KR20120029480A - 아자펩티드 유도체 - Google Patents

아자펩티드 유도체 Download PDF

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Publication number
KR20120029480A
KR20120029480A KR1020127003399A KR20127003399A KR20120029480A KR 20120029480 A KR20120029480 A KR 20120029480A KR 1020127003399 A KR1020127003399 A KR 1020127003399A KR 20127003399 A KR20127003399 A KR 20127003399A KR 20120029480 A KR20120029480 A KR 20120029480A
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KR
South Korea
Prior art keywords
compound
compounds
inhibitor
pharmaceutically acceptable
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020127003399A
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English (en)
Korean (ko)
Inventor
스코트 엘. 하베슨
로저 디. 텅
Original Assignee
콘서트 파마슈티컬즈, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 콘서트 파마슈티컬즈, 인크. filed Critical 콘서트 파마슈티컬즈, 인크.
Publication of KR20120029480A publication Critical patent/KR20120029480A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
KR1020127003399A 2007-06-12 2008-06-12 아자펩티드 유도체 Withdrawn KR20120029480A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93420107P 2007-06-12 2007-06-12
US60/934,201 2007-06-12
US6762708P 2008-02-29 2008-02-29
US61/067,627 2008-02-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107000675A Division KR101185899B1 (ko) 2007-06-12 2008-06-12 아자펩티드 유도체

Publications (1)

Publication Number Publication Date
KR20120029480A true KR20120029480A (ko) 2012-03-26

Family

ID=39730784

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020107000675A Expired - Fee Related KR101185899B1 (ko) 2007-06-12 2008-06-12 아자펩티드 유도체
KR1020127003399A Withdrawn KR20120029480A (ko) 2007-06-12 2008-06-12 아자펩티드 유도체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020107000675A Expired - Fee Related KR101185899B1 (ko) 2007-06-12 2008-06-12 아자펩티드 유도체

Country Status (25)

Country Link
US (4) US20090036357A1 (OSRAM)
EP (3) EP2116532B1 (OSRAM)
JP (1) JP2010529196A (OSRAM)
KR (2) KR101185899B1 (OSRAM)
CN (2) CN102424668A (OSRAM)
AR (1) AR066972A1 (OSRAM)
AT (2) ATE447554T1 (OSRAM)
AU (1) AU2008267048C1 (OSRAM)
BR (2) BRPI0823520A2 (OSRAM)
CA (1) CA2692028C (OSRAM)
CO (1) CO6241121A2 (OSRAM)
CY (1) CY1109766T1 (OSRAM)
DE (1) DE602008000255D1 (OSRAM)
DK (1) DK2003120T3 (OSRAM)
ES (3) ES2394952T3 (OSRAM)
HR (1) HRP20100065T1 (OSRAM)
MX (1) MX2009013565A (OSRAM)
PL (1) PL2003120T3 (OSRAM)
PT (1) PT2003120E (OSRAM)
RS (1) RS51226B (OSRAM)
RU (2) RU2448958C2 (OSRAM)
SI (1) SI2003120T1 (OSRAM)
TW (1) TW200908970A (OSRAM)
WO (1) WO2008156632A1 (OSRAM)
ZA (1) ZA200909079B (OSRAM)

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WO2021212022A1 (en) * 2020-04-16 2021-10-21 The Medical College Of Wisconsin, Inc. Aerosolized formulations of hiv protease inhibitors for the treatment of airway reflux
CN115583984A (zh) * 2022-01-11 2023-01-10 嘉兴安谛康生物科技有限公司 氮杂螺类化合物及其制备方法、药物组合物和用途
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CN116987024A (zh) * 2023-08-01 2023-11-03 浙江荣耀生物科技股份有限公司 一种阿扎那韦中间体的制备方法

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Also Published As

Publication number Publication date
ATE536343T1 (de) 2011-12-15
RU2012101881A (ru) 2013-07-27
CY1109766T1 (el) 2014-09-10
JP2010529196A (ja) 2010-08-26
PL2003120T3 (pl) 2010-04-30
CN101711237B (zh) 2013-08-07
US8258309B2 (en) 2012-09-04
TW200908970A (en) 2009-03-01
ZA200909079B (en) 2011-05-25
BRPI0823520A2 (pt) 2013-12-17
WO2008156632A1 (en) 2008-12-24
SI2003120T1 (sl) 2010-03-31
EP2116532A1 (en) 2009-11-11
ES2394952T3 (es) 2013-02-07
EP2003120B1 (en) 2009-11-04
CN102424668A (zh) 2012-04-25
AU2008267048B2 (en) 2012-05-31
CO6241121A2 (es) 2011-01-20
EP2322509B1 (en) 2012-08-22
ATE447554T1 (de) 2009-11-15
US8158805B2 (en) 2012-04-17
AU2008267048A1 (en) 2008-12-24
US20130041156A1 (en) 2013-02-14
US20110009355A1 (en) 2011-01-13
ES2395137T3 (es) 2013-02-08
CN101711237A (zh) 2010-05-19
DK2003120T3 (da) 2010-03-15
EP2322509A1 (en) 2011-05-18
EP2003120A1 (en) 2008-12-17
CA2692028C (en) 2013-06-04
CA2692028A1 (en) 2008-12-24
RU2010100821A (ru) 2011-07-20
US20090036357A1 (en) 2009-02-05
HK1136576A1 (en) 2010-07-02
RU2448958C2 (ru) 2012-04-27
HK1127345A1 (en) 2009-09-25
MX2009013565A (es) 2010-06-02
EP2116532B1 (en) 2011-12-07
AU2008267048C1 (en) 2013-01-17
RS51226B (sr) 2010-12-31
AR066972A1 (es) 2009-09-23
DE602008000255D1 (de) 2009-12-17
BRPI0813911A2 (pt) 2012-02-22
HRP20100065T1 (hr) 2010-03-31
EP2003120B9 (en) 2010-06-02
KR101185899B1 (ko) 2012-09-27
US20120165288A1 (en) 2012-06-28
ES2356334T3 (es) 2011-04-07
PT2003120E (pt) 2010-02-11
KR20100020033A (ko) 2010-02-19

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Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20120208

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid