KR20040076103A - Method of producing a cosmetic composition which contains mixed plant extracts - Google Patents

Method of producing a cosmetic composition which contains mixed plant extracts Download PDF

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Publication number
KR20040076103A
KR20040076103A KR1020030011442A KR20030011442A KR20040076103A KR 20040076103 A KR20040076103 A KR 20040076103A KR 1020030011442 A KR1020030011442 A KR 1020030011442A KR 20030011442 A KR20030011442 A KR 20030011442A KR 20040076103 A KR20040076103 A KR 20040076103A
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South Korea
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white
cosmetic composition
extract
cloves
skin
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KR1020030011442A
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Korean (ko)
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이재명
박성철
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(주) 인터코텍
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Priority to KR1020030011442A priority Critical patent/KR20040076103A/en
Publication of KR20040076103A publication Critical patent/KR20040076103A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. splints, casts or braces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. splints, casts or braces
    • A61F5/0102Orthopaedic devices, e.g. splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F5/0123Orthopaedic devices, e.g. splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations for the knees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. splints, casts or braces
    • A61F5/0102Orthopaedic devices, e.g. splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F5/013Orthopaedic devices, e.g. splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations for the arms, hands or fingers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. splints, casts or braces
    • A61F5/0102Orthopaedic devices, e.g. splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F2005/0181Protectors for articulations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. splints, casts or braces
    • A61F2005/0197Orthopaedic devices, e.g. splints, casts or braces with spring means

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  • Health & Medical Sciences (AREA)
  • Nursing (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)

Abstract

PURPOSE: A cosmetic composition including a herbal extract having antioxidant and skin aging preventing effects is provided. It has free radical scavenging properties, antioxidant action and skin whitening effects. The composition is in the shape of face lotion, lotion, cream and essence. CONSTITUTION: The cosmetic composition comprises an extract of Phaseolus radiatus L. Angelicae Dahuricae Radix, Bletilla striata Reichb., Amomi Semen, Cimicifugae Rhizoma, Caryophylli Flos, Radix Trichosanthis and white tea. The extract is prepared by extracting the material in a solvent and then concentrating it under reduced pressure after filtration. The solvent is selected from the group consisting of distilled water, ethanol, methanol, butanol, hydrous propyleneglycol, hexane, propanol, acetone and ethylacetate.

Description

항산화 및 피부노화방지 효능을 갖는 혼합 식물추출물을 함유한 화장료 조성물 및 이의 제조방법{Method of producing a cosmetic composition which contains mixed plant extracts}Cosmetic composition containing mixed plant extracts having antioxidant and anti-aging effects and a method for preparing the same {Method of producing a cosmetic composition which contains mixed plant extracts}

본 발명은 화장료 조성물에 관한 것으로, 더욱 상세하게는 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합물로부터 얻어지며 프리라디칼 소거작용, 항산화작용 및 미백효과를 갖는 백아단이라 칭하는 추출물을 함유하는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition, and more particularly, extracts, which are obtained from a mixture of mung bean, white paper, platinum, sine, horse riding, cloves, natural powder and white tea, and which have free radical scavenging, antioxidant and whitening effects. It relates to a cosmetic composition containing a.

일반적으로, 공기 중에 산소가 없으면 생물은 존재하지 않는다. 그러나, 산소는 자외선이나 효소 등의 영향을 받으면 활성산소가 된다. 이 활성산소는 지방산을 산화시켜 과산화물을 생성시키며, 생체의 생체막 인지질도 산화시켜 장해를 일으킨다. 이렇게 생성된 과산화물과 활성산소는 유전자 손상을 일으켜 노화를 촉진시킨다. 또한, 이 활성산소는 티로신에서 멜라닌을 생성하는 기구에도 영향을 일으켜 피부의 흑화에도 관여한다.In general, living things are absent if there is no oxygen in the air. However, oxygen becomes free radicals under the influence of ultraviolet rays or enzymes. This active oxygen oxidizes fatty acids to produce peroxides, and also oxidizes biological membrane phospholipids, causing damage. The peroxides and free radicals generated in this way cause gene damage and promote aging. In addition, this active oxygen also affects the mechanism for producing melanin in tyrosine and is also involved in skin blackening.

따라서, 활성산소를 억제하는 것은 피부노화 화장료에 있어서 매우 중요한기술적 과제이다. 일반 화장품, 의약품, 식품의 원료로서 사용되는 활성산소 억제와 항산화 효과가 있는 물질이 알려져 있지만, 합성품으로 이루어져 있어서 장기간 인간의 피부에 적용할 경우에 안전성이 나쁘므로 사용이 제한된다.Therefore, inhibiting free radicals is a very important technical problem in skin aging cosmetics. Although there are known active oxygen inhibitory and antioxidant substances used as raw materials for general cosmetics, medicines and foods, since they are composed of synthetic products, their use is limited because they are poorly applied to human skin for a long time.

이에 반해서, 천연물은 활성산소 억제 효과가 약한 것이 대부분이지만, 사람의 피부에 대해서는 안전성이 보증된다. 따라서, 활성산소 억제 효과 및 항산화 효과가 강하고 사람의 피부에 대해서도 또 다른 효과가 있는 물질의 개발이 요구된다.On the other hand, natural products have a weak active oxygen inhibitory effect in most cases, but safety is guaranteed for human skin. Therefore, there is a need for the development of a substance having a strong active oxygen inhibitory effect and an antioxidant effect and another effect on human skin.

한편, 사람의 피부는 여러 가지 중요한 기능을 가지고 있다. 그 중에서도 대표적인 것은 태양광의 자외선으로부터 신체를 보호하기 위하여 멜라닌 생성을 억제하는 기능이다. 멜라닌은 피부 세포의 일종인 멜라노사이트에서 생성되고, 피부 표면에 분포되어 인체에 유해한 자외선을 차단하는 자연적인 스크리닝을 가지고 있다. 멜라닌 생성 기저에는 멜라노사이트에서 합성되는 티로시나제라는 효소가 있다. 티로시나제는 티로신이라는 아미노산을 기질로 하여 도파(DOPA)를 거쳐 도파퀴논(Dopaquinone)을 생성시키며, 도파퀴논으로부터 여러 단계의 산화 축합 반응으로 흑색색소인 멜라닌이 생성된다. 천연물들은 안전성이 뛰어날 뿐만 아니라 여러 가지 유익한 성분들을 가지고 있기 때문에 미백 물질로서도 좋은 활용대상이 되고 있다.On the other hand, human skin has many important functions. Representative among them is a function of suppressing melanin production in order to protect the body from ultraviolet rays of sunlight. Melanin is produced from melanocytes, a kind of skin cells, and has a natural screening that is distributed on the surface of the skin and blocks ultraviolet rays harmful to the human body. Underlying melanogenesis is an enzyme called tyrosinase that is synthesized in melanocytes. Tyrosinase generates dopaquinone via dopa (DOPA) based on an amino acid called tyrosine, and melanin, which is a black pigment, is produced by several stages of oxidative condensation reaction from dopaquinone. Natural products are not only excellent in safety but also have various beneficial ingredients, making them a good candidate for whitening.

