KR20140121801A - Composition supplementing water of skin and drug supplementing water of skin using this - Google Patents

Abstract

The present invention relates to a composition for moisturizing skin. More specifically, the composition for moisturizing skin is manufactured by mixing a skin moisturizing peptide, a ceramide, and a solvent such as water, and is added to various kinds of skin moisturizers. Accordingly, the present invention can provide hypoallergenic skin moisturizers by using not chemical formulation but biological formulation, and can provide an excellent skin moisturizing ability and an excellent moisturizing maintenance effect.

Description

[0001] The present invention relates to a composition for skin moisturizing,

The present invention relates to a composition for skin moisturizing, and more particularly, to a composition for skin moisturizing which is made of cosmetics or the like and can provide cosmetics and the like that are excellent in moisturizing effect and holding power when applied to the skin, and has less irritation to the skin.

The stratum corneum of our skin forms the outermost layer of the skin and plays an important role in preventing moisture loss inside the skin from the dry external environment. At the same time, he / she possesses moderate moisture and shows flexibility or resilience. In general, the moisture content of the horny layer is about 15%, whereas when it is less than 10%, it is called dry skin. However, moisture of the stratum corneum is lost due to external factors such as wind, temperature, sunlight, etc., as well as endogenous changes such as aging and hormone secretion imbalance. If moisture is lost, the elasticity and flexibility of the skin are lost, and ultimately, the inherent protective function of the skin is lost, resulting in cracking, erythema, capillary vasodilation and itching of the skin tissue. If these symptoms become worse, , And atopic diseases. Therefore, in order to solve such a problem, studies for forming an artificial moisturizing membrane on the stratum corneum of the skin are being continuously carried out. In addition, despite the formation of such an artificial moisturizing film, it should be accompanied by safety such as not causing side effects to the skin. In recent years, efforts have been made to form a skin moisturizing film having excellent moisturizing effect by utilizing biological agents other than these chemical agents. Particularly, when a skin moisturizing composition is prepared using only a high molecular weight polymer type moisturizing agent such as conventional hyaluronic acid, there is a problem that it is difficult to attain a moisturizing effect to the skin endothelial layer even though the skin absorption rate is low and the skin moisturizing effect is excellent . Also, existing chemical agents are irritating to the skin.

1. Korean National Publication No. 10-2008-0074583 (title of the invention: medicines for the prevention and treatment of allergic diseases comprising hyaluronic acid, food and cosmetics, published on Aug. 13, 2008) 2. Korean National Publication No. 10-2003-0041738 (Name of the invention: cosmetic composition containing lysine-added succinic acid or sulfonated adelor collagen and hyaluronic acid as essential ingredients, published on May 27, 2003)

The present invention has been conceived to solve the above-mentioned problems, and it is an object of the present invention to provide a skin moisturizing composition which uses a biological agent with little skin irritation, excellent skin moisturizing effect, and excellent moisturizing effect . It is another object of the present invention to provide a skin moisturizing composition which can be absorbed to the skin endothelial layer by using a skin moisturizing peptide having a low molecular weight.

In order to solve the above problems, a skin moisturizing composition according to one aspect of the present invention comprises a skin inducing peptide inducer represented by the following formula (1), an acceptable salt thereof, a ceramide, and a solvent.

[Chemical Formula 1]

(Wherein X ₁ , X ₂ , Y ₁ and Y ₂ are each independently H or a substituent represented by the following formulas (2) to (5), and at least one of X ₁ , X ₂ , Y ₁ , and Y ₂ Is not H, n is an integer of 1 to 5, and m is independently an integer of 1 to 5.)

(2)

(3)

[Chemical Formula 4]

[Chemical Formula 5]

The molecular weight of the peptide derivative represented by Formula 1 is 500 to 1000. And 0.00001 to 0.5 parts by weight of the skin moisturizing peptide and 0.01 to 5.0 parts by weight of the ceramide are 100 parts by weight of the solvent. And n is an integer of 3 or 4, and m is an integer of 3 or 4. Also, the skin moisturizing composition containing at least one member selected from the group consisting of an oil, a moisturizer, an emulsifier and a softening agent may further contain 0.00001 to 0.5 parts by weight of the skin moisturizing peptide per 100 parts by weight of the solvent, The ceramide is characterized by being 0.01 to 5.0 parts by weight, 0.001 to 1.0 part by weight of the oil, 1.0 to 20.0 parts by weight of the moisturizer, 1 to 10.0 parts by weight of the emulsifier, and 0 to 80 parts by weight of the softener.

The skin moisturizing agent according to another aspect of the present invention includes the skin moisturizing composition.

