KR100733335B1 - 갈근 추출물의 발효물 및 이를 함유하는 골다공증 예방또는 치료용 조성물 - Google Patents
갈근 추출물의 발효물 및 이를 함유하는 골다공증 예방또는 치료용 조성물 Download PDFInfo
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- KR100733335B1 KR100733335B1 KR1020050127922A KR20050127922A KR100733335B1 KR 100733335 B1 KR100733335 B1 KR 100733335B1 KR 1020050127922 A KR1020050127922 A KR 1020050127922A KR 20050127922 A KR20050127922 A KR 20050127922A KR 100733335 B1 KR100733335 B1 KR 100733335B1
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- osteoporosis
- lactic acid
- fermented product
- root
- acid bacteria
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/41—Pediococcus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- Mycology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
Description
발효시간 성분 | 0 | 12 | 24 | 36 | 48 |
푸에라린 | 1606.0 | 1619.0 | 1615.0 | 1624.2 | 1665.4 |
다이드진 | 774.6 | - | - | - | - |
글리시틴 | 237.1 | - | - | - | - |
재니스틴 | 24.9 | - | - | - | - |
마로닐 다이드진 | 197.0 | - | - | - | - |
이리소리돈 | - | - | - | - | 207.1 |
다이드제인 | 476.7 | 3545.9 | 3759.2 | 3849.4 | 3850.4 |
칼칼라이드 | - | 259.3 | 278.9 | 270.2 | 273.4 |
제니스테인 | - | 36.8 | 46.9 | 66.4 | 48.2 |
군 | 동물수 (마리) | 동물번호 | 투여액량 (g/㎏) | 투여량 (㎖/㎏) |
C | 15 | 1∼15 | 0 | 10 |
N.C | 15 | 16∼30 | 0 | 10 |
T1 | 15 | 31∼45 | 5 | 10 |
T2 | 15 | 46∼60 | 5 | 10 |
T3 | 15 | 61∼75 | 5 | 10 |
T4 | 15 | 76∼90 | 5 | 10 |
성별 | 암컷 | |||||
실험군 | C | N.C | T1 | T2 | T3 | T4 |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 |
동물수 | 5 | 5 | 5 | 5 | 5 | 5 |
자궁 | 0.65(0.18)** | 0.10a(0.02)b | 0.10(0.01) | 0.10(0.01) | 0.23*(0.04) | 0.11(0.02) |
폐 | 1.24(0.12) | 1.31(0.24) | 1.45(0.15) | 1.52(0.14) | 1.32(0.08) | 1.40(0.08) |
심장 | 0.85*(0.06) | 1.05(0.09) | 1.10(0.09) | 1.09(0.09) | 0.87*(0.08) | 1.11(0.16) |
간 | 6.47(0.63) | 7.55(0.9) | 8.4(0.61) | 8.39(1.42) | 7.76(0.48) | 8.17(0.66) |
비장 | 0.40**(0.05) | 0.58(0.07) | 0.62(0.10) | 0.58(0.1) | 0.58(0.09) | 0.64(0.06) |
좌측신장 | 0.77(0.07) | 0.79(0.07) | 0.89(0.09) | 0.87(0.07) | 0.80(0.07) | 0.92(0.13) |
우측신장 | 0.77(0.05) | 0.79(0.08) | 0.87(0.06) | 0.88(0.04) | 0.81(0.08) | 0.92(0.13) |
부신(좌측) | 0.03(0.01) | 0.03(0.02) | 0.03(0.0) | 0.03(0.01) | 0.02(0.0) | 0.03(0.0) |
부신(우측) | 0.03(0.0) | 0.03(0.01) | 0.03(0.01) | 0.03(0.01) | 0.02(0.01) | 0.02(0.01) |
성별 | 암컷 | |||||
실험군 | C | N.C | T1 | T2 | T3 | T4 |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 |
동물수 | 5 | 5 | 5 | 5 | 5 | 5 |
ALP (IU/ℓ) SD | 110.4a* (31.67)b | 237.4 (81.05) | 246.8 (62.21) | 188.4 (10.19) | 280.8 (74.12) | 261.2 (93.96) |
인산(㎎/㎗) SD | 5.94 (1.17) | 6.62 (1.16) | 6.24 (0.33) | 6.08 (0.93) | 6.4 (0.51) | 6.98 (1.36) |
칼슘(㎎/㎗) SD | 10.4 (0.35) | 10.02 (0.44) | 10.02 (0.4) | 10.14 (0.38) | 10.0 (0.26) | 10.48 (0.61) |