최근에는 종래부터 생약 등으로 사용되어 오던 여러 가지 자연의 천연물로부터 탁월한 항산화작용 및 미백효과를 갖는 기능성 물질들을 찾고자 하는 연구가 시도되어 왔다. 즉, 종래부터 생약 등으로 사용되어 오던 여러 가지 자연의 천연물등은 안정성이 뛰어날 뿐만 아니라 여러 가지 유익한 약효성분 등을 함유하고 있어서 항산화작용 및 미백효과 개선을 위한 좋은 검색대상이 되어 오고 있다.Recently, research has been attempted to find functional substances having excellent antioxidant and whitening effects from various natural natural products that have been used as herbals in the past. That is, various natural natural products, which have been conventionally used as herbal medicines, have not only excellent stability but also contain various beneficial drug ingredients, and have been a good search target for improving antioxidant activity and whitening effect.

본 발명은 상기와 같은 종래의 문제점 및 과제를 해결하기 위해 안출된 것으로, 본 발명의 목적은 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합물로부터 프리라디칼 소거작용, 항산화작용 및 미백효과를 갖는 백아단이라 칭하는 추출물을 함유하는 화장료 조성물 및 이의 제조방법을 제공하는데 있다.The present invention has been made to solve the conventional problems and problems as described above, the object of the present invention is free radical scavenging action, antioxidant activity and a mixture of mung bean, white paper, white gram, sine, horse riding, cloves, natural powder, white tea and It is to provide a cosmetic composition containing an extract called white sandalwood having a whitening effect and a method for producing the same.

상기와 같은 목적을 달성하기 위해서, 본 발명은,In order to achieve the above object, the present invention,

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 일정량을 소정의 용매에 넣고 냉각 콘덴서가 달린 추출기에서 일정시간동안 끓여서 추출한 후 1차 여과하고, 상온으로 냉각시킨 다음 소정의 온도로 일정기간동안 방치하여 숙성시킨 후 2차 여과하며, 이때 얻어진 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 소정의 온도로 감압 농축하여 얻어지는 것을 특징으로 하는 화장료 조성물의 제조방법을 제공한다.Put a certain amount of mixed raw materials of completely dried green beans, white paper, white wheat, sine, horseback riding, cloves, natural powder and white tea in a predetermined solvent, boil for a certain period of time in an extractor equipped with a cooling condenser, filter it first, and then cool to room temperature. Provided a method for producing a cosmetic composition characterized in that the mixture is left for a predetermined temperature for a certain period of time and then aged for filtration, and the mixed plant extract obtained at this time is concentrated under reduced pressure at a predetermined temperature in a distillation apparatus equipped with a cooling condenser. .

상기 용매는, 증류수, 에탄올, 메탄올, 부탄올, 함수 부틸렌글리콜, 함수 프로필렌글리콜, 헥산, 프로판올, 아세톤, 에틸아세테이트로 이루어진 그룹으로부터 선택된다.The solvent is selected from the group consisting of distilled water, ethanol, methanol, butanol, hydrous butylene glycol, hydrous propylene glycol, hexane, propanol, acetone, ethyl acetate.

또한, 본 발명은,In addition, the present invention,

녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차로부터 얻은 백아단을 함유하는 화장료 조성물을 제공한다.Provided are a cosmetic composition containing white beans obtained from mung beans, white paper, white weight, sine, horse riding, cloves, natural powder and white tea.

바람직하게는, 화장료 조성물은 스킨, 로션, 크림, 에센스의 형태로 제조된다.Preferably the cosmetic composition is prepared in the form of a skin, lotion, cream, essence.

이상에서 설명한 바와같이, 본 발명에 따르면, 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합물로부터 프리라디칼 소거작용, 항산화작용 및 미백효과를 갖는 백아단이라 칭하는 추출물을 얻을 수 있고, 이를 이용한 화장료 조성물을 제조한다.As described above, according to the present invention, an extract called white ardan having free radical scavenging, antioxidant activity and whitening effect can be obtained from a mixture of mung bean, white paper, white wheat, sine, horse riding, cloves, natural powder and white tea. To prepare a cosmetic composition using the same.

이하, 본 발명에 따른 화장료 조성물 및 이의 제조방법에 대하여 상세히 설명하면 다음과 같다.Hereinafter, the cosmetic composition and the preparation method thereof according to the present invention will be described in detail.

본 발명의 핵심적인 특징은 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합물로부터 프리라디칼 소거작용, 항산화작용 및 미백효과를 갖는 백아단이라 칭하는 추출물을 얻는데 있다.A key feature of the present invention is to obtain an extract called white adan, which has free radical scavenging, antioxidant and whitening effects from a mixture of mung bean, white paper, platinum, sine, horseback riding, cloves, natural powder and white tea.

공지된 바와 같이, 녹두는 쌍떡잎식물 장미목 콩과의 한해살이풀로서, 씨에는 비타민과 당질이 풍부하며 헤미셀룰로오스가 3% 가량 포함되어 있다. 녹두는 원기회복과 오장을 도와 정신을 안정시키며 알칼리 식품으로 빈혈과 두통에 좋다.As is known, mung bean is an annual herb of the dicotyledonous rosemary legume, which is rich in vitamins and sugars and contains about 3% of hemicellulose. Mung beans help rejuvenate and stave off your mind and stabilize your mind. Alkaline foods are good for anemia and headaches.

백지는 쌍떡잎식물로 대활, 독활, 구리대라고도 한다. 열매는 타원형이며 백지는 구리때의 뿌리를 말한다. 쿠마린과 정유, 사포닌, 플라보노이드가 확인되었으며 항균 작용이 있다. 진정약, 아픔멎이약, 정혈약으로 사용되었으며 산후 통경약으로도 쓴다.White paper is a dicotyledonous plant, also known as Daebyeong, Dokyeong, and Guridae. Fruit is elliptical, white paper is copper root. Coumarin, essential oils, saponins and flavonoids have been identified and have antimicrobial activity. It is used as a sedative, pain medicine, or blood pill, and also used as a postpartum pain medication.

