KR100824958B1 - Cosmetic composition containing oriental herb extract and nano ceramide - Google Patents

Cosmetic composition containing oriental herb extract and nano ceramide Download PDF

Info

Publication number
KR100824958B1
KR100824958B1 KR1020060122330A KR20060122330A KR100824958B1 KR 100824958 B1 KR100824958 B1 KR 100824958B1 KR 1020060122330 A KR1020060122330 A KR 1020060122330A KR 20060122330 A KR20060122330 A KR 20060122330A KR 100824958 B1 KR100824958 B1 KR 100824958B1
Authority
KR
South Korea
Prior art keywords
ceramide
weight
nano
cosmetic composition
skin
Prior art date
Application number
KR1020060122330A
Other languages
Korean (ko)
Inventor
진상구
김형진
윤원식
박현미
Original Assignee
주식회사 피코스텍
주식회사 닥터비 아토키즈 랩
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 피코스텍, 주식회사 닥터비 아토키즈 랩 filed Critical 주식회사 피코스텍
Priority to KR1020060122330A priority Critical patent/KR100824958B1/en
Application granted granted Critical
Publication of KR100824958B1 publication Critical patent/KR100824958B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254Acanthopanax or Eleutherococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

A cosmetic composition comprising an oriental herb extract and nano ceramide is provided to show improved moisture retaining property and antibacterial effect on pathogenic bacteria causing skin trouble and be applied to skin with almost no irritation. A cosmetic composition comprising an oriental herb extract and nano ceramide is characterized in that it is prepared by heat-dissolving 30-88.9 wt.% of an aqueous ingredient including 1-20 wt.% of the oriental herb extract selected from the group consisting of Acanthopanax sessiliflorus, Portulaca oleracea, Althaea rosea, Pleuropterus multflorus, and Asparagus cochinchinensis, 0.1-10.0 wt.% of the nano ceramide, and 1.0-80 wt.% of purified water, and 10-40 wt.% of an oil phase ingredient at a temperature of 60-80 deg.C and then emulsifying the dissolved material, wherein the nano ceramide is prepared by nano-sizing a mixture consisting of 0.1-10 wt.% of ceramide, 0.1-70 wt.% of polyhydric alcohol, 0.1-10 wt.% of lecithin, 0.1-10 wt.% of alcohol and 0.1-80 wt.% of purified water using a microfluidizer. Further, the ceramide is one selected from ceramides 1 to 6, yeast ceramide and pseudo ceramide.

Description

한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물{COSMETIC COMPOSITION CONTAINING ORIENTAL HERB EXTRACT AND NANO CERAMIDE}Cosmetic composition containing herbal extract and nano ceramide {COSMETIC COMPOSITION CONTAINING ORIENTAL HERB EXTRACT AND NANO CERAMIDE}

본 발명은 화장품 조성물에 관한 것으로, 더욱 상세하게는 다량의 복합 한방 추출물과 나노 안정화시킨 나노 세라마이드를 함유시키는 것에 의해 트러블 피부를 개선할 수 있는 가용화 및 유화 화장품을 제조하기 위한 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물에 관한 것이다. The present invention relates to a cosmetic composition, and more particularly, by containing a large amount of complex herbal extracts and nano-stabilized nano ceramides, herbal extracts and nano ceramides for preparing solubilized and emulsified cosmetics that can improve troubled skin. It relates to a cosmetic composition containing.

일반적으로, 세라마이드(Ceramide)는 피부를 보호하는 피부 보호막이라고 불리우는 각질층을 구성하는 지질 성분 중 가장 중요한 성분으로 알려져 있고, 수분의 증발을 억제함과 동시에 수분과 결합되어 피부의 수분을 함유하는 기능이 뛰어난 것으로 알려져 피부가 최적의 대사기능을 수행하는데 최적의 환경을 제공한다.In general, ceramide is known as the most important component of the lipid components that make up the stratum corneum, called the skin protective film to protect the skin. It is known to be excellent and provides the optimal environment for the skin to perform its optimal metabolic function.

새롭게 성장하는 피부세포에는 세라마이드의 함량이 적고 주로 당이 연결되어 있는 당스핑고 지질의 형태로 존재한다. 그러나 새로운 피부세포가 외각층으로 이동하면서 각질층에 이르게 되면, 당이 떨어진 중성 세라마이드가 증가하여 각질층의 소수성 장벽을 형성하게 된다.Newly growing skin cells are present in the form of sugar spingo lipids with low ceramide content and mainly sugar linkages. However, when new skin cells reach the stratum corneum and reach the stratum corneum, the neutral ceramide in which sugar is dropped increases, forming a hydrophobic barrier of the stratum corneum.

기본적으로 세라마이드는 수분의 증발을 억제하는 지질 장벽의 역할과 각질 층의 정연한 구조를 유지하게 하는 기능을 가지고 있다. 피부 각질층은 각화된 세포가 벽돌모양의 다층구조로 구성되어 있으며 이러한 각화세포는 세라마이드, 콜레스테롤, 유리지방산에 의해 견고히 결합되어 있다. 피부세포는 인체의 다른 세포에 비해 세라마이드의 함량이 높으며, 특히 비극성인 중성 세라마이드의 함량이 많다. 이는 피부의 견고한 방어 장벽을 구성하게 하는데 필요한 구조적 특징이라고 할 수 있다.Basically, ceramides have the role of lipid barriers to inhibit evaporation of water and maintain the structure of the stratum corneum. In the stratum corneum of the skin, keratinocytes are composed of a brick-like multilayer structure, and these keratinocytes are firmly bound by ceramide, cholesterol, and free fatty acids. Skin cells have a higher content of ceramides than other cells of the human body, and especially high amounts of non-polar neutral ceramides. This is a structural feature necessary to make up the skin's strong protective barrier.

