KR102168535B1 - Cosmetic composition for whitening or improving the facial color containing herb extracts - Google Patents

Abstract

The present invention relates to a composition for whitening or improving complexion. The composition comprising the extract of yam root, licorice, windbreak, baekchul, ginger, jujube or a mixture thereof according to the present invention as an active ingredient can be used as a cosmetic composition for whitening or improving complexion by showing a whitening effect by inhibiting melanin synthesis. Do.

Description

Cosmetic composition for whitening or improving the facial color containing herb extracts}

The present invention relates to a cosmetic composition for whitening or improving complexion comprising an herbal extract, and more particularly, effective at least one extract selected from the group consisting of yam root, licorice, windbreak, baekchul, ginger and jujube It relates to a cosmetic composition for whitening or improving complexion comprising as an ingredient.

Melanin, which determines the color of human skin, is produced in melanocytes. Specifically, melanin is a dark brown pigment formed by polymerization and oxidation reactions by enzymes such as tyrosinase present in melanocytes using tyrosine, an amino acid present in vivo, as a substrate. The melanin formed in this way moves to epidermal cells called keratinocytes through dendritic processes of melanocytes. Melanin that has migrated to keratinocytes can be removed by releasing them together from the skin as the keratinocytes break away from the epidermis. However, since there is no enzyme that degrades melanin in the living body, melanin once formed is not degraded in vivo. Therefore, in order to brighten the skin, it can be said that suppressing the production of melanin is the key.

The need for research on whitening agents as cosmetics is gradually increasing as the living standards of the Eastern world, which emotionally prefer white skin, are improved, and skin blackening is recognized as skin aging due to ultraviolet rays. Accordingly, substances exhibiting tyrosinase inhibitory activity, such as ascorbic acid, hydroquinone, glutathione, and arbutin, have been formulated and used in cosmetics and pharmaceuticals (Patent Document 1 and 2) Most of these have insufficient effects or are unstable in their formulation, so their utilization is poor. In particular, compounds such as hydroquinone exhibit a strong bleaching action and have skin sensitization by themselves, which can cause skin allergies and other side effects, such as causing vitiligo by changing the normal skin function. Its use is limited in.

In addition, even if it is a substance that inhibits the activity of tyrosinase as described above, if these substances act on keratinocytes, which are keratinocytes, to increase the production of factors that promote the biosynthesis of melanin, as a result, the whitening effect is weakened or rather Since it can have an adverse effect, simply an inhibitor of tyrosinase activity cannot be considered as a good whitening agent. Accordingly, many tyrosinase inhibitors have been developed, but most of them are known to exhibit no excellent whitening effect.

Under this background, the present inventors have conducted research on a material that is not toxic from natural resources and has excellent skin condition improvement effect, and is selected from the group consisting of yam root, licorice, windbreak, baekchul, ginger and jujube. It was found that the extracts of one or more types of medicinal herbs exhibited the inhibitory effect of melanin synthesis, and a cosmetic composition for whitening or improving complexion was completed using this.

Korean Registered Patent Publication No. 10-0923141 Korean Registered Patent Publication No. 10-0921947

It is an object of the present invention to provide a cosmetic composition for whitening or improving complexion, characterized in that it comprises one or more extracts selected from the group consisting of yam root, licorice, windbreak, baekchul, ginger, and jujube as an active ingredient. will be.

In order to solve the above problems, as an embodiment of the present invention, characterized in that it comprises one or more extracts selected from the group consisting of yam root, licorice, windbreak, baekchul, ginger, and jujube as an active ingredient. It provides a cosmetic composition for whitening or improving complexion.

In another embodiment of the present invention, it provides a cosmetic composition for whitening or improving complexion, comprising a mixed extract of yam root, licorice, windbreak, baekchul, ginger and jujube or a fraction thereof as an active ingredient.

In another embodiment of the present invention, the mixing ratio of the yam root, licorice, windbreak, baekchul, ginger and jujube is 15 to 45: 15 to 45: 5 to 15: 5 to 15: 5 to 15: 5 by weight To 15 may be.

In the present invention, the yam root refers to the root diameter of the yam (Dioscorea japonica) belonging to the Dioscoreaceae family, and is also used as a medicinal material such as goiter, heart inflammation and detoxification, stomach, burns, frostbite, low back pain, oil, and as a tonic and antidiarrheal agent. Preferably, dried yam root may be used.

