KR20110022713A - 인간 만능줄기세포로부터 인간 피부 대체물을 제조하는 방법 - Google Patents

인간 만능줄기세포로부터 인간 피부 대체물을 제조하는 방법 Download PDF

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KR20110022713A
KR20110022713A KR1020117001947A KR20117001947A KR20110022713A KR 20110022713 A KR20110022713 A KR 20110022713A KR 1020117001947 A KR1020117001947 A KR 1020117001947A KR 20117001947 A KR20117001947 A KR 20117001947A KR 20110022713 A KR20110022713 A KR 20110022713A
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human
stem cells
cells
pluripotent stem
keratinocytes
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잉드 그누
질르 르매트르
크리스틴느 발데시
마끄 뻬샹스키
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인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)
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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
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    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
KR1020117001947A 2008-06-25 2009-06-23 인간 만능줄기세포로부터 인간 피부 대체물을 제조하는 방법 Withdrawn KR20110022713A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP08305320 2008-06-25
EP08305320.7 2008-06-25
EP08305447 2008-08-04
EP08305447.8 2008-08-04
US9095708P 2008-08-22 2008-08-22
US61/090,957 2008-08-22
EP09305077.1 2009-01-28
EP09305077 2009-01-28

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Publication Number Publication Date
KR20110022713A true KR20110022713A (ko) 2011-03-07

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KR1020117001947A Withdrawn KR20110022713A (ko) 2008-06-25 2009-06-23 인간 만능줄기세포로부터 인간 피부 대체물을 제조하는 방법

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Country Link
US (1) US20110165130A1 (enExample)
EP (1) EP2297299A1 (enExample)
JP (1) JP2011525370A (enExample)
KR (1) KR20110022713A (enExample)
CN (1) CN102186969A (enExample)
AU (1) AU2009264336A1 (enExample)
BR (1) BRPI0914422A2 (enExample)
WO (1) WO2009156398A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019004533A1 (ko) * 2017-06-30 2019-01-03 주식회사 스템랩 소변세포로부터 케라티노사이트 줄기세포로의 직접 역분화 방법 및 역분화된 케라티노사이트 줄기세포를 이용한 피부재생 촉진용 조성물의 제조방법

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WO2010134619A1 (ja) * 2009-05-18 2010-11-25 国立大学法人東北大学 人工多能性幹細胞からの上皮系前駆細胞・幹細胞群及び角膜上皮細胞群の分化誘導方法
US8529883B2 (en) * 2010-05-07 2013-09-10 Fibrocell Technologies, Inc. Dosage unit formulations of autologous dermal fibroblasts
RU2458983C1 (ru) * 2011-07-18 2012-08-20 Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации Способ получения индуцированных плюрипотентных стволовых клеток из фибробластов пациентов с болезнью хангингтона
AU2014239954B2 (en) * 2013-03-15 2020-07-16 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
US20160237400A1 (en) * 2013-03-15 2016-08-18 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
US9545302B2 (en) 2013-11-20 2017-01-17 Dermagenesis Llc Skin printing and auto-grafting
CN104789521B (zh) * 2014-01-22 2017-11-07 广州康睿生物医药科技股份有限公司 一种晶状体上皮干细胞的分离培养方法
SG10202103834VA (en) * 2014-02-21 2021-05-28 Sumitomo Dainippon Pharma Co Ltd Eye disease treatment agent, screening method therefor, and method for predicting rejection response associated with retinal pigment epithelial cell transplant
WO2016057833A1 (en) * 2014-10-10 2016-04-14 Vygantas Garrett Methods of manufacturing keratin products and uses thereof
JP6736253B2 (ja) * 2014-12-22 2020-08-05 ザ チャイニーズ ユニバーシティ オブ ホンコン 体細胞から多能性幹細胞を作製するための機械的操作とプログラミンの併用
US10167451B2 (en) 2014-12-22 2019-01-01 The Chinese University Of Hong Kong Combinational use of mechanical manipulation and programin derivatives to increase Oct4, Sox2, or Nanog expression in fibroblasts
GB201510913D0 (en) * 2015-06-22 2015-08-05 Nat University Of Singapore And Agency For Science Technology And Res Vascularized tissue, skin or mucosa quivalent
CA3002164A1 (en) * 2015-10-21 2017-04-27 Indiana University Research And Technology Corporation Derivation of human skin organoids from pluripotent stem cells
AU2016341982B2 (en) 2015-10-21 2022-07-07 Indiana University Research And Technology Corporation Methods of generating human inner ear sensory epithelia and sensory neurons
US10273549B2 (en) 2016-04-21 2019-04-30 Vitrolabs Inc. Engineered skin equivalent, method of manufacture thereof and products derived therefrom
EP3551746A1 (en) * 2016-12-09 2019-10-16 The University of Chicago Tissue organoids
CN106754652B (zh) * 2017-03-06 2019-04-02 广州润虹医药科技股份有限公司 iPS细胞分化成外胚层祖细胞的无血清诱导培养基及诱导方法
CN106834214B (zh) * 2017-03-27 2020-02-14 广州润虹医药科技股份有限公司 一种诱导多能干细胞形成角质形成细胞的诱导培养基及诱导方法
CN107988147B (zh) * 2017-12-19 2021-11-09 江汉大学 基于器官芯片与诱导多能干细胞的定向分化用于3d拟表皮构建的方法
CN110093306B (zh) * 2018-01-31 2022-12-02 中山大学 人工毛囊及其制备方法和应用
EP3875581A1 (en) 2020-03-02 2021-09-08 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing keratinocytes
EP3875124A1 (fr) 2020-03-02 2021-09-08 Urgo Recherche Innovation Et Developpement Procede d'obtention d'un tissu dermo-epidermique pre-vascularise
EP3875580A1 (en) 2020-03-02 2021-09-08 Centre d'Etude des Cellules Souches (CECS) Methods for preparing keratinocytes
CN112941015B (zh) * 2021-03-19 2022-03-18 上海爱萨尔生物科技有限公司 一种基于多能干细胞分化制备角质细胞的添加剂及方法
CN112980775B (zh) * 2021-03-19 2024-01-23 上海爱萨尔生物科技有限公司 一种基于多能干细胞分化制备角质细胞的培养液
CN113046300B (zh) * 2021-03-19 2024-08-06 上海爱萨尔生物科技有限公司 一种基于多能干细胞分化制备角质细胞的培养方法
JP7315184B2 (ja) * 2022-02-16 2023-07-26 株式会社コーセー 多能性幹細胞から表皮角化細胞への分化誘導方法

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FR2825370A1 (fr) * 2001-05-31 2002-12-06 Inst Nat Sante Rech Med Keratinocytes obtenus a partir de cellules souches embryonnaires de mammiferes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019004533A1 (ko) * 2017-06-30 2019-01-03 주식회사 스템랩 소변세포로부터 케라티노사이트 줄기세포로의 직접 역분화 방법 및 역분화된 케라티노사이트 줄기세포를 이용한 피부재생 촉진용 조성물의 제조방법

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BRPI0914422A2 (pt) 2017-03-21
JP2011525370A (ja) 2011-09-22
US20110165130A1 (en) 2011-07-07
EP2297299A1 (en) 2011-03-23
WO2009156398A1 (en) 2009-12-30
AU2009264336A1 (en) 2009-12-30
CN102186969A (zh) 2011-09-14

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