JP5507567B2 - Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物 - Google Patents
Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物 Download PDFInfo
- Publication number
- JP5507567B2 JP5507567B2 JP2011529154A JP2011529154A JP5507567B2 JP 5507567 B2 JP5507567 B2 JP 5507567B2 JP 2011529154 A JP2011529154 A JP 2011529154A JP 2011529154 A JP2011529154 A JP 2011529154A JP 5507567 B2 JP5507567 B2 JP 5507567B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- pyridine
- pyrazolo
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CN1C=CC(C*)=CC1S(C)(=O)=O Chemical compound CN1C=CC(C*)=CC1S(C)(=O)=O 0.000 description 3
- CQPSZEGSPIRRJJ-JFQJCAQQSA-N C/C=C(\C(C=C(N1)S(C)(=O)=O)=CC1=O)/NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O Chemical compound C/C=C(\C(C=C(N1)S(C)(=O)=O)=CC1=O)/NC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O CQPSZEGSPIRRJJ-JFQJCAQQSA-N 0.000 description 1
- YLHJEZFTBYEOCY-UHFFFAOYSA-N CCC(C(CCC1)CN1C(N)=O)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CCC(C(CCC1)CN1C(N)=O)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O YLHJEZFTBYEOCY-UHFFFAOYSA-N 0.000 description 1
- BDHZAIHUXHLQRY-UHFFFAOYSA-N CCC(C1CNCCC1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CCC(C1CNCCC1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O BDHZAIHUXHLQRY-UHFFFAOYSA-N 0.000 description 1
- YXFMDUKJYYWGQJ-UHFFFAOYSA-N CCC(c1cc(S(C)(=O)=O)nc(OC)c1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CCC(c1cc(S(C)(=O)=O)nc(OC)c1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O YXFMDUKJYYWGQJ-UHFFFAOYSA-N 0.000 description 1
- SXQRTSYTHHDLLS-QMMMGPOBSA-N CC[C@@H](c1ccnc(S(C)(=O)=O)c1)N Chemical compound CC[C@@H](c1ccnc(S(C)(=O)=O)c1)N SXQRTSYTHHDLLS-QMMMGPOBSA-N 0.000 description 1
- LZGOHOFWAKLDIJ-IBGZPJMESA-M CC[C@@H](c1ccnc(S(C)([O-])=O)c1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O Chemical compound CC[C@@H](c1ccnc(S(C)([O-])=O)c1)NC(c1cncc2c1cn[n]2-c(cc1)ccc1F)=O LZGOHOFWAKLDIJ-IBGZPJMESA-M 0.000 description 1
- BQLGCIUPZRALSH-UHFFFAOYSA-N CS(c1nccc(C#N)c1)(=O)=O Chemical compound CS(c1nccc(C#N)c1)(=O)=O BQLGCIUPZRALSH-UHFFFAOYSA-N 0.000 description 1
- JDXXHVSRKHJAQD-UHFFFAOYSA-N CS(c1nccc(CN)c1)(=O)=O Chemical compound CS(c1nccc(CN)c1)(=O)=O JDXXHVSRKHJAQD-UHFFFAOYSA-N 0.000 description 1
- DOJYLWMKMFONQG-UHFFFAOYSA-N C[n]1ncc2c1cncc2C(O)=O Chemical compound C[n]1ncc2c1cncc2C(O)=O DOJYLWMKMFONQG-UHFFFAOYSA-N 0.000 description 1
- HTGDXQVCBISJRX-UHFFFAOYSA-N Cc1nc(Br)cc(C(OC)=O)c1 Chemical compound Cc1nc(Br)cc(C(OC)=O)c1 HTGDXQVCBISJRX-UHFFFAOYSA-N 0.000 description 1
- RLCCKUXOBHSYIX-UHFFFAOYSA-N Cc1nc(Br)cc(CNC)c1 Chemical compound Cc1nc(Br)cc(CNC)c1 RLCCKUXOBHSYIX-UHFFFAOYSA-N 0.000 description 1
- BDYCNXLYRGFBFC-UHFFFAOYSA-N Cc1nc(Br)cc(CO)c1 Chemical compound Cc1nc(Br)cc(CO)c1 BDYCNXLYRGFBFC-UHFFFAOYSA-N 0.000 description 1
- VIEDTXGWMQTPOE-UHFFFAOYSA-N Cc1nc(Br)cc(COS(C)(=O)=O)c1 Chemical compound Cc1nc(Br)cc(COS(C)(=O)=O)c1 VIEDTXGWMQTPOE-UHFFFAOYSA-N 0.000 description 1
- SBWJLHPCEHEABR-UHFFFAOYSA-N Cc1nccc(C#N)c1 Chemical compound Cc1nccc(C#N)c1 SBWJLHPCEHEABR-UHFFFAOYSA-N 0.000 description 1
- JTXOGWNTNOJMLN-UHFFFAOYSA-N OC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O Chemical compound OC(c1c(cn[n]2-c(cc3)ccc3F)c2cnc1)=O JTXOGWNTNOJMLN-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10040108P | 2008-09-26 | 2008-09-26 | |
| US61/100,401 | 2008-09-26 | ||
| PCT/US2009/057778 WO2010036632A1 (en) | 2008-09-26 | 2009-09-22 | Azaindazole compounds as ccr1 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503664A JP2012503664A (ja) | 2012-02-09 |
| JP2012503664A5 JP2012503664A5 (enExample) | 2012-05-24 |
