KR20130027005A - 마니디핀의 다형 형태 - Google Patents

마니디핀의 다형 형태 Download PDF

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Publication number
KR20130027005A
KR20130027005A KR1020127007646A KR20127007646A KR20130027005A KR 20130027005 A KR20130027005 A KR 20130027005A KR 1020127007646 A KR1020127007646 A KR 1020127007646A KR 20127007646 A KR20127007646 A KR 20127007646A KR 20130027005 A KR20130027005 A KR 20130027005A
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KR
South Korea
Prior art keywords
manidipine
dihydrochloride
manidipine dihydrochloride
crystalline form
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020127007646A
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English (en)
Korean (ko)
Inventor
다르마라즈 라마찬드라 라오
라젠드라 나라얀라오 칸칸
마루티 간파티 가가레
Original Assignee
씨아이피엘에이 엘티디.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 씨아이피엘에이 엘티디. filed Critical 씨아이피엘에이 엘티디.
Publication of KR20130027005A publication Critical patent/KR20130027005A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020127007646A 2009-08-27 2010-08-26 마니디핀의 다형 형태 Ceased KR20130027005A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1970MU2009 2009-08-27
IN1970/MUM/2009 2009-08-27
PCT/GB2010/001615 WO2011023954A2 (en) 2009-08-27 2010-08-26 Polymorphic forms of manidipine

Publications (1)

Publication Number Publication Date
KR20130027005A true KR20130027005A (ko) 2013-03-14

Family

ID=43530516

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127007646A Ceased KR20130027005A (ko) 2009-08-27 2010-08-26 마니디핀의 다형 형태

Country Status (8)

Country Link
US (1) US9018376B2 (https=)
EP (1) EP2470505A2 (https=)
JP (1) JP2013503145A (https=)
KR (1) KR20130027005A (https=)
AU (1) AU2010288273A1 (https=)
CA (1) CA2772499A1 (https=)
NZ (1) NZ598718A (https=)
WO (1) WO2011023954A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011023954A2 (en) 2009-08-27 2011-03-03 Cipla Limited Polymorphic forms of manidipine
CN102875451B (zh) * 2012-04-05 2014-12-03 常州制药厂有限公司 一种盐酸马尼地平合成工艺的改进方法
CN103467364B (zh) * 2013-06-21 2015-07-15 四川海思科制药有限公司 一种盐酸马尼地平化合物
CN104292150A (zh) * 2013-07-19 2015-01-21 许昌恒生制药有限公司 一种盐酸马尼地平的合成工艺
CN104447513B (zh) * 2014-11-26 2018-05-29 许昌恒生制药有限公司 一种高纯度盐酸马尼地平β晶型的制备方法
CN108218765A (zh) * 2017-11-24 2018-06-29 扬子江药业集团北京海燕药业有限公司 一种改进盐酸马尼地平ii晶型的生产方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004023A1 (en) * 1982-05-10 1983-11-24 Takeda Chemical Industries, Ltd. Dihydropyridine derivatives
EP0094159B1 (en) 1982-05-10 1990-03-14 Takeda Chemical Industries, Ltd. Dihydropyridine derivatives, their production and use
WO1988007525A1 (fr) * 1987-03-27 1988-10-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Enantiomeres de 1,4-dihydropyridine
ITMI20072226A1 (it) * 2007-11-23 2009-05-24 Chiesi Farma Spa Un metodo per determinare la purezza polimorfica di manidipina dicloridrato
WO2011023954A2 (en) 2009-08-27 2011-03-03 Cipla Limited Polymorphic forms of manidipine

Also Published As

Publication number Publication date
EP2470505A2 (en) 2012-07-04
CA2772499A1 (en) 2011-03-03
NZ598718A (en) 2014-10-31
WO2011023954A3 (en) 2011-04-21
US20120232091A1 (en) 2012-09-13
WO2011023954A2 (en) 2011-03-03
JP2013503145A (ja) 2013-01-31
US9018376B2 (en) 2015-04-28
AU2010288273A1 (en) 2012-04-12

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Patent event date: 20120323

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