KR20050057305A - 디벤족사제핀 - Google Patents

디벤족사제핀 Download PDF

Info

Publication number
KR20050057305A
KR20050057305A KR1020057004210A KR20057004210A KR20050057305A KR 20050057305 A KR20050057305 A KR 20050057305A KR 1020057004210 A KR1020057004210 A KR 1020057004210A KR 20057004210 A KR20057004210 A KR 20057004210A KR 20050057305 A KR20050057305 A KR 20050057305A
Authority
KR
South Korea
Prior art keywords
mmol
formula
alkyl
hydroxyl
compound
Prior art date
Application number
KR1020057004210A
Other languages
English (en)
Korean (ko)
Inventor
클라우디아 히르트-디트리히
두마-쟈끄
엘리자베쓰 볼테링
베아트릭스 스텔테-루드빅
드미트리 추보브
미하엘 브랜스
페터 엘링하우즈
디르크 하임바흐
요하네스 쾨베르링
카를-하인츠 슐레머
지그프리트 차이즈
프란츠 츰페
Original Assignee
바이엘 헬스케어 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이엘 헬스케어 아게 filed Critical 바이엘 헬스케어 아게
Publication of KR20050057305A publication Critical patent/KR20050057305A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020057004210A 2002-09-13 2003-08-30 디벤족사제핀 KR20050057305A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10242488.8 2002-09-13
DE10242488A DE10242488A1 (de) 2002-09-13 2002-09-13 Dibenzoxazeptine

Publications (1)

Publication Number Publication Date
KR20050057305A true KR20050057305A (ko) 2005-06-16

Family

ID=31895918

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057004210A KR20050057305A (ko) 2002-09-13 2003-08-30 디벤족사제핀

Country Status (15)

Country Link
EP (1) EP1539721A1 (es)
JP (1) JP2006503869A (es)
KR (1) KR20050057305A (es)
CN (1) CN1694876A (es)
AR (1) AR040907A1 (es)
AU (1) AU2003266336A1 (es)
BR (1) BR0314109A (es)
CA (1) CA2498658A1 (es)
DE (1) DE10242488A1 (es)
GT (1) GT200300191A (es)
MX (1) MXPA05002702A (es)
PL (1) PL375563A1 (es)
TW (1) TW200413340A (es)
UY (1) UY27973A1 (es)
WO (1) WO2004033437A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004004928A1 (de) * 2004-01-31 2005-08-18 Bayer Healthcare Ag Dibenzoxazepine II
CN101889000B (zh) * 2007-12-05 2012-11-28 詹森药业有限公司 二苯并氮杂*和二苯并氧氮杂*trpa1激动剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) * 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
JPS58225073A (ja) * 1982-06-25 1983-12-27 Chugai Pharmaceut Co Ltd ジベンゾオキサゼピノン誘導体
EP1169042A4 (en) * 1999-02-17 2003-05-02 Merck & Co Inc DIBENZO-AZEPINE DERIVATIVES AS ANTAGONISTS OF THE ALPHA V INTEGRIN RECEPTOR

Also Published As

Publication number Publication date
DE10242488A1 (de) 2004-03-25
AR040907A1 (es) 2005-04-20
WO2004033437A1 (de) 2004-04-22
PL375563A1 (en) 2005-11-28
CA2498658A1 (en) 2004-04-22
TW200413340A (en) 2004-08-01
BR0314109A (pt) 2005-07-26
EP1539721A1 (de) 2005-06-15
GT200300191A (es) 2004-05-12
MXPA05002702A (es) 2005-06-08
AU2003266336A1 (en) 2004-05-04
CN1694876A (zh) 2005-11-09
UY27973A1 (es) 2004-04-30
JP2006503869A (ja) 2006-02-02

Similar Documents

Publication Publication Date Title
JP4163252B2 (ja) 三環式ベンゾアゼピンバソプレッシンアンタゴニスト類
JP5844358B2 (ja) ベンゾトリアゾロジアゼピン化合物を含むブロモドメイン阻害剤
FI108433B (fi) Menetelmõ terapeuttisesti kõytt÷kelpoisten trisyklisten bentsatsepiinien valmistamiseksi
US7560454B2 (en) Condensed azepines as vasopressin agonists
EP3749672A1 (en) Inhibitors of the bcl6 btb domain protein-protein interaction and uses thereof
US20040038962A1 (en) Fused azepine derivatives and their use as antidiuretic agents
KR20070042568A (ko) 화합물
UA73781C2 (en) Dicyclic pyrolylamides as inhibitors of glucogenphosphorylase
CA2258885A1 (en) Tricyclic benzazepine vasopressin antagonists
PL191502B1 (pl) Pochodna diazepiny
US6194407B1 (en) Tricyclic pyrido vasopressin agonists
KR20040036939A (ko) 카르바졸 유도체 및 ｎｐｙ5 수용체 길항 물질로서의이들의 용도
CN1307178C (zh) 用作保胎催产素受体拮抗剂的新型三环吡啶基苯并氮杂䓬羧酰胺及其衍生物
US7189851B2 (en) Condensed heterocyclic compounds as calcitonin agonists
US6900200B2 (en) Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
CA2077420C (en) Imidazoindolizine derivatives and process for preparation thereof
WO2005072741A1 (de) ((11-oxo-10,11-dihydrodibenzo [b, f] [1, 4] oxazepin-1-yl)oxy) essigsäure-derivate und verwandte verbindungen als herz-kreislaufmittel zur behandlung von atherosclerose
WO1997049708A1 (en) Tricyclic benzazepine vasopressin antagonists
WO1997049708A9 (en) Tricyclic benzazepine vasopressin antagonists
KR20050057305A (ko) 디벤족사제핀
EP1000059A1 (en) Tricyclic vasopressin agonists
JP2002536378A (ja) ピロロベンゾジアゼピンカルボキシアミドバソプレシンアゴニスト
CA2358895A1 (en) Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
PT94922A (pt) Processo para a preparacao de derivados peptideos
JPH04178387A (ja) 新規なイソインドール誘導体およびその塩

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid