KR20110089180A - 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도 - Google Patents

직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도 Download PDF

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Publication number
KR20110089180A
KR20110089180A KR1020117013939A KR20117013939A KR20110089180A KR 20110089180 A KR20110089180 A KR 20110089180A KR 1020117013939 A KR1020117013939 A KR 1020117013939A KR 20117013939 A KR20117013939 A KR 20117013939A KR 20110089180 A KR20110089180 A KR 20110089180A
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KR
South Korea
Prior art keywords
binder
microcrystalline cellulose
slurry
excipient
disintegrant
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020117013939A
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English (en)
Korean (ko)
Inventor
난두 데오르카르
제임스 파리나
릴리아나 미니아
사미어 란디브
Original Assignee
아반토르 퍼포먼스 머티리얼스, 인크.
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Publication of KR20110089180A publication Critical patent/KR20110089180A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020117013939A 2008-11-19 2009-11-16 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도 Ceased KR20110089180A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11602508P 2008-11-19 2008-11-19
US61/116,025 2008-11-19

Publications (1)

Publication Number Publication Date
KR20110089180A true KR20110089180A (ko) 2011-08-04

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ID=42077071

Family Applications (1)

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KR1020117013939A Ceased KR20110089180A (ko) 2008-11-19 2009-11-16 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도

Country Status (13)

Country Link
US (1) US20110288146A1 (https=)
EP (1) EP2376067A2 (https=)
JP (1) JP2012509329A (https=)
KR (1) KR20110089180A (https=)
CN (1) CN102215825A (https=)
AU (1) AU2009316812A1 (https=)
BR (1) BRPI0921507A2 (https=)
CA (1) CA2744142A1 (https=)
IL (1) IL212955A0 (https=)
MX (1) MX2011005168A (https=)
SG (1) SG171752A1 (https=)
TW (1) TW201023897A (https=)
WO (1) WO2010059534A2 (https=)

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KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
IN2014DN09313A (https=) * 2012-04-27 2015-07-10 Japan Corn Starch Co Ltd
US9492535B2 (en) 2013-03-14 2016-11-15 Aimmune Therapeutics, Inc. Peanut formulations and uses thereof
WO2014159607A1 (en) 2013-03-14 2014-10-02 Allergen Research Corporation Manufacture of peanut formulations for oral desensitization
US20150343075A1 (en) * 2014-06-02 2015-12-03 Aimmune Therapeutics Placebo formulations and uses thereof
CN104189915B (zh) * 2014-07-30 2016-08-10 上海新亚药业闵行有限公司 一种固体制剂预混剂及其制备方法
CN104258411A (zh) * 2014-09-19 2015-01-07 安徽山河药用辅料股份有限公司 一种硅化微晶纤维素复合辅料及其制备方法
CN106265077A (zh) * 2015-05-30 2017-01-04 天士力制药集团股份有限公司 一种中药浸膏雾化分散工艺及其制剂
JP6650750B2 (ja) * 2015-12-22 2020-02-19 アサヒグループ食品株式会社 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒
WO2020037151A1 (en) 2018-08-16 2020-02-20 Aimmune Therapeutics, Inc. Peanut oral immunotherapy with maintenance dose
CA3123605A1 (en) 2018-12-20 2020-06-25 Aimmune Therapeutics, Inc. Peanut oral immunotherapy dosing schedule for missed doses
EP3965815A4 (en) 2019-05-10 2023-05-31 Société des Produits Nestlé S.A. METHOD OF IMPROVING THE QUALITY OF LIFE IN A PEANUT ALLERGY PATIENT
EP3993646B1 (en) 2019-07-05 2023-08-16 Swedish Match North Europe AB An oral pouched nicotine product including a filling material comprising nicotine-containing particles
PL4115746T3 (pl) 2019-11-20 2024-01-29 Swedish Match North Europe Ab Doustny produkt nikotynowy w saszetce, zawierający materiał wypełniający obejmujący cząstki nikotyny
PL4018848T3 (pl) 2020-12-22 2024-11-25 Swedish Match North Europe Ab Wyrób w saszetkach do użytku doustnego zawierający materiał pokrywający przepuszczalny dla cieczy oraz materiał wypełniający
CN116036291B (zh) * 2022-08-31 2025-08-26 瑞普（天津）生物药业有限公司 一种具有增溶作用的组合物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
WO1993012768A1 (en) * 1991-12-30 1993-07-08 Fmc Corporation Microcrystalline cellulose spheronization composition
US5686107A (en) * 1995-01-30 1997-11-11 Fmc Corporation Chewable pharmaceutical tablets
DE19628617A1 (de) * 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
DE59914598D1 (de) * 1999-07-19 2008-02-14 Fit Gmbh Coprozessiertes Polysaccharidprodukt mit unlöslicher Carboxymethylcellulose
CA2427991C (en) * 2000-11-06 2008-01-22 Asahi Kasei Kabushiki Kaisha Cellulose particles for pharmaceuticals
KR20030094244A (ko) * 2001-02-05 2003-12-11 알.피.쉐러 테크놀러지즈 인코포레이티드 약리학적 활성제의 맛을 감소시키기 위한 방법 및 조성물
AU2006211023B2 (en) * 2005-02-03 2012-05-24 Takeda Nycomed As Fast wet-massing method for the preparation of calcium-containing compositions
WO2008020990A1 (en) * 2006-08-09 2008-02-21 Mallinckrodt Baker, Inc. New direct compressible excipient blend
WO2008057266A2 (en) * 2006-10-27 2008-05-15 Fmc Corporation Dry granulation binders, products, and use thereof
MY164765A (en) * 2007-10-10 2018-01-30 Avantor Performance Mat Llc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof

Also Published As

Publication number Publication date
EP2376067A2 (en) 2011-10-19
JP2012509329A (ja) 2012-04-19
US20110288146A1 (en) 2011-11-24
IL212955A0 (en) 2011-07-31
TW201023897A (en) 2010-07-01
WO2010059534A3 (en) 2011-01-20
CA2744142A1 (en) 2010-05-27
AU2009316812A1 (en) 2011-07-07
BRPI0921507A2 (pt) 2016-01-19
SG171752A1 (en) 2011-07-28
MX2011005168A (es) 2011-05-30
CN102215825A (zh) 2011-10-12
WO2010059534A2 (en) 2010-05-27

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