KR20070085454A - 중추신경계 손상의 치료 및 관리를 위하여 pde4조절제를 사용하는 방법 및 조성물 - Google Patents

중추신경계 손상의 치료 및 관리를 위하여 pde4조절제를 사용하는 방법 및 조성물 Download PDF

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Publication number
KR20070085454A
KR20070085454A KR1020077011855A KR20077011855A KR20070085454A KR 20070085454 A KR20070085454 A KR 20070085454A KR 1020077011855 A KR1020077011855 A KR 1020077011855A KR 20077011855 A KR20077011855 A KR 20077011855A KR 20070085454 A KR20070085454 A KR 20070085454A
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KR
South Korea
Prior art keywords
carbon atoms
alkyl
substituted
injury
phenyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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KR1020077011855A
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English (en)
Korean (ko)
Inventor
제롬 비. 젤디스
허버트 팔렉
도날드 씨. 매닝
Original Assignee
셀진 코포레이션
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Publication of KR20070085454A publication Critical patent/KR20070085454A/ko
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077011855A 2004-10-28 2005-10-26 중추신경계 손상의 치료 및 관리를 위하여 pde4조절제를 사용하는 방법 및 조성물 Withdrawn KR20070085454A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62380304P 2004-10-28 2004-10-28
US60/623,803 2004-10-28

Publications (1)

Publication Number Publication Date
KR20070085454A true KR20070085454A (ko) 2007-08-27

Family

ID=36319648

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077011855A Withdrawn KR20070085454A (ko) 2004-10-28 2005-10-26 중추신경계 손상의 치료 및 관리를 위하여 pde4조절제를 사용하는 방법 및 조성물

Country Status (14)

Country Link
US (1) US20060106085A1 (https=)
EP (1) EP1811992A2 (https=)
JP (1) JP2008518924A (https=)
KR (1) KR20070085454A (https=)
CN (1) CN101309585A (https=)
AR (1) AR052223A1 (https=)
AU (1) AU2005302523A1 (https=)
BR (1) BRPI0518062A (https=)
CA (1) CA2585423A1 (https=)
IL (1) IL182825A0 (https=)
MX (1) MX2007005040A (https=)
PE (1) PE20061167A1 (https=)
WO (1) WO2006050057A2 (https=)
ZA (1) ZA200704251B (https=)

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US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
EP3914701B1 (en) * 2019-01-23 2025-12-03 Path Therapeutics Inc. Methods of treating epilepsy via phosphodiesterase 4 b (pde4) inhibition
EP4281065A1 (en) * 2021-01-20 2023-11-29 Alto Neuroscience, Inc. Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions
TW202325275A (zh) 2021-10-29 2023-07-01 美商感覺中樞治療公司 治療性生物鹼化合物之遞送
US12410128B1 (en) 2022-04-15 2025-09-09 Sensorium Therapeutics, Inc. Therapeutic alkaloid compounds

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Also Published As

Publication number Publication date
ZA200704251B (en) 2008-11-26
JP2008518924A (ja) 2008-06-05
AR052223A1 (es) 2007-03-07
WO2006050057A2 (en) 2006-05-11
EP1811992A2 (en) 2007-08-01
US20060106085A1 (en) 2006-05-18
AU2005302523A1 (en) 2006-05-11
MX2007005040A (es) 2007-06-19
CN101309585A (zh) 2008-11-19
IL182825A0 (en) 2007-09-20
WO2006050057A3 (en) 2008-07-10
BRPI0518062A (pt) 2008-10-28
PE20061167A1 (es) 2006-11-08
CA2585423A1 (en) 2006-05-11

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PA0105 International application

Patent event date: 20070525

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid