KR20070066572A - 갈근 또는 갈화 추출물의 발효물을 함유하는 비만 또는고지혈증의 예방 또는 치료용 조성물 - Google Patents
갈근 또는 갈화 추출물의 발효물을 함유하는 비만 또는고지혈증의 예방 또는 치료용 조성물 Download PDFInfo
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- KR20070066572A KR20070066572A KR1020050127923A KR20050127923A KR20070066572A KR 20070066572 A KR20070066572 A KR 20070066572A KR 1020050127923 A KR1020050127923 A KR 1020050127923A KR 20050127923 A KR20050127923 A KR 20050127923A KR 20070066572 A KR20070066572 A KR 20070066572A
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- Prior art keywords
- obesity
- brown
- lactic acid
- acid bacteria
- fermentation
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Abstract
Description
발효시간 성분 | 0 | 12 | 24 | 36 | 48 |
푸에라린 | 1606.0 | 1619.0 | 1615.0 | 1624.2 | 1665.4 |
다이드진 | 774.6 | - | - | - | - |
글리시틴 | 237.1 | - | - | - | - |
재니스틴 | 24.9 | - | - | - | - |
마로닐 다이드진 | 197.0 | - | - | - | - |
이리소리돈 | - | - | - | - | 207.1 |
다이드제인 | 476.7 | 3545.9 | 3759.2 | 3849.4 | 3850.4 |
칼칼라이드 | - | 259.3 | 278.9 | 270.2 | 273.4 |
제니스테인 | - | 36.8 | 46.9 | 66.4 | 48.2 |
군 | 동물수 (마리) | 동물번호 | 투여액량 (g/㎏) | 투여량 (㎖/㎏) |
C | 15 | 1∼15 | 0 | 10 |
N.C | 15 | 16∼30 | 0 | 10 |
T1 | 15 | 31∼45 | 5 | 10 |
T2 | 15 | 46∼60 | 5 | 10 |
T3 | 15 | 61∼75 | 5 | 10 |
T4 | 15 | 76∼90 | 5 | 10 |
성별 | 암컷 | |||||
실험군 | C | N.C | T1 | T2 | T3 | T4 |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 |
동물수 | 5 | 5 | 5 | 5 | 5 | 5 |
자궁 | 0.65(0.18)** | 0.10a(0.02)b | 0.10(0.01) | 0.10(0.01) | 0.23*(0.04) | 0.11(0.02) |
폐 | 1.24(0.12) | 1.31(0.24) | 1.45(0.15) | 1.52(0.14) | 1.32(0.08) | 1.40(0.08) |
심장 | 0.85*(0.06) | 1.05(0.09) | 1.10(0.09) | 1.09(0.09) | 0.87*(0.08) | 1.11(0.16) |
간 | 6.47(0.63) | 7.55(0.9) | 8.4(0.61) | 8.39(1.42) | 7.76(0.48) | 8.17(0.66) |
비장 | 0.40**(0.05) | 0.58(0.07) | 0.62(0.10) | 0.58(0.1) | 0.58(0.09) | 0.64(0.06) |
좌측신장 | 0.77(0.07) | 0.79(0.07) | 0.89(0.09) | 0.87(0.07) | 0.80(0.07) | 0.92(0.13) |
우측신장 | 0.77(0.05) | 0.79(0.08) | 0.87(0.06) | 0.88(0.04) | 0.81(0.08) | 0.92(0.13) |
부신(좌측) | 0.03(0.01) | 0.03(0.02) | 0.03(0.0) | 0.03(0.01) | 0.02(0.0) | 0.03(0.0) |
부신(우측) | 0.03(0.0) | 0.03(0.01) | 0.03(0.01) | 0.03(0.01) | 0.02(0.01) | 0.02(0.01) |
성별 | 암컷 | |||||
실험군 | C | N.C | T1 | T2 | T3 | T4 |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 |
동물수 | 10 | 10 | 10 | 10 | 10 | 10 |
복벽지방(g) | 3.83** (1.85) | 9.72a (2.74)b | 7.31 (1.67) | 7.04 (1.87) | 3.48** (1.23) | 8.68 (3.97) |
복부지방(g) | 6.7** (1.76) | 18.03 (7.36) | 14.34 (4.6) | 12.98* (3.94) | 5.05** (2.55) | 17.22 (3.31) |
성별 | 암컷 | |||||
실험군 | C | N.C | T1 | T2 | T3 | T4 |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 |
14 주간 투여 | ||||||
에스트로겐(pg/㎗) | 183.38a (44.37)b | 144.2 (48.64) | 175.14 (38.86) | 169.4 (38.06) | 184.22 (32.36) | 215.75** (42.88) |
투여용량 (㎎/㎏) | 혈중 농도 (㎎/㎗) | ||||
TC | TG | HDL | LDL | ||
정상대조군 | - | 69.5±5.2 | 48.5±5.9 | 34.0±1.1 | 26.5±1.2 |
음성대조군 | - | 193.6±5.0 | 159.9±10.43 | 26.8±0.8 | 143.0±0.9 |
