KR20100102632A - 경점막 흡수용 페닐에프린 약제학적 제형 및 조성물 - Google Patents
경점막 흡수용 페닐에프린 약제학적 제형 및 조성물 Download PDFInfo
- Publication number
- KR20100102632A KR20100102632A KR1020107014733A KR20107014733A KR20100102632A KR 20100102632 A KR20100102632 A KR 20100102632A KR 1020107014733 A KR1020107014733 A KR 1020107014733A KR 20107014733 A KR20107014733 A KR 20107014733A KR 20100102632 A KR20100102632 A KR 20100102632A
- Authority
- KR
- South Korea
- Prior art keywords
- phenylephrine
- composition
- pharmaceutically acceptable
- acceptable salt
- carrier device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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| US20190008759A1 (en) * | 2014-07-03 | 2019-01-10 | Darren Rubin | Safer and more effective methods of transmucosal delivery for raising blood pressure and stimulating the body |
| MA41689A (fr) * | 2014-10-15 | 2017-08-22 | Bioxcel Corp | Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| JP7653218B2 (ja) * | 2016-05-05 | 2025-03-28 | アクエスティブ セラピューティクス インコーポレイテッド | 送達増強エピネフリン組成物 |
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| US5025019A (en) * | 1984-04-09 | 1991-06-18 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
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| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
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| US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
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| ATE118345T1 (de) * | 1990-08-07 | 1995-03-15 | Pfizer | Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen. |
| US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
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| WO1998027971A1 (en) * | 1996-12-23 | 1998-07-02 | Michael Albert Kamm | Pharmaceutical composition for treating fecal incontinence and anal itch |
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| US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
| US6521254B2 (en) * | 1998-12-07 | 2003-02-18 | J-Med Pharmaceuticals, Inc. | Single-dose antihistamine/decongestant formulations for treating rhinitis |
| US6267986B1 (en) * | 1999-09-24 | 2001-07-31 | Ranbaxy Laboratories Limited | Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine |
| US6114346A (en) * | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
| AU2276801A (en) * | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
| WO2001045668A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
| US6955821B2 (en) * | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
| WO2001089476A1 (en) * | 2000-05-19 | 2001-11-29 | Npd Llc | Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements |
| WO2003009834A1 (en) * | 2000-08-17 | 2003-02-06 | Battey Alyce S | Oral delivery of pharmaceuticals via encapsulation |
| US20030236275A1 (en) * | 2002-06-20 | 2003-12-25 | Schering Corporation | Treatment methods of nasal congestion and nasal obstruction |
| US6585997B2 (en) * | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| WO2003019948A1 (en) * | 2001-08-27 | 2003-03-06 | Koninklijke Philips Electronics N.V. | Video data processor |
| US7163696B2 (en) * | 2001-10-11 | 2007-01-16 | Pfizer Inc. | Pharmaceutical formulations |
| US20030083354A1 (en) * | 2001-10-26 | 2003-05-01 | Pediamed Pharmaceuticals, Inc. | Phenylephrine tannate and pyrilamine tannate salts in pharmaceutical compositions |
| US20030114535A1 (en) * | 2001-12-14 | 2003-06-19 | Jame Fine Chemicals, Inc. | Dextrochlorpheniramine tannate |
| US20040122107A1 (en) * | 2002-09-13 | 2004-06-24 | Fine Jeffrey R | Method of alleviating barometric-induced symptoms in airline passengers |
| JP2004121962A (ja) * | 2002-10-01 | 2004-04-22 | National Institute Of Advanced Industrial & Technology | ナノバブルの利用方法及び装置 |
