KR20130004370A - 아자비사이클로헥산의 신규한 다형체 - Google Patents

아자비사이클로헥산의 신규한 다형체 Download PDF

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Publication number
KR20130004370A
KR20130004370A KR1020127030289A KR20127030289A KR20130004370A KR 20130004370 A KR20130004370 A KR 20130004370A KR 1020127030289 A KR1020127030289 A KR 1020127030289A KR 20127030289 A KR20127030289 A KR 20127030289A KR 20130004370 A KR20130004370 A KR 20130004370A
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KR
South Korea
Prior art keywords
polymorph
mixture
polymorphs
dichlorophenyl
azabicyclo
Prior art date
Application number
KR1020127030289A
Other languages
English (en)
Korean (ko)
Inventor
에릭 제이. 하겐
케빈 할로란
Original Assignee
도브 파마슈티칼 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도브 파마슈티칼 인코포레이티드 filed Critical 도브 파마슈티칼 인코포레이티드
Publication of KR20130004370A publication Critical patent/KR20130004370A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020127030289A 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체 KR20130004370A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
US10/920,748 2004-08-18
PCT/US2005/029420 WO2006023659A2 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020077006293A Division KR20070054208A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020137024105A Division KR20130108489A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체

Publications (1)

Publication Number Publication Date
KR20130004370A true KR20130004370A (ko) 2013-01-09

Family

ID=35968183

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020137024105A KR20130108489A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체
KR1020127030289A KR20130004370A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체
KR1020077006293A KR20070054208A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020137024105A KR20130108489A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020077006293A KR20070054208A (ko) 2004-08-18 2005-08-17 아자비사이클로헥산의 신규한 다형체

Country Status (14)

Country Link
EP (1) EP1786417A4 (ru)
JP (1) JP2008510715A (ru)
KR (3) KR20130108489A (ru)
CN (1) CN101052393A (ru)
AU (1) AU2005277351A1 (ru)
BR (1) BRPI0515193A (ru)
CA (1) CA2619817A1 (ru)
IL (1) IL181185A (ru)
MX (1) MX2007001827A (ru)
NO (1) NO20071372L (ru)
NZ (1) NZ589033A (ru)
RU (1) RU2007109817A (ru)
WO (1) WO2006023659A2 (ru)
ZA (1) ZA200701570B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10349989B2 (en) 2013-12-27 2019-07-16 University-Industry Cooperation Group Of Kyung Hee University Bone fragment-fixing device and drill assembly for cutting bone fragment

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
BRPI0613943B1 (pt) 2005-07-27 2021-06-22 Otsuka America Pharmaceutical, Inc Composto, composição farmacêutica o compreendendo, usos de um composto e de uma composição farmacêutica, bem como composição neurobiologicamente ativa
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
JP2013544850A (ja) * 2010-12-03 2013-12-19 ユーシミクス バイオサイエンス，インク． モノアミン神経伝達物質によって影響を受ける病態の処置における（＋）−１−（３，４−ジクロロフェニル）−３−アザビシクロ［３．１．０］ヘキサンの調製および使用
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
EP2994129A4 (en) * 2013-05-07 2017-01-25 Euthymic Bioscience, Inc. Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive and alcohol-related disorders
CA2989431C (en) 2015-06-17 2023-08-29 Franklin Bymaster Crystalline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10349989B2 (en) 2013-12-27 2019-07-16 University-Industry Cooperation Group Of Kyung Hee University Bone fragment-fixing device and drill assembly for cutting bone fragment

Also Published As

Publication number Publication date
CN101052393A (zh) 2007-10-10
NZ589033A (en) 2012-06-29
JP2008510715A (ja) 2008-04-10
IL181185A (en) 2012-10-31
ZA200701570B (en) 2008-08-27
WO2006023659A3 (en) 2006-12-07
AU2005277351A1 (en) 2006-03-02
EP1786417A4 (en) 2009-05-20
KR20130108489A (ko) 2013-10-02
WO2006023659A2 (en) 2006-03-02
RU2007109817A (ru) 2008-09-27
CA2619817A1 (en) 2006-03-02
NO20071372L (no) 2007-05-18
MX2007001827A (es) 2007-04-23
EP1786417A2 (en) 2007-05-23
IL181185A0 (en) 2007-07-04
KR20070054208A (ko) 2007-05-28
BRPI0515193A (pt) 2008-07-08

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