PE20080892A1 - N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida - Google Patents

N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida

Info

Publication number
PE20080892A1
PE20080892A1 PE2007001423A PE2007001423A PE20080892A1 PE 20080892 A1 PE20080892 A1 PE 20080892A1 PE 2007001423 A PE2007001423 A PE 2007001423A PE 2007001423 A PE2007001423 A PE 2007001423A PE 20080892 A1 PE20080892 A1 PE 20080892A1
Authority
PE
Peru
Prior art keywords
methyl
iliden
quinolin
benzamide
piperidin
Prior art date
Application number
PE2007001423A
Other languages
English (en)
Inventor
Khanh Bui
Cathy Dantzman
Glen Ernst
Valerie Hoesch
Thomas Hudzik
Megan Murphy King
Jie Liu
Jingbo Yan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20080892A1 publication Critical patent/PE20080892A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UN COMPUESTO QUE ES N-(2-HIDROXIETIL)-N-METIL-4-(QUINOLIN-8-IL(1-(TIAZOL-4-ILMETIL)PIPERIDIN-4-ILIDEN)METIL)BENZAMIDA Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHO COMPUESTO Y ADEMAS VEHICULOS INERTES COMO CARBONATO O ESTEARATO DE MAGNESIO, TALCO, LACTOSA, CARBOXIMETILCELULOSA, CERAS DE BAJO PUNTO DE FUSION, AGUA, PROPILENGLICOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: A) HACER REACCIONAR 4-(BROMO-{4-[(2-HIDROXI-ETIL)-METIL-CARBAMOIL]-FENIL}-METILEN)-PIPERIDINA PROTEGIDA CON ACIDO 8-QUINOLINBORICO PARA OBTENER N-(2-HIDROXIETIL)-N-METIL-4-(PIPERIDIN-4-ILIDEN-QUINOLIN-8-IL-METIL)BENZAMIDA PROTEGIDA, EL CUAL ES DESPROTEGIDO POSTERIORMENTE; B) HACER REACCIONAR N-(2-HIDROXIETIL)-N-METIL-4-(PIPERIDIN-4-ILIDEN-QUINOLIN-8-IL-METIL)BENZAMIDA CON TIAZOL-4-CARBALDEHIDO PARA FORMAR N-(2-HIDROXIETIL)-N-METIL-4-(QUINOLIN-8-IL(1-(TIAZOL-4-ILMETIL)PIPERIDIN-4-ILIDEN)METIL)BENZAMIDA. DICHO COMPUESTO ES AGONISTA DEL RECEPTOR OPIODE SIENDO UTIL EN LA TERAPIA DEL DOLOR, ANSIEDAD, DEPRESION, ENFERMEDAD DE PARKINSON
PE2007001423A 2006-10-20 2007-10-19 N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida PE20080892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86232706P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
PE20080892A1 true PE20080892A1 (es) 2008-09-11

Family

ID=39314285

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2007001423A PE20080892A1 (es) 2006-10-20 2007-10-19 N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida
PE2012001060A PE20140634A1 (es) 2006-10-20 2012-07-24 N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2012001060A PE20140634A1 (es) 2006-10-20 2012-07-24 N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida

Country Status (33)