Licorice (Glycyrrhiza glabra) in the present invention means a perennial herb belonging to the legumes (Leguminosae). Preferably, the roots or stems of licorice may be dried and used. Licorice harmonizes the toxicity of all medicines so that the medicinal effects appear well, control the fever and morale of the ledger, communicate well with all blood veins, and strengthen muscles and bones. Pharmacological action is effective in detoxification, hepatitis, hives, and eczema. Jinhae·Gotdam, muscle relaxation, diuretic, anti-inflammatory, and suppresses peptic ulcer. The outer bark of licorice is reddish brown or dark brown, with vertical wrinkles, sometimes with blood trees, sprouts and scale leaves. Peeled licorice is light yellow on the outside and fibrous.

In the present invention, windbreak (Ledebouriella divaricata) means a perennial herb belonging to the umbel (Umbelliferae). Preferably, the roots or rhizomes of windproof can be dried and used. Windproof is effective for all types of wind disease, such as external headaches, chills, fever, body aches, and sore throats. It is used for limb joint pain, tetanus, muscle cramps, hemiplegia due to stroke, paralysis pain, etc. As pharmacological action, antipyretic, anti-inflammatory, antispasmodic, immune activation, anti-allergic, anti-ulcer, and antibacterial have been reported. The windbreak has a columnar shape and the lower part is slightly thin. The outer surface is light brown, and the upper part of the rhizome has densely rounded longitudinal wrinkles, and there are some with the residues of weeds in the shape of brown hair. The root has many longitudinal wrinkles and fine root marks. There are many fine hairs like a brush on the brain head, and there are radial patterns.

In the present invention, Baekchul refers to the rootstock of Atractylodes japonica belonging to Compositae. Preferably, a dry baekchul may be used. Baekchul is a weak stomach (脾胃) function of the weak news, a feeling of boredom occurs, the face is yellow, and the stool is thin, good for diarrhea. It is also used for chest leaps, coughs, and clear phlegm due to the accumulation of water and moisture in the rain. It is also used for spontaneous sweating of the skin due to weakness of the secretion, and for vomiting during pregnancy. do. It is also used for cold and limb pain with gastrointestinal disorders. Pharmacologically, mice have been reported to gain weight, increase endurance, increase phagocytosis, and promote cellular immune function. In addition, intestinal suppression and control of excitatory action, anti-ulcer and liver function protection, immune function enhancement, vasodilation, diuretic and blood sugar lowering, and anticancer activity have been reported.

In the present invention, ginger refers to the root diameter of ginger (Zingiber officinale), a perennial herb belonging to the ginger family (Zingiberaceae). Preferably, the ginger may be dried. Ginger cures chills, fever, headache, vomiting, seawater, and phlegm caused by colds. It is also effective for abdominal pain, diarrhea and stomach caused by food poisoning. As a pharmacological action, gastric juice secretion promotion, digestion enhancement, heart excitation, blood circulation promotion, and inhibition have been reported.

In the present invention, jujube refers to a mature fruit of the jujube (Zizyphus jujube) belonging to the Rhamnaceae family. Preferably, the date may be dried. Jujube is eaten raw or is used for cooking rice cakes and medicinal herbs.Dried jujube in September has the effect of nutrition, tonicity, pain relief, detoxification, etc. in oriental medicine, so lack of energy, systemic pain, insomnia, muscle cramps, drug addiction Used for the back.

The term "extract" used in the present invention refers to an extract obtained by extraction treatment of the yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof, a diluent or pesticide solution of the extract, and obtained by drying the extract. It includes the extract of all formulations that can be formed using the extract itself and the extract, such as a dried product, a preparation or purified product of the extract, or a mixture thereof.

The extract of the present invention may be extracted from natural, hybrid or variant plants of the respective plants, and may be extracted from plant tissue culture.

In the herbal extracts of the yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof of the present invention, the method of extracting the extract is not particularly limited, and extraction according to a method commonly used in the art can do. Non-limiting examples of the extraction method include a hot water extraction method, an ultrasonic extraction method, a filtration method, a reflux extraction method, and the like, which may be performed alone or in combination of two or more methods.