백급은 외떡잎식물로 난초목 난초과의 여러해살이풀로 이의 덩이뿌리를 일컫는다. 항균작용과 점액질을 가지고 있다. 수렴제, 지혈제로 많이 사용되었으며 세포 재생효과가 우수하다.Pangteum is a monocotyledonous plant and is a perennial herb of the Orchidaceae orchid family. Has antibacterial action and mucus. It is widely used as astringent and hemostatic agent and has excellent cell regeneration effect.

사인은 동남아시아에 주로 서식하거나 재배되며 씨의 주요성분으로 보르네올, 보닐 아세테이트 등이 있다. 동의치료에서 기체 도는 식체로 아프거나 설사, 이질에 사용한다.Cod lives and is cultivated mainly in Southeast Asia, and the main components of seeds are bornol and bonyl acetate. In motion therapy, the gas or plant is used for pain, diarrhea and dysentery.

승마는 미나리아재비과의 여러해살이풀로 뿌리줄기를 승마라 하고, 주요 성분은 페놀라산. 시미게놀, 베타 시토스테롤 등이 있다. 전초에는 쿠에르세틴과 알칼로이드가 있다. 동의치료에서 발한해열약으로, 민간에서는 설사에 쓰며 뿌리줄기가 천연두에 효과가 있다고 한다.Horseback riding is a perennial plant of the Ranunculus family. Horseback riding is known as horseback riding. The main ingredient is phenolic acid. Simigenol, beta sitosterol, and the like. Outposts include quercetin and alkaloids. It is an antipyretic fever medicine that is used for the treatment of copper.

정향은 물푸레나무과의 낙엽관목으로 몰루카섬이 원산지이다. 열대성의 점토질 토영에서 잘 자라며 일반적으로 정향이라 함은 정향나무의 열매를 말한다. 주요성분은 에우게놀 계열의 정유, 타닌, 올레아놀산 등이 있다. 곽란, 건위약에 쓰인다.Clove is a deciduous shrub of ash family, native to Moluka Island. It grows well in tropical clay soils and generally clove refers to the fruit of the clove. The main ingredients are eugenol oil, tannins and oleanolic acid. Kwak Ran is used in placebo.

천화분은 하눌타리, 과루등이라고 불리우며 뿌리를 약용한다. 주요 성분으로 스티그마스테롤. 트리코산틴이 있으며 동의보감에 청열지갈작용이 있다고 한다. 열내림약, 지갈약, 염증약으로 황달, 당뇨병에 사용한다.Cranberries are called Hanultari, fruit trees, and medicinal roots. Stigmasterol as the main ingredient. It has tricoxanthin and it is said that there is a clear heat acting effect. It is used for jaundice and diabetes as a fever lowering medicine, jigger, and inflammatory medicine.

백차는 솜털이 덮인 차의 어린 싹을 덖거나 비비기를 하지 않고 그대로 건조시켜 만든 차로 차잎이 은색의 광택을 낸다. 중국 복건성 정화, 복정 등이 주산지이다.White tea is a tea that is made of dried tea without cutting or rubbing the young shoots of fluffy tea. Fujian, Fujian, and Fujian are the main producers.

일반적으로, 피부노화 메카니즘은 다음과 같다. 자외선이나 외부환경적 요인에 의해 활성산소나 프리라디칼이 생성되며, 생성된 활성산소나, 프리라디칼에 의해 세포막이 공격을 당하게 되어 피부는 염증(inflammation)이 일어나며, 염증화된(inflammated) 조직은 생리학적 진행 메카니즘에 의해 단백질이나 유전자 물질 등을 파괴 하여 주름 등을 형성하는 피부노화가 일어난다. 피부노화 메카니즘에 관여 되는 단계를 모두 억제, 막아 주는 것이 피부노화를 근본적으로 방지할 수 있다.In general, the skin aging mechanism is as follows. Free radicals or free radicals are produced by UV rays or external environmental factors. Cell membranes are attacked by the generated free radicals or free radicals, resulting in inflammation of the skin and inflammated tissues. The aging process leads to skin aging that destroys proteins and genetic material and forms wrinkles. Inhibiting and preventing all steps involved in the skin aging mechanism can fundamentally prevent skin aging.

본 발명에서는 피부노화 방지와 미백효과에 탁월한 성능을 갖는 화장료 조성무를 제조하기 위해서, 일차로 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차를 완전건조한 후, 각각 녹두는 5∼15%, 백지는 1∼5%, 백급은 10∼20%, 사인은 5∼10%, 승마는 10∼20%, 정향은 1∼5%, 천화분은 5∼10%, 백차는 5∼10%의 건조중량비로 혼합한 다음, 추출 용매로서 증류수, 에탄올, 메탄올, 부탄올, 아세톤, 에틸아세테이트, 헥산, 프로판올, 함수 부틸렌글리콜, 함수 프로필렌글리콜로 구성된 그룹으로부터 선택된 하나이상의 용매를 10∼20배 부피량을 가한다.In the present invention, in order to prepare a cosmetic composition radish having excellent performance in preventing skin aging and whitening effect, after first drying the green beans, white paper, white weight, sine, horse riding, cloves, natural powder, white tea, each 5-15% , 1-5% of white paper, 10-20% of white paper, 5-10% of autographs, 10-20% of horse riding, 1-5% of cloves, 5-10% of natural flowers, 5-10% of white tea 10 to 20 times by volume of one or more solvents selected from the group consisting of distilled water, ethanol, methanol, butanol, acetone, ethyl acetate, hexane, propanol, hydrous butylene glycol and hydrous propylene glycol as extraction solvents Add.

추출 방법으로는 냉각 콘덴서가 장치되어 용매가 증발되는 것을 방지한 상태에서 50∼95??의 온도로 4∼20시간 동안 가열하여 추출하거나, 5∼37??의 온도조건하에서 1∼15일간 침적시켜 유효성분을 추출하는 방법을 사용할 수 있다.Extraction method is carried out by heating for 4 to 20 hours at a temperature of 50 to 95 ?? in a state in which a cooling condenser is installed to prevent evaporation of the solvent, or immersing for 1 to 15 days under a temperature condition of 5 to 37 ?? Can be used to extract the active ingredient.

이렇게 추출한 백아단을 냉각 콘덴서가 달린 증류장치를 이용하여 증발되어 나오는 용매를 회수하면서 완전히 감압 농축한 후 그 건조중량으로서 0.001∼50%, 바람직하게는 0.01∼10%의 양만큼 화장료에 첨가하는 것이다.The extracted white granules are concentrated under reduced pressure while recovering the solvent evaporated using a distillation apparatus equipped with a cooling condenser, and then added to the cosmetic by an amount of 0.001 to 50%, preferably 0.01 to 10% as dry weight thereof. .

아래의 실시예 및 실험 예는 단지 본 발명의 기술적 사상을 설명하기 위한것으로, 본 발명의 내용이 여기에 한정되지는 않는다.The following Examples and Experimental Examples are only for illustrating the technical idea of the present invention, but the content of the present invention is not limited thereto.

추출물 제조 실시예 1Extract Preparation Example 1

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 증류수 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬(mesh)의 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 29g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of distilled water, boiled for 3 hours in an extractor equipped with a cooling condenser, filtered through a 400 mesh filter cloth, and filtered at room temperature. After cooling to 5 days and left for 7 days to ripen and filtered with Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 29 g (dry weight).

추출물 제조 실시예 2Extract Preparation Example 2

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 에탄올 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 28g(건조중량)을 얻었다.1kg of mixed dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were mixed with 15kg of ethanol, boiled for 3 hours in an extractor equipped with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 28 g (dry weight).

추출물 제조 실시예 3Extract Preparation Example 3

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 메탄올 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 31g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of methanol, boiled for 3 hours in an extractor with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 31 g (dry weight).

추출물 제조 실시예 4Extract Preparation Example 4

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 부탄올 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 29g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried mung bean, white paper, white weight, sine, horseback riding, cloves, cheonhwa powder and white tea were added to 15 kg of butanol, boiled for 3 hours in an extractor with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 29 g (dry weight).

추출물 제조 실시예 5Extract Preparation Example 5

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 함수 부틸렌글리콜 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 32g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of hydrated butylene glycol, boiled for 3 hours in an extractor equipped with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After cooling, the mixture was left to mature for 5 days at 5 to 15 °, and then aged and filtered through Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 32 g (dry weight).

추출물 제조 실시예 6Extract Preparation Example 6

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 함수 프로필렌글리콜 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 26g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of hydrous propylene glycol, boiled for 3 hours in an extractor with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 26 g (dry weight).

추출물 제조 실시예 7Extract Preparation Example 7

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 헥산 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 35g(건조중량)을 얻었다.1 kg of mixed raw materials of completely dried mung bean, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of hexane, boiled for 3 hours in an extractor with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 35 g (dry weight).

추출물 제조 실시예 8Extract Preparation Example 8

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 프로판올 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 33g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of propanol, boiled for 3 hours in an extractor with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 33 g (dry weight).

추출물 제조 실시예 9Extract Preparation Example 9

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 1kg을 아세톤 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 32g(건조중량)을 얻었다.1kg of mixed dried green beans, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15kg of acetone, boiled for 3 hours in an extractor with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 32 g (dry weight).

추출물 제조 실시예 10Extract Preparation Example 10

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합원료 1kg을 에틸아세테이트 15kg에 넣고 냉각 콘덴서가 달린 추출기에서 3시간 끓여서 추출한 후, 400 메쉬 여과포로 여과하고 상온으로 냉각한 후 5∼15??에서 7일간 방치하여 숙성시킨 후 와트만 2번 여과지로 여과 하였다. 이 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 60??로 감압 농축하여 31g(건조중량)을 얻었다.1 kg of mixed ingredients of completely dried mung bean, white paper, white weight, sine, horseback riding, cloves, natural powder and white tea were added to 15 kg of ethyl acetate, boiled for 3 hours in an extractor equipped with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. After aging for 5 days at 5 ~ 15 ?? was filtered by Whatman No. 2 filter paper. The mixed plant extract was concentrated under reduced pressure at 60 ° in a distillation apparatus equipped with a cooling condenser to obtain 31 g (dry weight).

〈결과 및 고찰〉<Results and Discussion>

실험예 1Experimental Example 1

상기 백아단 추출물 제조 실시예 5에 대하여 항산화 효과를 측정하였다.Antioxidant effect was measured for Example 5 preparation of the sandalwood extract.

(1) 실험 방법(1) Experiment Method

항산화 효과 측정은 펜톤반응 (Fenton reaction)에 의한 지질과산화 반응계(lipid peroxidation system)을 이용한 티오부틸레이트아세트산(TBA) 시험으로 측정하였다. 에틸리놀레이트 10㎕, 0.02% 도데실황산염, 염화제이철 10umol, 과산화수소 2umol을 함유하는 25mM 트리스 완충용액/ 0.75mM 칼륨 완충용액 5ml에 혼합 추출물의 도데실메칠황산염 용액을 가한후 55도에서 16시간 배양후, 4% 부틸히드록실톨루엔 50㎕를 가한후 반응을 정지시킨다.Antioxidant effect was measured by thiobutylate acetic acid (TBA) test using a lipid peroxidation system by the Fenton reaction. 5 ml of 25 mM Tris buffer solution / 0.75 mM potassium buffer solution containing 10 µl of ethyl linoleate, 0.02% dodecyl sulfate, 10 µl of ferric chloride, and 2 µol of hydrogen peroxide were added to the solution of dodecyl methyl sulfate of the mixed extract and incubated at 55 ° C for 16 hours. Thereafter, 50 µl of 4% butylhydroxytoluene was added and the reaction was stopped.

다음에는, 이 용액 0.3ml을 시험관에 넣고 0.05 몰 염산 3.0ml, 0.67% 티오부틸레이트아세트산 용액을 가하고 30분간 끓인다. 이 반응액을 냉각 시킨후 85% 부탄올 4.0ml을 가하고 원심 분리 후 부탄올 등의 흡광도를 535nm에서 측정하여 항산화 효과(%)를 구한다. 이때 대조시험을 동시에 실시한다.Next, 0.3 ml of this solution is placed in a test tube, and 0.05 ml hydrochloric acid 3.0 ml and 0.67% thiobutylate acetic acid solution are added and boiled for 30 minutes. After cooling the reaction solution, 4.0 ml of 85% butanol was added, and after centrifugation, the absorbance of butanol was measured at 535 nm to obtain an antioxidant effect (%). At this time, the control test is performed simultaneously.

도표 1. 백아단의 항산화 효과(실시예 5의 것을 사용)Table 1. Antioxidant Effect of White Sandalwood (Using Example 5)

표1. 백아단의 항산화 효과Table 1. Antioxidant Effect of White Algae

실시예Example 반응액중에 함유시킨 백아단의최종 농도(㎍/㎖)Final concentration of white granules contained in the reaction solution (µg / ml) 항산화 효과(%)Antioxidative effect(%) 실시예 1Example 1 2,0002002,000200 75257525 실시예 2Example 2 2,0002002,000200 80258025 실시예 3Example 3 2,0002002,000200 82338233 실시예 4Example 4 2,0002002,000200 79387938 실시예 5Example 5 2,0002002,000200 93359335 실시예 6Example 6 2,0002002,000200 82408240 실시예 7Example 7 2,0002002,000200 88278827 실시예 8Example 8 2,0002002,000200 91189118 실시예 9Example 9 2,0002002,000200 69196919 실시예 10Example 10 2,0002002,000200 85308530

실험예 2Experimental Example 2

상기 백아단 추출물 제조 실시예 5에 대하여 프리라디칼 소거 효과를 측정 하였다.The free radical scavenging effect was measured for Example 5 preparation of the sandalwood extract.

(1) 실험 방법(1) Experiment Method

60uM의 디펜닐피크릴히드라질(DPPH)용액 2ml에 백아단을 각 농도별로 상온에서 10분간 반응시킨후 520㎚에서 흡광도를 측정하여 프리라디칼 소거작용(%)를 구한다. 이때 대조시험을 실시한다.2 ml of 60 uM of dipenylpicrylhydrazyl (DPPH) solution was reacted with white sand for 10 minutes at room temperature for each concentration, and the absorbance was measured at 520 nm to determine the free radical scavenging activity (%). At this time, a control test is performed.

도표 2. 백아단의 프리라디칼 소거효과(실시예 5의 것을 사용)Table 2. Free radical scavenging effect of white sandalwood (using Example 5)

표 2. 백아단에 대한 프리라디칼 소거작용 효과Table 2. Free radical scavenging effect on white sandal

실 시 예Example 반응액중에 함유시킨 백아단의최종 농도(㎍/㎖)Final concentration of white granules contained in the reaction solution (µg / ml) 프리라디칼 소거작용(%)Free radical scavenging effect (%) 실시예 1Example 1 2002020020 88348834 실시예 2Example 2 2002020020 89238923 실시예 3Example 3 2002020020 93349334 실시예 4Example 4 2002020020 79427942 실시예 5Example 5 2002020020 94439443 실시예 6Example 6 2002020020 92359235 실시예 7Example 7 2002020020 81388138 실시예 8Example 8 2002020020 75387538 실시예 9Example 9 2002020020 83448344 실시예 10Example 10 2002020020 90369036

실험예 3Experimental Example 3

상기 백아단 추출물 제조 실시예 5에 대하여 티로시나제 활성저해 효과를 측정 하였다.Tyrosinase inhibitory effect was measured for Example 5 preparation of the sandalwood extract.

(1) 실험 방법(1) Experiment Method

L-Tyrosine(0.3㎎/㎖) 1.0㎖에 Potassium phosphate buffer solution (pH 6.8, 0.1M) 1.0㎖와 여러 농도의 혼합 식물 추출물 0.9ml을 상온조건에서 넣고 37??에서 10∼20분간 유지한다. 그 후 Tyrosinase(1250 units /ml) 0.1㎖를 넣고 10분간 유지한다. 10분±5초 이내로 꺼내서 얼음물로 구성된 냉동조건에서 반응을 종결 시켰다. 이때 대조군은 각 농도의 혼합 식물 추출물 대신 30% 부틸렌글리콜을 넣었다. 마지막으로 475㎚에서 흡광도를 조사한다. 각농도의 혼합 식물 추출물의 티로시나제 저해 효과는 다음의 공식으로 구한다.1.0 ml of L-Tyrosine (0.3 mg / ml) and 1.0 ml of Potassium phosphate buffer solution (pH 6.8, 0.1M) and 0.9 ml of mixed plant extracts of various concentrations were added at room temperature and maintained at 37 ° for 10-20 minutes. After that add 0.1 ml of Tyrosinase (1250 units / ml) and hold for 10 minutes. The reaction was terminated under freezing conditions consisting of ice water after taking out within 10 minutes ± 5 seconds. At this time, the control group was added 30% butylene glycol instead of the mixed plant extract of each concentration. Finally, the absorbance is examined at 475 nm. The tyrosinase inhibitory effect of each plant extract at each concentration is determined by the following formula.

티로시나제 저해율(%) = [1 - (각 농도 혼합 식물 추출물의 효소 활성도/대조군의 효소 활성도)] X 100% Tyrosinase inhibition = [1-(enzyme activity of control plant extract at each concentration / enzyme activity of control)] X 100

도표 3. 백아단의 티로시나제 활성 저해효과(실시예 5의 것을 사용)Table 3. Tyrosinase Activity Inhibitory Effect of Sandalwood (using Example 5)

표 3. 백아단에 대한 미백효과 측정 결과Table 3. Measurement of whitening effect on white sandal

실 시 예Example 반응액중에 함유시킨 백아단의최종 농도(㎍/㎖)Final concentration of white granules contained in the reaction solution (µg / ml) 티로시나제 저해율(%)Tyrosinase inhibition rate (%) 실시예 1Example 1 20002002000200 81258125 실시예 2Example 2 20002002000200 88358835 실시예 3Example 3 20002002000200 78257825 실시예 4Example 4 20002002000200 79407940 실시예 5Example 5 20002002000200 92519251 실시예 6Example 6 20002002000200 91499149 실시예 7Example 7 20002002000200 69326932 실시예 8Example 8 20002002000200 75287528 실시예 9Example 9 20002002000200 81438143 실시예 10Example 10 20002002000200 77537753

실험예 4Experimental Example 4

상기 백아단 추출물 제조 실시예 5에 대하여 멜라노마 B16의 멜라닌 생성 억제 작용으로 미백 효과를 측정하였다.The whitening effect of Melanoma B16 was measured by the whitening extract preparation Example 5 as a melanin inhibitory action.

(1) 실험 방법(1) Experiment Method

멜라노사이트 배양을 통하여 멜라닌 생성 억제 기능을 세포 수준에서 검정 하였다. B16 멜라노마 세포는 10% 소의 멜라노마 세포를 5% 이산화탄소가 존재하는 곳에서 2일간 배양하여 1.0X108 세포/T25프라스크이 될 때까지 배양한다. 그 다음 농도별로 혼합 식물 추출물을 넣고 5% 이산화탄소가 존재하는 곳에서 2일간 배양한다. 그 후 트립신을 첨가하여 세포들을 수거하여 세포의 흑화 정도를 관찰한다.Melanin production inhibition function was assayed at the cellular level through melanocyte culture. B16 melanoma cells are cultured for 10 days in 10% bovine melanoma cells in the presence of 5% carbon dioxide until 1.0X108 cells / T25 flask. Then mix the plant extracts by concentration and incubate for 2 days in the presence of 5% carbon dioxide. Then trypsin is added to collect the cells and observe the degree of blackening of the cells.

멜라닌이 생성되어 배출된 T25프라스크의 상층액을 취해 475nm에서 흡광도를측정하여 멜라닌을 정량하고, 세포수는 수거된 세포: tryphan blue = 1 : 9 의 비율로 혼합하여 현미경으로 관찰하여 살아있는 세포수를 세어 단위 세포당 생성된 멜라닌의 양을 정량하여 %로 저해 효과를 나타낸다.Melanin was determined by measuring the absorbance at 475 nm after taking up the supernatant of the T25 flask, which had been produced and discharged. Count the amount of melanin produced per unit cell to show the inhibitory effect in%.

도표 4. 백아단의 멜라노마 B16의 멜라닌 생성 억제 작용효과Figure 4. Effect of Melanoma B16 on Melanin Production from Sandalwood

(실시예 5의 것을 사용)(Use of Example 5)

각 농도의 혼합 식물 추출물 농도(㎍/㎖)Mixed Plant Extract Concentration (µg / ml) at Each Concentration

표 4. 백아단에 대한 미백효과 측정 결과Table 4. Measurement results of whitening effect on white sandalwood

실 시 예Example 반응액중에 함유시킨 백아단의최종 농도(㎍/㎖)Final concentration of white granules contained in the reaction solution (µg / ml) 멜라닌생성 저해율(%)Melanogenesis inhibition rate (%) 실시예 1Example 1 2002020020 85148514 실시예 2Example 2 2002020020 80228022 실시예 3Example 3 2002020020 75137513 실시예 4Example 4 2002020020 77187718 실시예 5Example 5 2002020020 76257625 실시예 6Example 6 2002020020 78137813 실시예 7Example 7 2002020020 68136813 실시예 8Example 8 2002020020 88258825 실시예 9Example 9 2002020020 65136513 실시예 10Example 10 2002020020 71157115

처방예 1Prescription Example 1

백아단을 함유한 화장료중 화장수(스킨, 로션)의 처방예는 다음과 같다. 여기에서 백아단은 상기 백아단 추출물 제조 실시예 5의 것이다.A prescription example of a lotion (skin, lotion) among cosmetics containing white sandal is as follows. Here, the sandalwood is that of the preparation of the sandalwood extract Example 5.

번호number 원 료Raw material 실시예 1Example 1 비교예 1Comparative Example 1 1One 백아단White adan 0.001 ∼50.00.001-50.0 -- 22 프로필렌 글라이콜Propylene glycol 5.005.00 5.005.00 33 에탄올ethanol 3.003.00 3.003.00 44 이미다졸리디닐우레아Imidazolidinylurea 0.200.20 0.200.20 55 알란토인Allantoin 0.200.20 0.200.20 66 시트릭애씨드Citrix Acid 0.200.20 0.200.20 77 소듐시트레이트Sodium citrate 0.120.12 0.200.20 88 하이드로제네이티드 캐스터오일Hydrogenated Castor Oil 0.100.10 0.200.20 99 메칠파라벤Methylparaben 0.100.10 0.200.20 1010 조합향료Combination spices 0.100.10 0.100.10 1111 정제수Purified water 총합이 100Total 100 총합이 100Total 100

〈제조방법〉<Manufacturing method>

에탄올에 하이드로제네이티드 캐스터오일, 메칠파라벤, 조합항료를 용해하고 나머지 성분을 용해한 정제수에 투입하여 용해한다.Hydrogenated castor oil, methylparaben and combination chemicals are dissolved in ethanol and dissolved in purified water containing the remaining ingredients.

처방예 2Prescription Example 2

백아단을 함유한 화장료중 로션의 처방예는 다음과 같다. 여기에서 백아단은 상기 백아단 추출물 제조 실시예 5의 것이다.Prescription examples of lotions in cosmetics containing white sandal are as follows. Here, the sandalwood is that of the preparation of the sandalwood extract Example 5.

번호number 원 료Raw material 실시예 5Example 5 비교예 5Comparative Example 5 1One 백아단White adan 0.001∼50.00.001-50.0 -- 22 스쿠알란Squalane 3.503.50 3.503.50 33 세틸알코올Cetyl alcohol 3.003.00 3.003.00 44 글리세린glycerin 3.003.00 3.003.00 55 글리세릴스테아레이트Glyceryl Stearate 2.502.50 2.502.50 66 세틸옥타노에이트Cetyloctanoate 6.006.00 6.006.00 77 소르비탄 세스퀴올리에이트Sorbitan Sesquioleate 1.501.50 1.501.50 88 피이지-100 스테아레이트Fiji-100 Stearate 1.001.00 1.001.00 99 쉐어버터Shea Butter 0.500.50 0.500.50 1010 카보머Carbomer 0.300.30 0.300.30 1111 트리에탄올아민Triethanolamine 0.300.30 0.300.30 1212 메칠파라벤Methylparaben 0.200.20 0.200.20 1313 이미다졸리디닐우레아Imidazolidinylurea 0.150.15 0.150.15 1414 프로필파라벤Propylparaben 0.100.10 0.100.10 1515 조합향료Combination spices 0.100.10 0.100.10 1616 정제수Purified water 총합이 100Total 100 총합이 100Total 100

〈제조방법〉<Manufacturing method>

상기와 같은 함량의 원료를 일반 유화방법으로 오일에 용해되는 성분을 유상성분으로, 정제수에 용해되는 성분을 수상성분으로 하여 일정온도(80∼85??)에서 수상성분과 유상성분을 일반 호모믹서로 균질혼합하는 유화공정을 거처, 증점제(카보머)를 중화한 다음 냉각, 부향, 백아단 첨가, 탈포과정을 거쳐 제조를 완료한다.General homomixer for the water phase component and oil phase component at a constant temperature (80 ~ 85 ??) with the ingredients dissolved in oil as oil phase components and the ingredients dissolved in purified water as water phase components. After homogeneous mixing, the thickener (carbomer) is neutralized, followed by cooling, flavoring, sandalwood addition, and defoaming.

처방예 3Prescription Example 3

백아단을 함유한 화장료중 크림의 처방예는 다음과 같다. 여기에서 혼합 식물 추출물은 상기 백아단 추출물 제조 실시예 5의 것이다.A prescription example of a cream in cosmetics containing white sand is as follows. Here, the mixed plant extract is that of the white sandalwood extract preparation example 5.