또한 세라마이드는 피부표면에서 파이토스핑고신으로 분해됨으로서 외부 유해 미생물에 대한 항균장벽으로 작용하며 염증의 조절과 상처회복에도 중요한 기능을 수행하는 것으로 밝혀져 세라마이드의 피부과학적 중요성은 더욱 부각되고 있다. 많은 연구결과에서 세라마이드는 아토피를 비롯한 피부질환과 직접적으로 관련이 있는 것으로 확인되었으며, 피부과의 임상결과에서도 세라마이드와 파이토스핑고신을 함께 사용하여 아토피 피부염에 효과가 뛰어난 것을 입증하였다.In addition, since ceramide is decomposed into phytosphingosine on the surface of the skin, it acts as an antimicrobial barrier against harmful harmful microorganisms and plays an important role in controlling inflammation and wound healing. In many studies, ceramide has been found to be directly related to atopic dermatitis and other dermatological disorders. Ceramide and phytosphingosine have also been shown to be effective in treating atopic dermatitis.

보통 인체에 존재하는 세라마이드는 극성 정도에 따라서 세라마이드 1 ~ 6의 6종류로 구분되어 있으며 화장품에서는 이들 여섯 종류 외에 발효 세라마이드와 합성 슈도(pseudo) 세라마이드가 많이 사용되고 있다. Normally, ceramides present in the human body are classified into six types of ceramides 1 to 6 according to the degree of polarity, and in addition to these six kinds, cosmetics are used fermented ceramides and synthetic pseudo ceramides.

그러나, 이러한 특성에도 불구하고 세라마이드는 안정화가 어렵다는 단점으로 인하여 0.1중량% 이상 함유시키기가 어렵고, 0.1중량% 이상 다량 함유시키기 위해서는 국내공개특허 제10-1999-066273호에서와 같이 다량의 계면활성제 및 에탄올 등을 이용하거나 리퀴드 크리스탈 상태로 만든 후 이용해야 하는 등 사용적 제한이 많아 실제 시중에서 판매되고 있는 화장품들의 세라마이드 사용량은 0.1 중 량% 미만이 대부분인 상황이다. However, despite such characteristics, ceramide is difficult to contain more than 0.1% by weight due to the difficulty of stabilization, in order to contain a large amount of 0.1% by weight or more, as described in Korean Patent Publication No. 10-1999-066273 Since there are many usage restrictions, such as using ethanol or liquid crystal, the ceramide consumption in the market is mostly less than 0.1% by weight.

또한 한방 화장품에 대한 관심이 고조되면서 피부를 개선하는 성분으로 한방 추출물에 대한 연구 및 제품이 많이 소개 되고 있으나 대부분이 동의보감, 중약 대사전 등에 소개되어 있는 피부에 좋다고 하는 옥용단, 단방 등의 소재를 활용하여 제품화 하여 왔다. 특히 각 화장품 제조사에서 가장 선호 하는 옥용단의 경우는 녹두, 천화분, 백지, 고본, 조각자 등을 함유하여 피부트러블 개선, 피부 미백, 혈액순환 개선, 피부탄력 등 다양한 피부 개선 효과를 기대로 사용하고 있으나 체계적인 연구 결과 보다는 문헌 등의 소개를 중심으로 사용되어 왔다. In addition, as the interest in herbal cosmetics increases, many researches and products about herbal extracts have been introduced as ingredients that improve skin, but most of them use materials such as Okyongdan and Danbang, which are said to be good for skin, which are introduced in Dongbobogam and Chinese medicine metabolism. Has been commercialized. In particular, the most preferred jade yongdan by each cosmetics manufacturer contains mung bean, hwahwahwa, white paper, hard bones, sculptors, etc., and it is used to expect various skin improvement effects such as skin trouble, skin whitening, blood circulation, and skin elasticity. Rather than systematic research results, it has been used mainly for introduction of literatures.

최근 대기업, 한의원 등을 중심으로 한 한방 화장품들에서 한방 성분의 전문가인 한의사, 한방병원등과의 연계를 통해 한의사의 전문적인 한방 전문성과 화장품 기술자의 제형 전문성을 이용한 공동연구 형태의 제품들이 나오기 시작하였다.Recently, in the form of herbal cosmetics, mainly large corporations and oriental medical clinics, joint research-type products using professional medicine expertise of herbal medicines and formulation expertise of cosmetic technicians have emerged in connection with herbal medicine specialists and herbal hospitals. .

따라서 한층 고품질의 제품들이 가능해지고, 수입 해외 명품들과 견줄 수 있는 제품화, 브랜드화가 가능해지면서 시장의 신뢰와 한방화장품에 대한 관심 또한 더욱 높아지고 있다.As a result, higher quality products are possible, and productization and branding that are comparable to imported overseas luxury goods are possible, and the market's trust and interest in oriental cosmetics are also increasing.

하지만 이러한 한방 제품들은 한방 고유의 이미지를 유지하기 위하여 한방 혹은 천연 원료만으로 원하는 효능효과를 찾고자 하는 제품 개발로 다양한 제품 전개에는 다소 한계를 가질 수밖에 없는 것은 부인할 수 없는 현실이다. However, these herbal products are undeniable reality that there are bound to be limited to the development of a variety of products by developing a product to find the desired efficacy effect only with herbal or natural raw materials in order to maintain the unique image of the herbal.

따라서, 본 발명은 상기한 바와 같은 종래의 문제점을 개선하기 위하여 안출된 것으로, 그 목적은 효능 극대화를 위해 수년간 연구 결과로 피부 트러블 완화 효과가 검증된 복합 한방 성분과 나노 안정화 시킨 세라마이드를 이용하여 가용화 및 유화 화장품을 제조함으로써 피부보습, 탄력 뿐 아니라 피부트러블 개선에도 효과가 있는 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물을 제공하는데 있다.Therefore, the present invention has been made in order to improve the conventional problems as described above, the purpose of the solubilization using a composite herbal ingredient and nano-stabilized ceramide that has been proven to reduce skin problems as a result of years of research to maximize efficacy And to prepare an emulsified cosmetics to provide a cosmetic composition containing herbal extracts and nano ceramides that are effective for skin moisturizing, elasticity as well as skin problems.

상기한 바와 같은 목적을 달성하기 위하여 본 발명은, 복합 한방 추출물 1~20 중량%, 나노 안정화시킨 나노 세라마이드 0.1~10.0 중량%, 정제수 1.0~80 중량%를 적어도 포함하는 수상성분 10~30 중량%, 유상성분 10~40 중량%를 60~80℃로 가열 용해한 후 유화하여 제조되는 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물에 특징이 있다.In order to achieve the above object, the present invention, 10 ~ 30% by weight of the aqueous composition containing at least 1 to 20% by weight of the composite herbal extract, 0.1 to 10.0% by weight of nano-stabilized nano ceramide, 1.0 to 80% by weight of purified water , Characterized in that the cosmetic composition containing a herbal extract and nano ceramide prepared by dissolving 10 to 40% by weight of the oil phase component at 60 to 80 ℃.

또한 본 발명의 상기 나노 세라마이드는, 세라마이드 0.1~10중량%, 다가알코올 0.1~70 중량%, 레시친 1~10 중량%, 알코올 0.1~10 중량%, 정제수 0.1~80 중량%를 혼합하여 고압유화기로 나노화시킨 것을 사용하는 것이 바람직하다.In addition, the nano ceramide of the present invention, 0.1 to 10% by weight of ceramide, 0.1 to 70% by weight of polyhydric alcohol, 1 to 10% by weight of lecithin, 0.1 to 10% by weight of alcohol, 0.1 to 80% by weight of purified water to a high pressure emulsifier It is preferable to use what was nanoized.

또한 본 발명의 상기 세라마이드는, 세라마이드 1에서 6의 6종류, 효모 세라마이드, 슈도 세라마이드중에서 선택한 어느 하나이고, 복합 한방 추출물은, 오가피, 오행초, 촉규근, 하수오, 천문동중에서 선택된 적어도 하나 이상인 것이 바람직하다. In addition, the ceramide of the present invention is any one selected from six kinds of ceramides 1 to 6, yeast ceramide, pseudo ceramide, and the complex herbal extract is preferably at least one selected from among the stamens of Ogapi, Pentachocho, Tsukyu-geun, Sewao, and Astronomical dong Do.

이러한 본 발명의 한방 화장품 조성물에 의하면, 크림, 로션 등의 유화 화장품 뿐 아니라, 가용화 제품을 제조하여 피부에 바르는 경우, 보습, 탄력 뿐 아니라 피부트러블 개선에도 탁월한 효과가 있다.According to the herbal cosmetic composition of the present invention, as well as emulsified cosmetics, such as creams and lotions, when the solubilized product is manufactured and applied to the skin, there is an excellent effect not only moisturizing, elasticity but also improve skin troubles.

이하, 본 발명의 바람직한 실시예를 설명한다.Hereinafter, preferred embodiments of the present invention will be described.

<실시예 1><Example 1>

먼저 수상성분으로서 디프로필렌글리콜 6.0 중량%, 글리세린 6.0 중량%, 판테놀 0.5 중량%, 히아루론산 3.0%, 트리소듐이디티에이 0.03 중량%, 트리에탄올아민 0.05 중량%, 메칠파라벤 0.15 중량%, 페녹시에탄올 0.1 중량%, 카보폴 0.05 중량%와, 유상성분으로서 마카데미아넛츠 오일 3.0 중량%, 스쿠알란 5.0 중량%, 밀랍 0.6 중량%, 폴리옥시에틸렌소르비탄 1.5 중량%, 세스퀴올레인산소르비탄 0.5중량%, 이소세틸에틸헥사노에이트 4.0 중량%, 프로필파바벤 0.05 중량%를 각각 70도 가온 용해하고, 이어서 유상성분을 수상성분에 가하여 3500RPM으로 10분간 호모믹서를 이용하여 혼합한 후, 냉각시켜 50도 부근에서 오가피, 오행초, 촉규근, 하수오, 천문동중에서 선택된 하나 또는 둘이상의 한약재를 3일간 다려 추출한 복합 한방 추출물 10 중량%와, 나노 세라마이드 10 중량%를 효능 물질로서 가하고, 정제수 49.47 중량%를 가하여 다시 2분간 호모믹서를 이용하여 혼합하고, 30도 까지 서서히 냉각하여 얻은 한방 화장품조성물로 크림형태의 화장품을 제조하였다.First, as an aqueous phase component, 6.0% by weight of dipropylene glycol, 6.0% by weight of glycerin, 0.5% by weight of panthenol, 3.0% of hyaluronic acid, 0.03% by weight of trisodium idieti, 0.05% by weight of triethanolamine, 0.15% of methylparaben, and phenoxyethanol 0.1 Wt%, Carbopol 0.05 wt%, macadamia nut oil 3.0 wt%, squalane 5.0 wt%, beeswax 0.6 wt%, polyoxyethylene sorbitan 1.5 wt%, sesquioleic acid sorbitan 0.5 wt%, 4.0% by weight of isocetylethylhexanoate and 0.05% by weight of propylpababen were dissolved by heating at 70 degrees, and then the oil phase component was added to the aqueous phase and mixed at 10 using a homomixer at 3500 RPM for 10 minutes before cooling. 10% by weight of the combined herbal extract extracted by one or two or more Chinese herbal medicines selected from Ogapi, Ohaengcho, Chok Keun-Geun, Shou-O, Astronomical Dong for 3 days Was added to 10% by weight of polyimide as a material effect, it was added to and mixed with purified water 49.47% by weight, again for 2 minutes using a homomixer to prepare a cosmetic cream in the form of a one shot cosmetic composition obtained was gradually cooled to 30 ° C.

<실시예 2><Example 2>

먼저 수상성분으로서 디프로필렌글리콜 6.0 중량%, 글리세린 6.0 중량%, 판테놀 0.5 중량%, 히아루론산 10.0%, 트리소듐이디티에이 0.03 중량%, 트리에탄올아민 0.15 중량%, 메칠파라벤 0.15 중량%, 페녹시에탄올 0.05 중량%, 카보폴 0.15 중량%와, 유상성분으로서 피이지40경화피마자유 0.5 중량%, 프로필파바벤 0.05 중량%를 각각 70도 가온 용해하고, 이어서 유상성분을 수상성분에 가하여 3500RPM으로 10분간 호모믹서를 이용하여 혼합한 후, 냉각시켜 50도 부근에서 오가피, 오행초, 촉규근, 하수오, 천문동중에서 선택된 하나 또는 둘이상의 한약재를 3일간 다려 추출한 복합 한방 추출물 20 중량%와, 나노 세라마이드 5 중량%를 효능 물질로서 가하고, 정제수 51.42 중량%를 가하여 다시 2분간 호모믹서를 이용하여 혼합하고, 30도 까지 서서히 냉각하여 얻은 한방 화장품조성물로 가용화 형태의 화장품을 제조하였다.First, as a water phase component, 6.0% by weight of dipropylene glycol, 6.0% by weight of glycerin, 0.5% by weight of panthenol, 10.0% of hyaluronic acid, 0.03% by weight of trisodium idieti, 0.15% by weight of triethanolamine, 0.15% by weight of methyl paraben, and phenoxyethanol 0.05 70 wt% of Carbopol, 0.15 wt% of Carbopol, 0.5 wt% of Fiji 40-cured castor oil, and 0.05 wt% of propylpababen were dissolved as warm oils, and then the oily ingredients were added to the aqueous phase and homogenized at 3500 RPM for 10 minutes. After mixing by using a mixer, 20% by weight of the composite herbal extract extracted by simmering one or two or more Chinese herbal medicines selected from among Ogapi, Ohaengcho, Tsukyu-Geun, Sewao and Astronomical Dong at 50 ° C for 3 days, and 5% by weight of nano ceramide Was added as an agonist, 51.42% by weight of purified water was mixed again using a homomixer for 2 minutes, and cooled slowly to 30 ° C. Herbal Cosmetic composition was prepared by soluble form of the cosmetic.

<실시예 3><Example 3>

먼저 수상성분으로서 디프로필렌글리콜 6.0 중량%, 글리세린 6.0 중량%, 판테놀 0.5 중량%, 히아루론산 3.0%, 트리소듐이디티에이 0.03 중량%, 트리에탄올아민 0.05 중량%, 메칠파라벤 0.15 중량%, 페녹시에탄올 0.1 중량%, 카보폴 0.05 중량%와, 유상성분으로서 마카데미아넛츠 오일 3.0 중량%, 스쿠알란 5.0 중량%, 밀랍 0.6 중량%, 폴리옥시에틸렌소르비탄 1.5 중량%, 세스퀴올레인산소르비탄 0.5중량%, 이소세틸에틸헥사노에이트 4.0 중량%, 프로필파바벤 0.05 중량%를 각각 70도 가온 용해하고, 이어서 유상성분을 수상성분에 가하여 3500RPM으로 10분간 호모믹서를 이용하여 혼합한 후, 냉각시켜 50도 부근에서 오가피, 오행초, 촉규근, 하수오, 천문동중에서 선택된 하나 또는 둘이상의 한약재를 3일간 다려 추출한 복합 한방 추출물 1.0 중량%와, 나노 세라마이드 0.1 중량%를 효능 물질로서 가하고, 정제수 68.37 중량%를 가하여 다시 2분간 호모믹서를 이용하여 혼합하고, 30도 까지 서서히 냉각하여 얻은 한방 화장품조성물로 크림형태의 화장품을 제조하였다.First, as an aqueous phase component, 6.0% by weight of dipropylene glycol, 6.0% by weight of glycerin, 0.5% by weight of panthenol, 3.0% of hyaluronic acid, 0.03% by weight of trisodium idieti, 0.05% by weight of triethanolamine, 0.15% of methylparaben, and phenoxyethanol 0.1 Wt%, Carbopol 0.05 wt%, macadamia nut oil 3.0 wt%, squalane 5.0 wt%, beeswax 0.6 wt%, polyoxyethylene sorbitan 1.5 wt%, sesquioleic acid sorbitan 0.5 wt%, 4.0% by weight of isocetylethylhexanoate and 0.05% by weight of propylpababen were dissolved by heating at 70 degrees, and then the oil phase component was added to the aqueous phase and mixed at 10 using a homomixer at 3500 RPM for 10 minutes before cooling. 1.0% by weight of the composite herbal extracts extracted by one or two or more Chinese herbal medicines selected from Ogapi, Ohaengcho, Chok Keun-Geun, Shou-O and Astronomical Dong for 3 days 0.1% by weight of amide was added as a potent substance, 68.37% by weight of purified water was added thereto, followed by mixing for 2 minutes using a homomixer, and a cosmetic product in the form of a cream was prepared with a herbal cosmetic composition obtained by gradually cooling to 30 ° C.

<비교예 1>Comparative Example 1

먼저 수상성분으로서 디프로필렌글리콜 6.0 중량%, 글리세린 6.0 중량%, 판테놀 0.5 중량%, 히아루론산 3.0%, 트리소듐이디티에이 0.03 중량%, 트리에탄올아민 0.05 중량%, 메칠파라벤 0.15 중량%, 페녹시에탄올 0.1 중량%, 카보폴 0.05 중량%와, 유상성분으로서 마카데미아넛츠 오일 3.0 중량%, 스쿠알란 5.0 중량%, 밀랍 0.6 중량%, 폴리옥시에틸렌소르비탄 1.5 중량%, 세스퀴올레인산소르비탄 1.5중량%, 이소세틸에틸헥사노에이트 4.0 중량%, 프로필파바벤 0.05 중량%를 각각 70도 가온 용해하고, 이어서 유상성분을 수상성분에 가하여 3500RPM으로 10분간 호모믹서를 이용하여 혼합한 후, 냉각시켜 50도 부근에서 정제수 68.47 중량%를 가하여 다시 2분간 호모믹서를 이용하여 혼합하고, 30도 까지 서서히 냉각하여 얻은 화장품조성물로 크림형태의 화장품을 제조하였다.First, as an aqueous phase component, 6.0% by weight of dipropylene glycol, 6.0% by weight of glycerin, 0.5% by weight of panthenol, 3.0% of hyaluronic acid, 0.03% by weight of trisodium idieti, 0.05% by weight of triethanolamine, 0.15% of methylparaben, and phenoxyethanol 0.1 Wt%, Carbopol 0.05 wt%, macadamia nut oil 3.0 wt%, squalane 5.0 wt%, beeswax 0.6 wt%, polyoxyethylene sorbitan 1.5 wt%, sesquioleic acid sorbitan 1.5 wt%, 4.0% by weight of isocetylethylhexanoate and 0.05% by weight of propylpababen were dissolved by heating at 70 degrees, and then the oil phase component was added to the aqueous phase and mixed at 10 using a homomixer at 3500 RPM for 10 minutes before cooling. 68.47% by weight of purified water was added to the mixture for 2 minutes, followed by mixing using a homomixer. Prepared.

이때, 상기 실시예1 내지 실시예3에서 사용한 복합 한방 추출물은, 본 발명자들이 수십년간 임상을 거쳐 검증된 100여개의 약재들 가운데 알러지 및 피부 패치 테스트 결과 약간의 홍반 발생 가능성이 있는 성분을 스크리닝 하여 얻어진 12개의 약재 화피, 하수오, 황정, 백장잠, 구기자, 지골피, 상백피, 오가피, 매실, 사삼, 천화분, 천문동 등 이들 중에서 피부 트러블 개선효과가 우수하다고 입증된 6개성분 중 오가피, 오행초, 촉규근, 하수오, 천문동을 선정 하였다.At this time, the complex herbal extracts used in Examples 1 to 3, the present inventors screen the ingredients of the possibility of slight erythema as a result of allergy and skin patch test among about 100 drugs that have been clinically proven for decades Among the 12 medicinal herbs such as Hwapi, Sewao, Hwangjeong, Baekjangjam, Gojija, Jigolpi, Sangbaekpi, Ogapi, Plum, Sasam, Cheonhwabun, and Astronomical dong, among these 6 ingredients, Ogapi, Haengcho, Takgyu Geun, Sewao, and Astronomical Dong were selected.

또한 나노 세라마이드 베이스의 주성분인 세라마이드는 피부 트러블 및 보습 탄력 효과가 검증된 세라마이드 1에서 6의 6종류를 사용하고, 이 외에 피치아 시페리(Pichia ciferrii)라는 효모를 이용한 효모 세라마이드와 가오(일본) 등에서 합성으로 만든 슈도(pseudo)세라마이드를 사용할 수 있으며, 세라마이드 효능 극대화를 위해 1차로 독자 개발한 수용성 나노 기술을 이용한 것이다.In addition, ceramide, the main component of nano ceramide base, uses six types of ceramides 1 to 6, which have proven skin trouble and moisturizing elasticity, and yeast ceramide and gao (Japan) using yeast called Pichia ciferrii. Pseudo ceramides made synthetically in the back can be used, and the first use of water-soluble nanotechnology developed exclusively for maximizing ceramide efficacy.

