KR20130117501A - Composition supplementing water of skin and drug supplementing water of skin using this - Google Patents
Composition supplementing water of skin and drug supplementing water of skin using this Download PDFInfo
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- KR20130117501A KR20130117501A KR1020120040265A KR20120040265A KR20130117501A KR 20130117501 A KR20130117501 A KR 20130117501A KR 1020120040265 A KR1020120040265 A KR 1020120040265A KR 20120040265 A KR20120040265 A KR 20120040265A KR 20130117501 A KR20130117501 A KR 20130117501A
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- moisturizing
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
Description
The present invention relates to a composition for skin moisturizing, and more particularly, to a composition for skin moisturizing which is made of cosmetics or the like and can provide cosmetics and the like that are excellent in moisturizing effect and holding power when applied to the skin, and has less irritation to the skin.
The stratum corneum of our skin forms the outermost layer of the skin and plays an important role in preventing moisture loss inside the skin from the dry external environment. At the same time, he / she possesses moderate moisture and shows flexibility or resilience. In general, the moisture content of the horny layer is about 15%, whereas when it is less than 10%, it is called dry skin. However, moisture of the stratum corneum is lost due to external factors such as wind, temperature, sunlight, etc., as well as endogenous changes such as aging and hormone secretion imbalance. If moisture is lost, the elasticity and flexibility of the skin are lost, and ultimately, the inherent protective function of the skin is lost, resulting in cracking, erythema, capillary vasodilation and itching of the skin tissue. If these symptoms become worse, , And atopic diseases. Therefore, in order to solve such a problem, studies for forming an artificial moisturizing membrane on the stratum corneum of the skin are being continuously carried out. In addition, despite the formation of such an artificial moisturizing film, it should be accompanied by safety such as not causing side effects to the skin. In recent years, efforts have been made to form a skin moisturizing film having excellent moisturizing effect by utilizing biological agents other than these chemical agents. Particularly, when a skin moisturizing composition is prepared using only a high molecular weight polymer type moisturizing agent such as conventional hyaluronic acid, there is a problem that it is difficult to attain a moisturizing effect to the skin endothelial layer even though the skin absorption rate is low and the skin moisturizing effect is excellent . Also, existing chemical agents are irritating to the skin.
The present invention has been conceived to solve the above-mentioned problems, and it is an object of the present invention to provide a skin moisturizing composition which uses a biological agent with little skin irritation, excellent skin moisturizing effect, and excellent moisturizing effect . It is another object of the present invention to provide a skin moisturizing composition which can be absorbed to the skin endothelial layer by using a skin moisturizing peptide having a low molecular weight.
In order to solve the above problems, a skin moisturizing composition according to one aspect of the present invention comprises a skin inducing peptide inducer represented by the following formula (1), an acceptable salt thereof, a ceramide, and a solvent.
[Formula 1]
(Wherein X1, X2, Y1, and Y2 are each independently H or any one of substituents represented by the following Formulas 2 to 5, at least one of X1, X2, Y1, and Y2 is not H, and n is An integer of 1 to 5, and m is each independently an integer of 1 to 5).
(2)
(3)
[Formula 4]
[Chemical Formula 5]
The molecular weight of the peptide derivative represented by Formula 1 is 500 to 1000. In addition, the skin moisturizing peptide 0.00001 ~ 0.5 parts by weight, the ceramide is characterized in that 0.01 to 5.0 parts by weight based on 100 parts by weight of the solvent. And n is an integer of 3 or 4, and m is an integer of 3 or 4. The skin moisturizing composition further comprises one or more selected from the group consisting of oil, moisturizer, emulsifier or emollient in the skin moisturizing composition, 0.00001 to 0.5 parts by weight of the skin moisturizing peptide based on 100 parts by weight of the solvent. Ceramide is characterized in that 0.01 to 5.0 parts by weight, 0.001 to 1.0 parts by weight of the oil, 1.0 to 20.0 parts by weight of the moisturizer, 1 to 10.0 parts by weight of the emulsifier, 0 to 80 parts by weight of the emollient.
The skin moisturizing agent according to another aspect of the present invention includes the skin moisturizing composition.
The composition according to the present invention is excellent in skin moisturizing effect. Also, by using a biological agent, it is less irritating to the skin and is a composition having excellent moisturizing and retention ability. Thus, when a cosmetic product is manufactured using the composition according to the present invention, it is possible to provide a cosmetic product having excellent moisturizing effect. In addition, by using a skin moisturizing peptide having a low molecular weight, the absorption rate can be increased, and a moisturizing effect can be achieved up to the skin endothelial layer.
Accordingly, the present inventors have made intensive researches to provide a composition which is harmless to human body and excellent in skin moisturizing effect and skin moisturizing retention. As a result, the present invention has been completed upon development of a composition for skin moisturizing according to the present invention.
Specifically, the skin moisturizing composition according to the present invention may include a skin moisturizing peptide derivative represented by the following formula (I), an acceptable salt thereof, a ceramide, and a solvent.
(However, in Formula 1, X1, X2, Y1 and Y2 may preferably be independently substituted with H or any one substituent represented by Formulas 2 to 5. However, X1, X2, Y1 and At least one of Y 2 is not H, n is preferably an integer of 1 to 5, and m may preferably be each independently an integer of 1 to 5. Also, more preferably, n is 3 or 4 May be an integer of 3, and m may be an integer of 3 or 4.
The peptide of the peptide derivative according to Formula 1 may have a molecular weight of 500 to 1000. The peptides prepared by the peptide derivatives are characterized in that the skin moisturizing peptide according to the above formula (1) is lower in molecular weight than the conventional polymeric moisturizing material and has excellent skin absorption rate. Since it is a low molecular peptide, It is easier to quantify and purify than the moisturizing material of the present invention.
Thus, the skin moisturizing composition according to the present invention may include a skin moisturizing peptide synthesized by the skin moisturizing peptide derivative. Concretely, the skin moisturizing peptide may preferably contain 0.00001 to 0.5 parts by weight, and the ceramide may preferably include 0.01 to 5.0 parts by weight, based on 100 parts by weight of the solvent. When the moisturizing peptide is added in an amount less than 0.00001 parts by weight, it is difficult to achieve an appropriate skin moisturizing effect. When the moisturizing peptide is added in an amount of 0.5 parts by weight or more, the manufacturing cost increases significantly. In addition, the addition of the low molecular weight skin moisturizing peptide within the above range can maintain the skin moisturizing effect and the retention of the moisturizing effect to the skin up to the skin endothelium to the maximum, and the skin moisturizing peptide added not being a chemical preparation but biocompatible, It is possible to provide a skin moisturizing composition. If less than 0.01 part by weight of the ceramide is added, skin protection effect and skin moisturizing effect can not be sufficiently attained. If more than 5.0 parts by weight is added, there is a problem in that a large amount of expensive ceramide is added to secure stability and increase the manufacturing cost. The ceramide may be used in combination with any one or more selected from the group consisting of ceramides, yeast ceramides and pseudoceramide selected from the group consisting of compounds represented by the following formulas (6) to (11). Ceramide is a type of sphingoid lipid that has a structure in which fatty acids are linked to sphingosine or phytosphingosine, and ceramide has about 40% or more of the intercellular lipid constituting the stratum corneum of the skin and shows the structure or function of the stratum corneum It is an essential ingredient. The ceramide present in the human body is divided into six kinds according to the degree of polarity, and these are represented by the following Chemical Formulas 6 to 11.
Ceramides also have the function of lipid barrier to inhibit the evaporation of water and to maintain the square structure of the stratum corneum. In the stratum corneum of the skin, keratinocytes are composed of a brick-like multilayer structure, and these keratinocytes are firmly bound by ceramide, cholesterol, and free fatty acids. Skin cells have a higher content of ceramides than other cells of the human body, and especially high amounts of non-polar neutral ceramides. This is a structural feature that is necessary to form a solid defense barrier of the skin. In addition, ceramide is decomposed into phytosphingosine from the skin surface, and it acts as an antibacterial barrier against external harmful microorganisms, and it is found that ceramide plays an important function in regulating inflammation and wound healing.
