KR20130049766A - 트리사이클릭 피라졸 아민 유도체 - Google Patents
트리사이클릭 피라졸 아민 유도체 Download PDFInfo
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- KR20130049766A KR20130049766A KR1020127015183A KR20127015183A KR20130049766A KR 20130049766 A KR20130049766 A KR 20130049766A KR 1020127015183 A KR1020127015183 A KR 1020127015183A KR 20127015183 A KR20127015183 A KR 20127015183A KR 20130049766 A KR20130049766 A KR 20130049766A
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- pyrazole
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- XHFLCJZBEDRWRZ-UHFFFAOYSA-N ethyl 1-(3-bromophenyl)-4h-thiochromeno[4,3-c]pyrazole-3-carboxylate Chemical compound C1SC2=CC=CC=C2C2=C1C(C(=O)OCC)=NN2C1=CC=CC(Br)=C1 XHFLCJZBEDRWRZ-UHFFFAOYSA-N 0.000 description 2
- LVGNGYARTIUSHX-UHFFFAOYSA-N ethyl 1-(3-bromophenyl)-5,5-dioxo-4h-thiochromeno[4,3-c]pyrazole-3-carboxylate Chemical compound C1S(=O)(=O)C2=CC=CC=C2C2=C1C(C(=O)OCC)=NN2C1=CC=CC(Br)=C1 LVGNGYARTIUSHX-UHFFFAOYSA-N 0.000 description 2
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- UFWITQAQSZEQSZ-UHFFFAOYSA-N ethyl 1-(3-methoxyphenyl)-5,5-dioxo-4h-thiochromeno[4,3-c]pyrazole-3-carboxylate Chemical compound C1S(=O)(=O)C2=CC=CC=C2C2=C1C(C(=O)OCC)=NN2C1=CC=CC(OC)=C1 UFWITQAQSZEQSZ-UHFFFAOYSA-N 0.000 description 2
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- OIGCKFCAQKWKGI-UHFFFAOYSA-N ethyl 1-(3-methylphenyl)-5,5-dioxo-4h-thiochromeno[4,3-c]pyrazole-3-carboxylate Chemical compound C1S(=O)(=O)C2=CC=CC=C2C2=C1C(C(=O)OCC)=NN2C1=CC=CC(C)=C1 OIGCKFCAQKWKGI-UHFFFAOYSA-N 0.000 description 2
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- UHUUYVZLXJHWDV-UHFFFAOYSA-N trimethyl(methylsilyloxy)silane Chemical compound C[SiH2]O[Si](C)(C)C UHUUYVZLXJHWDV-UHFFFAOYSA-N 0.000 description 1
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- SCHZCUMIENIQMY-UHFFFAOYSA-N tris(trimethylsilyl)silicon Chemical compound C[Si](C)(C)[Si]([Si](C)(C)C)[Si](C)(C)C SCHZCUMIENIQMY-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
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- 210000001635 urinary tract Anatomy 0.000 description 1
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- 230000028973 vesicle-mediated transport Effects 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
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Classifications
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| EP09175933.2 | 2009-11-13 | ||
| EP09175933 | 2009-11-13 | ||
| US26185409P | 2009-11-17 | 2009-11-17 | |
| US61/261,854 | 2009-11-17 | ||
| PCT/EP2010/067412 WO2011058149A1 (en) | 2009-11-13 | 2010-11-12 | Tricyclic pyrazol amine derivatives |
Publications (1)
| Publication Number | Publication Date |
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| KR20130049766A true KR20130049766A (ko) | 2013-05-14 |
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| EP (1) | EP2499146B1 (https=) |
| JP (1) | JP5735526B2 (https=) |
| KR (1) | KR20130049766A (https=) |
| CN (1) | CN102695710B (https=) |
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| AU (1) | AU2010317883B2 (https=) |
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| EA (1) | EA201290305A1 (https=) |
| ES (1) | ES2607952T3 (https=) |
| IL (1) | IL219602A (https=) |