| JP5507567B2 true JP5507567B2 (ja) | 2014-05-28 |
Family
ID=41349302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529154A Active JP5507567B2 (ja) | 2008-09-26 | 2009-09-22 | Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US7879873B2 (enExample) |
| EP (1) | EP2346868B1 (enExample) |
| JP (1) | JP5507567B2 (enExample) |
| KR (1) | KR20110060904A (enExample) |
| CN (1) | CN102227425A (enExample) |
| AP (1) | AP2739A (enExample) |
| AR (1) | AR073689A1 (enExample) |
| AU (1) | AU2009296839A1 (enExample) |
| BR (1) | BRPI0919844A2 (enExample) |
| CA (1) | CA2737472A1 (enExample) |
| CL (1) | CL2011000668A1 (enExample) |
| CO (1) | CO6351735A2 (enExample) |
| EA (1) | EA201100524A1 (enExample) |
| EC (1) | ECSP11010932A (enExample) |
| IL (1) | IL210857A0 (enExample) |
| MA (1) | MA32655B1 (enExample) |
| MX (1) | MX2011002951A (enExample) |
| NZ (1) | NZ591115A (enExample) |
| PE (1) | PE20110854A1 (enExample) |
| TW (1) | TW201018683A (enExample) |
| UA (1) | UA103634C2 (enExample) |
| UY (1) | UY32140A (enExample) |
| WO (1) | WO2010036632A1 (enExample) |
| ZA (1) | ZA201100625B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| JP5411927B2 (ja) * | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１アンタゴニストとしてのピラゾール化合物 |
| US7879873B2 (en) | 2008-09-26 | 2011-02-01 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as CCR1 receptor antagonists |
| PE20120506A1 (es) * | 2009-03-19 | 2012-05-14 | Medical Res Council Technology | Derivados de pirazolopiridina como inhibidores de quinasas |
| SI2491028T1 (sl) | 2009-10-21 | 2014-03-31 | Boehringer Ingelheim International Gmbh | Indazolne in pirazolopiridinske spojine kot antagonisti receptorja CCR1 |
| EP2493875B1 (en) * | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Heterocyclic compounds as ccr1 receptor antagonists |
| IN2012DN05081A (enExample) * | 2009-12-08 | 2015-10-09 | Boehringer Ingelheim Int | |
| EP2563787B1 (en) * | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Azaindazole amide compounds as ccr1 receptor antagonists |
| EP2388260A1 (de) * | 2010-05-21 | 2011-11-23 | Archimica GmbH | Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors |
| CN103384668B (zh) | 2010-09-03 | 2017-05-31 | 福马Tm有限责任公司 | 用于抑制nampt的化合物和组合物 |
| US8546442B2 (en) | 2010-12-23 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as CCR1 receptor antagonists |
| JP2014511389A (ja) | 2011-02-28 | 2014-05-15 | エピザイム インコーポレイテッド | 置換６，５−縮合二環式ヘテロアリール化合物 |
| CN102775365A (zh) * | 2011-05-10 | 2012-11-14 | 无锡立诺康医药科技有限公司 | 5-氨基取代基-异噁唑类化合物或其酸式盐的合成工艺 |
| WO2012163848A1 (en) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of crohn's disease |
| WO2013062945A1 (en) | 2011-10-24 | 2013-05-02 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
| WO2013060865A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| EP2820017B1 (en) * | 2012-03-02 | 2016-12-21 | Genentech, Inc. | Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives |
| AR091858A1 (es) | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) |
| US9045477B2 (en) * | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| EP2970306A4 (en) * | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED 6.5-CONDENSED BICYCLIC HETEROARYL COMPOUNDS |
| FR3016879A1 (fr) * | 2014-01-29 | 2015-07-31 | Guillaume Laconde | Procede de preparation de benzotriazole n-acyles |
| ES2674240T3 (es) | 2014-03-17 | 2018-06-28 | Pfizer Inc. | Inhibidores de diacilglicerol aciltransferasa 2 para su uso en el tratamiento de trastornos metabólicos y relacionados |
| NZ723530A (en) | 2014-04-14 | 2023-05-26 | Boehringer Ingelheim Int | Compounds as modulators of ror gamma |