Many studies have shown that ceramides are directly related to skin diseases including atopy, and clinical results of dermatologists have proved that ceramide and phytosphingosine are also effective in atopic dermatitis.
Thus, ceramides are generally known to play an important role in skin protection. Particularly, epidermal lipids consist of ceramide, cholesterol, and fatty acid. Ceramide is known to play the most important role in skin protection. Ceramide is also known to maintain the moisturization of the skin as a substance that exists in the human body. If the skin lacks ceramide, moisture in the horny layer of the skin is easily evaporated, resulting in skin troubles such as skin elasticity reduction, rash formation, wrinkle formation, and sensitivity to external stimuli. In addition, with age, the amount of ceramide in the stratum corneum decreases, which causes skin aging. In the case of dry skin or troubled soap, the production of ceramide in the body is not well achieved, and keratin occurs frequently and dries. Therefore, since the ceramide is included in the composition according to the present invention, the skin protection effect and the skin moisturizing effect can be further improved. The solvent may be any one or more selected from the group consisting of water, glycerin, butylene glycol, propylene glycol, dipropylene glycol, hyaluronic acid, and collagen extract.
In addition, the skin moisturizing composition may preferably include any one or more selected from the group consisting of oils, moisturizers, emulsifiers or emollients. In this case, the skin moisturizing peptide is preferably based on 100 parts by weight of the solvent. 0.00001 to 0.5 parts by weight, the ceramide is preferably 0.01 to 5.0 parts by weight, the moisturizing agent is preferably 1.0 to 20.0 parts by weight, the emulsifier is preferably 1 to 10.0 parts by weight, the softener is preferably 0 ~ It may be made of 80 parts by weight. When the composition is produced within the above range, the moisture retention and moisturizing effect can be maximized, and the production cost can be appropriately controlled. In addition, since it contains a low molecular weight skin moisturizing peptide, it is possible to achieve a sufficient moisturizing effect and its maintenance effect to the inner skin layer of the skin. The oil may preferably be at least one selected from the group consisting of rose oil, macadamia oil, jojoba oil, lavender oil, and isocetyl ethyl hexanoate. The moisturizing agent may be any one or more selected from the group consisting of hyaluronic acid, propylene glycol, dipropylene glycol, butylene glycol, glycerin or collagen extract. The emulsifier may be at least one selected from the group consisting of lecithin, phage 40 hardened castor oil, polyoxyethylene sorbitan and sesquioleic acid sorbitan. Further, the softening agent may preferably be any one or more selected from the group consisting of alcohol, dipropylene glycol, and purified water.
The skin moisturizing agent according to another aspect of the present invention may preferably include the skin moisturizing composition. Specifically, the skin moisturizing composition may include a skin moisturizing peptide derivative represented by the formula (1), an acceptable salt thereof, a ceramide, and a solvent. The skin moisturizing peptide of Formula 1 has a molecular weight of preferably 500 to 1000. In addition, the skin moisturizing peptide with respect to 100 parts by weight of the solvent is preferably 0.00001 ~ 0.5 parts by weight, the ceramide may be preferably made of 0.01 to 5.0 parts by weight. When the composition is prepared in the above-described range, the skin moisturizing effect and the holding power can be maximized, and the manufacturing cost can be appropriately adjusted. In addition, by adding a skin moisturizing peptide having a low molecular weight, it is possible to achieve a skin moisturizing effect and retentivity to the skin endothelial layer. In addition, since the skin-moisturizing peptide, which is not a chemical agent but is biocompatible, is added, it is possible to provide a safer skin-moisturizing composition to the human body. The composition for skin moisturizing may further comprise an oil, a moisturizer, an emulsifier, and a softener. In this case, the skin moisturizing peptide is preferably 0.00001 to 0.5 parts by weight, the ceramide is preferably 0.01 to 5.0 parts by weight, the oil is preferably 0.001 to 1.0 parts by weight, and the moisturizing agent is preferably 100 parts by weight of the solvent. Preferably 1.0 to 20.0 parts by weight, the emulsifier is preferably 1 to 10.0 parts by weight, the softener may be preferably composed of 0 to 80.0 parts by weight. The oil may preferably be at least one selected from the group consisting of rose oil, macadamia oil, jojoba oil, lavender oil, and isocetyl ethyl hexanoate. The moisturizing agent may be any one or more selected from the group consisting of hyaluronic acid, propylene glycol, dipropylene glycol, butylene glycol, glycerin or collagen extract. The emulsifier may be at least one selected from the group consisting of lecithin, phage 40 hardened castor oil, polyoxyethylene sorbitan and sesquioleic acid sorbitan. The softening agent may preferably be any one or more selected from the group consisting of alcohol, dipropylene glycol, and purified water.
