KR20120130173A - 플라비바이러스 감염을 치료 또는 예방하기 위한 유사체들 - Google Patents
플라비바이러스 감염을 치료 또는 예방하기 위한 유사체들 Download PDFInfo
- Publication number
- KR20120130173A KR20120130173A KR1020127019619A KR20127019619A KR20120130173A KR 20120130173 A KR20120130173 A KR 20120130173A KR 1020127019619 A KR1020127019619 A KR 1020127019619A KR 20127019619 A KR20127019619 A KR 20127019619A KR 20120130173 A KR20120130173 A KR 20120130173A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- substituted
- alkyl
- independently
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 0 *C(CC(C=O)N1C(O*)=O)C1=O Chemical compound *C(CC(C=O)N1C(O*)=O)C1=O 0.000 description 12
- APDAUBNBDJUQGW-UHFFFAOYSA-N Brc1cc([s]c(Br)c2)c2[s]1 Chemical compound Brc1cc([s]c(Br)c2)c2[s]1 APDAUBNBDJUQGW-UHFFFAOYSA-N 0.000 description 1
- ZXXQXFXNIJYXPM-UHFFFAOYSA-N C#Cc(cc1)c2OCOc2c1C#C Chemical compound C#Cc(cc1)c2OCOc2c1C#C ZXXQXFXNIJYXPM-UHFFFAOYSA-N 0.000 description 1
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- GJVPUXHKCUBWIL-VIFPVBQESA-N CC(C)CC(N(CCC1)[C@@H]1c([nH]1)ncc1I)=O Chemical compound CC(C)CC(N(CCC1)[C@@H]1c([nH]1)ncc1I)=O GJVPUXHKCUBWIL-VIFPVBQESA-N 0.000 description 1
- NIIVIQPQFFPQAW-STQMWFEESA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(C#C)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(C#C)c[nH]1)=O)NC(OC)=O NIIVIQPQFFPQAW-STQMWFEESA-N 0.000 description 1
- ZWUOECVAXBTRCI-CHQNGUEUSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(C#Cc(cc2)c3OCOc3c2C#Cc2cnc([C@H](CCC3)N3C(C(C(C)C)=C)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(C#Cc(cc2)c3OCOc3c2C#Cc2cnc([C@H](CCC3)N3C(C(C(C)C)=C)=O)[nH]2)[nH]1)=O)NC(OC)=O ZWUOECVAXBTRCI-CHQNGUEUSA-N 0.000 description 1
- ZGIDEUBXBSCQND-UKZHMXIBSA-N CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1nc(C#Cc(cc2)cc(C(OC)=O)c2C#Cc2c[nH]c([C@H](C[C@H](C)C3)N3C(/C(/C(C)C)=C\NC(OC)=O)=O)n2)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1nc(C#Cc(cc2)cc(C(OC)=O)c2C#Cc2c[nH]c([C@H](C[C@H](C)C3)N3C(/C(/C(C)C)=C\NC(OC)=O)=O)n2)c[nH]1)=O)NC(OC)=O ZGIDEUBXBSCQND-UKZHMXIBSA-N 0.000 description 1
- NQHGIMJKFGVWOG-JVGMIBGKSA-N CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1nc(C)c(C#Cc(cc2)cc(cc3)c2cc3C#Cc2c(C)nc([C@H](C[C@H](C)C3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1nc(C)c(C#Cc(cc2)cc(cc3)c2cc3C#Cc2c(C)nc([C@H](C[C@H](C)C3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O NQHGIMJKFGVWOG-JVGMIBGKSA-N 0.000 description 1
- OJHWKGLLRLJIFC-DRZSPHRISA-N CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1nc(C)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1nc(C)c[nH]1)=O)NC(OC)=O OJHWKGLLRLJIFC-DRZSPHRISA-N 0.000 description 1
- PDEFXYSXSDSFJC-PADFDGBLSA-N CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1ncc(-c(cc2)ccc2-c(cc2)ccc2-c2cnc([C@H](C[C@H](C)C3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1ncc(-c(cc2)ccc2-c(cc2)ccc2-c2cnc([C@H](C[C@H](C)C3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O PDEFXYSXSDSFJC-PADFDGBLSA-N 0.000 description 1
- VRUZIJHCRVLVCQ-KXDYXHLPSA-N CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1ncc(-c(cc2)ccc2-c2c(-c3cc([s]cc4)c4[s]3)nc([C@H](C[C@H](C)C3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(C[C@@H](C)C1)[C@@H]1c1ncc(-c(cc2)ccc2-c2c(-c3cc([s]cc4)c4[s]3)nc([C@H](C[C@H](C)C3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O VRUZIJHCRVLVCQ-KXDYXHLPSA-N 0.000 description 1
- VIHQUXCGKYTKAO-ANFUHZJESA-N CC(C)[C@H](CNC(OC)=O)C(N(CCC1=C)[C@@H]1c1nc(C#Cc2cc([s]c(C#Cc3c[nH]c([C@H](CCC4)N4C([C@H](C(C)C)NC(OC)=O)=O)n3)c3)c3[s]2)c[nH]1)=O Chemical compound CC(C)[C@H](CNC(OC)=O)C(N(CCC1=C)[C@@H]1c1nc(C#Cc2cc([s]c(C#Cc3c[nH]c([C@H](CCC4)N4C([C@H](C(C)C)NC(OC)=O)=O)n3)c3)c3[s]2)c[nH]1)=O VIHQUXCGKYTKAO-ANFUHZJESA-N 0.000 description 1
- ZWSJOFDCYISVDG-UHFFFAOYSA-N CC(C1)=C(C#CC)SC(C)=C1P=C Chemical compound CC(C1)=C(C#CC)SC(C)=C1P=C ZWSJOFDCYISVDG-UHFFFAOYSA-N 0.000 description 1
- YWWWGFSJHCFVOW-QMMMGPOBSA-N CCOC([C@H](CC1)N(C(OC(C)(C)C)=O)C1=O)=O Chemical compound CCOC([C@H](CC1)N(C(OC(C)(C)C)=O)C1=O)=O YWWWGFSJHCFVOW-QMMMGPOBSA-N 0.000 description 1
- VTVADGRWNUBMBF-LLVKDONJSA-N C[C@@H](CN(Cc1ncc(C)[nH]1)C(OC(C)(C)C)=O)C=C Chemical compound C[C@@H](CN(Cc1ncc(C)[nH]1)C(OC(C)(C)C)=O)C=C VTVADGRWNUBMBF-LLVKDONJSA-N 0.000 description 1
- BYBKDIRBSHPVAJ-YUMQZZPRSA-N C[C@@H](C[C@H]1c([nH]2)nc(I)c2I)CN1C(OC(C)(C)C)=O Chemical compound C[C@@H](C[C@H]1c([nH]2)nc(I)c2I)CN1C(OC(C)(C)C)=O BYBKDIRBSHPVAJ-YUMQZZPRSA-N 0.000 description 1
- VWSUUXABFFFLAH-UHFFFAOYSA-N Cc(cc(cc1)C#C)c1C#C Chemical compound Cc(cc(cc1)C#C)c1C#C VWSUUXABFFFLAH-UHFFFAOYSA-N 0.000 description 1
- GDEWXFQKAYEKLX-UHFFFAOYSA-N Cc1c[s]c2c1[s]cc2C Chemical compound Cc1c[s]c2c1[s]cc2C GDEWXFQKAYEKLX-UHFFFAOYSA-N 0.000 description 1
- SYSGWPLRRPINQC-UHFFFAOYSA-N Cc1cc(CN)ccn1 Chemical compound Cc1cc(CN)ccn1 SYSGWPLRRPINQC-UHFFFAOYSA-N 0.000 description 1
- PDWJNGHGJTUCOA-ONEGZZNKSA-N N/C=C/c1ccc[s]1 Chemical compound N/C=C/c1ccc[s]1 PDWJNGHGJTUCOA-ONEGZZNKSA-N 0.000 description 1
- ZQSLNSHMUQXSQJ-UHFFFAOYSA-N NCCc1ccc[o]1 Chemical compound NCCc1ccc[o]1 ZQSLNSHMUQXSQJ-UHFFFAOYSA-N 0.000 description 1
- TXQWFIVRZNOPCK-UHFFFAOYSA-N NCc1ccncc1 Chemical compound NCc1ccncc1 TXQWFIVRZNOPCK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29003009P | 2009-12-24 | 2009-12-24 | |
| US61/290,030 | 2009-12-24 | ||
| US31699810P | 2010-03-24 | 2010-03-24 | |
| US61/316,998 | 2010-03-24 | ||
| PCT/US2010/062168 WO2011079327A1 (en) | 2009-12-24 | 2010-12-27 | Analogues for the treatment or prevention of flavivirus infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120130173A true KR20120130173A (ko) | 2012-11-29 |
Family
ID=43530715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127019619A Withdrawn KR20120130173A (ko) | 2009-12-24 | 2010-12-27 | 플라비바이러스 감염을 치료 또는 예방하기 위한 유사체들 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20130072523A1 (enExample) |
| EP (1) | EP2515902A1 (enExample) |
| JP (1) | JP2013515746A (enExample) |
| KR (1) | KR20120130173A (enExample) |
| CN (1) | CN102883718A (enExample) |
| AU (1) | AU2010336355A1 (enExample) |
| CA (1) | CA2784036A1 (enExample) |
| IL (1) | IL220215A0 (enExample) |
| MX (1) | MX2012007420A (enExample) |
| SG (1) | SG181614A1 (enExample) |
| WO (1) | WO2011079327A1 (enExample) |
| ZA (1) | ZA201204625B (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102264737A (zh) | 2008-12-23 | 2011-11-30 | 雅培制药有限公司 | 抗病毒化合物 |
| RU2505539C2 (ru) | 2008-12-23 | 2014-01-27 | Эбботт Лэборетриз | Антивирусные соединения |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