| JP6810988B2 (ja) | 2015-10-23 | 2021-01-13 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 新規なフェロポーチン阻害剤 |
| EP3373732A1 (en) | 2015-11-13 | 2018-09-19 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| WO2017081312A1 (en) | 2015-11-13 | 2017-05-18 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| JP6997095B2 (ja) | 2016-03-07 | 2022-02-03 | ザ グローバル アライアンス フォー ティービー ドラッグ デベロップメント， インコーポレイテッド | 抗菌性化合物およびその使用 |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| TWI853814B (zh) | 2018-05-31 | 2024-09-01 | 南韓商Ｃ＆Ｃ新藥研究所 | 雜環衍生物及其用途 |
| CN111393376B (zh) * | 2020-05-11 | 2022-05-13 | 安徽赛迪生物科技有限公司 | 一种2-氯嘧啶-4-甲酸的合成方法 |
| WO2021262878A1 (en) * | 2020-06-24 | 2021-12-30 | Oregon Health & Science University | Novel molecule for modulation of innate immune responses controlled by sting protein |
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| CA2195129C (en) | 1991-03-28 | 2002-09-10 | Anabella Villalobos | Substituted piperidine intermediates for producing heterocyclic-cyclic amine derivatives capable of inhibiting cholinesterase |
| US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| BR9305569A (pt) | 1992-07-03 | 1995-12-26 | Kumiai Chemical Industry Co | Derivados heterocíclicos condensados e herbicidas |
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| JPH10509721A (ja) | 1994-12-06 | 1998-09-22 | メルク シヤープ エンド ドーム リミテツド | ５ｈｔ１レセプターアゴニストとしてのアゼチジン、ピロリジン及びピペリジン誘導体 |
| GB9519563D0 (en) | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| GB9523583D0 (en) | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| US5760028A (en) | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
| AU1345697A (en) | 1995-12-22 | 1997-07-17 | Du Pont Merck Pharmaceutical Company, The | Novel integrin receptor antagonists |
| JPH101478A (ja) | 1996-06-11 | 1998-01-06 | Kumiai Chem Ind Co Ltd | インダゾールスルホニル尿素誘導体及び除草剤 |
| GB9615449D0 (en) | 1996-07-23 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
| IL135714A0 (en) | 1997-11-04 | 2001-05-20 | Pfizer Prod Inc | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
| US6331640B1 (en) | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
| ES2248084T3 (es) | 1999-06-14 | 2006-03-16 | Eli Lilly And Company | Inhibidores de serinproteasa. |
| WO2000076970A2 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Serine protease inhibitors |
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| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
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| US8163918B2 (en) | 2012-04-24 |
| CO6351735A2 (es) | 2011-12-20 |
| UY32140A (es) | 2010-04-30 |
| EP2346868A1 (en) | 2011-07-27 |
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| IL210857A0 (en) | 2011-04-28 |
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| ZA201100625B (en) | 2011-09-28 |
| US20120136158A1 (en) | 2012-05-31 |
| BRPI0919844A2 (pt) | 2019-09-24 |
| UA103634C2 (en) | 2013-11-11 |
| US20110086846A1 (en) | 2011-04-14 |
| EP2346868B1 (en) | 2016-01-27 |
| AR073689A1 (es) | 2010-11-24 |
| EA201100524A1 (ru) | 2011-10-31 |
| US20120035370A1 (en) | 2012-02-09 |
| TW201018683A (en) | 2010-05-16 |
| US8063065B2 (en) | 2011-11-22 |
| MA32655B1 (fr) | 2011-09-01 |
| JP2012503664A (ja) | 2012-02-09 |
| ECSP11010932A (es) | 2011-04-29 |
| PE20110854A1 (es) | 2011-12-23 |
| US8338610B2 (en) | 2012-12-25 |
| WO2010036632A1 (en) | 2010-04-01 |
| US20100093724A1 (en) | 2010-04-15 |
| CA2737472A1 (en) | 2010-04-01 |
| AP2011005685A0 (en) | 2011-04-30 |
| CN102227425A (zh) | 2011-10-26 |
| US7879873B2 (en) | 2011-02-01 |
| CL2011000668A1 (es) | 2011-10-28 |
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