즉, 세라마이드의 나노 안정화는, 상기 세라마이드 1에서 6의 6종류, 효모 세라마이드, 슈도 세라마이드중에서 선택된 어느 하나의 세라마이드 0.1~10중량%, 다가알코올 0.1~70 중량%, 레시친 0.1~10 중량%, 알코올 0.1~10 중량%, 정제수 0.1~80 중량%를 혼합하여 고압유화기로 나노화시킴으로써 이루어지고, 이와 같이하여 세라마이드 10중량%를 함유하고, 평균입자가 30 내지 70 나노미터(Nanometer) 크기를 갖는 투명한 액상의 수용성 나노 세라마이드를 제조하여 사용하였다. That is, the nano-stabilization of the ceramide, 0.1 to 10% by weight of any one of the ceramides selected from the ceramide 1 to 6, yeast ceramide, pseudo ceramide, 0.1 to 70% by weight of polyhydric alcohol, 0.1 to 10% by weight of lecithin, alcohol 0.1 to 10% by weight, purified water to 0.1 to 80% by weight of a high-pressure emulsifier is made by the nano-particles, thus containing 10% by weight of ceramide, the transparent liquid liquid having an average particle size of 30 to 70 nanometers (Nanometer) Water-soluble nano ceramides were prepared and used.

성 분       ingredient 실시예1Example 1 실시예2Example 2 실시예3Example 3 비교예1Comparative Example 1 수상 성분Water component 디프로필렌글리콜 글리세린 판테놀 히아루론산 트리소듐이디티에이 트리에탄올아민 메칠파라벤 페녹시에탄올 카보폴  Dipropylene Glycol Glycerine Panthenol Hyaluronate Trisodium Ithietiol Ethanolamine Methylparaben Phenoxyethanol Carbopol 6.0 6.0 0.5 3.0 0.03 0.05 0.15 0.1 0.05 6.0 6.0 0.5 3.0 0.03 0.05 0.15 0.1 0.05 6.0 6.0 0.5 10.0 0.03 0.15 0.15 0.05 0.15 6.0 6.0 0.5 10.0 0.03 0.15 0.15 0.05 0.15 6.0 6.0 0.5 3.0 0.03 0.05 0.15 0.1 0.05 6.0 6.0 0.5 3.0 0.03 0.05 0.15 0.1 0.05 6.0 6.0 0.5 3.0 0.03 0.05 0.15 0.1 0.05 6.0 6.0 0.5 3.0 0.03 0.05 0.15 0.1 0.05 유상 성분 Oily ingredients 마카데미아넛츠 오일 스쿠알란 밀랍 피이지40경화피마자유 폴리옥시에틸렌소르비탄 세스퀴올레인산소르비탄 이소세틸에틸헥사노에이트 프로필파라벤 Macadamia Nuts Oil Squalane Beeswax Fiji 40 Cured Castor Oil Polyoxyethylene sorbitan Sesquioleate Sorbitane Isocetylethylhexanoate Propylparaben 3.0 5.0 0.6 - 1.5 0.5 4.0 0.05 3.0 5.0 0.6-1.5 0.5 4.0 0.05 - - - 0.5 - - - 0.05  ---0.5---0.05 3.0 5.0 0.6 - 1.5 0.5 4.0 0.05 3.0 5.0 0.6-1.5 0.5 4.0 0.05 3.0 5.0 0.6 - 1.5 1,5 4.0 0.05 3.0 5.0 0.6-1.5 1,5 4.0 0.05 첨가제 additive 복합 한방추출물 나노 세라마이드 정제수  Complex Herbal Extract Nano Ceramide Purified Water 10.0 10.0 49.47 10.0 10.0 49.47 20.0 5.0 51.42 20.0 5.0 51.42 1.0 0.1 68.37 1.0 0.1 68.37 - - 68.47  --68.47

상기와 같은 실시예1 내지 실시예3, 비교예1의 방법으로 투명 앰플 및 크림을 제조하여 안정성 및 효능성을 평가하였다. In Example 1 to Example 3, Comparative Example 1 as described above was prepared a transparent ampoule and cream to evaluate the stability and efficacy.

(안정성 평가결과)(Stability evaluation result)

실내에서 0℃, 40℃, 50℃로 4주간 보관한 후, 경시에 따른 변화를 체크한 결과, 분리나 변취, 색상변화, 점경도 변화 등에서 모두 안정한 것으로 판명됨. After 4 weeks of storage at room temperature at 0 ° C, 40 ° C, and 50 ° C, the change over time was checked and found to be stable in separation, deodorization, color change, and point hardness change.

(효능성 평가결과)(Efficacy evaluation result)

1) 수분 보유량 변화1) Change in water retention

원리 : 전극이 내장된 프로브(Probe)를 피부표면에 대고 전기 전도도를 측정하면 각질층의 수분함량이 디지털로 표시 되는 스키콘(Skicon) 200을 이용하여 피부 수분량 측정.Principle: Measure the skin moisture by using the SKICON 200, which digitally displays the moisture content of the stratum corneum by measuring the electrical conductivity by applying an electrode with a built-in probe to the skin surface.

시료 : 컨트롤(정제수), 실시예1~3, 비교예 1Sample: Control (purified water), Examples 1 to 3, Comparative Example 1

측정방법 : 5회 측정 후 평균값.Method of measurement: Average after 5 measurements.