| SG176015A1 (en) | 2009-05-13 | 2011-12-29 | Gilead Sciences Inc | Antiviral compounds |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| EP2853531A3 (en) | 2009-06-11 | 2015-08-12 | AbbVie Bahamas Ltd. | Antiviral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| MY159958A (en) | 2009-12-18 | 2017-02-15 | Idenix Pharmaceuticals Inc | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201141857A (en) * | 2010-03-24 | 2011-12-01 | Vertex Pharma | Analogues for the treatment or prevention of flavivirus infections |
| WO2011119853A1 (en) * | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| US20140364616A1 (en) * | 2010-12-15 | 2014-12-11 | Abbvie Inc. | Anti-viral compounds |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20120252721A1 (en) * | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| AU2012283609B2 (en) * | 2011-07-09 | 2016-09-29 | Sunshine Lake Pharma Co., Ltd. | Spiro compounds as hepatitis C virus inhibitors |
| HRP20180237T4 (hr) | 2011-09-16 | 2020-12-11 | Gilead Pharmasset Llc | Metode za liječenje hcv-a |
| AR088630A1 (es) | 2011-11-03 | 2014-06-25 | Theravance Inc | Inhibidores del virus de la hepatitis c |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9073943B2 (en) | 2012-02-10 | 2015-07-07 | Lupin Limited | Antiviral compounds with a dibenzooxaheterocycle moiety |
| LT2850075T (lt) | 2012-04-25 | 2017-05-10 | Theravance Biopharma R&D Ip, Llc | Piperazino-piperidino junginiai, kaip hepatito c viruso inhibitoriai |
| US9079887B2 (en) * | 2012-05-16 | 2015-07-14 | Gilead Sciences, Inc. | Antiviral compounds |
| CN103420991B (zh) * | 2012-05-17 | 2017-07-07 | 乳源东阳光药业有限公司 | 作为丙型肝炎抑制剂的吡咯烷衍生物及其在药物中的应用 |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| TW201412709A (zh) * | 2012-09-28 | 2014-04-01 | Sunshine Lake Pharma Co Ltd | 作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用 |
| EP2920210B1 (en) * | 2012-11-19 | 2017-08-30 | Baliopharm AG | Recombinant bispecific antibody binding to cd20 and cd95 |
| CN103848819B (zh) * | 2012-11-29 | 2017-04-12 | 广东东阳光药业有限公司 | 作为丙型肝炎抑制剂的螺环化合物、药物组合物及它们在药物中的应用 |
| WO2014082380A1 (en) | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co., Ltd. | Fused ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| US9416139B2 (en) | 2012-11-29 | 2016-08-16 | Sunshine Lake Pharma Co., Ltd. | Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof |
| EP2950786B1 (en) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
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- 2010-12-27 KR KR1020127019619A patent/KR20120130173A/ko not_active Withdrawn
- 2010-12-27 CA CA2784036A patent/CA2784036A1/en not_active Abandoned
- 2010-12-27 JP JP2012546254A patent/JP2013515746A/ja active Pending
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| CA2784036A1 (en) | 2011-06-30 |
| SG181614A1 (en) | 2012-07-30 |
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| US20130072523A1 (en) | 2013-03-21 |
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| MX2012007420A (es) | 2012-07-23 |
| IL220215A0 (en) | 2012-07-31 |
| AU2010336355A1 (en) | 2012-07-05 |
| ZA201204625B (en) | 2014-06-25 |
| WO2011079327A1 (en) | 2011-06-30 |
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