성별 | 암컷 | |||||
실험군 | C | N.C | T1 | T2 | T3 | T4 |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 |
14 주간 투여 | ||||||
에스트로겐(pg/㎗) | 183.38a (44.37)b | 144.2 (48.64) | 175.14 (38.86) | 169.4 (38.06) | 184.22 (32.36) | 215.75** (42.88) |
성별 | 암컷 | ||||||
실험군 | C | N.C | T1 | T2 | T3 | T4 | |
용량(g/㎏/day) | 0 | 0 | 5 | 5 | 5 | 5 | |
AD 7주 | 흉골 | 0.0750a (0.005)b | 0.0732 (0.016) | 0.0729 (0.012) | 0.0762 (0.004) | 0.0701 (0.005) | 0.071 (0.007) |
대퇴골 | 0.1814 (0.112) | 0.1863 (0.008) | 0.1891 (0.008) | 0.183 (0.008) | 0.1839 (0.010) | 0.1853 (0.009) | |
AD 14주 | 흉골 | 0.0658 (0.005) | 0.056 (0.003) | 0.0571 (0.005) | 0.0563 (0.003) | 0.0592 (0.006) | 0.0558 (0.005) |
대퇴골 | 0.2068 (0.007) | 0.1875 (0.01) | 0.1912 (0.012) | 0.1878 (0.007) | 0.1955 (0.008) | 0.1867 (0.009) |
Claims (7)
- 갈근에 물을 가한 후 열수추출하고 상기 수추출물에 유산균을 접종하여 발효시킴으로써 제조되는 것을 특징으로 하는 갈근 수추출물의 유산균 발효물.
- 제 1항에 있어서, 상기 유산균은 비피도박테리움, 락토바실러스, 스트렙토코커스, 류코노스톡, 페디오코카스 및 락토코커스 속(屬)의 미생물로 구성된 군으로부터 선택되는 것을 특징으로 하는 발효물.
- 제 2항에 있어서, 상기 유산균은 비피도박테리움 속의 미생물인 것을 특징으로 하는 발효물.
- 제 1항 내지 제 3항 중 어느 한 항에 있어서, 상기 유산균은 시료 중량의 1 내지 5 중량%의 양으로 접종하는 것을 특징으로 하는 발효물.
- 제 1항 내지 제 3항 중 어느 한 항에 있어서, 상기 유산균은 30 내지 40℃의 온도에서 24 내지 52시간 동안 발효시키는 것을 특징으로 하는 발효물.
- 제 1항의 갈근 수추출물의 유산균 발효물을 유효성분으로 함유하는 골다공증 예방 또는 치료용 약학적 조성물.
- 제 1항의 갈근 수추출물의 유산균 발효물을 유효성분으로 함유하는 골다공증 예방 또는 개선용 건강식품.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011034225A1 (ko) * | 2009-09-18 | 2011-03-24 | 한국 한의학 연구원 | 갈근탕 또는 갈근탕 유산균 발효물을 유효성분으로 함유하는 간 독성 예방 또는 치료용 조성물 |
KR20120001283A (ko) * | 2010-06-29 | 2012-01-04 | 한국 한의학 연구원 | 생약 추출물 또는 이의 유산균 발효물을 포함하는 골다공증 예방 또는 치료용 조성물 |
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CN109700009A (zh) * | 2018-12-29 | 2019-05-03 | 江瀚生物科技(上海)有限公司 | 一种修复骨质疏松人群骨骼机能的天然营养素及其制备方法 |
KR102653255B1 (ko) * | 2022-12-22 | 2024-04-02 | 진연준 | 즉석 양념갈비 소스의 제조방법 및 이에 의해 제조된 즉석 양념갈비 소스 |
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JP2003095971A (ja) * | 2001-09-27 | 2003-04-03 | National Institute Of Health & Nutrition | 骨粗鬆症治療剤または組成物 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011034225A1 (ko) * | 2009-09-18 | 2011-03-24 | 한국 한의학 연구원 | 갈근탕 또는 갈근탕 유산균 발효물을 유효성분으로 함유하는 간 독성 예방 또는 치료용 조성물 |
US9549961B2 (en) | 2009-09-18 | 2017-01-24 | Korea Institute Of Oriental Medicine | Composition for preventing or treating liver toxicity comprising Galgeuntang or lactic acid bacteria fermented Galgeuntang |
KR20120001283A (ko) * | 2010-06-29 | 2012-01-04 | 한국 한의학 연구원 | 생약 추출물 또는 이의 유산균 발효물을 포함하는 골다공증 예방 또는 치료용 조성물 |
KR101709281B1 (ko) * | 2010-06-29 | 2017-02-24 | 한국 한의학 연구원 | 생약 추출물 또는 이의 유산균 발효물을 포함하는 골다공증 예방 또는 치료용 조성물 |
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