측정결과 : 컨트롤 대비 Result of measurement: Control

- 실시예1 : 1일후 252% 5일후 263% 수분 보유능력 향상 Example 1 252% after 1 day 5% 263% moisture retention after 5 days

- 실시예2 : 1일후 218% 5일후 226 % 수분 보유능력 향상Example 2 218% moisture retention after 5 days 226% water retention

- 실시예3 : 1일후 160 % 5일후 168 % 수분 보유능력 향상Example 3 160% after 1 day 5% after 168% moisture retention

- 비교예1 : 1일후 80 % 5일후 86 % 수분 보유능 향상됨Comparative Example 1: 80% moisture retention after 1 day 86% moisture retention improved

2) 항균력 테스트2) Antibacterial test

배지에 아토피 피부 관련균으로 알려진 황색 포도상구균, 비듬균을 깔고 일주일 정도 경과 후 체크한 결과, 실시예1~3 제품들에서는 균들이 증가하지 않아 항균 효과가 있음을 확인하였으나, 비교예1에서는 초기의 관련균들이 증가하여 항균 효과가 없는 것을 확인하였다.A staphylococcus aureus known as atopic dermatitis and dandruff were placed on the medium and checked after about a week. As a result, bacteria were not increased in Examples 1 to 3, but the antibacterial effect was confirmed. It was confirmed that there is no antibacterial effect due to the increase in the related bacteria.

3) 인체 피부 테스트3) human body skin test

평가대상 제품에 대한 인체 1차 자극성 확인을 위한 인체 피부 테스트(Human Patch Test)를 실시하여 육안으로 관찰한 결과, 미세자극을 0.0~0.1, 중간자극을 0.1~0.2, 심한자극을 0.2 이상으로 평가할 때, 실시예1은 0.0, 실시예2는 0.05, 실시예3은 0.08로 각각 평가되어 미세자극 범위내로 나타났고, 비교예 1은 0.15로 평가되어 중간자극 범위내로 나타났다.Human skin test (Human Patch Test) to confirm the primary irritant of the product to be evaluated by the naked eye, the micro-stimulation 0.0 ~ 0.1, the intermediate stimulation 0.1 ~ 0.2, severe stimulation 0.2 or more When Example 1 was 0.0, Example 2 was 0.05, and Example 3 was 0.08, respectively, and the results were within the micro-stimulus range, and Comparative Example 1 was evaluated to 0.15, and the medial stimulation range was present.

이러한 평가 결과로부터 효능성에 있어서 실시예1은 수분 보유량 변화, 항균력 테스트 및 인체 피부 테스트에서 모두 가장 우수한 것으로 나타났고, 비교예1은 항균력 테스트와 인체 피부 테스트에서 개선되지 않은 것으로 나타났다.From the evaluation results, Example 1 was found to be the best in all the water retention change, antibacterial activity test and human skin test, Comparative Example 1 was not improved in the antibacterial activity test and human skin test.

이상에서 설명한 바와 같이 본 발명의 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물에 의하면, 복합 한방 추출물 1~20 중량%와, 나노 세라마이드 0.1~10.0 중량%를 수상성분 및 유상성분에 함유시켜 제조됨으로써 수분 보유능이 향상되고 피부 트러블을 일으키는 병원균에 대한 항균효과가 있을 뿐 아니라, 피부에 사용시 자극이 거의 없이 안전하게 사용할 수 있는 화장품을 제조할 수 있다.As described above, according to the cosmetic composition containing the herbal extract of the present invention and nano ceramide, the water content is prepared by containing 1 to 20% by weight of the composite herbal extract and 0.1 to 10.0% by weight of the nano ceramide in the aqueous phase and the oily component. As well as having an antimicrobial effect on pathogens that improve retention and cause skin troubles, cosmetics can be manufactured that can be used safely with little irritation when used on the skin.

또한, 본 발명은, 복합 한방 추출물의 효능과 나노 세라마이드의 효능이 더하여 지속적으로 피부를 개선할 수 있어 한방 화장품의 새로운 방향을 제시할 수 있는 제품으로서 시장에서의 안정적인 성장성과 수입 명품과의 경쟁에서 우위를 가질 수 있는 유용한 발명인 것이다.In addition, the present invention, as the product of the combination of herbal extracts and nano ceramides can improve the skin continuously, suggesting a new direction of herbal cosmetics in the stable growth in the market and competition with imported luxury goods It is a useful invention that can have an advantage.

Claims (4)

오가피, 오행초, 촉규근, 하수오, 천문동, 중에서 선택된 적어도 하나의 복합 한방 추출물 1~20 중량%, 나노 안정화시킨 나노 세라마이드 0.1~10.0 중량%, 정제수 1.0~80%를 적어도 포함하는 수상성분 30~88.9 중량%, 유상성분 10~40 중량%를 60~80℃로 가열 용해한 후 유화하여 제조함을 특징으로 하는 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물.Aquatic ingredient, containing at least one complex herbal extract 1-20% by weight, nano stabilized nano ceramide 0.1-10.0% by weight, and purified water 1.0-80% Cosmetic composition containing herbal extract and nano ceramide, characterized in that 88.9% by weight, 10 to 40% by weight of the oil phase component is prepared by heating and dissolving at 60 to 80 ° C. 제 1 항에 있어서, 상기 나노 세라마이드는, 세라마이드 0.1~10 중량%, 다가알코올 0.1~70 중량%, 레시친 0.1~10 중량%, 알코올 0.1~10 중량%, 정제수 0.1~80 중량%를 혼합하여 고압유화기로 나노화시킨 것을 사용함을 특징으로 하는 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물.The method of claim 1, wherein the nano ceramide is 0.1 to 10% by weight of ceramide, 0.1 to 70% by weight of polyhydric alcohol, 0.1 to 10% by weight of lecithin, 0.1 to 10% by weight of alcohol, 0.1 to 80% by weight of purified water A cosmetic composition containing an herbal extract and nano ceramide, characterized by using nanonized emulsifiers. 제 2 항에 있어서, 상기 세라마이드는, 세라마이드 1에서 6의 6종류, 효모 세라마이드, 슈도 세라마이드중에서 선택한 어느 하나인 것을 특징으로 하는 한방 추출물과 나노 세라마이드를 함유하는 화장품 조성물.The cosmetic composition according to claim 2, wherein the ceramide is any one selected from six types of ceramides 1 to 6, yeast ceramide, and pseudo ceramide. 삭제delete
KR1020060122330A 2006-12-05 2006-12-05 Cosmetic composition containing oriental herb extract and nano ceramide KR100824958B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020060122330A KR100824958B1 (en) 2006-12-05 2006-12-05 Cosmetic composition containing oriental herb extract and nano ceramide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020060122330A KR100824958B1 (en) 2006-12-05 2006-12-05 Cosmetic composition containing oriental herb extract and nano ceramide