The composition according to the present invention is excellent in skin moisturizing effect. Also, by using a biological agent, it is less irritating to the skin and is a composition having excellent moisturizing and retention ability. Thus, when a cosmetic product is manufactured using the composition according to the present invention, it is possible to provide a cosmetic product having excellent moisturizing effect. In addition, by using a skin moisturizing peptide having a low molecular weight, the absorption rate can be increased, and a moisturizing effect can be achieved up to the skin endothelial layer.

Accordingly, the present inventors have made intensive researches to provide a composition which is harmless to human body and excellent in skin moisturizing effect and skin moisturizing retention. As a result, the present invention has been completed upon development of a composition for skin moisturizing according to the present invention.

Specifically, the skin moisturizing composition according to the present invention may include a skin moisturizing peptide derivative represented by the following formula (I), an acceptable salt thereof, a ceramide, and a solvent.

Wherein X ₁ , X ₂ , Y ₁ and Y ₂ are each independently preferably H or any substituent represented by the following formulas (2) to (5), provided that X ₁ , At least one of X ₂ , Y ₁ and Y ₂ is not H, n is preferably an integer of 1 to 5, and m is preferably an integer of 1 to 5, , N may be an integer of 3 or 4, and m may be an integer of 3 or 4.)

The peptide of the peptide derivative according to Formula 1 may have a molecular weight of 500 to 1000. The peptides prepared by the peptide derivatives are characterized in that the skin moisturizing peptide according to the above formula (1) is lower in molecular weight than the conventional polymeric moisturizing material and has excellent skin absorption rate. Since it is a low molecular peptide, It is easier to quantify and purify than the moisturizing material of the present invention.

Thus, the skin moisturizing composition according to the present invention may include a skin moisturizing peptide synthesized by the skin moisturizing peptide derivative. Concretely, the skin moisturizing peptide may preferably contain 0.00001 to 0.5 parts by weight, and the ceramide may preferably include 0.01 to 5.0 parts by weight, based on 100 parts by weight of the solvent. When the amount of the moisturizing peptide is less than 0.00001 parts by weight, it is difficult to achieve an adequate skin moisturizing effect. When the amount of the moisturizing peptide is more than 0.5 parts by weight, the manufacturing cost increases greatly. In addition, the addition of the low molecular weight skin moisturizing peptide within the above range can maintain the skin moisturizing effect and the retention of the moisturizing effect to the skin up to the skin endothelium to the maximum, and the skin moisturizing peptide added not being a chemical preparation but biocompatible, It is possible to provide a skin moisturizing composition. If less than 0.01 part by weight of the ceramide is added, skin protection effect and skin moisturizing effect can not be sufficiently attained. If more than 5.0 parts by weight is added, there is a problem in that a large amount of expensive ceramide is added to secure stability and increase the manufacturing cost. The ceramide may be used in combination with any one or more selected from the group consisting of ceramides, yeast ceramides and pseudoceramide selected from the group consisting of compounds represented by the following formulas (6) to (11). Ceramide is a type of sphingoid lipid that has a structure in which fatty acids are linked to sphingosine or phytosphingosine, and ceramide has about 40% or more of the intercellular lipid constituting the stratum corneum of the skin and shows the structure or function of the stratum corneum It is an essential ingredient. The ceramide present in the human body is divided into six kinds according to the degree of polarity, and these are represented by the following Chemical Formulas 6 to 11.

Ceramides also have the function of lipid barrier to inhibit the evaporation of water and to maintain the square structure of the stratum corneum. The skin stratum corneum is composed of brick-shaped multi-layered cells, and these keratinized cells are firmly bound by ceramides, cholesterol, and free fatty acids. Skin cells have a higher content of ceramide than other cells in the human body, especially the content of non-polar neutral ceramide. This is a structural feature that is necessary to form a solid defense barrier of the skin. In addition, ceramide is decomposed into phytosphingosine from the skin surface, and it acts as an antibacterial barrier against external harmful microorganisms, and it is found that ceramide plays an important function in regulating inflammation and wound healing.

Many studies have shown that ceramides are directly related to skin diseases including atopy, and clinical results of dermatologists have proved that ceramide and phytosphingosine are also effective in atopic dermatitis.

Thus, ceramides are generally known to play an important role in skin protection. Particularly, epidermal lipids consist of ceramide, cholesterol, and fatty acid. Ceramide is known to play the most important role in skin protection. Ceramide is also known to maintain the moisturization of the skin as a substance that exists in the human body. If the skin lacks ceramide, moisture in the horny layer of the skin is easily evaporated, resulting in skin troubles such as skin elasticity reduction, rash formation, wrinkle formation, and sensitivity to external stimuli. In addition, as the age increases, ceramide amount in the stratum corneum decreases and causes aging of the skin. In the case of dry skin and troublesome soap, the ceramides are not produced well in the body, and the keratin is frequently generated and dried. Therefore, since the composition according to the present invention includes the ceramide, the skin protection effect and the skin moisturizing effect can be further improved. The solvent may be any one or more selected from the group consisting of water, glycerin, butylene glycol, propylene glycol, dipropylene glycol, hyaluronic acid, and collagen extract.

The skin moisturizing composition may preferably contain at least one selected from the group consisting of an oil, a moisturizer, an emulsifier, and a softening agent. In this case, the skin moisturizing peptide is preferably 0.00001 The emulsifier is preferably used in an amount of from 1 to 10.0 parts by weight and the softener is preferably used in an amount of from 0 to 80 parts by weight, Parts by weight. When the composition is produced within the above range, the moisture retention and moisturizing effect can be maximized, and the production cost can be appropriately controlled. In addition, since a low molecular weight skin moisturizing peptide is contained, a sufficient moisturizing effect and maintaining effect can be achieved even on the skin endothelial layer. The oil may preferably be at least one selected from the group consisting of rose oil, macadamia oil, jojoba oil, lavender oil, and isocetyl ethyl hexanoate. The moisturizing agent may be any one or more selected from the group consisting of hyaluronic acid, propylene glycol, dipropylene glycol, butylene glycol, glycerin or collagen extract. The emulsifier may be at least one selected from the group consisting of lecithin, phage 40 hardened castor oil, polyoxyethylene sorbitan and sesquioleic acid sorbitan. Further, the softening agent may preferably be any one or more selected from the group consisting of alcohol, dipropylene glycol, and purified water.

The skin moisturizing agent according to another aspect of the present invention may preferably include the skin moisturizing composition. Specifically, the skin moisturizing composition may include a skin moisturizing peptide derivative represented by the formula (1), an acceptable salt thereof, a ceramide, and a solvent. The skin moisturizing peptide of Formula 1 has a molecular weight of preferably 500 to 1000. The skin moisturizing peptide may be used in an amount of 0.00001 to 0.5 parts by weight, and the ceramide may be 0.01 to 5.0 parts by weight based on 100 parts by weight of the solvent. When the composition is prepared in the above-described range, the skin moisturizing effect and the holding power can be maximized, and the manufacturing cost can be appropriately adjusted. In addition, by adding a skin moisturizing peptide having a low molecular weight, it is possible to achieve a skin moisturizing effect and retentivity to the skin endothelial layer. In addition, since the skin-moisturizing peptide, which is not a chemical agent but is biocompatible, is added, it is possible to provide a safer skin-moisturizing composition to the human body. The composition for skin moisturizing may further comprise an oil, a moisturizer, an emulsifier, and a softener. In this case, the skin moisturizing peptide is preferably 0.00001 to 0.5 part by weight, the ceramide is preferably 0.01 to 5.0 parts by weight, the oil is preferably 0.001 to 1.0 part by weight based on 100 parts by weight of the solvent, , The emulsifier is preferably 1 to 10.0 parts by weight, and the softening agent is preferably 0 to 80.0 parts by weight. The oil may preferably be at least one selected from the group consisting of rose oil, macadamia oil, jojoba oil, lavender oil, and isocetyl ethyl hexanoate. The moisturizing agent may be any one or more selected from the group consisting of hyaluronic acid, propylene glycol, dipropylene glycol, butylene glycol, glycerin or collagen extract. The emulsifier may be at least one selected from the group consisting of lecithin, phage 40 hardened castor oil, polyoxyethylene sorbitan and sesquioleic acid sorbitan. The softening agent may preferably be any one or more selected from the group consisting of alcohol, dipropylene glycol, and purified water.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Example

< Example  1: Preparation of skin moisturizing composition &gt;

The other purified water was added to 100 g of the resulting solution at a temperature of about 75 캜 to 80 캜, and the mixture was heated at 3500 RPM for 10 minutes Mixed using a homomixer, passed through a microfluidizer twice at 1000 atm, and a skin moisturizing composition was prepared.

At this time, the skin moisturizing peptide is a skin moisturizing peptide represented by the following formula (1).

[Chemical Formula 1]

(2)

[Chemical Formula 5]

In Formula 1, X ₁ is a substituent represented by Formula 2, X ₂ is -H, Y ₁ and Y ₂ are substituents represented by Formula 5, and n in Formula 1 and m in Formula 2 are 4 It is an integer.

< Example  2: Example  1 &lt; SEP &gt; 1 wt% &lt; tb &

6.0 g of butylene glycol, 6.0 g of glycerin, 4.0 g of dipropylene glycol, 1.0 g of panthenol, 0.03 g of trisodium dithiene, 0.05 g of triethanolamine, 0.05 g of carbopole and 1.0 g of betaine were mixed, And dissolved. Further, 3.0 g of cetostearyl alcohol, 3.0 g of jojoba oil, 5.0 g of argan oil, 0.6 g of beeswax, 2.0 g of polyoxyethylene sorbitan, 0.5 g of sorbitan sesquioleate, 4.0 g of cetyl hexanoate, 60.82 g of purified water was added to 2.0 g of hexanediol, and the mixture was dissolved by heating to about 75 캜. Subsequently, each of the dissolved materials was added, mixed at 3500 RPM for 10 minutes using a homomixer, and then cooled. Thereafter, 1.0 wt% of the composition according to Example 1 was added at about 50 DEG C, mixed again using a homomixer for 2 minutes, and slowly cooled to 30 DEG C to prepare a cream-form cosmetic.

< Example  3: Example  1 &lt; SEP &gt; 10 wt% &lt; tb &

6.0 g of butylene glycol, 6.0 g of glycerin, 0.5 g of panthenol, 0.03 g of trisodium dithiene, 0.15 g of triethanolamine, 0.15 g of carbomer, 1.0 g of betaine and 1.0 g of trehalose were heated at 75 DEG C Lt; / RTI &gt; 1.5 g of stearothiostearyl alcohol, 2.0 g of jojoba oil, 1.0 g of argan oil, 1.2 g of polyoxyethylene sorbitan, 0.5 g of sesquioleic acid sorbitan, 4.0 g of cetyl hexyl hexanoate, And 58.97 g of purified water were combined and dissolved by heating at 75 占 폚. Thereafter, the materials that had been melted separately were combined and mixed at 3500 RPM for 10 minutes using a homomixer. The mixture was cooled, and 10 g of a pillared green complex was added at about 50 DEG C and mixed again for 2 minutes using a homomixer. Followed by cooling to prepare a cosmetic product.

< Example  4: Example  1 &lt; SEP &gt; 20 wt% &lt; tb &

6.0 g of butylene glycol, 6.0 g of glycerin, 4.0 g of dipropylene glycol, 1.0 g of panthenol, 0.03 g of trisodium dithiene, 0.05 g of triethanolamine, 0.05 wt% of carbomer, 1.0 g of betaine and 1.0 g of trehalose The mixture was heated to about 75 DEG C and dissolved. To the solution were added 3.0 g of stearoctostearyl alcohol, 3.0 g of jojoba oil, 5.0 g of argan oil, 0.6 g of beeswax, 2.0 g of polyoxyethylene sorbitan, 0.5 g of sorbitan sesquioleate, 4.0 g of ethylhexanoate, 2.0 g of 1,2-hexanediol and 40.77 g of purified water were mixed and dissolved by heating to around 75 DEG C, and the respective heating and melting mixtures were combined. And mixed at 3500 RPM for 10 minutes using a homomixer. Thereafter, it was cooled to about 50 캜, 2 g of the composition according to Example 1 was added, and the mixture was further mixed for 2 minutes using a homomixer. Thereafter, the mixture was slowly cooled to 30 DEG C to obtain a cosmetic composition, which was used to make a cream-form cosmetic.

Comparative Example

< Comparative Example  One: Examples  1 &lt; / RTI &gt; Cosmetics 1 >

6.0 g of butylene glycol, 6.0 g of glycerin, 0.5 g of panthenol, 0.03 g of trisodium dithiene, 0.15 g of triethanolamine, 0.15 g of carbomer, 1.0 g of betaine and 1.0 g of trehalose were mixed And then dissolved by heating to around 75 ° C. 1.5 g of stearothiostearyl alcohol, 2.0 g of jojoba oil, 1.0 g of argan oil, 1.2 g of polyoxyethylene sorbitan, 0.5 g of sesquioleic acid sorbitan, 4.0 g of cetyl hexyl hexanoate, And 70.97 g of purified water were added and mixed. The mixture was heated and dissolved at about 75 占 폚, and then the respective heat dissolution materials were mixed. Thereafter, the mixture was stirred at 3500 RPM for 10 minutes using a homomixer, and then gradually cooled to 30 DEG C to obtain a cosmetic composition, and a cosmetic composition in the form of a liquid was prepared.

