KR20090065534A - Ｎ-(2-히드록시에틸)-ｎ-메틸-4-(퀴놀린-8-일(1-(티아졸-4-일메틸)피페리딘-4-일리덴)메틸)벤즈아미드, 그의 제조 방법, 및 통증, 불안증 및 우울증의 치료에 있어서의 그의 용도 - Google Patents

Ｎ-(2-히드록시에틸)-ｎ-메틸-4-(퀴놀린-8-일(1-(티아졸-4-일메틸)피페리딘-4-일리덴)메틸)벤즈아미드, 그의 제조 방법, 및 통증, 불안증 및 우울증의 치료에 있어서의 그의 용도 Download PDF

Info

Publication number
KR20090065534A
KR20090065534A KR1020097007893A KR20097007893A KR20090065534A KR 20090065534 A KR20090065534 A KR 20090065534A KR 1020097007893 A KR1020097007893 A KR 1020097007893A KR 20097007893 A KR20097007893 A KR 20097007893A KR 20090065534 A KR20090065534 A KR 20090065534A
Authority
KR
South Korea
Prior art keywords
methyl
quinolin
ylidene
benzamide
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097007893A
Other languages
English (en)
Korean (ko)
Inventor
칸 부이
캐씨 단츠맨
글렌 에른스트
발레리 호에쉬
토마스 허드직
메간 머피 킹
지 리우
징보 얀
Original Assignee
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20090065534A publication Critical patent/KR20090065534A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020097007893A 2006-10-20 2007-10-19 Ｎ-(2-히드록시에틸)-ｎ-메틸-4-(퀴놀린-8-일(1-(티아졸-4-일메틸)피페리딘-4-일리덴)메틸)벤즈아미드, 그의 제조 방법, 및 통증, 불안증 및 우울증의 치료에 있어서의 그의 용도 Ceased KR20090065534A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86232706P 2006-10-20 2006-10-20
US60/862,327 2006-10-20

Publications (1)

Publication Number Publication Date
KR20090065534A true KR20090065534A (ko) 2009-06-22

Family

ID=39314285

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097007893A Ceased KR20090065534A (ko) 2006-10-20 2007-10-19 Ｎ-(2-히드록시에틸)-ｎ-메틸-4-(퀴놀린-8-일(1-(티아졸-4-일메틸)피페리딘-4-일리덴)메틸)벤즈아미드, 그의 제조 방법, 및 통증, 불안증 및 우울증의 치료에 있어서의 그의 용도

Country Status (32)

Country Link
US (2) US7659286B2 (enExample)
EP (1) EP2079735B1 (enExample)
JP (1) JP4668346B2 (enExample)
KR (1) KR20090065534A (enExample)
CN (1) CN101528739B (enExample)
AR (1) AR063345A1 (enExample)
AT (1) ATE543818T1 (enExample)
AU (2) AU2007313515B2 (enExample)
BR (1) BRPI0717631A2 (enExample)
CA (1) CA2667041C (enExample)
CL (1) CL2007003009A1 (enExample)
CO (1) CO6180450A2 (enExample)
CY (1) CY1112718T1 (enExample)
DK (1) DK2079735T3 (enExample)
ES (1) ES2379519T3 (enExample)
HR (1) HRP20120344T1 (enExample)
IL (1) IL197876A0 (enExample)
MX (1) MX2009003974A (enExample)
MY (1) MY148880A (enExample)
NO (1) NO20091969L (enExample)
NZ (1) NZ577060A (enExample)
PE (2) PE20080892A1 (enExample)
PL (1) PL2079735T3 (enExample)
PT (1) PT2079735E (enExample)
RS (1) RS52260B (enExample)
RU (1) RU2454414C2 (enExample)
SA (1) SA07280549B1 (enExample)
SI (1) SI2079735T1 (enExample)
TW (1) TW200826939A (enExample)
UA (1) UA97648C2 (enExample)
UY (1) UY30652A1 (enExample)
WO (1) WO2008048171A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1641757A1 (en) * 2003-05-16 2006-04-05 AstraZeneca AB Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
MY148880A (en) 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
BRPI0912756A2 (pt) * 2008-05-20 2015-10-13 Astrazeneca Ab método para tratar transtorno depressivo maior ansioso em um animal de sangue quente, uso de um composto, composto, e, composição farmacêutica
CN101906078B (zh) * 2009-06-08 2012-02-01 上海威智医药科技有限公司 噻唑衍生物的合成方法
CN102106807B (zh) * 2009-12-29 2013-03-27 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
WO2016099393A1 (en) * 2014-12-19 2016-06-23 Pharmnovo Ab Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
EP3853435B1 (en) 2018-09-21 2024-08-21 Garland Industries, Inc. Helical hardbanding

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2009799A (en) * 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
US6492375B2 (en) * 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
AU784848B2 (en) 1999-12-20 2006-07-06 Zalicus Pharmaceuticals Ltd. Partially saturated calcium channel blockers
CN1426411A (zh) * 2000-03-03 2003-06-25 奥索-麦克尼尔药品公司 3－(二芳基亚甲基)－8－氮杂双环[3.2.1]辛烷衍生物
SE0001208D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101768D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
US20040204404A1 (en) * 2002-09-30 2004-10-14 Robert Zelle Human N-type calcium channel blockers
SE0300105D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0301444D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
EP1641757A1 (en) * 2003-05-16 2006-04-05 AstraZeneca AB Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301445D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301441D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400025D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
MY148880A (en) * 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression

Also Published As

Publication number Publication date
CY1112718T1 (el) 2016-02-10
TW200826939A (en) 2008-07-01
EP2079735A4 (en) 2010-12-29
EP2079735A1 (en) 2009-07-22
CL2007003009A1 (es) 2008-06-06
ES2379519T3 (es) 2012-04-26
EP2079735B1 (en) 2012-02-01
RU2009111337A (ru) 2010-11-27
HK1131556A1 (en) 2010-01-29
IL197876A0 (en) 2009-12-24
CA2667041C (en) 2011-09-06
ATE543818T1 (de) 2012-02-15
CA2667041A1 (en) 2008-04-24
RU2454414C2 (ru) 2012-06-27
AR063345A1 (es) 2009-01-21
SA07280549B1 (ar) 2010-09-29
AU2007313515A1 (en) 2008-04-24
PL2079735T3 (pl) 2012-07-31
CN101528739B (zh) 2011-11-30
MX2009003974A (es) 2009-04-27
RS52260B (sr) 2012-10-31
PE20140634A1 (es) 2014-06-19
JP2010506910A (ja) 2010-03-04
PT2079735E (pt) 2012-05-07
UY30652A1 (es) 2008-05-31
US20080182875A1 (en) 2008-07-31
MY148880A (en) 2013-06-14
US20100160374A1 (en) 2010-06-24
BRPI0717631A2 (pt) 2013-10-29
WO2008048171A1 (en) 2008-04-24
SI2079735T1 (sl) 2012-05-31
CO6180450A2 (es) 2010-07-19
UA97648C2 (ru) 2012-03-12
NZ577060A (en) 2011-01-28
US7659286B2 (en) 2010-02-09
HRP20120344T1 (hr) 2012-05-31
NO20091969L (no) 2009-05-20
AU2010226996A1 (en) 2010-10-28
JP4668346B2 (ja) 2011-04-13
DK2079735T3 (da) 2012-05-21
PE20080892A1 (es) 2008-09-11
US7977355B2 (en) 2011-07-12
AU2007313515B2 (en) 2010-11-25
CN101528739A (zh) 2009-09-09

Similar Documents

Publication Publication Date Title
JP4488891B2 (ja) Ｎ−［フェニル（ピペリジン−２−イル）メチル］ベンズアミド誘導体、その製造法、およびその治療用途
CN1185228C (zh) 治疗疼痛的羟苯基－亚哌啶－4－基－甲基－苯甲酰胺衍生物
KR102810105B1 (ko) 치료 화합물
KR20090065534A (ko) Ｎ-(2-히드록시에틸)-ｎ-메틸-4-(퀴놀린-8-일(1-(티아졸-4-일메틸)피페리딘-4-일리덴)메틸)벤즈아미드, 그의 제조 방법, 및 통증, 불안증 및 우울증의 치료에 있어서의 그의 용도
EP1870405A1 (en) Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
JP2007509140A (ja) ５−ＨＴ６受容体に関連する疾患の処置において有用な新規テトラヒドロスピロ｛ピペリジン−２，７’−ピロロ［３，２−ｂ］ピリジン誘導体および新規インドール誘導体
KR20030063455A (ko) 정신의학적 및 신경학적 장애의 치료에 유용한 3-인돌린유도체
TW200811179A (en) mGluR5 modulators VI
EP1789410B1 (en) Methylene dipiperidine derivatives
RU2526055C2 (ru) Терапевтические агенты 713
CN1993338B (zh) 二芳基甲基哌嗪衍生物及其制备方法和用途
US10160745B2 (en) Piperidine and azepine derivatives as prokineticin receptor modulators
HK1131556B (en) N- (2 -hydroxyethyl) -n-methyl- 4- (quinolin- 8-yl (1- (thiazol-4- ylmethyl) piperidin- 4 -ylidene) methyl) benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
EP3074385B1 (en) Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions
JP2011512407A (ja) 化合物（Ｒ）−Ｎ＊６＊−エチル−６，７−ジヒドロ−５Ｈ−インデノ（５，６−ｄ）チアゾール−２，６−ジアミン及びその抗精神病薬としての使用
UA77672C2 (en) 4-(phenyl-piperazinyl-methyl)-benzamide derivatives and use thereof for the treatment of pain, anxiety or gastrointestinal disorders, a process for preparation thereof and a pharmaceutical composition based thereon
JP2002138080A (ja) ピペリジン化合物、その製造法および用途

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20090417

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20121019

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20140102

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20140901

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20140102

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I