KR20110060904A - Ｃｃｒ1 수용체 길항제로서의 아자인다졸 화합물 - Google Patents
Ｃｃｒ1 수용체 길항제로서의 아자인다졸 화합물 Download PDFInfo
- Publication number
- KR20110060904A KR20110060904A KR1020117006720A KR20117006720A KR20110060904A KR 20110060904 A KR20110060904 A KR 20110060904A KR 1020117006720 A KR1020117006720 A KR 1020117006720A KR 20117006720 A KR20117006720 A KR 20117006720A KR 20110060904 A KR20110060904 A KR 20110060904A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- pyridine
- mmol
- pyrazolo
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C[C@](C=CNC)(N)S(*)(=O)=O Chemical compound C[C@](C=CNC)(N)S(*)(=O)=O 0.000 description 2
- ZXXCSPUBTIMEKQ-ALCCZGGFSA-N CC(C)/N=C(\SC)/Br Chemical compound CC(C)/N=C(\SC)/Br ZXXCSPUBTIMEKQ-ALCCZGGFSA-N 0.000 description 1
- NVWBKOFBNKNGRP-VOTSOKGWSA-N CC(C)/N=C(\SC)/S(C)(=O)=O Chemical compound CC(C)/N=C(\SC)/S(C)(=O)=O NVWBKOFBNKNGRP-VOTSOKGWSA-N 0.000 description 1
- YLHJEZFTBYEOCY-UHFFFAOYSA-N CCC(C(CCC1)CN1C(N)=O)NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O Chemical compound CCC(C(CCC1)CN1C(N)=O)NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O YLHJEZFTBYEOCY-UHFFFAOYSA-N 0.000 description 1
- BDHZAIHUXHLQRY-UHFFFAOYSA-N CCC(C1CNCCC1)NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O Chemical compound CCC(C1CNCCC1)NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O BDHZAIHUXHLQRY-UHFFFAOYSA-N 0.000 description 1
- DESBKHJIFCPTRM-UHFFFAOYSA-N CCC(c1nc(C(NC)=O)c(C)[o]1)NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O Chemical compound CCC(c1nc(C(NC)=O)c(C)[o]1)NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O DESBKHJIFCPTRM-UHFFFAOYSA-N 0.000 description 1
- UGKCBEKPZGQGKQ-UHFFFAOYSA-N CCC(c1nc(C(OC)=O)c(C)[o]1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CCC(c1nc(C(OC)=O)c(C)[o]1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O UGKCBEKPZGQGKQ-UHFFFAOYSA-N 0.000 description 1
- ZFLDTEIDAGWEEI-UHFFFAOYSA-N CCOC(c([o]1)cnc1Cl)=O Chemical compound CCOC(c([o]1)cnc1Cl)=O ZFLDTEIDAGWEEI-UHFFFAOYSA-N 0.000 description 1
- CVSPVJDFDFTASP-UHFFFAOYSA-N CCOC(c([o]1)cnc1SC)=O Chemical compound CCOC(c([o]1)cnc1SC)=O CVSPVJDFDFTASP-UHFFFAOYSA-N 0.000 description 1
- XEBOWXHULQMKDX-SFHVURJKSA-N CC[C@@H](C(C=C(N1)S(C)(=O)=O)=CC1=O)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CC[C@@H](C(C=C(N1)S(C)(=O)=O)=CC1=O)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O XEBOWXHULQMKDX-SFHVURJKSA-N 0.000 description 1
- VXHLJEYPWMVMQK-YFKPBYRVSA-N CC[C@@H](c([o]1)cnc1SC)N Chemical compound CC[C@@H](c([o]1)cnc1SC)N VXHLJEYPWMVMQK-YFKPBYRVSA-N 0.000 description 1
- RNIRWMOJNPDUEF-YFKPBYRVSA-N CC[C@@H](c([s]1)cnc1S(C)(=O)=O)N Chemical compound CC[C@@H](c([s]1)cnc1S(C)(=O)=O)N RNIRWMOJNPDUEF-YFKPBYRVSA-N 0.000 description 1
- YXFMDUKJYYWGQJ-IBGZPJMESA-N CC[C@@H](c1cc(S(C)(=O)=O)nc(OC)c1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CC[C@@H](c1cc(S(C)(=O)=O)nc(OC)c1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O YXFMDUKJYYWGQJ-IBGZPJMESA-N 0.000 description 1
- GUHRLVXLOQHLDG-UHFFFAOYSA-N COC(CCS(c1cc(CNC(c2c(cn[n]3-c(cc4)ccc4F)c3cnc2)=O)ccn1)(=O)=O)=O Chemical compound COC(CCS(c1cc(CNC(c2c(cn[n]3-c(cc4)ccc4F)c3cnc2)=O)ccn1)(=O)=O)=O GUHRLVXLOQHLDG-UHFFFAOYSA-N 0.000 description 1
- HPNBULOPMFDFJG-IBGZPJMESA-N COC(C[C@@H](c1cc(S(C)(=O)=O)ncc1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O)=O Chemical compound COC(C[C@@H](c1cc(S(C)(=O)=O)ncc1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O)=O HPNBULOPMFDFJG-IBGZPJMESA-N 0.000 description 1
- HCMZYRRVOXAHHF-XLDIYJRPSA-N CS(c1nccc([C@H](CC(CCO)CO)NC(c2cncc3c2cn[n]3-c(cc2)ccc2F)=O)c1)(=O)=O Chemical compound CS(c1nccc([C@H](CC(CCO)CO)NC(c2cncc3c2cn[n]3-c(cc2)ccc2F)=O)c1)(=O)=O HCMZYRRVOXAHHF-XLDIYJRPSA-N 0.000 description 1
