KR20100049698A - 바이사이클 피리미디논 및 그 용도 - Google Patents

바이사이클 피리미디논 및 그 용도 Download PDF

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Publication number
KR20100049698A
KR20100049698A KR1020107008711A KR20107008711A KR20100049698A KR 20100049698 A KR20100049698 A KR 20100049698A KR 1020107008711 A KR1020107008711 A KR 1020107008711A KR 20107008711 A KR20107008711 A KR 20107008711A KR 20100049698 A KR20100049698 A KR 20100049698A
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KR
South Korea
Prior art keywords
alkyl
compound
hydroxy
oxo
pyrimidine
Prior art date
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Ceased
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KR1020107008711A
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English (en)
Korean (ko)
Inventor
에릭 데일 존스
조나단 앨런 빅터 코츠
데이비드 이안 로즈
존 조셉 데드맨
니콜라스 앤드류 밴드그라프
리사 제인 윈필드
니라낫 티엔통
윌리암 이싸
네일 초이
캐서린 맥팔레인
Original Assignee
아벡사 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from AU2006907283A external-priority patent/AU2006907283A0/en
Application filed by 아벡사 리미티드 filed Critical 아벡사 리미티드
Publication of KR20100049698A publication Critical patent/KR20100049698A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020107008711A 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도 Ceased KR20100049698A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
AU2006907283A AU2006907283A0 (en) 2006-12-22 Bicyclic pyrimidinones and uses thereof
AU2006907283 2006-12-22
AU2007902479 2007-05-09
AU2007902479A AU2007902479A0 (en) 2007-05-09 Bicyclic pyrimidinones and uses thereof (2)
AU2007903401A AU2007903401A0 (en) 2007-06-25 Bicyclic pyrimidinodes and uses thereof (3)
AU2007903401 2007-06-25
AU2007904114 2007-07-31
AU2007904114A AU2007904114A0 (en) 2007-07-31 Bicyclic pyrimidinones and uses thereof (4)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020097014886A Division KR20090097194A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도

Publications (1)

Publication Number Publication Date
KR20100049698A true KR20100049698A (ko) 2010-05-12

Family

ID=39562030

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020107008711A Ceased KR20100049698A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도
KR1020097014886A Ceased KR20090097194A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020097014886A Ceased KR20090097194A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도

Country Status (15)

Country Link
US (3) US8143268B2 (cg-RX-API-DMAC7.html)
EP (2) EP2114903B1 (cg-RX-API-DMAC7.html)
JP (2) JP5208962B2 (cg-RX-API-DMAC7.html)
KR (2) KR20100049698A (cg-RX-API-DMAC7.html)
CN (1) CN101880280B (cg-RX-API-DMAC7.html)
AR (2) AR064517A1 (cg-RX-API-DMAC7.html)
AT (1) ATE496898T1 (cg-RX-API-DMAC7.html)
AU (2) AU2007336703B9 (cg-RX-API-DMAC7.html)
BR (2) BRPI0720564A2 (cg-RX-API-DMAC7.html)
CA (1) CA2673183C (cg-RX-API-DMAC7.html)
DE (1) DE602007012308D1 (cg-RX-API-DMAC7.html)
DK (1) DK2114903T3 (cg-RX-API-DMAC7.html)
MX (1) MX2009006764A (cg-RX-API-DMAC7.html)
NZ (1) NZ577491A (cg-RX-API-DMAC7.html)
WO (1) WO2008077188A1 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011000149A (es) * 2008-07-02 2011-02-24 Avexa Ltd Compuestos que tienen propiedades antivirales.
WO2010000030A1 (en) * 2008-07-02 2010-01-07 Avexa Limited Thiazopyrimidinones and uses thereof
US8431581B2 (en) * 2008-07-02 2013-04-30 Avexa Limited Imidazopyrimidines and uses thereof
CN102336751A (zh) * 2010-07-16 2012-02-01 爱维艾珂瑟有限公司 新型抗病毒剂
ES2821394T3 (es) 2013-09-12 2021-04-26 Alios Biopharma Inc Compuestos de 7,8-dihidro-3H-pirazino[1,2-b]piridazin-3,5(6H)-diona y usos de los mismos
EP3082820B1 (en) 2013-12-19 2022-07-20 PTC Therapeutics, Inc. Methods for modulating the amount of rna transcripts
CA2979216A1 (en) 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
MX391850B (es) 2015-12-10 2025-03-19 Ptc Therapeutics Inc Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington
CA3043755A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc. Methods for modulating rna splicing
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
BR112019026508A2 (pt) 2017-06-14 2020-07-14 Ptc Therapeutics, Inc. métodos para modificar o splicing do rna
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
WO2019005980A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
AU2019243048A1 (en) 2018-03-27 2020-10-15 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
BR112020026534A2 (pt) 2018-06-27 2021-03-23 Ptc Therapeutics, Inc. Compostos de heteroarila para o tratamento da doença de huntington
MX2020014098A (es) 2018-06-27 2021-05-27 Ptc Therapeutics Inc Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington.
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
CA3162166A1 (en) 2019-12-02 2021-06-10 Storm Therapeutics Limited Polyheterocyclic compounds as mettl3 inhibitors
US12070445B2 (en) * 2021-08-27 2024-08-27 Wisconsin Alumni Research Foundation System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60107586T2 (de) 2000-09-20 2005-10-06 Schering Corp. Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten
SI1564210T1 (sl) 2002-11-20 2010-01-29 Japan Tobacco Inc 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
JP4915734B2 (ja) 2003-12-18 2012-04-11 テイボテク・フアーマシユーチカルズ 呼吸器合胞体ウイルス複製阻害剤としてのアミノベンズイミダゾールおよびベンズイミダゾール
TW200526635A (en) * 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
CN101072758B (zh) 2004-10-12 2013-07-31 阿斯利康(瑞典)有限公司 喹唑啉衍生物
JP5116660B2 (ja) * 2005-03-31 2013-01-09 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ Ｈｉｖインテグラーゼ阻害剤
US7939537B2 (en) * 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors

Also Published As

Publication number Publication date
US8859563B2 (en) 2014-10-14
JP5208962B2 (ja) 2013-06-12
ATE496898T1 (de) 2011-02-15
WO2008077188A1 (en) 2008-07-03
CN101880280A (zh) 2010-11-10
DK2114903T3 (da) 2011-04-18
KR20090097194A (ko) 2009-09-15
AR064517A1 (es) 2009-04-08
CA2673183A1 (en) 2008-07-03
US8207334B2 (en) 2012-06-26
HK1131615A1 (en) 2010-01-29
DE602007012308D1 (de) 2011-03-10
JP2010222370A (ja) 2010-10-07
EP2114903A4 (en) 2009-12-30
AU2007336703B2 (en) 2012-04-12
EP2114903B1 (en) 2011-01-26
AU2010201160A1 (en) 2010-04-15
US20110009366A1 (en) 2011-01-13
EP2269992A1 (en) 2011-01-05
AU2007336703A1 (en) 2008-07-03
CN101880280B (zh) 2014-07-16
US8143268B2 (en) 2012-03-27
US20120232035A1 (en) 2012-09-13
NZ577491A (en) 2011-06-30
JP2010513322A (ja) 2010-04-30
BRPI0720564A2 (pt) 2011-08-16
US20100168063A1 (en) 2010-07-01
EP2114903A1 (en) 2009-11-11
CA2673183C (en) 2014-06-10
AU2007336703B9 (en) 2014-03-27
BRPI0722411A2 (pt) 2012-06-05
MX2009006764A (es) 2009-11-26
AR077043A2 (es) 2011-07-27

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