< Comparative Example  2: Example  1 &lt; / RTI &gt; Cosmetics 2 >

6.0 g of butylene glycol, 6.0 g of glycerin, 4.0 g of dipropylene glycol, 1.0 g of panthenol, 0.03 g of trisodium dithiophosphate, 0.05 g of triethanolamine, 0.05 g of carbomer and 1.0 g of betaine were mixed, And the solution was heated to about 75 캜. Thereafter, 3.0 g of cetostearyl alcohol, 3.0 g of jojoba oil, 5.0 g of argan oil, 0.6 g of beeswax, 2.0 g of polyoxyethylene sorbitan, 0.5 g of sorbitan sesquioleate, 4.0 g of cetyl hexyl hexanoate, , 2.0 g of 2-hexanediol, and 61.77 g of purified water were added and mixed and dissolved by heating to about 75 캜. Then, each of the warm-melt mixtures were mixed together, mixed at 3500 RPM for 10 minutes using a homomixer, and gradually cooled to 30 DEG C to obtain a cream-form cosmetic composition.

Experimental Example

< Experimental Example  1: Stability evaluation>

Each of the cosmetics according to Example 2, Example 3, Example 4, Comparative Example 1, and Comparative Example 2 was stored at 0 ° C, 40 ° C, and 50 ° C for 4 weeks in the room, , Separation and removal, change of color, change of tie diameter, and so on.

< Experimental Example  2: Evaluation of moisture content>

Each of the cosmetics according to Example 2, Example 3, Example 4, Comparative Example 1, and Comparative Example 2 was applied to the surface of the skin, and a probe having electrodes embedded therein was placed on the surface of the skin. Respectively. At this time, skin moisture content was measured using Skicom 200, which displays the water content of the stratum corneum digitally. The total of five measurements were made and the mean value of these measurements was finally measured. The measured results are as follows.

- Example 2: Improved water retention by 180% immediately after application and 140% after 1 day

-Example 3: Improved water retention by 280% immediately after application and 240% after 1 day

- Example 4: Improvement of water retention ability by 380% immediately after righting and 356% after 1 day

- Comparative Example 1: Improved moisture retention after 80% right after 60% after 1 day

- Comparative Example 2: Improved moisture retention by 86% immediately after application and 62% after 1 day

As a result, when the skin moisturizing composition according to Example 1 was added, it was confirmed that moisture was sufficiently retained in the skin right after the skin was not added. This is evidenced by the improved electrical conductivity. Also, it was confirmed that the water retained in addition to the greatly improved water retention was not abruptly lost over time. That is, it was confirmed that moisture retention and retention were improved.

< Experimental Example  3: Human skin test>

The human skin test (Human Patch Test) for confirming the first stimulation of the human body was performed on the cosmetics according to Examples 2, 3, 4, and Comparative Examples 1 and 2 and visually observed. As a result, , The middle stimulus was 0.1 to 0.2, the severe stimulus was 0.2 or more, Example 2 was evaluated as 0.01, Example 3 was 0.02, and Example 4 was evaluated as 0.01, 0.08 in Example 1 and 0.12 in Comparative Example 2, and appeared within the range of the micro stimulus and the intermediate stimulus.

From the above results, the cosmetics according to Examples 2, 3 and 4 prepared by adding the composition according to Example 1 showed more irritation than the cosmetics according to Comparative Examples 1 and 2 prepared only with chemical agents It was confirmed that a cosmetic product with a remarkably lowered stimulus could be produced. This is the result of using biomedical skin moisturizing peptides, not chemical preparations.

From the above-mentioned experimental results, it was confirmed that when the skin moisturizing composition according to Example 1 is added at the time of manufacturing cosmetics, skin moisturizing power and retention are improved, and low stimulus cosmetics with less irritation to human body can be produced.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. It is natural.

Claims (2)

0.00001 to 0.5 parts by weight of a skin moisturizing peptide derivative represented by the following formula (1) or acceptable salts thereof, 0.01 to 5.0 parts by weight of ceramide, 0.001 to 1.0 part by weight of an oil, 1.0 to 20.0 parts by weight of a moisturizer, 1 to 10.0 parts by weight, and 0 to 80 parts by weight of a softening agent;
[Chemical Formula 1]

(2)

[Chemical Formula 5]

In Formula 1, X ₁ is a substituent represented by Formula 2, X ₂ is -H, Y ₁ and Y ₂ are substituents represented by Formula 5, and n in Formula 1 and m in Formula 2 are 4 It is an integer. A skin moisturizer comprising the skin moisturizing composition according to claim 1.