Country Link
US (2) US7659286B2 (es)
EP (1) EP2079735B1 (es)
JP (1) JP4668346B2 (es)
KR (1) KR20090065534A (es)
CN (1) CN101528739B (es)
AR (1) AR063345A1 (es)
AT (1) ATE543818T1 (es)
AU (2) AU2007313515B2 (es)
BR (1) BRPI0717631A2 (es)
CA (1) CA2667041C (es)
CL (1) CL2007003009A1 (es)
CO (1) CO6180450A2 (es)
CY (1) CY1112718T1 (es)
DK (1) DK2079735T3 (es)
ES (1) ES2379519T3 (es)
HK (1) HK1131556A1 (es)
HR (1) HRP20120344T1 (es)
IL (1) IL197876A0 (es)
MX (1) MX2009003974A (es)
MY (1) MY148880A (es)
NO (1) NO20091969L (es)
NZ (1) NZ577060A (es)
PE (2) PE20080892A1 (es)
PL (1) PL2079735T3 (es)
PT (1) PT2079735E (es)
RS (1) RS52260B (es)
RU (1) RU2454414C2 (es)
SA (1) SA07280549B1 (es)
SI (1) SI2079735T1 (es)
TW (1) TW200826939A (es)
UA (1) UA97648C2 (es)
UY (1) UY30652A1 (es)
WO (1) WO2008048171A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007503457A (ja) * 2003-05-16 2007-02-22 アストラゼネカ・アクチエボラーグ ジアリールメチリデンピペリジン誘導体、その製造およびその使用
MY148880A (en) 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
NZ590041A (en) * 2008-05-20 2012-11-30 Astrazeneca Ab Method of treating anxious major depressive disorder
CN101906078B (zh) * 2009-06-08 2012-02-01 上海威智医药科技有限公司 噻唑衍生物的合成方法
CN102106807B (zh) * 2009-12-29 2013-03-27 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
WO2020061165A1 (en) 2018-09-21 2020-03-26 Garland Industries, Inc. Helical hardbanding

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US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
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AU2001241676A1 (en) * 2000-03-03 2001-09-17 Ortho-Mcneil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives
SE0001208D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101768D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
US20040204404A1 (en) * 2002-09-30 2004-10-14 Robert Zelle Human N-type calcium channel blockers
SE0300105D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0301445D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301444D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301441D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
JP2007503457A (ja) * 2003-05-16 2007-02-22 アストラゼネカ・アクチエボラーグ ジアリールメチリデンピペリジン誘導体、その製造およびその使用
SE0400025D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
MY148880A (en) 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression

Also Published As

Publication number Publication date
HRP20120344T1 (hr) 2012-05-31
MX2009003974A (es) 2009-04-27
RS52260B (en) 2012-10-31
PT2079735E (pt) 2012-05-07
JP4668346B2 (ja) 2011-04-13
PE20140634A1 (es) 2014-06-19
ES2379519T3 (es) 2012-04-26
EP2079735A1 (en) 2009-07-22
CY1112718T1 (el) 2016-02-10
AR063345A1 (es) 2009-01-21
ATE543818T1 (de) 2012-02-15
SI2079735T1 (sl) 2012-05-31
AU2007313515B2 (en) 2010-11-25
CA2667041A1 (en) 2008-04-24
US7659286B2 (en) 2010-02-09
RU2009111337A (ru) 2010-11-27
SA07280549B1 (ar) 2010-09-29
JP2010506910A (ja) 2010-03-04
CN101528739A (zh) 2009-09-09
AU2010226996A1 (en) 2010-10-28
NO20091969L (no) 2009-05-20
RU2454414C2 (ru) 2012-06-27
NZ577060A (en) 2011-01-28
EP2079735A4 (en) 2010-12-29
AU2007313515A1 (en) 2008-04-24
BRPI0717631A2 (pt) 2013-10-29
IL197876A0 (en) 2009-12-24
US7977355B2 (en) 2011-07-12
CN101528739B (zh) 2011-11-30
UA97648C2 (ru) 2012-03-12
UY30652A1 (es) 2008-05-31
KR20090065534A (ko) 2009-06-22
DK2079735T3 (da) 2012-05-21
US20080182875A1 (en) 2008-07-31
EP2079735B1 (en) 2012-02-01
CA2667041C (en) 2011-09-06
CL2007003009A1 (es) 2008-06-06
PL2079735T3 (pl) 2012-07-31
WO2008048171A1 (en) 2008-04-24
US20100160374A1 (en) 2010-06-24
MY148880A (en) 2013-06-14
HK1131556A1 (es) 2010-01-29
CO6180450A2 (es) 2010-07-19
TW200826939A (en) 2008-07-01

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