| MX (1) | MX2012005518A (https=) |
| WO (1) | WO2011058149A1 (https=) |
| ZA (1) | ZA201202641B (https=) |
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| EP2595623B1 (en) | 2010-07-19 | 2018-02-28 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Use of delta tocopherol for the treatment of lysosomal storage disorders |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| EP2790705B1 (en) | 2011-12-15 | 2017-12-06 | Novartis AG | Use of inhibitors of the activity or function of pi3k |
| DE102012016908A1 (de) | 2012-08-17 | 2014-02-20 | Aicuris Gmbh & Co. Kg | Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung |
| CN104870432B (zh) | 2012-11-16 | 2017-05-03 | 美国健康及人类服务部 | 作为溶酶体贮积症的修复剂的生育酚和生育醌衍生物 |
| WO2014121901A1 (en) | 2013-02-07 | 2014-08-14 | Merck Patent Gmbh | Polymorphic forms |
| KR102318498B1 (ko) * | 2013-06-24 | 2021-10-27 | 메르크 파텐트 게엠베하 | Fshr의 조절인자로서의 피라졸 화합물 및 이의 용도 |
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| ES2862727T3 (es) | 2015-08-26 | 2021-10-07 | Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio | Compuestos tricíclicos condensados como inhibidores de proteínas quinasas |
| UY37556A (es) | 2017-01-10 | 2018-07-31 | Bayer Ag | Derivados heterocíclicos como pesticidas |
| AR113206A1 (es) | 2017-01-10 | 2020-02-19 | Bayer Cropscience Ag | Derivados heterocíclicos como pesticidas |
| CN108434150B (zh) * | 2018-02-09 | 2020-03-10 | 天津医科大学总医院 | Zstk474用于制备ean治疗药物的应用 |
| EP3608326A1 (en) * | 2018-08-10 | 2020-02-12 | Irbm S.P.A. | Tricyclic inhibitors of hepatitis b virus |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| CN113754685B (zh) * | 2020-06-02 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| KR20230039665A (ko) | 2020-07-02 | 2023-03-21 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 헤테로사이클 유도체 |
| CN115835863B (zh) * | 2020-07-09 | 2025-08-12 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| JP2023536442A (ja) | 2020-07-29 | 2023-08-25 | 江蘇恒瑞医薬股▲ふん▼有限公司 | オキサアザスピロ環系誘導体、その調製方法及びその医薬的応用 |
| JP2024511836A (ja) * | 2021-03-29 | 2024-03-15 | アイオンクチュラ・ソシエテ・アノニム | 膵臓癌の治療のためのｐｉ３ｋ－デルタ阻害剤 |
| WO2022207646A1 (en) | 2021-03-29 | 2022-10-06 | Ionctura Sa | A pi3k-delta inhibitor for use in treatment regimens |
| GB202117511D0 (en) * | 2021-12-03 | 2022-01-19 | Ionctura Sa | Treatment regimens |
| CN114524828B (zh) * | 2022-02-22 | 2024-07-09 | 深圳市儿童医院 | 一种用于治疗神经重症的噻唑衍生物及其应用 |
| CN114524827B (zh) * | 2022-02-22 | 2024-07-09 | 深圳市儿童医院 | 一种用于治疗神经重症的吡唑衍生物及其应用 |
| CN115491252B (zh) * | 2022-09-29 | 2023-05-02 | 江苏四新界面剂科技有限公司 | 一种宝石切割用低泡润湿剂及其制备方法 |
| JP2026510567A (ja) | 2023-03-03 | 2026-04-08 | アイオンクチュラ・ソシエテ・アノニム | 血液悪性腫瘍の治療におけるロギノリシブ及びｂｃｌ－２阻害剤の組み合わせ |
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| GB202308807D0 (en) | 2023-06-13 | 2023-07-26 | Ionctura Sa | Combinations |
| WO2025073968A1 (en) | 2023-10-06 | 2025-04-10 | Ionctura Sa | Combination of roginolisib with a malt1-gls inhibitor |
| CN120682241A (zh) * | 2024-03-22 | 2025-09-23 | 复旦大学附属中山医院 | 三环骨架化合物及其在制备抗肿瘤药物中的应用 |
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| US4816467A (en) | 1987-01-09 | 1989-03-28 | Farmitalia Carlo Erba S.R.L | Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use |