번호number 원 료Raw material 실시예 5Example 5 비교예 5Comparative Example 5 1One 백아단White adan 0.001∼500.001-50 -- 22 글리세린glycerin 6.006.00 6.006.00 33 스쿠알란Squalane 6.006.00 6.006.00 44 이소헥사데칸Isohexadecane 5.505.50 5.505.50 55 세틸옥타노에이트Cetyloctanoate 4.004.00 4.004.00 66 글리세릴 스테아레이트Glyceryl Stearate 2.502.50 2.502.50 77 폴리소르베이트 60Polysorbate 60 1.001.00 1.001.00 88 피이지-100 스테아레이트Fiji-100 Stearate 1.001.00 1.001.00 99 스테아린산Stearic acid 1.001.00 1.001.00 1010 라놀린lanolin 1.001.00 1.001.00 1111 라우레쓰-12Laureth-12 1.001.00 1.001.00 1212 세틸알코올Cetyl alcohol 0.500.50 0.500.50 1313 소르비탄 시쓰퀴올리에이트Sorbitan cisquioleate 0.300.30 0.300.30 1414 카보머Carbomer 0.300.30 0.300.30 1515 트리에탄올아민Triethanolamine 0.300.30 0.300.30 1616 메칠파라벤Methylparaben 0.200.20 0.200.20 1717 이미다졸리디닐우레아Imidazolidinylurea 0.150.15 0.150.15 1818 프로필파라벤Propylparaben 0.100.10 0.100.10 1919 조합향료Combination spices 0.100.10 0.100.10 2020 정제수Purified water 총합이 100Total 100 총합이 100Total 100

〈제조방법〉<Manufacturing method>

상기와 같은 함량의 원료를 일반 유화방법으로 오일에 용해되는 성분을 유상성분으로, 정제수에 용해되는 성분을 수상성분으로 하여 일정온도(80∼85??)에서 수상성분과 유상성분을 일반 호모믹서로 균질혼합하는 유화공정을 거쳐, 증점제(카보머)를 중화한 다음 냉각, 부향, 백아단 첨가, 탈포과정을 거쳐 제조를 완료한다.General homomixer for the water phase component and oil phase component at a constant temperature (80 ~ 85 ??) with the ingredients dissolved in oil as oil phase components and the ingredients dissolved in purified water as water phase components. After homogeneous mixing, the thickener (carbomer) is neutralized, followed by cooling, flavoring, sandalwood addition, and defoaming.

처방예 4Prescription Example 4

백아단을 함유한 화장료중 에센스의 처방예는 다음과 같다. 여기에서 혼합 식물 추출물은 상기 백아단 추출물 제조 실시예 5의 것이다.Prescription examples of essences in cosmetics containing white sandal are as follows. Here, the mixed plant extract is that of the white sandalwood extract preparation example 5.

번호number 원 료Raw material 실시예 4Example 4 비교예 4Comparative Example 4 1One 백아단White adan 0.001∼50.00.001-50.0 -- 22 글리세린glycerin 8.008.00 8.008.00 33 부틸렌글라이콜Butylene Glycol 5.005.00 5.005.00 44 피이지-8Fiji-8 3.003.00 3.003.00 55 폴리아크릴아마이드Polyacrylamide 1.001.00 1.001.00 66 라우레쓰-7Laureth-7 1.001.00 1.001.00 77 메칠파라벤Methylparaben 0.200.20 0.200.20 88 이미다졸리디닐우레아Imidazolidinylurea 0.150.15 0.150.15 99 프로필파라벤Propylparaben 0.100.10 0.100.10 1010 조합향료Combination spices 0.100.10 0.100.10 1111 디소듐이디티에이Disodium ID 0.020.02 0.020.02 1212 정제수Purified water 총합이 100Total 100 총합이 100Total 100

〈제조방법〉<Manufacturing method>

상기와 같은 함량의 원료를 일반 유화방법으로 오일에 용해되는 성분을 유상성분으로, 정제수에 용해되는 성분을 수상성분으로 하여 일정온도(80∼85??)에서 수상성분과 유상성분을 일반 호모믹서로 균질혼합하는 유화공정을 거쳐 냉각, 부향, 백아단 첨가, 탈포과정을 거쳐 제조를 완료한다.General homomixer for the water phase component and oil phase component at a constant temperature (80 ~ 85 ??) with the ingredients dissolved in oil as oil phase components and the ingredients dissolved in purified water as water phase components. After homogeneous mixing, the process is completed by cooling, flavoring, sandalwood addition, and defoaming.

[피부에서의 항노화 확인 실험][Anti-aging confirmation experiment in skin]

시험예 1. 피부에 대한 탄력성 증가 시험Test Example 1. Increased elasticity test on the skin

실시예 2와 비교예 2의 로션을 피부에 도포했을 때 피부의 탄력성이 증가되는 효과를 측정하기 위하여 20세∼55세의 여성층으로서 정상, 지성, 건성, 복합성 피부의 소유자 20명에게 안면 왼쪽부분에는 실시예 2의 영양로션을, 안면 오른쪽부분에는 비교예 2의 영양로션을 아침, 저녁으로 1일 2회 도포하여 사용하게 한 후 1주, 2주, 3주 및 4주후에 피부 탄력 측정기기(Ballistometer)를 이용하여 피부의 탄력성을 측정하였다. 측정결과는 다음의 표5 및 그림4에 나타낸다.In order to measure the effect of increasing the elasticity of the skin when the lotions of Example 2 and Comparative Example 2 were applied to the skin, the left part of the face was applied to 20 owners of normal, oily, dry and combination skin as a female layer of 20 to 55 years old. The nutritional lotion of Example 2, the right side of the face is applied to the nutritional lotion of Comparative Example 2 twice a day, morning and evening, and then used for 1 week, 2 weeks, 3 weeks and 4 weeks after the skin elasticity measuring device The elasticity of the skin was measured using a (Ballistometer). The measurement results are shown in Table 5 and Figure 4 below.