Publications (1)

Publication Number Publication Date
KR100824958B1 true KR100824958B1 (en) 2008-04-28

Family

ID=39572494

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020060122330A KR100824958B1 (en) 2006-12-05 2006-12-05 Cosmetic composition containing oriental herb extract and nano ceramide

Country Status (1)

Country Link
KR (1) KR100824958B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140105153A (en) * 2013-02-22 2014-09-01 주식회사 피코스텍 transparent gel solubilization composition containing ceramide, peptide, and hyaluronic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020076375A (en) * 2001-03-28 2002-10-11 (주)바이오랩 Cosmetics Useful for atopic skin
KR100603814B1 (en) * 2004-03-11 2006-07-25 바이오스펙트럼 주식회사 Nano liposome composition
KR100752990B1 (en) 2006-08-02 2007-08-30 주식회사 대웅 Compositions for preventing or treating skin diseases comprising nanoliposomes and natural extracts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020076375A (en) * 2001-03-28 2002-10-11 (주)바이오랩 Cosmetics Useful for atopic skin
KR100603814B1 (en) * 2004-03-11 2006-07-25 바이오스펙트럼 주식회사 Nano liposome composition
KR100752990B1 (en) 2006-08-02 2007-08-30 주식회사 대웅 Compositions for preventing or treating skin diseases comprising nanoliposomes and natural extracts

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140105153A (en) * 2013-02-22 2014-09-01 주식회사 피코스텍 transparent gel solubilization composition containing ceramide, peptide, and hyaluronic acid
KR101598210B1 (en) 2013-02-22 2016-03-03 주식회사 피코스텍 transparent gel solubilization composition containing ceramide, peptide, and hyaluronic acid

Similar Documents

Publication Publication Date Title
KR101290760B1 (en) Cosmetic or pharmaceutical composition for topical application
TWI417112B (en) Emulsified composition
KR101418980B1 (en) Solubilization Method of Poor Water-Soluble Ingredients through Preparation Method of Multi Lamellar Liquid Crystalline
TW200526260A (en) Cosmetic composition and methods
KR20130134532A (en) Multilayer liquid crystal vesicle for relieving skin irritation and for recovering skin barrier, and cosmetic composition comprising the same
WO2008072941A1 (en) Compositions comprising compounds of natural origin for damaged skin
KR20130055069A (en) O/w emulsion having recrystallized particle and cosmetic composition comprising thereof
CH700328B1 (en) O / W emulsion for the care of the hand.
KR20110047374A (en) Cosmetic composition for improving the male skin
WO2016104618A1 (en) Medical dermatological preparation for external use
KR101096277B1 (en) Cosmetic composition for moisturizing the skin
Isnaini et al. Trends in Formulation of Night Cream Containing Essential Oil
KR20120057020A (en) Cosmetic composition for moisturizing or improving skin elasticity
KR101361569B1 (en) Cosmetic composition for the calming and applying an electric current of skins and manufacturing the same
KR101155807B1 (en) Cosmetic composition for moisturizing and firming the skin
KR100824958B1 (en) Cosmetic composition containing oriental herb extract and nano ceramide
JP2004131401A (en) Skin cosmetic
KR20080090741A (en) Cosmetic composition for protecting skin comprising aminolevulinic acid contained in liquid crystal base
KR102036141B1 (en) Cosmetic Composition Containing Cholesteric Liquid Crystal With Dual Capsule Process
KR102013804B1 (en) Cosmetic composition comprising cubosome containing active ingredient
KR102203168B1 (en) Method for production of o/w gel cream with high content of ethanol
KR101502027B1 (en) Cosmetic composition containing Adansonia digitata fruit extract and hydrolyzed collagen for moisturizing and firming the skin
KR101598210B1 (en) transparent gel solubilization composition containing ceramide, peptide, and hyaluronic acid
KR20080059820A (en) A anti-wrinkle agent containing camellia japonica oil
KR101967576B1 (en) Anti-Atopy, Anti-microbial and Anti-inflammatory Cosmetic Composition Containing a White Rose Extract Stabilized with Lamella Liposome

Legal Events

Date Code Title Description
A201 Request for examination
N231 Notification of change of applicant
A302 Request for accelerated examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20130410

Year of fee payment: 6

FPAY Annual fee payment

Payment date: 20140418

Year of fee payment: 7

FPAY Annual fee payment

Payment date: 20150417

Year of fee payment: 8

FPAY Annual fee payment

Payment date: 20160418

Year of fee payment: 9

FPAY Annual fee payment

Payment date: 20170410

Year of fee payment: 10

FPAY Annual fee payment

Payment date: 20180416

Year of fee payment: 11