KR20100030335A - 생분자 검출 장치 및 검출 방법 - Google Patents
생분자 검출 장치 및 검출 방법 Download PDFInfo
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- KR20100030335A KR20100030335A KR1020080089237A KR20080089237A KR20100030335A KR 20100030335 A KR20100030335 A KR 20100030335A KR 1020080089237 A KR1020080089237 A KR 1020080089237A KR 20080089237 A KR20080089237 A KR 20080089237A KR 20100030335 A KR20100030335 A KR 20100030335A
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- G01N27/07—Construction of measuring vessels; Electrodes therefor
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- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
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- B01L2200/143—Quality control, feedback systems
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- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/00—Additional constructional details
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- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/163—Biocompatibility
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Abstract
Description
Claims (20)
- 기판, 상기 기판에 서로 이격되어 배치된 소오스 및 드레인 전극, 상기 소오스 및 드레인 전극 사이의 채널 영역 및 상기 채널 영역에 고정된 프로브 분자를 포함하는 FET;상기 프로브 분자가 고정된 상기 FET의 채널 영역으로, 저이온 농도의 기준 버퍼 용액 및 타겟 분자를 포함하는 고이온 농도의 반응 용액을 선택적으로 공급하는 미세 유체 공급부; 및상기 프로브 분자가 고정된 상기 FET의 채널 영역에서의 제 1 전류 값과, 상기 고이온 농도의 반응 용액에서 결합된 상기 프로브 분자와 상기 타겟 분자가 고정된 상기 FET의 채널 영역에서의 제 2 전류 값을 측정하여 상기 타겟 분자를 검출하는 생분자 검출부를 포함하는 생분자 검출 장치.
- 제 1 항에 있어서,상기 제 1 및 제 2 전류 값은, 상기 FET의 채널 영역에 상기 저이온 농도의 기준 버퍼 용액을 공급하여 측정된 생분자 검출 장치.
- 제 2 항에 있어서,상기 생분자 검출부는, 상기 제 1 전류 값과, 상기 제 2 전류 값의 차이에 따라 상기 타겟 분자를 검출하는 생분자 검출 장치.
- 제 1 항에 있어서,상기 미세 유체 공급부는 상기 저이온 농도의 기준 버퍼 용액, 상기 타겟 분자를 포함하는 고이온 농도의 반응 용액 및 안정화 용액을 선택적으로 공급하는 생분자 검출 장치.
- 제 4 항에 있어서,상기 고이온 농도의 반응 용액은, 상기 타겟 분자를 포함하는 혈액, 혈청, 혈장, 소변, 타액, 또는 고이온 농도 용액인 생분자 검출 장치.
- 제 4 항에 있어서,상기 안정화 용액은, 상기 고이온 농도의 반응 용액과 비슷한 이온 세기나 이온을 갖는 버퍼 용액인 생분자 검출 장치.
- 제 4 항에 있어서,상기 저이온 농도의 기준 버퍼 용액, 상기 타겟 분자를 포함하는 고이온 농도의 반응 용액 및 상기 안정화 용액의 공급 시간을 제어하는 제어부를 더 포함하는 생분자 검출 장치.
- 제 1 항에 있어서,상기 미세 유체 공급부는 상기 각각의 용액들을 공급하는 복수 개의 유체 채널들 및 상기 복수 개의 유체 채널들과 상기 FET의 채널 영역을 연결하는 합류 채널을 포함하는 생분자 검출 장치.
- 제 1 항에 있어서,상기 FET의 채널 영역은 불순물이 도핑된 도핑층, 반도체층, 산화물층, 화합물층, 탄소 나노 튜브(CNT) 또는 반도체 나노 와이어를 포함하는 생분자 검출 장치.
- 기판, 상기 기판에 서로 이격되어 배치된 소오스 및 드레인 전극, 상기 소오스 및 드레인 전극 사이의 채널 영역 및 상기 채널 영역에 고정된 프로브 분자를 포함하는 FET를 제공하는 단계;상기 프로브 분자가 고정된 상기 채널 영역으로 저이온 농도의 기준 버퍼 용액을 제공하고, 상기 채널 영역에 흐르는 제 1 전류 값을 측정하는 단계;상기 프로브 분자가 고정된 상기 채널 영역으로 타겟 분자를 포함하는 고이온 농도의 반응 용액을 제공하여, 상기 프로브 분자와 상기 타겟 분자를 결합시키는 단계;상기 프로브 분자와 상기 타겟 분자가 결합된 상기 채널 영역으로 상기 저이온 농도의 기준 버퍼 용액을 공급하여, 반응이 끝난 후의 상기 고이온 농도의 반응 용액을 제거하고, 상기 채널 영역에 흐르는 저이온 농도에서의 제 2 전류 값을 측정하는 단계; 및상기 제 1 및 제 2 전류 값들 사이의 차이를 이용하여, 상기 타겟 분자를 검출하는 단계를 포함하는 생분자 검출 방법.
- 제 10 항에 있어서, 제 1 전류 값을 측정하기 전,저이온 농도의 기준 버퍼 용액을 공급하는 단계 및 안정화 버퍼 용액을 공급하는 단계를 더 포함하는 생분자 검출 방법.
- 제 11 항에 있어서,상기 저이온 농도의 기준 버퍼 용액을 공급하는 단계 및 상기 안정화 버퍼 용액을 공급하는 단계를 1회 이상 번갈아 반복하는 생분자 검출 방법.
- 제 11 항에 있어서,상기 고이온 농도의 반응 용액은 타겟 분자를 포함하는 혈액, 혈청, 혈장, 소변, 타액, 고이온 농도의 용액인 생분자 검출 방법.
- 제 11 항에 있어서,상기 안정화 용액은 상기 고이온 농도의 반응 용액과 비슷한 이온 세기나 이온을 갖는 생분자 검출 방법.
- 제 11 항에 있어서,상기 채널 영역의 제 1 또는 제 2 전류 값을 측정하는 것은, 상기 저이온 농도의 기준 버퍼 용액을 공급 후 상기 채널 영역의 포화 전류를 측정하는 생분자 검출 방법.
- 제 10 항에 있어서,상기 FET의 채널 영역은 불순물이 도핑된 도핑층, 반도체층, 산화물층, 화합물층, 금속층, 탄소 나노 튜브(CNT) 또는 반도체 나노 와이어를 포함하는 생분자 검출 방법.
- 제 10 항에 있어서,상기 프로브 분자 또는 타겟 분자는 핵산, 세포, 바이러스, 단백질, 유기 분자, 무기 분자 혹은 바이오 분자로 이루어진 군으로부터 선택하는 생분자 검출 방법.
- 제 17 항에 있어서,상기 핵산은 DNA, RNA, PNA, LNA 및 그들의 혼성체로 이루어진 군으로부터 선택하는 생분자 검출 방법.
- 제 17 항에 있어서,상기 단백질은 효소, 기질, 항원, 항체, 리간드, 압타머 및 수용체로 이루어진 군으로부터 선택하는 생분자 검출 방법.
- 제 17 항에 있어서,상기 프로브 분자와 상기 타겟 분자와의 결합은, 핵산 혼성화, 항원-항체 반응 또는 효소 결합 반응을 포함하는 생분자 검출 방법.
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KR1020080089237A KR101026468B1 (ko) | 2008-09-10 | 2008-09-10 | 생분자 검출 장치 및 검출 방법 |
PCT/KR2008/006843 WO2010030057A1 (en) | 2008-09-10 | 2008-11-20 | Apparatus and method for detecting biomolecules |
US13/062,146 US8529750B2 (en) | 2008-09-10 | 2008-11-20 | Apparatus and method for detecting biomolecules |
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KR20120060937A (ko) * | 2010-09-16 | 2012-06-12 | 한국전자통신연구원 | 전계효과 트랜지스터를 이용한 미량 분석 방법 및 미량 분석 시스템 |
KR20190084420A (ko) * | 2018-01-08 | 2019-07-17 | 주식회사 지앤시바이오 | 생분자 검출장치 |
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KR20120060937A (ko) * | 2010-09-16 | 2012-06-12 | 한국전자통신연구원 | 전계효과 트랜지스터를 이용한 미량 분석 방법 및 미량 분석 시스템 |
KR20190084420A (ko) * | 2018-01-08 | 2019-07-17 | 주식회사 지앤시바이오 | 생분자 검출장치 |
CN112881493A (zh) * | 2020-11-05 | 2021-06-01 | 北京大学 | 场效应晶体管型生物传感器件及生物分子检测方法 |
CN112881493B (zh) * | 2020-11-05 | 2023-02-17 | 北京大学 | 场效应晶体管型生物传感器件及生物分子检测方法 |
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