실시예 2의 화장료Cosmetics of Example 2 비교예 2의 화장료Cosmetics of Comparative Example 2 비고Remarks T0T0 T1T1 T2T2 T3T3 T4T4 T0T0 T1T1 T2T2 T3T3 T4T4 탄력성Elasticity 튀어오름 수Spring water 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 진폭amplitude 첫번째first 1.91.9 4.84.8 5.05.0 5.15.1 5.65.6 1.91.9 3.03.0 3.33.3 3.63.6 3.63.6 두번째second 1.31.3 4.64.6 5.25.2 5.25.2 5.85.8 1.61.6 2.02.0 2.32.3 2.52.5 2.92.9 세번째third 0.00.0 2.42.4 3.63.6 3.73.7 3.73.7 0.00.0 0.00.0 1.91.9 2.52.5 2.52.5 네번째fourth 0.00.0 1.01.0 2.92.9 3.33.3 3.53.5 0.00.0 0.00.0 0.00.0 0.00.0 0.00.0 평 균Average 0.800.80 3.203.20 4.174.17 4.334.33 4.654.65 0.880.88 1.251.25 1.881.88 2.152.15 2.252.25

(주) T0;사용전(Note) T0; before use

T1 ; 1주 사용후T1; After 1 week

T2 ; 2주 사용후T2; After 2 weeks

T3 ; 3주 사용후T3; After 3 weeks

T4 ; 4주 사용후T4; After 4 weeks

이상의 결과에서 알 수 있는 바와 같이 본 발명에 따른 백아단을 함유하는 실시예 2의 영양로션이 첨가하지 않고 제조된 비교예 2의 영양로션에 비해 피부상태 개선효과에 의해 피부탄력 효과가 매우 우수함을 알 수 있다.As can be seen from the above results, compared to the nutrient lotion of Comparative Example 2 prepared without adding the nutrient lotion of Example 2 containing white sandal extract according to the present invention, the skin elasticity effect was very excellent by the skin condition improvement effect. Able to know.

이상에서 설명한 바와같이, 본 발명에 따르면, 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합물로부터 프리라디칼 소거작용, 항산화작용 및 미백효과를 갖는 백아단이라 칭하는 추출물을 얻으며, 이를 기초로 화장료 조성물을 제조한다.As described above, according to the present invention, an extract called white adan having free radical scavenging, antioxidant activity and whitening effect is obtained from a mixture of mung bean, white paper, white wheat, sine, horseback riding, cloves, natural powder and white tea. A cosmetic composition is prepared on the basis.

상기에서는 본 발명의 바람직한 실시예를 참조하여 설명하였지만, 해당기술 분야의 숙련된 당업자는 하기의 특허청구범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음을 이해할수 있을 것이다.Although the above has been described with reference to a preferred embodiment of the present invention, those skilled in the art will be able to variously modify and change the present invention without departing from the spirit and scope of the invention as set forth in the claims below. It will be appreciated.

Claims (4)

완전 건조시킨 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차의 혼합 원료 일정량을 소정의 용매에 넣고 냉각 콘덴서가 달린 추출기에서 일정시간동안 끓여서 추출한 후 1차 여과하고, 상온으로 냉각시킨 다음 소정의 온도로 일정기간동안 방치하여 숙성시킨 후 2차 여과하며, 이때 얻어진 혼합 식물 추출물을 냉각 콘덴서가 달린 증류장치에서 소정의 온도로 감압 농축하여 얻어지는 것을 특징으로 하는 화장료 조성물의 제조방법.Put a certain amount of mixed raw materials of completely dried green beans, white paper, white wheat, sine, horseback riding, cloves, natural powder and white tea in a predetermined solvent, boil for a certain period of time in an extractor equipped with a cooling condenser, filter it first, and then cool to room temperature. A method of producing a cosmetic composition, characterized in that the mixture is left at a predetermined temperature for a certain period of time for aging, followed by secondary filtration. 제 1 항에 있어서, 상기 용매는, 증류수, 에탄올, 메탄올, 부탄올, 함수 부틸렌글리콜, 함수 프로필렌글리콜, 헥산, 프로판올, 아세톤, 에틸아세테이트로 이루어진 그룹으로부터 선택된 물질인 것을 특징으로 하는 화장료 조성물의 제조방법.The method of claim 1, wherein the solvent is a substance selected from the group consisting of distilled water, ethanol, methanol, butanol, hydrous butylene glycol, hydrous propylene glycol, hexane, propanol, acetone, ethyl acetate Way. 녹두, 백지, 백급, 사인, 승마, 정향, 천화분, 백차로부터 얻은 백아단을 함유하는 화장료 조성물.Cosmetic composition containing white bean obtained from mung bean, white paper, white powder, sine, horseback riding, cloves, natural powder and white tea. 제 3 항에 있어서, 스킨, 로션, 크림, 에센스의 형태로 제조되는 것을 특징으로 하는 화장료 조성물.The cosmetic composition according to claim 3, which is prepared in the form of a skin, lotion, cream, essence.
KR1020030011442A 2003-02-24 2003-02-24 Method of producing a cosmetic composition which contains mixed plant extracts KR20040076103A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060093164A (en) * 2005-02-21 2006-08-24 주식회사 엘지생활건강 Anti-wrinkle cosmetic composition
KR20140120655A (en) 2013-04-04 2014-10-14 최응순 Cosmetic composition containing Hypsizigus marmoreus and the method of manufacturing thereof
KR101521752B1 (en) * 2014-05-09 2015-05-19 주식회사 엘지생활건강 Cosmetic composition having antioxidation activity
CN106726898A (en) * 2016-12-07 2017-05-31 杭州银茗生物技术有限公司 A kind of Ramulus et Folium Mussaendae Pubescentis extract and preparation method and application
KR20180038638A (en) * 2016-10-07 2018-04-17 (주)스와니코코 Cosmetic herbal essence composition having excellent of antioxidant effect and skin improvement and a method for preparing it
CN115737569A (en) * 2022-11-17 2023-03-07 天地恒一制药股份有限公司 Preparation method of radix angelicae formula granules

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060093164A (en) * 2005-02-21 2006-08-24 주식회사 엘지생활건강 Anti-wrinkle cosmetic composition
KR20140120655A (en) 2013-04-04 2014-10-14 최응순 Cosmetic composition containing Hypsizigus marmoreus and the method of manufacturing thereof
KR101521752B1 (en) * 2014-05-09 2015-05-19 주식회사 엘지생활건강 Cosmetic composition having antioxidation activity
KR20180038638A (en) * 2016-10-07 2018-04-17 (주)스와니코코 Cosmetic herbal essence composition having excellent of antioxidant effect and skin improvement and a method for preparing it
CN106726898A (en) * 2016-12-07 2017-05-31 杭州银茗生物技术有限公司 A kind of Ramulus et Folium Mussaendae Pubescentis extract and preparation method and application
CN115737569A (en) * 2022-11-17 2023-03-07 天地恒一制药股份有限公司 Preparation method of radix angelicae formula granules

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