| US6979689B2 (en) * | 2002-12-20 | 2005-12-27 | Pediamed Pharmaceuticals, Inc. | Compositions and methods for treating upper respiratory congestion |
| US20040214215A1 (en) * | 2003-03-07 | 2004-10-28 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
| US20050152967A1 (en) * | 2003-03-28 | 2005-07-14 | Pfab, Lp | Dynamic variable release |
| US20050026890A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease |
| US20070219253A1 (en) * | 2003-09-17 | 2007-09-20 | Gul Balwani | Decongestant / antihistaminic / expectorant compositions |
| US20050095288A1 (en) * | 2003-11-03 | 2005-05-05 | Andrx Labs, Llc | Decongestant and expectorant tablets |
| US20050266032A1 (en) * | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| JP2007517806A (ja) * | 2004-01-15 | 2007-07-05 | オーラル バイオサイエンス ピーティーワイ. リミテッド | 口腔用麻酔ゲル |
| CA2590834A1 (en) * | 2004-12-13 | 2006-06-22 | Mcneil-Ppc, Inc. | Compositons and methods for stabilizing active pharmaceutical ingredients |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| ES2398960T3 (es) * | 2005-06-17 | 2013-03-22 | Aft Pharmaceuticals Limited | Composición farmacéutica novedosa y su uso en un método para el tratamiento de pacientes con cangestión mucosa de las vías respiratorias altas |
| US20070141147A1 (en) * | 2005-12-21 | 2007-06-21 | Auriga Laboratories, Inc. | Sequential release pharmaceutical formulations |
| US8940796B2 (en) * | 2006-02-21 | 2015-01-27 | Wyeth Llc | Phenylephrine liquid formulations |
| US20080014274A1 (en) * | 2006-07-14 | 2008-01-17 | Wyeth | Enhanced stability phenylephrine liquid compositions |
| US9005652B2 (en) * | 2006-07-25 | 2015-04-14 | Wyeth | Chewable tablet containing phenylephrine |
| US7378082B1 (en) * | 2007-11-05 | 2008-05-27 | Inspire Pharmaceuticals, Inc. | Method for treating allergic rhinitis without adverse effects |
-
2008
- 2008-12-03 PE PE2008002013A patent/PE20091084A1/es not_active Application Discontinuation
- 2008-12-04 CL CL2008003615A patent/CL2008003615A1/es unknown
- 2008-12-04 EP EP08858399A patent/EP2237767A1/en not_active Withdrawn
- 2008-12-04 KR KR1020107014733A patent/KR20100102632A/ko not_active Withdrawn
- 2008-12-04 AU AU2008335464A patent/AU2008335464A1/en not_active Abandoned
- 2008-12-04 MX MX2010006284A patent/MX2010006284A/es not_active Application Discontinuation
- 2008-12-04 RU RU2010127737/15A patent/RU2010127737A/ru not_active Application Discontinuation
- 2008-12-04 CN CN2008801263844A patent/CN101938991A/zh active Pending
- 2008-12-04 TW TW097147189A patent/TW200932208A/zh unknown
- 2008-12-04 US US12/328,429 patent/US20090280160A1/en not_active Abandoned
- 2008-12-04 AR ARP080105286A patent/AR069572A1/es not_active Application Discontinuation
- 2008-12-04 WO PCT/US2008/085523 patent/WO2009076165A1/en not_active Ceased
- 2008-12-04 CA CA2709208A patent/CA2709208A1/en not_active Abandoned
- 2008-12-04 JP JP2010537049A patent/JP2011506337A/ja not_active Withdrawn
- 2008-12-04 BR BRPI0820673-2A patent/BRPI0820673A2/pt not_active IP Right Cessation
-
2010
- 2010-07-01 ZA ZA2010/04654A patent/ZA201004654B/en unknown
- 2010-07-07 CO CO10082162A patent/CO6321221A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010127737A (ru) | 2012-01-20 |
| EP2237767A1 (en) | 2010-10-13 |
| JP2011506337A (ja) | 2011-03-03 |
| CA2709208A1 (en) | 2009-06-18 |
| AR069572A1 (es) | 2010-02-03 |
| ZA201004654B (en) | 2011-03-30 |
| TW200932208A (en) | 2009-08-01 |
| WO2009076165A1 (en) | 2009-06-18 |
| BRPI0820673A2 (pt) | 2015-06-16 |
| MX2010006284A (es) | 2010-09-07 |
| CL2008003615A1 (es) | 2009-10-16 |
| AU2008335464A1 (en) | 2009-06-18 |
| PE20091084A1 (es) | 2009-07-23 |
| US20090280160A1 (en) | 2009-11-12 |
| CN101938991A (zh) | 2011-01-05 |
| CO6321221A2 (es) | 2011-09-20 |
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