学院附属协和医院 一种胶质母细胞瘤鉴别诊断及胶质瘤生存预后的分型方法
KR102159538B1 (ko) * 2019-01-11 2020-09-24 충남대학교 산학협력단 폐암 환자의 면역항암제에 대한 치료 반응성 예측용 il-6 마커 및 이의 용도
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
CN113614537B (zh) * 2019-03-28 2025-10-17 豪夫迈·罗氏有限公司 癌症预后
CN111257563B (zh) * 2020-01-22 2022-08-23 广州泛恩生物科技有限公司 Cxcl13检测剂在制备预测免疫治疗效果的试剂盒中的用途
EP4168802A4 (en) * 2020-06-21 2025-03-19 Oncohost Ltd HOST SIGNATURES THAT PREDICTE IMMUNOTHERAPY RESPONSE
WO2022006514A1 (en) * 2020-07-02 2022-01-06 Gopath Laboratories Llc Immune profiling and methods of using same to predict responsiveness to an immunotherapy and treat cancer
US20230266337A1 (en) * 2020-07-10 2023-08-24 Sekisui Medical Co., Ltd. Composition containing tarc, and method for improving storage stability of tarc
CN113219173A (zh) * 2021-05-11 2021-08-06 中南大学湘雅医院 Sh2b1在肺癌诊断中的应用
CN113462776B (zh) * 2021-06-25 2023-03-28 复旦大学附属肿瘤医院 m6A修饰相关联合基因组在预测肾透明细胞癌患者免疫治疗疗效中的应用
CN115058440B (zh) * 2022-06-08 2023-08-15 郑州轻工业大学 催化合成天然蔗糖酯的工程菌及其构建方法和应用
CN115612737A (zh) * 2022-08-03 2023-01-17 皖南医学院第一附属医院(皖南医学院弋矶山医院) 一种胃癌免疫治疗疗效预测和预后评估的方法及其应用
CN118072954A (zh) * 2024-02-06 2024-05-24 江南大学附属医院 一种基于trp评分系统的胃癌免疫治疗反应预测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
JP3490893B2 (ja) * 1998-06-02 2004-01-26 富士レビオ株式会社 胃癌の診断方法
WO2005098446A2 (en) * 2004-03-31 2005-10-20 The Johns Hopkins University Biomarkers for ovarian cancer
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
BRPI0618564A2 (pt) * 2005-11-02 2011-09-06 Bayer Healthcare Llc métodos para predição e prognóstico de cáncer e para monitoração de terapia contra cáncer
US20090035801A1 (en) * 2005-12-27 2009-02-05 Power3 Medical Products, Inc. Twelve (12) protein biomarkers for diagnosis and early detection of breast cancer
WO2007127749A2 (en) * 2006-04-24 2007-11-08 Critical Care Diagnostics, Inc. Predicting mortality and detecting severe disease
AT504231A1 (de) * 2006-10-03 2008-04-15 Hans Dr Loibner Prädiktive parameter
WO2009015841A1 (en) * 2007-07-27 2009-02-05 Immatics Biotechnologies Gmbh Composition of tumour-associated peptides and related anti-cancer vaccine
GB0718167D0 (en) * 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
EP2080812A1 (en) * 2008-01-18 2009-07-22 Transmedi SA Compositions and methods of detecting post-stop peptides
EP2105740A1 (en) * 2008-03-28 2009-09-30 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Biomarkers for monitoring or predicting the treatment of cancer
RU2011101378A (ru) 2008-06-16 2012-07-27 Сайвидон Дайагностикс Гмбх (De) Алгоритмы предсказания исхода у пациентов с узловой формой рака молочной железы после химиотерапии
WO2010076322A1 (en) 2008-12-30 2010-07-08 Siemens Healthcare Diagnostics Inc. Prediction of response to taxane/anthracycline-containing chemotherapy in breast cancer
US20100240546A1 (en) * 2009-03-20 2010-09-23 Samuel Chun Lap Lo Use of biomarkers for the diagnosis and prognosis of lung cancer

Also Published As

Publication number Publication date
JP2014500493A (ja) 2014-01-09
SG190698A1 (en) 2013-07-31
GB201021289D0 (en) 2011-01-26
US9389235B2 (en) 2016-07-12
US20120128702A1 (en) 2012-05-24
ES2592957T3 (es) 2016-12-02
CN103384827B (zh) 2016-06-08
BR112013012820A2 (pt) 2017-05-09
PL2643698T3 (pl) 2016-12-30
AU2011333819A1 (en) 2013-05-23
CA2818738A1 (en) 2012-05-31
KR20130119453A (ko) 2013-10-31
NZ609712A (en) 2015-05-29
EA201390762A1 (ru) 2013-09-30
WO2012069462A1 (en) 2012-05-31
EP2643698A1 (en) 2013-10-02
CN103384827A (zh) 2013-11-06
US20140234347A1 (en) 2014-08-21
EP2643698B1 (en) 2016-06-22
MX341734B (es) 2016-08-31
US8669063B2 (en) 2014-03-11
MX2013005762A (es) 2013-08-12
JP6005051B2 (ja) 2016-10-12

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