KR20080042804A - 뇌혈관장벽을 통하여 뇌 암세포 내로 침투하는 운반제 및이의 이용 방법 - Google Patents

뇌혈관장벽을 통하여 뇌 암세포 내로 침투하는 운반제 및이의 이용 방법 Download PDF

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KR20080042804A
KR20080042804A KR1020087002479A KR20087002479A KR20080042804A KR 20080042804 A KR20080042804 A KR 20080042804A KR 1020087002479 A KR1020087002479 A KR 1020087002479A KR 20087002479 A KR20087002479 A KR 20087002479A KR 20080042804 A KR20080042804 A KR 20080042804A
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South Korea
Prior art keywords
peptide
compound
seq
neisseria
carrier
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KR1020087002479A
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Korean (ko)
Inventor
창 홍
토루 야마다
아르세니오 피알로
타파스 다스 구프타
아난다 차카라바티
Original Assignee
더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이
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Priority claimed from US11/244,105 external-priority patent/US7691383B2/en
Application filed by 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 filed Critical 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이
Publication of KR20080042804A publication Critical patent/KR20080042804A/ko
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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    • A61K49/221—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
KR1020087002479A 2005-07-19 2006-07-19 뇌혈관장벽을 통하여 뇌 암세포 내로 침투하는 운반제 및이의 이용 방법 Ceased KR20080042804A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US70029705P 2005-07-19 2005-07-19
US60/700,297 2005-07-19
US11/244,105 2005-10-06
US11/244,105 US7691383B2 (en) 2004-10-07 2005-10-06 Cupredoxin derived transport agents and methods of use thereof
US81851006P 2006-07-06 2006-07-06
US60/818,510 2006-07-06

Publications (1)

Publication Number Publication Date
KR20080042804A true KR20080042804A (ko) 2008-05-15

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Application Number Title Priority Date Filing Date
KR1020087002479A Ceased KR20080042804A (ko) 2005-07-19 2006-07-19 뇌혈관장벽을 통하여 뇌 암세포 내로 침투하는 운반제 및이의 이용 방법

Country Status (11)

Country Link
US (4) US7807183B2 (enExample)
EP (1) EP1904642A4 (enExample)
JP (1) JP2009502135A (enExample)
KR (1) KR20080042804A (enExample)
AU (1) AU2006269879A1 (enExample)
BR (1) BRPI0615562A2 (enExample)
CA (1) CA2615617A1 (enExample)
IL (1) IL188719A0 (enExample)
MX (1) MX2008000994A (enExample)
NO (1) NO20080830L (enExample)
WO (1) WO2007012004A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150083600A (ko) * 2014-01-10 2015-07-20 주식회사 젬백스앤카엘 혈뇌장벽 투과성 펩티드 및 이를 포함하는 컨쥬게이트

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381701B2 (en) 2001-02-15 2008-06-03 The Borad Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
US7491394B2 (en) 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
PT1583562E (pt) * 2003-01-06 2011-09-19 Angiochem Inc Angiopep-1, compostos relacionados, e suas utilizações
US10675326B2 (en) 2004-10-07 2020-06-09 The Board Of Trustees Of The University Of Illinois Compositions comprising cupredoxins for treating cancer
RU2422143C2 (ru) 2005-07-15 2011-06-27 Анджиокем Инк. Усиление действия противораковых агентов
MX2008000994A (es) * 2005-07-19 2008-03-19 Univ Illinois Agentes de transporte para cruzar la barrera hematoencefalica y hacia el interior de las celulas de cancer cerebral, y metodos para el uso de los mismos.
CA2663188A1 (en) * 2006-09-11 2008-03-20 The Board Of Trustees Of The University Of Illinois Modifications of cupredoxin derived peptides and methods of use thereof
BRPI0718360A2 (pt) 2006-12-04 2013-11-12 Univ Illinois "composições e métodos para o tratamento do câncer com cupredoxinas e dna rico em cpg"
AU2008212788A1 (en) * 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CA2702494A1 (en) 2007-10-19 2009-04-23 The Regents Of The University Of California Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss
ES2936256T3 (es) * 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
PT2279008T (pt) 2008-04-18 2019-05-20 Angiochem Inc Composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e utilização
CN102245636A (zh) 2008-10-15 2011-11-16 安吉奥开米公司 用于药物递送的依托泊苷和多柔比星结合物
CN102245642A (zh) 2008-10-15 2011-11-16 安吉奥开米公司 Glp-1激动剂的结合物及其用途
BRPI0922689A2 (pt) 2008-12-05 2018-11-06 Angiochem Inc. conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
ES2729261T3 (es) 2009-04-20 2019-10-31 Angiochem Inc Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2
JP5932642B2 (ja) 2009-07-02 2016-06-08 アンジオケム インコーポレーテッド 多量体ペプチドコンジュゲートおよびその使用
EP3000481A3 (en) * 2009-07-14 2016-05-11 Mayo Foundation for Medical Education and Research Peptide-mediated non-covalent delivery of active agent agents across the blood brain barrier
WO2011031892A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
WO2011031877A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
US20130287808A1 (en) * 2010-11-05 2013-10-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vaccines for preventing meningococcal infections
EP2638057B1 (en) 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
WO2013086207A1 (en) * 2011-12-06 2013-06-13 The Ohio State University Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease
EP2877492A1 (en) 2012-07-27 2015-06-03 Institut National de la Santé et de la Recherche Médicale (INSERM) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
CA2881602A1 (en) 2012-08-14 2014-02-20 Angiochem Inc. Peptide-dendrimer conjugates and uses thereof
EP3094347A4 (en) * 2014-01-17 2018-04-04 Wake Forest University Health Sciences Methods for enhancing the delivery of active agents
US10039808B2 (en) 2014-10-22 2018-08-07 Michael Chez Method of treating or improving neurological function in a human subject
US9925244B1 (en) 2015-02-17 2018-03-27 Michael Chez Treatment of warts in non-immunosuppressed patients
US11136613B2 (en) 2015-04-30 2021-10-05 Board Of Regents, The University Of Texas System Antibacterial polypeptide libraries and methods for screening the same
CN107921143B (zh) 2015-06-15 2021-11-19 安吉奥开米公司 用于治疗软脑膜癌病的方法
US10072065B2 (en) 2015-08-24 2018-09-11 Mayo Foundation For Medical Education And Research Peptide-mediated delivery of immunoglobulins across the blood-brain barrier
US11752315B1 (en) 2016-10-07 2023-09-12 Carlos A. Hakim Method of treating normal pressure hydrocephalus
US10688191B2 (en) 2018-01-19 2020-06-23 Hr Biomed, Llc Delivery of a chemotherapy agent across the blood-brain barrier
WO2020172515A1 (en) * 2019-02-22 2020-08-27 The Trustees Of Columbia University In The City Of New York Preparing tissues for delivery of therapeutic and diagnostic agents and delivering the agents

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827934A (en) 1988-03-08 1998-10-27 The University Of Wyoming Cytotoxic diphtheria toxin fragments
US5972899A (en) 1996-01-25 1999-10-26 New York University Apoptosis induced by Shigella IpaB
EP1144605B1 (en) 1999-01-26 2009-12-16 University College London Dimethylarginine dimethylaminohydrolases
US6800437B1 (en) * 1999-08-06 2004-10-05 Tibotec Bvba Method of monitoring a biological system by labeling with an apo metal binding protein
US20020164703A1 (en) 2000-12-21 2002-11-07 Krzysztof Pawlowski Card-domain containing polypeptides, encoding nucleic acids, and methods of use
GB0103424D0 (en) * 2001-02-12 2001-03-28 Chiron Spa Gonococcus proteins
US7338766B2 (en) * 2001-02-15 2008-03-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating malaria with cupredoxin and cytochrome
US7301010B2 (en) * 2001-02-15 2007-11-27 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating HIV infection with cupredoxin and cytochrome c
US7084105B2 (en) 2001-02-15 2006-08-01 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
US7491394B2 (en) * 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
CA2439986A1 (en) * 2001-03-02 2002-09-12 Florigene Limited Cell visual characteristic-modifying sequences
GB0211295D0 (en) 2002-05-16 2002-06-26 Univ London Treatment of pain
WO2004046177A2 (en) * 2002-11-15 2004-06-03 Chiron Srl Unexpected surface proteins in neisseria meningitidis
KR20070108128A (ko) 2004-10-07 2007-11-08 아난다 차크라바르티 쿠프레독신 유래된 수송제 및 이들의 이용 방법
US7377597B2 (en) 2005-02-15 2008-05-27 Geo Plastics Wheel assembly having wheel-mounting sleeve and retainer
BRPI0612456A2 (pt) 2005-05-20 2009-02-17 Univ Illinois composiÇÕes e mÉtodos para o tratamento da malÁria com cupredoxina e citocromo
AU2006251644A1 (en) 2005-05-20 2006-11-30 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating HIV infection with cupredoxin and cytochrome c
BRPI0612424A2 (pt) 2005-05-20 2009-01-27 Univ Illinois composiÇÕes e mÉtodos para tratar condiÇÕes relacionadas com a sinalizaÇço da efrina com cupredoxinas
MX2008000994A (es) * 2005-07-19 2008-03-19 Univ Illinois Agentes de transporte para cruzar la barrera hematoencefalica y hacia el interior de las celulas de cancer cerebral, y metodos para el uso de los mismos.
CA2663188A1 (en) 2006-09-11 2008-03-20 The Board Of Trustees Of The University Of Illinois Modifications of cupredoxin derived peptides and methods of use thereof
EP2061498A4 (en) 2006-09-14 2009-11-04 Univ Illinois COMPOSITIONS AND METHOD FOR CANCER PREPARATION WITH CUPREDOXINES
AU2008212788A1 (en) 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
WO2009078977A2 (en) 2007-12-14 2009-06-25 Cdg Therapeutics Inc Compositions and methods to concurrently treat or prevent multiple diseases with cupredoxins
GB0802126D0 (en) 2008-02-05 2008-03-12 Level 5 Networks Inc Scalable sockets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150083600A (ko) * 2014-01-10 2015-07-20 주식회사 젬백스앤카엘 혈뇌장벽 투과성 펩티드 및 이를 포함하는 컨쥬게이트

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