L. 애시도필러스 | 10 | 172.9±11.2 | 147.2±9.9 | - | - |
L. 불가리쿠스 | 10 | 193.6±5.0 | 159.9±10.43 | - | - |
B. 브레브 K-111 | 10 | 153.2±8.9 | 139.5±9.2 | - | - |
B. 롱굼 | 10 | 183.5±6.2 | 157.2±9.5 | - | - |
S. 패시움 | 10 | 173.3±11.2 | 149.2±7.8 | - | - |
L. 메센테로이데스 | 10 | 183.5±4.0 | 136.5±11.2 | - | - |
갈근 수추출물 | 100 | 129.1±17.4 | 118.0±18.6 | 29.3±0.8 | 87.2±2.4 |
갈화 수추출물 | 100 | 137.0±4.5 | 105.8±8.5 | 30.0±0.5 | 95.7±3.0 |
갈근 발효물 실시예 <1-3> | 100 (유산균 10 ㎎) | 112.1±15.3 | 105.0±16.2 | 28.2±1.7 | 85.8±11.2 |
갈근 발효물 실시예 <1-4> | 100 (유산균 <1 ㎎) | 92.1±15.3 | 75.0±16.2 | 29.5±1.5 | 65.8±7.1 |
갈화 발효물 (1) | 100 (유산균 10 ㎎) | 98.5±17.8 | 88.3±12.4 | 31.2±3.2 | 81.2±9.2 |
갈화 발효물 (2) | 100 (유산균 <1 ㎎) | 138.5±7.8 | 102.3±7.4 | 32.1±1.5 | 91.8±12.1 |
제니칼 | 10 | 87.6±3.3 | 67.6±6.8 | 31.5±2.3 | 64.5±2.2 |
Claims (10)
- 갈근 또는 갈화에 물을 가한 후 열수추출하고 상기 수추출물에 유산균을 접종하여 발효시킴으로써 제조되는 것을 특징으로 하는 갈근 또는 갈화 수추출물의 유산균 발효물을 유효성분으로 함유하는 비만 또는 고지혈증의 예방 또는 치료용 약학적 조성물.
- 제 1항에 있어서, 상기 유산균은 비피도박테리움, 락토바실러스, 스트렙토코커스, 류코노스톡, 페디오코카스 및 락토코커스 속(屬)의 미생물로 구성된 군으로부터 선택되는 것을 특징으로 하는 약학적 조성물.
- 제 2항에 있어서, 상기 유산균은 비피도박테리움 속의 미생물인 것을 특징으로 하는 약학적 조성물.
- 제 1항 내지 제 3항 중 어느 한 항에 있어서, 상기 유산균은 시료 중량의 1 내지 5 중량%의 양으로 접종하는 것을 특징으로 하는 약학적 조성물.
- 제 1항 내지 제 3항 중 어느 한 항에 있어서, 상기 유산균은 30 내지 40℃의 온도에서 24 내지 52시간 동안 발효시키는 것을 특징으로 하는 약학적 조성물.
- 갈근 또는 갈화에 물을 가한 후 열수추출하고 상기 수추출물에 유산균을 접종하여 발효시킴으로써 제조되는 것을 특징으로 하는 갈근 또는 갈화 수추출물의 유산균 발효물을 유효성분으로 함유하는 비만 또는 고지혈증의 예방 또는 치료용 건강식품.
- 제 6항에 있어서, 상기 유산균은 비피도박테리움, 락토바실러스, 스트렙토코커스, 류코노스톡, 페디오코카스 및 락토코커스 속(屬)의 미생물로 구성된 군으로부터 선택되는 것을 특징으로 하는 건강식품.
- 제 7항에 있어서, 상기 유산균은 비피도박테리움 속의 미생물인 것을 특징으로 하는 건강식품.
- 제 6항 내지 제 8항 중 어느 한 항에 있어서, 상기 유산균은 시료 중량의 1 내지 5 중량%의 양으로 접종하는 것을 특징으로 하는 건강식품.
- 제 6항 내지 제 8항 중 어느 한 항에 있어서, 상기 유산균은 30 내지 40℃의 온도에서 24 내지 52시간 동안 발효시키는 것을 특징으로 하는 건강식품.
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US20100303936A1 (en) * | 2009-04-28 | 2010-12-02 | Bionovo, Inc. A Delaware Corporation | Method of reducing fat accumulation and inducing weight loss |
KR101065639B1 (ko) * | 2008-10-15 | 2011-09-19 | 전경미 | 다이어트 식품 조성물 |
KR102597809B1 (ko) * | 2023-03-02 | 2023-11-07 | 농업회사법인 맑을청웰빙 주식회사 | 체지방 감소를 위한 다이어트 조성물 및 그 제조방법 |
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WO2011074765A2 (ko) | 2009-12-15 | 2011-06-23 | 동국대학교 산학협력단 | 한약재 발효물을 유효성분으로 포함한 비만 또는 고지혈증의 예방 및 치료용 조성물 |
KR101978982B1 (ko) | 2017-07-17 | 2019-05-15 | 장희수 | 물체 이송용 워터젯 이젝터 |
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KR100557006B1 (ko) * | 2003-04-01 | 2006-03-03 | 주식회사 바름인 | 식물성 여성 호르몬 물질인 이소플라본을 강화한 칡유산균 발효물 및 그의 제조 방법 |
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KR101065639B1 (ko) * | 2008-10-15 | 2011-09-19 | 전경미 | 다이어트 식품 조성물 |
US20100303936A1 (en) * | 2009-04-28 | 2010-12-02 | Bionovo, Inc. A Delaware Corporation | Method of reducing fat accumulation and inducing weight loss |
KR102597809B1 (ko) * | 2023-03-02 | 2023-11-07 | 농업회사법인 맑을청웰빙 주식회사 | 체지방 감소를 위한 다이어트 조성물 및 그 제조방법 |
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