- QIBWTJNNWRXJPG-IBGZPJMESA-N CS(c1nccc([C@H](CC=O)NC(c2c(cn[n]3-c(cc4)ccc4F)c3cnc2)=O)c1)(=O)=O Chemical compound CS(c1nccc([C@H](CC=O)NC(c2c(cn[n]3-c(cc4)ccc4F)c3cnc2)=O)c1)(=O)=O QIBWTJNNWRXJPG-IBGZPJMESA-N 0.000 description 1
- YKZYEUAXINVCEK-UHFFFAOYSA-N CSc1ncc(C(O)=O)[o]1 Chemical compound CSc1ncc(C(O)=O)[o]1 YKZYEUAXINVCEK-UHFFFAOYSA-N 0.000 description 1
- RPUISAUQWDFAIR-UHFFFAOYSA-N NS(c1nccc(CNC(c2cncc3c2cn[n]3-c(cc2)ccc2F)=O)c1)(=O)=O Chemical compound NS(c1nccc(CNC(c2cncc3c2cn[n]3-c(cc2)ccc2F)=O)c1)(=O)=O RPUISAUQWDFAIR-UHFFFAOYSA-N 0.000 description 1
- DJUWIZUEHXRECB-UHFFFAOYSA-N O=Cc([s]1)cnc1Br Chemical compound O=Cc([s]1)cnc1Br DJUWIZUEHXRECB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10040108P | 2008-09-26 | 2008-09-26 | |
| US61/100,401 | 2008-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110060904A true KR20110060904A (ko) | 2011-06-08 |
Family
ID=41349302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117006720A Withdrawn KR20110060904A (ko) | 2008-09-26 | 2009-09-22 | Ｃｃｒ1 수용체 길항제로서의 아자인다졸 화합물 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US7879873B2 (enExample) |
| EP (1) | EP2346868B1 (enExample) |
| JP (1) | JP5507567B2 (enExample) |
| KR (1) | KR20110060904A (enExample) |
| CN (1) | CN102227425A (enExample) |
| AP (1) | AP2739A (enExample) |
| AR (1) | AR073689A1 (enExample) |
| AU (1) | AU2009296839A1 (enExample) |
| BR (1) | BRPI0919844A2 (enExample) |
| CA (1) | CA2737472A1 (enExample) |
| CL (1) | CL2011000668A1 (enExample) |
| CO (1) | CO6351735A2 (enExample) |
| EA (1) | EA201100524A1 (enExample) |
| EC (1) | ECSP11010932A (enExample) |
| IL (1) | IL210857A0 (enExample) |
| MA (1) | MA32655B1 (enExample) |
| MX (1) | MX2011002951A (enExample) |
| NZ (1) | NZ591115A (enExample) |
| PE (1) | PE20110854A1 (enExample) |
| TW (1) | TW201018683A (enExample) |
| UA (1) | UA103634C2 (enExample) |
| UY (1) | UY32140A (enExample) |
| WO (1) | WO2010036632A1 (enExample) |
| ZA (1) | ZA201100625B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| EP2297112B1 (en) | 2008-05-06 | 2013-04-03 | Boehringer Ingelheim International GmbH | Pyrazole compounds as ccr1 antagonists |
| AP2739A (en) | 2008-09-26 | 2013-09-30 | Boehringer Ingelheim Int | Azaindazole compounds as CCRI receptor antagonists |
| US20100317646A1 (en) * | 2009-03-19 | 2010-12-16 | Medical Research Council Technology | Compounds |
| PL2491028T3 (pl) | 2009-10-21 | 2014-05-30 | Boehringer Ingelheim Int | Związki indazolowe i pirazolopirydynowe jako antagoniści receptora CCR1 |
| EP2493875B1 (en) | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Heterocyclic compounds as ccr1 receptor antagonists |
| PH12012501153A1 (en) * | 2009-12-08 | 2012-10-22 | Boehringer Ingelheim Int | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| EP2388260A1 (de) * | 2010-05-21 | 2011-11-23 | Archimica GmbH | Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors |
| CN103384668B (zh) | 2010-09-03 | 2017-05-31 | 福马Tm有限责任公司 | 用于抑制nampt的化合物和组合物 |
| US8546442B2 (en) | 2010-12-23 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as CCR1 receptor antagonists |
| JP2014511389A (ja) | 2011-02-28 | 2014-05-15 | エピザイム インコーポレイテッド | 置換６，５−縮合二環式ヘテロアリール化合物 |
| CN102775365A (zh) * | 2011-05-10 | 2012-11-14 | 无锡立诺康医药科技有限公司 | 5-氨基取代基-异噁唑类化合物或其酸式盐的合成工艺 |
| WO2012163848A1 (en) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of crohn's disease |
| EP2771011A4 (en) * | 2011-10-24 | 2015-04-15 | Glaxosmithkline Ip No 2 Ltd | CHEMICAL COMPOUNDS |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| US9458172B2 (en) * | 2012-03-02 | 2016-10-04 | Kenneth W Bair | Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives |
| AR091858A1 (es) | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) |
| US9776996B2 (en) * | 2013-03-15 | 2017-10-03 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| US9045477B2 (en) * | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| FR3016879A1 (fr) * | 2014-01-29 | 2015-07-31 | Guillaume Laconde | Procede de preparation de benzotriazole n-acyles |
| TR201809388T4 (tr) | 2014-03-17 | 2018-07-23 | Pfizer | Metabolik ve ilişkili hastalıkların tedavisinde kullanılmaya yönelik diasilgliserol asiltransferaz 2 inhibitörleri. |
| UA120094C2 (uk) | 2014-04-14 | 2019-10-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Сполуки як модулятори ror-гамма |
| JP6810988B2 (ja) | 2015-10-23 | 2021-01-13 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 新規なフェロポーチン阻害剤 |
| BR112018009566A2 (pt) | 2015-11-13 | 2018-11-06 | Basf Se | compostos, mistura, composição agroquímica, uso de compostos e método para combater fungos nocivos fitopatogênicos |
| US20180354921A1 (en) | 2015-11-13 | 2018-12-13 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| CA3016068C (en) | 2016-03-07 | 2024-02-27 | The Global Alliance For Tb Drug Development, Inc. | Antibacterial compounds and uses thereof |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| TWI853814B (zh) | 2018-05-31 | 2024-09-01 | 南韓商Ｃ＆Ｃ新藥研究所 | 雜環衍生物及其用途 |
| CN111393376B (zh) * | 2020-05-11 | 2022-05-13 | 安徽赛迪生物科技有限公司 | 一种2-氯嘧啶-4-甲酸的合成方法 |
| WO2021262878A1 (en) * | 2020-06-24 | 2021-12-30 | Oregon Health & Science University | Novel molecule for modulation of innate immune responses controlled by sting protein |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242931A (en) | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
| US4999363A (en) | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| RU2119920C1 (ru) | 1991-03-28 | 1998-10-10 | Эйсай Ко., Лтд. | Гетероцикло-циклические производные аминов или их фармацевтически приемлемые соли, промежуточные соединения, фармацевтическая композиция, способ ингибирования холинэстеразы, способ получения соединений |
| US5750542A (en) | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
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2009
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- 2009-09-22 EP EP09792818.8A patent/EP2346868B1/en active Active
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| IL210857A0 (en) | 2011-04-28 |
| ECSP11010932A (es) | 2011-04-29 |
| UY32140A (es) | 2010-04-30 |
| MA32655B1 (fr) | 2011-09-01 |
| US8063065B2 (en) | 2011-11-22 |
| MX2011002951A (es) | 2011-04-26 |
| NZ591115A (en) | 2012-10-26 |
| AP2011005685A0 (en) | 2011-04-30 |
| US20110086846A1 (en) | 2011-04-14 |
| AU2009296839A1 (en) | 2010-04-01 |
| AP2739A (en) | 2013-09-30 |
| US8163918B2 (en) | 2012-04-24 |
| EP2346868B1 (en) | 2016-01-27 |
| US7879873B2 (en) | 2011-02-01 |
| JP5507567B2 (ja) | 2014-05-28 |
| UA103634C2 (en) | 2013-11-11 |
| CO6351735A2 (es) | 2011-12-20 |
| EP2346868A1 (en) | 2011-07-27 |
| ZA201100625B (en) | 2011-09-28 |
| US20120035370A1 (en) | 2012-02-09 |
| TW201018683A (en) | 2010-05-16 |
| CL2011000668A1 (es) | 2011-10-28 |
| PE20110854A1 (es) | 2011-12-23 |
| CN102227425A (zh) | 2011-10-26 |
| AR073689A1 (es) | 2010-11-24 |
| US20120136158A1 (en) | 2012-05-31 |
| JP2012503664A (ja) | 2012-02-09 |
| BRPI0919844A2 (pt) | 2019-09-24 |
| WO2010036632A1 (en) | 2010-04-01 |
| CA2737472A1 (en) | 2010-04-01 |
| US20100093724A1 (en) | 2010-04-15 |
| EA201100524A1 (ru) | 2011-10-31 |
| US8338610B2 (en) | 2012-12-25 |
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