CN101309585A - 使用pde4调节剂治疗和控制中枢神经系统损伤的方法和组合物 - Google Patents

使用pde4调节剂治疗和控制中枢神经系统损伤的方法和组合物 Download PDF

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Publication number
CN101309585A
CN101309585A CNA2005800452239A CN200580045223A CN101309585A CN 101309585 A CN101309585 A CN 101309585A CN A2005800452239 A CNA2005800452239 A CN A2005800452239A CN 200580045223 A CN200580045223 A CN 200580045223A CN 101309585 A CN101309585 A CN 101309585A
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CN
China
Prior art keywords
carbon atoms
alkyl
substituted
injury
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800452239A
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English (en)
Chinese (zh)
Inventor
杰罗米·B·杰奥迪斯
赫伯特·费莱克
唐纳德·C·曼宁
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Celgene Corp
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Celgene Corp
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Publication date
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Publication of CN101309585A publication Critical patent/CN101309585A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2005800452239A 2004-10-28 2005-10-26 使用pde4调节剂治疗和控制中枢神经系统损伤的方法和组合物 Pending CN101309585A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62380304P 2004-10-28 2004-10-28
US60/623,803 2004-10-28

Publications (1)

Publication Number Publication Date
CN101309585A true CN101309585A (zh) 2008-11-19

Family

ID=36319648

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800452239A Pending CN101309585A (zh) 2004-10-28 2005-10-26 使用pde4调节剂治疗和控制中枢神经系统损伤的方法和组合物

Country Status (14)

Country Link
US (1) US20060106085A1 (https=)
EP (1) EP1811992A2 (https=)
JP (1) JP2008518924A (https=)
KR (1) KR20070085454A (https=)
CN (1) CN101309585A (https=)
AR (1) AR052223A1 (https=)
AU (1) AU2005302523A1 (https=)
BR (1) BRPI0518062A (https=)
CA (1) CA2585423A1 (https=)
IL (1) IL182825A0 (https=)
MX (1) MX2007005040A (https=)
PE (1) PE20061167A1 (https=)
WO (1) WO2006050057A2 (https=)
ZA (1) ZA200704251B (https=)

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US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
EP3914701B1 (en) * 2019-01-23 2025-12-03 Path Therapeutics Inc. Methods of treating epilepsy via phosphodiesterase 4 b (pde4) inhibition
EP4281065A1 (en) * 2021-01-20 2023-11-29 Alto Neuroscience, Inc. Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions
TW202325275A (zh) 2021-10-29 2023-07-01 美商感覺中樞治療公司 治療性生物鹼化合物之遞送
US12410128B1 (en) 2022-04-15 2025-09-09 Sensorium Therapeutics, Inc. Therapeutic alkaloid compounds

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Also Published As

Publication number Publication date
ZA200704251B (en) 2008-11-26
JP2008518924A (ja) 2008-06-05
AR052223A1 (es) 2007-03-07
KR20070085454A (ko) 2007-08-27
WO2006050057A2 (en) 2006-05-11
EP1811992A2 (en) 2007-08-01
US20060106085A1 (en) 2006-05-18
AU2005302523A1 (en) 2006-05-11
MX2007005040A (es) 2007-06-19
IL182825A0 (en) 2007-09-20
WO2006050057A3 (en) 2008-07-10
BRPI0518062A (pt) 2008-10-28
PE20061167A1 (es) 2006-11-08
CA2585423A1 (en) 2006-05-11

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