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.
Example
< Example 1: Preparation of skin moisturizing composition >
0.1 g of skin moisturizing peptide, 4.0 g of ceramide, 0.1 g of rose oil, 2.0 g of hyaluronic acid, 4.0 g of lecithin, and 88.0 g of polyhydric alcohol are added to the remaining purified water to make 100 g and dissolve it to around 75 to 80 degrees. After mixing using a mixer, using a microfluidizer after passing twice at 1000 atmospheres to prepare a skin moisturizing composition.
< Example 2: Example 1 < SEP > 1 wt% < tb &
Butylene glycol 6.0g, glycerin 6.0g, dipropylene glycol 4.0g, panthenol 1.0g, trisodium eddiey 0.03g, triethanolamine 0.05g, carbopol 0.05g, betaine 1.0g 75 degrees It melt | dissolved by heating to the vicinity. In addition, cetostearyl alcohol 3.0g, jojoba oil 3.0g, argan oil 5.0g, beeswax 0.6g, polyoxyethylene sorbitan 2.0g, sesquioleic acid sorbitan 0.5g, cetyl hexahexanoate 4.0g, 1,2 60.82 g of purified water was added to 2.0 g of hexanediol, and then dissolved by heating to around 75 degrees. Subsequently, each of the dissolved materials was added, mixed at 3500 RPM for 10 minutes using a homomixer, and then cooled. Thereafter, 1.0 wt% of the composition according to Example 1 was added at about 50 ° C, mixed using a homomixer for 2 minutes, and cooled slowly to 30 ° C to prepare a cream cosmetic.
< Example 3: Example 1 < SEP > 10 wt% < tb &
Dipropylene glycol 6.0g, butylene glycol 4.0g, glycerin 6.0g, panthenol 0.5g, trisodium eddiey 0.03g, triethanolamine 0.15g, carbomer 0.15g, betaine 1.0g, trehalose 1.0g 75 degrees Warmed at In addition, cetostearyl alcohol 1.5g, jojoba oil 2.0g, argan oil 1.0g, polyoxyethylene sorbitan 1.2g, sesquioleic acid sorbitan 0.5g, cetylethylhexanoate 4.0g, 1,2 hexanediol 2.0 After combining g and 58.97 g of purified water, the solution was warmed and dissolved at 75 degrees. After that, the materials dissolved separately were mixed and mixed at 10 using a homomixer at 3500 RPM for 10 minutes, cooled, and then added to 10 g of the Filagrin complex at about 50 degrees, followed by mixing using a homo mixer for 2 minutes, and then cooled slowly to 30 degrees. Cosmetics were prepared.
< Example 4: Example 1 < SEP > 20 wt% < tb &
Butylene glycol 6.0 g, glycerin 6.0 g, dipropylene glycol 4.0 g, panthenol 1.0 g, trisodium eddiey 0.03 g, triethanolamine 0.05 g, carbomer 0.05% by weight, betaine 1.0 g, trehalose 1.0 g After dissolving it to around 75 ° C, cetostearyl alcohol 3.0g, jojoba oil 3.0g, argan oil 5.0g, beeswax 0.6g, polyoxyethylene sorbitan 2.0g, sesquioleic acid sorbitan 0.5g, cetylethyl 4.0 g of hexanoate, 2.0 g of 1,2-hexanediol, and 40.77 g of purified water were mixed and warmed to about 75 degrees, and then the respective warm dissolved mixtures were combined. And mixed at 3500 RPM for 10 minutes using a homomixer. Thereafter, it was cooled to around 50 degrees, and then 2 g of the composition according to Example 1 was added and mixed again using a homomixer for 2 minutes. Then slowly cooled to 30 degrees to obtain a cosmetic composition, which was prepared in the form of a cosmetic cream.
Comparative Example
< Comparative Example One: Example 1 < / RTI > Cosmetics 1 >
Dipropylene glycol 6.0g, butylene glycol 4.0g, glycerin 6.0g, panthenol 0.5g, trisodium eddiey 0.03g, triethanolamine 0.15g, carbomer 0.15g, betaine 1.0g, trehalose 1.0g It was then dissolved in warming to around 75 degrees. In addition, cetostearyl alcohol 1.5g, jojoba oil 2.0g, argan oil 1.0g, polyoxyethylene sorbitan 1.2g, sesquioleic acid sorbitan 0.5g, cetylethylhexanoate 4.0g, 1,2 hexanediol 2.0 g and purified water 70.97 g were added and mixed, followed by warm dissolving at about 75 ° C, followed by mixing of each warm dissolving material. Thereafter, the mixture was mixed with a homomixer at 3500 RPM for 10 minutes, and then slowly cooled to 30 degrees to obtain a cosmetic composition, which was used to prepare a cosmetic in the form of an emulsion.
< Comparative Example 2: Example 1 < / RTI > Cosmetics 2 >
Butylene glycol 6.0g, glycerin 6.0g, dipropylene glycol 4.0g, panthenol 1.0g, trisodium eddiey 0.03g, triethanolamine 0.05g, carbomer 0.05g, betaine 1.0g 75 It was warmed up to near the island. Thereafter, 3.0 g of cetostearyl alcohol, 3.0 g of jojoba oil, 5.0 g of argan oil, 0.6 g of beeswax, 2.0 g of polyoxyethylene sorbitan, 0.5 g of sesquioleic acid sorbitan, 4.0 g of cetyl hexahexanoate, 1 To 2 g of dihexanediol, 61.77 g of purified water was added, mixed, and dissolved by heating to around 75 degrees. Thereafter, each of the warm dissolving mixtures was mixed together, which was mixed at 3500 RPM for 10 minutes using a homomixer, and then a cream cosmetic was prepared from the cosmetic composition obtained by slowly cooling to 30 degrees.
Experimental Example
< Experimental Example 1: Stability evaluation>
After keeping the cosmetics according to Example 2, Example 3, Example 4, Comparative Example 1 and Comparative Example 2 in the room at 0 ℃, 40 ℃, 50 ℃ for 4 weeks, the result of checking the change over time , It was found to be stable in separation, deodorization, color change, and point hardness change.
< Experimental Example 2: Evaluation of moisture content>
Each of the cosmetics according to Example 2, Example 3, Example 4, Comparative Example 1, and Comparative Example 2 was applied to the surface of the skin, and a probe having electrodes embedded therein was placed on the surface of the skin. Respectively. At this time, skin moisture content was measured using Skicom 200, which displays the water content of the stratum corneum digitally. The total of five measurements were made and the mean value of these measurements was finally measured. The measured results are as follows.
Example 2: 180% immediately after application and 140% moisture retention after 1 day
Example 3: 280% immediately after application, 240% moisture retention after 1 day
Example 4 380% moisture retention immediately after application, 356% moisture retention after 1 day
Comparative Example 1: 80% immediately after application, 60% moisture retention after 1 day
Comparative Example 2: 86% immediately after application and 62% moisture retention after 1 day
As a result, when the skin moisturizing composition according to Example 1 is added, it was confirmed that sufficient moisture is retained in the skin immediately after application, compared with the case where it is not added. This is evidenced by the improved electrical conductivity. In addition, it was confirmed that the moisture retained in addition to the significantly improved water retention capacity is not rapidly lost over time. That is, it was confirmed that moisture retention and retention were improved.
< Experimental Example 3: Human skin test>
As a result of microscopic stimulation, the human skin test (Human Patch Test) for confirming the primary human irritation of the cosmetics according to Examples 2, 3, 4, Comparative Example 1 and Comparative Example 2 When evaluated as 0.0 ~ 0.1, intermediate stimulation 0.1 ~ 0.2, severe stimulation of 0.2 or more, Example 2 was evaluated as 0.01, Example 3 was 0.02, Example 4 was 0.01 and appeared within the micro-irrit range, and compared Example 1 was evaluated to be 0.08 and Comparative Example 2 was 0.12, indicating that they were within the range of micro- and mid-stimulus.
From the above results, the cosmetics according to Examples 2, 3 and 4 prepared by adding the composition according to Example 1 showed more irritation than the cosmetics according to Comparative Examples 1 and 2 prepared only with chemical agents It was confirmed that a cosmetic product with a remarkably lowered stimulus could be produced. This is the result of using biomedical skin moisturizing peptides, not chemical preparations.
From the above-mentioned experimental results, it was confirmed that when the skin moisturizing composition according to Example 1 is added at the time of manufacturing cosmetics, skin moisturizing power and retention are improved, and low stimulus cosmetics with less irritation to human body can be produced.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. It is natural.
Claims (7)
[Formula 1]
(Wherein X1, X2, Y1, and Y2 are each independently H or any one of substituents represented by the following Formulas 2 to 5, at least one of X1, X2, Y1, and Y2 is not H, and n is An integer of 1 to 5, and m is each independently an integer of 1 to 5).
(2)
(3)
[Chemical Formula 4]
[Chemical Formula 5]
Moisturizing composition, characterized in that the molecular weight of the peptide derivative according to Formula 1 is 500 to 1000.
0.00001 to 0.5 parts by weight of the skin moisturizing peptide, and the ceramide is 0.01 to 5.0 parts by weight based on 100 parts by weight of a solvent.
Where n is an integer of 3 or 4, m is an integer of 3 or 4 skin moisturizing composition, characterized in that.
The skin moisturizing composition further comprises any one or more selected from the group consisting of oils, moisturizers, emulsifiers or emollients.
0.00001 to 0.5 parts by weight of the skin moisturizing peptide, 0.01 to 5.0 parts by weight, 0.001 to 1.0 parts by weight of oil, 1.0 to 20.0 parts by weight of moisturizer, 1 to 10.0 parts by weight of emulsifier, and 100 parts by weight of the solvent. Skin softening composition, characterized in that 0 to 80 parts by weight of the softener.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120040265A KR20130117501A (en) | 2012-04-18 | 2012-04-18 | Composition supplementing water of skin and drug supplementing water of skin using this |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120040265A KR20130117501A (en) | 2012-04-18 | 2012-04-18 | Composition supplementing water of skin and drug supplementing water of skin using this |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20140114107A Division KR20140121801A (en) | 2014-08-29 | 2014-08-29 | Composition supplementing water of skin and drug supplementing water of skin using this |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130117501A true KR20130117501A (en) | 2013-10-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020120040265A KR20130117501A (en) | 2012-04-18 | 2012-04-18 | Composition supplementing water of skin and drug supplementing water of skin using this |
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| KR (1) | KR20130117501A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017222345A1 (en) | 2016-06-24 | 2017-12-28 | Incospharm Corporation | Novel autophagy activation-inducing compound for improving skin inflammation or aging |
-
2012
- 2012-04-18 KR KR1020120040265A patent/KR20130117501A/en not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017222345A1 (en) | 2016-06-24 | 2017-12-28 | Incospharm Corporation | Novel autophagy activation-inducing compound for improving skin inflammation or aging |
| CN109476585A (en) * | 2016-06-24 | 2019-03-15 | 因科斯医药公司 | For improving the novel autophagy activation-inducing compound of scytitis or aging |
| US10617662B2 (en) | 2016-06-24 | 2020-04-14 | Incospharm Corporation | Autophagy activation-induced compound for improving skin inflammation for aging |
| CN109476585B (en) * | 2016-06-24 | 2022-04-29 | 因科斯医药公司 | Novel autophagy activation-inducing compound for ameliorating skin inflammation or aging |
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