CO6180450A2 - N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazn-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-ilideno)metil)benzamida eol-4-ilmetil)piperidin-4-ilideno)metil)benzamida el proceso para su sintesis asi como su uso para ell proceso para su sintesis asi como su uso para el tratamiento del dolor la ansiedad y la depresion tratamiento del dolor la ansiedad y la depresion - Google Patents

N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazn-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-ilideno)metil)benzamida eol-4-ilmetil)piperidin-4-ilideno)metil)benzamida el proceso para su sintesis asi como su uso para ell proceso para su sintesis asi como su uso para el tratamiento del dolor la ansiedad y la depresion tratamiento del dolor la ansiedad y la depresion

Info

Publication number
CO6180450A2
CO6180450A2 CO0903310009033100A CO09033100A CO6180450A2 CO 6180450 A2 CO6180450 A2 CO 6180450A2 CO 0903310009033100 A CO0903310009033100 A CO 0903310009033100A CO 09033100 A CO09033100 A CO 09033100A CO 6180450 A2 CO6180450 A2 CO 6180450A2
Authority
CO
Colombia
Prior art keywords
methyl
hydroxyethyl
piperidin
benzamide
ylmethyl
Prior art date
Application number
CO0903310009033100A
Other languages
English (en)
Spanish (es)
Inventor
Khanh Bui
Cathy Dantzman
Jingbo Yan
Jie Liu
Megan Murphy King
Thomas Hudzik
Valerie Hoesch
Glen Ernest
Original Assignee
Astrazeneca A B Astrazeneca A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca A B Astrazeneca A filed Critical Astrazeneca A B Astrazeneca A
Publication of CO6180450A2 publication Critical patent/CO6180450A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CO0903310009033100A 2006-10-20 2009-03-31 N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazn-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-ilideno)metil)benzamida eol-4-ilmetil)piperidin-4-ilideno)metil)benzamida el proceso para su sintesis asi como su uso para ell proceso para su sintesis asi como su uso para el tratamiento del dolor la ansiedad y la depresion tratamiento del dolor la ansiedad y la depresion CO6180450A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86232706P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
CO6180450A2 true CO6180450A2 (es) 2010-07-19

Family

ID=39314285

Family Applications (1)

Application Number Title Priority Date Filing Date
CO0903310009033100A CO6180450A2 (es) 2006-10-20 2009-03-31 N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazn-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-ilideno)metil)benzamida eol-4-ilmetil)piperidin-4-ilideno)metil)benzamida el proceso para su sintesis asi como su uso para ell proceso para su sintesis asi como su uso para el tratamiento del dolor la ansiedad y la depresion tratamiento del dolor la ansiedad y la depresion

Country Status (32)

Country Link
US (2) US7659286B2 (enExample)
EP (1) EP2079735B1 (enExample)
JP (1) JP4668346B2 (enExample)
KR (1) KR20090065534A (enExample)
CN (1) CN101528739B (enExample)
AR (1) AR063345A1 (enExample)
AT (1) ATE543818T1 (enExample)
AU (2) AU2007313515B2 (enExample)
BR (1) BRPI0717631A2 (enExample)
CA (1) CA2667041C (enExample)
CL (1) CL2007003009A1 (enExample)
CO (1) CO6180450A2 (enExample)
CY (1) CY1112718T1 (enExample)
DK (1) DK2079735T3 (enExample)
ES (1) ES2379519T3 (enExample)
HR (1) HRP20120344T1 (enExample)
IL (1) IL197876A0 (enExample)
MX (1) MX2009003974A (enExample)
MY (1) MY148880A (enExample)
NO (1) NO20091969L (enExample)
NZ (1) NZ577060A (enExample)
PE (2) PE20080892A1 (enExample)
PL (1) PL2079735T3 (enExample)
PT (1) PT2079735E (enExample)
RS (1) RS52260B (enExample)
RU (1) RU2454414C2 (enExample)
SA (1) SA07280549B1 (enExample)
SI (1) SI2079735T1 (enExample)
TW (1) TW200826939A (enExample)
UA (1) UA97648C2 (enExample)
UY (1) UY30652A1 (enExample)
WO (1) WO2008048171A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007503457A (ja) * 2003-05-16 2007-02-22 アストラゼネカ・アクチエボラーグ ジアリールメチリデンピペリジン誘導体、その製造およびその使用
MY148880A (en) 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
JP2011520956A (ja) * 2008-05-20 2011-07-21 アストラゼネカ・アクチエボラーグ 不安大うつ病性障害を処置する方法
CN101906078B (zh) * 2009-06-08 2012-02-01 上海威智医药科技有限公司 噻唑衍生物的合成方法
CN102106807B (zh) * 2009-12-29 2013-03-27 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
CA2970256C (en) * 2014-12-19 2022-03-29 Pharmnovo Ab Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
EP3853435B1 (en) 2018-09-21 2024-08-21 Garland Industries, Inc. Helical hardbanding

