TW200932208A - Phenylephrine pharmaceutical formulations and compositions for transmucosal absorption - Google Patents

Info

Publication number

TW200932208A

TW200932208A TW097147189A TW97147189A TW200932208A TW 200932208 A TW200932208 A TW 200932208A TW 097147189 A TW097147189 A TW 097147189A TW 97147189 A TW97147189 A TW 97147189A TW 200932208 A TW200932208 A TW 200932208A

Authority

TW

Taiwan

Prior art keywords

composition

phenylephrine

release

pharmaceutically acceptable

doc

Prior art date

2007-12-07

Links

• Espacenet
• Global Dossier
• Discuss

• 229960001802 phenylephrine Drugs 0.000 title claims abstract description 153
• SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 title claims abstract description 153
• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 26
• 238000010521 absorption reaction Methods 0.000 title claims abstract description 22
• 239000000203 mixture Substances 0.000 claims abstract description 178
• 210000002200 mouth mucosa Anatomy 0.000 claims abstract description 33
• 150000003839 salts Chemical class 0.000 claims abstract description 32
• 230000009885 systemic effect Effects 0.000 claims abstract description 20
• 238000000034 method Methods 0.000 claims abstract description 19
• 241001465754 Metazoa Species 0.000 claims abstract description 7
• -1 hydroxyethyl methyl Chemical group 0.000 claims description 36
• 239000010410 layer Substances 0.000 claims description 27
• 239000000227 bioadhesive Substances 0.000 claims description 25
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
• 210000000214 mouth Anatomy 0.000 claims description 21
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
• 239000011859 microparticle Substances 0.000 claims description 20
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
• 239000007787 solid Substances 0.000 claims description 16
• 239000011159 matrix material Substances 0.000 claims description 15
• 239000003795 chemical substances by application Substances 0.000 claims description 14
• 210000004877 mucosa Anatomy 0.000 claims description 13
• 241000282414 Homo sapiens Species 0.000 claims description 12
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 12
• 238000012384 transportation and delivery Methods 0.000 claims description 12
• 239000002253 acid Substances 0.000 claims description 11
• UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 claims description 11
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 10
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• 210000005178 buccal mucosa Anatomy 0.000 claims description 10
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• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
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• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
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• UFLGIAIHIAPJJC-UHFFFAOYSA-N Tripelennamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 UFLGIAIHIAPJJC-UHFFFAOYSA-N 0.000 claims description 2
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