KR20080111118A - Ｐｉ3-키나제 억제제로서 사용하기 위한 티아졸릴디하이드로사이클로펜타피라졸 - Google Patents
Ｐｉ3-키나제 억제제로서 사용하기 위한 티아졸릴디하이드로사이클로펜타피라졸 Download PDFInfo
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- KR20080111118A KR20080111118A KR1020087027183A KR20087027183A KR20080111118A KR 20080111118 A KR20080111118 A KR 20080111118A KR 1020087027183 A KR1020087027183 A KR 1020087027183A KR 20087027183 A KR20087027183 A KR 20087027183A KR 20080111118 A KR20080111118 A KR 20080111118A
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- Prior art keywords
- alkyl
- formula
- cycloalkyl
- aryl
- optionally substituted
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| EP06112298.2 | 2006-04-06 | ||
| EP06112298 | 2006-04-06 |
Publications (1)
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| KR20080111118A true KR20080111118A (ko) | 2008-12-22 |
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| US (1) | US7517995B2 (https=) |
| EP (1) | EP2007382A1 (https=) |
| JP (1) | JP2009532415A (https=) |
| KR (1) | KR20080111118A (https=) |
| CN (1) | CN101460167A (https=) |
| AR (1) | AR060267A1 (https=) |
| AU (1) | AU2007236045A1 (https=) |
| BR (1) | BRPI0710306A2 (https=) |
| CA (1) | CA2647292A1 (https=) |
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| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| US7691868B2 (en) | 2006-04-06 | 2010-04-06 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-quinazoline |
| US20110230472A1 (en) * | 2008-08-29 | 2011-09-22 | Shionogi & Co., Ltd. | Ring-fused azole derivative having pi3k-inhibiting activity |
| CN102170873B (zh) | 2008-10-01 | 2014-07-30 | 诺华股份有限公司 | 用于治疗与hedgehog通路有关的病症的smoothened拮抗 |
| JP5579724B2 (ja) * | 2008-10-17 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環 |
| US20120071475A1 (en) * | 2009-04-27 | 2012-03-22 | Shionogi & Co., Ltd. | Urea derivatives having pi3k-inhibiting activity |
| AU2010268058A1 (en) | 2009-07-02 | 2012-01-19 | Novartis Ag | 2-carboxamide cycloamino ureas useful as PI3K inhibitors |
| US20140213630A1 (en) * | 2011-03-08 | 2014-07-31 | Thomas Diacovo | Methods and pharmaceutical compositions for treating lymphoid malignancy |
| JP2014114212A (ja) * | 2011-03-29 | 2014-06-26 | Dainippon Sumitomo Pharma Co Ltd | 新規ベンズイミダゾール誘導体 |
| AU2013249280B2 (en) * | 2012-04-17 | 2017-10-12 | Gilead Sciences, Inc. | Compounds and methods for antiviral treatment |
| WO2020136650A1 (en) | 2018-12-25 | 2020-07-02 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an egfr inhibitor |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020084116A (ko) | 2000-02-07 | 2002-11-04 | 애보트 게엠베하 운트 콤파니 카게 | 2-벤조티아졸릴 우레아 유도체 및 이의 단백질 키나제억제제로서의 용도 |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| AR038703A1 (es) | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| JP4782564B2 (ja) | 2002-07-10 | 2011-09-28 | メルク セローノ ソシエテ アノニム | アゾリジノン−ビニル縮合−ベンゼン誘導体 |
| ATE411996T1 (de) | 2002-09-30 | 2008-11-15 | Bayer Healthcare Ag | Kondensierte azolpyrimidinderivate |
| AU2003280602A1 (en) | 2002-10-30 | 2004-05-25 | Toppan Printing Co., Ltd. | Wiring pattern inspection device, inspection method, detection device, and detection method |
| WO2004052373A1 (en) | 2002-12-06 | 2004-06-24 | Warner-Lambert Company Llc | Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k |
| CA2510851A1 (en) | 2002-12-20 | 2004-07-08 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| CA2528938A1 (en) | 2003-06-13 | 2005-02-24 | Zentaris Gmbh | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof |
| GB0315966D0 (en) | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| DE10344223A1 (de) | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
| UY29149A1 (es) | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| EP2343303A1 (de) * | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2007115931A8 (de) | 2008-06-12 |
| JP2009532415A (ja) | 2009-09-10 |
| ZA200807713B (en) | 2009-08-26 |
| RU2008143547A (ru) | 2010-05-20 |
| TW200806679A (en) | 2008-02-01 |
| AU2007236045A1 (en) | 2007-10-18 |
| CN101460167A (zh) | 2009-06-17 |
| CA2647292A1 (en) | 2007-10-18 |
| US20070238730A1 (en) | 2007-10-11 |
| EP2007382A1 (de) | 2008-12-31 |
| MX2008012534A (es) | 2008-10-10 |
| IL194494A0 (en) | 2009-08-03 |
| BRPI0710306A2 (pt) | 2011-08-09 |
| AR060267A1 (es) | 2008-06-04 |
| WO2007115931A1 (de) | 2007-10-18 |
| US7517995B2 (en) | 2009-04-14 |
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