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2898339A (en) 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en) 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
ATE306472T1 (de) 1997-12-24 2005-10-15 Ortho Mcneil Pharm Inc (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
MXPA02006137A (es) 1999-12-20 2002-12-05 Neuromed Tech Inc Bloqueadores del canal de calcio parcialmente saturados.
IL151550A0 (en) 2000-03-03 2003-04-10 Ortho Mcneil Pharm Inc 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives
SE0001208D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101768D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
US20040204404A1 (en) 2002-09-30 2004-10-14 Robert Zelle Human N-type calcium channel blockers
SE0300105D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
SE0301444D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301445D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
JP2007503457A (ja) 2003-05-16 2007-02-22 アストラゼネカ・アクチエボラーグ ジアリールメチリデンピペリジン誘導体、その製造およびその使用
SE0301441D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400025D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
MY148880A (en) 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression

Also Published As

Publication number Publication date
US7659286B2 (en) 2010-02-09
PE20140634A1 (es) 2014-06-19
CL2007003009A1 (es) 2008-06-06
UA97648C2 (ru) 2012-03-12
TW200826939A (en) 2008-07-01
KR20090065534A (ko) 2009-06-22
US20100160374A1 (en) 2010-06-24
UY30652A1 (es) 2008-05-31
AU2007313515B2 (en) 2010-11-25
MX2009003974A (es) 2009-04-27
RS52260B (sr) 2012-10-31
IL197876A0 (en) 2009-12-24
CA2667041A1 (en) 2008-04-24
AU2010226996A1 (en) 2010-10-28
JP4668346B2 (ja) 2011-04-13
BRPI0717631A2 (pt) 2013-10-29
CY1112718T1 (el) 2016-02-10
NZ577060A (en) 2011-01-28
MY148880A (en) 2013-06-14
PT2079735E (pt) 2012-05-07
SA07280549B1 (ar) 2010-09-29
HRP20120344T1 (hr) 2012-05-31
PL2079735T3 (pl) 2012-07-31
ATE543818T1 (de) 2012-02-15
RU2454414C2 (ru) 2012-06-27
EP2079735B1 (en) 2012-02-01
CN101528739A (zh) 2009-09-09
AU2007313515A1 (en) 2008-04-24
US20080182875A1 (en) 2008-07-31
EP2079735A4 (en) 2010-12-29
JP2010506910A (ja) 2010-03-04
HK1131556A1 (en) 2010-01-29
EP2079735A1 (en) 2009-07-22
NO20091969L (no) 2009-05-20
DK2079735T3 (da) 2012-05-21
US7977355B2 (en) 2011-07-12
CN101528739B (zh) 2011-11-30
WO2008048171A1 (en) 2008-04-24
CA2667041C (en) 2011-09-06
SI2079735T1 (sl) 2012-05-31
ES2379519T3 (es) 2012-04-26
PE20080892A1 (es) 2008-09-11
AR063345A1 (es) 2009-01-21
RU2009111337A (ru) 2010-11-27

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