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| GB8907799D0 (en) * | 1989-04-06 | 1989-05-17 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases |
| GB8916290D0 (en) * | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis |
| JP3542826B2 (ja) | 1994-07-11 | 2004-07-14 | 帝国臓器製薬株式会社 | 新規な二環式化合物縮合［２，１−ｄ］イソキサゾール−３−カルボン酸誘導体 |
| GB9720901D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed benzothiopyranic compounds |
| FR2800375B1 (fr) * | 1999-11-03 | 2004-07-23 | Sanofi Synthelabo | Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| JP4782564B2 (ja) | 2002-07-10 | 2011-09-28 | メルク セローノ ソシエテ アノニム | アゾリジノン−ビニル縮合−ベンゼン誘導体 |
| CA2510851A1 (en) | 2002-12-20 | 2004-07-08 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| GB0305152D0 (en) | 2003-03-06 | 2003-04-09 | Novartis Ag | Organic compounds |
| GB0320197D0 (en) | 2003-08-28 | 2003-10-01 | Novartis Ag | Organic compounds |
| EP2343303A1 (de) | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
| EP1968583A4 (en) | 2005-12-20 | 2010-09-15 | Harvard College | COMPOUNDS, SCREENING AND TREATMENT PROCEDURES |
| WO2008035356A2 (en) | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| WO2009010824A1 (en) | 2007-07-13 | 2009-01-22 | Glenmark Pharmaceuticals, S.A. | Dihydrochromenopyrazole derivatives as vanilloid receptor ligands |
| WO2009071895A1 (en) * | 2007-12-04 | 2009-06-11 | Ucb Pharma S.A. | Fused thiazole and thiophene derivatives as kinase inhibitors |
| MX2010010659A (es) | 2008-03-31 | 2010-10-26 | Genentech Inc | Compuestos de benzopirano y benzoxepina, inhibidores de fosfoinoinositida 3-cinasas y metodos para utilizarlos. |
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2010
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- 2010-11-12 AU AU2010317883A patent/AU2010317883B2/en active Active
- 2010-11-12 JP JP2012538350A patent/JP5735526B2/ja active Active
- 2010-11-12 US US13/509,291 patent/US9073940B2/en active Active
- 2010-11-12 CN CN201080061082.0A patent/CN102695710B/zh active Active
- 2010-11-12 KR KR1020127015183A patent/KR20130049766A/ko not_active Withdrawn
- 2010-11-12 WO PCT/EP2010/067412 patent/WO2011058149A1/en not_active Ceased
- 2010-11-12 MX MX2012005518A patent/MX2012005518A/es not_active Application Discontinuation
- 2010-11-12 AR ARP100104189A patent/AR078979A1/es unknown
- 2010-11-12 EP EP10775841.9A patent/EP2499146B1/en active Active
- 2010-11-12 ES ES10775841.9T patent/ES2607952T3/es active Active
- 2010-11-12 CA CA2778174A patent/CA2778174C/en active Active
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|---|---|
| US9073940B2 (en) | 2015-07-07 |
| CN102695710B (zh) | 2015-08-19 |
| CA2778174C (en) | 2018-02-20 |
| MX2012005518A (es) | 2012-06-19 |
| AR078979A1 (es) | 2011-12-14 |
| IL219602A0 (en) | 2012-07-31 |
| EP2499146B1 (en) | 2016-09-21 |
| AU2010317883A1 (en) | 2012-05-03 |
| WO2011058149A1 (en) | 2011-05-19 |
| US20120238545A1 (en) | 2012-09-20 |
| IL219602A (en) | 2017-04-30 |
| EP2499146A1 (en) | 2012-09-19 |
| AU2010317883B2 (en) | 2015-08-06 |
| ZA201202641B (en) | 2013-06-26 |
| ES2607952T3 (es) | 2017-04-04 |
| CA2778174A1 (en) | 2011-05-19 |
| JP2013510825A (ja) | 2013-03-28 |
| JP5735526B2 (ja) | 2015-06-17 |
| EA201290305A1 (ru) | 2012-12-28 |
| CN102695710A (zh) | 2012-09-26 |
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