In the present invention, the kind of the extraction solvent used to extract the yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water; C ₁ to C ₄ lower alcohols such as methanol, ethanol, propyl alcohol, and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol, and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof may be used, and preferably, water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in combination of two or more. In the present invention, more preferably, water (or distilled water), 1,3-butylene glycol, or a mixed solvent thereof is used as a solvent for extracting herbal medicines of yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof. In addition, more preferably, a solvent obtained by mixing water (or distilled water): 1,3-butylene glycol in a weight ratio of about 7:3 may be used. In addition, more preferably, a solvent in which water (or distilled water): 1,3-butylene glycol is mixed in a weight ratio of about 6:4 may be used. A solvent extract can be prepared by extracting yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof at least once using the solvent, and the solvent extract is distilled under reduced pressure and then freeze-dried or spray-dried. Dry extract can be prepared. In a specific embodiment of the present invention, using a solvent in which water (or distilled water): 1,3-butylene glycol is mixed in a weight ratio of 6:4, yam root extract, licorice extract, windbreak extract, white extract extract, ginger extract, jujube Extracts and extracts of the herbal mixture were prepared respectively (Examples 1 to 7).

In the present invention, the extract obtained by heat extraction or cold needle extraction is filtered to remove suspended solid particles, for example, nylon, etc. to filter the particles, or after filtration using a freeze filtration method, etc. It can be used after drying by spray drying or the like.

As used herein, the term "fraction" means a result obtained by performing fractionation in order to separate a specific component or a specific component group from a mixture containing several different constituents.

The fractionation method for obtaining the fraction in the present invention is not particularly limited, and may be performed according to a method commonly used in the art. Non-limiting examples of the fractionation method include a method of obtaining a fraction from the extract by treating an extract obtained by extracting yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof.

In the present invention, the type of solvent used to obtain the fraction is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the fractionation solvent include polar solvents such as water and alcohol; Nonpolar solvents, such as hexane, ethyl acetate, chloroform, and dichloromethane, etc. are mentioned. These may be used alone or in combination of two or more. In the case of using an alcohol in the fractionation solvent, preferably a C ₁ to C ₄ alcohol may be used.

The yam root extract, licorice extract, windbreak extract, baekchul extract, ginger extract, jujube extract, or a mixed extract thereof of the present invention has an effect of effectively inhibiting the production of melanin, and specifically shows the effect of reducing the total amount of melanin synthesized. . In addition, since the composition of the present invention is a material derived from a natural product, it is not toxic, and even when applied to the human body, side effects are not caused, so it can be used as a cosmetic composition.

Melanin is a dark brown pigment produced from melanocytes, which determines the color of human skin, and can be expected to brighten skin by inhibiting melanin pigment.

In relation to the above efficacy, according to a specific embodiment of the present invention, yam root extract, licorice extract, windbreak extract, white extract, ginger extract, jujube extract, or a mixture extract thereof are used in mouse melanoma cells (B-16 mouse melanoma cells). When treated by concentration, it was confirmed that the melanin content of melanoma cells decreased depending on the treatment concentration of the extract (Example 8), and it was found that the extract can be used for whitening or improving complexion. .

In particular, the extract of the mixture containing all of the yam root, licorice, windbreak, baekchul, ginger, and jujube of the present invention or a fraction thereof is a synergistic effect or cooperative action between the extracts and/or the active ingredients in the extract. Compared to the single extract of the plant, it was able to exhibit more excellent skin whitening or complexion improving efficacy, which was first identified in the present invention.

Specifically, the extract of a mixture containing all of the yam root, licorice, windbreak, baekchul, ginger and jujube of the present invention or a fraction thereof is used as herbal medicine than the extract of yam root, licorice, windbreak, baekchul, ginger or jujube alone or a fraction thereof By further reducing the total amount of melanin in melanoma cells relative to the weight, as a result, it was possible to exhibit more excellent skin whitening or complexion improvement effect.

In the present invention, the mixing ratio of the yam root, licorice, windbreak, baekchul, ginger and jujube is preferably 15 to 45: 15 to 45: 5 to 15: 5 to 15: 5 to 15: 5 to 15 days by weight have.

According to a specific embodiment of the present invention, a mixture of the yam root, licorice, windbreak, baekchul, ginger and jujube in a mixture ratio of 30: 30: 10: 10: 10: 10 was prepared, and the melanin of their melanoma cells As a result of examining the degree of reduction in total amount, it was confirmed that the degree of reduction in the total amount of melanin in melanoma cells was greater than that of a single extract of yam root, licorice, windbreak, baekchul, ginger or jujube (Example 8).

The term "whitening" used in the present invention refers to any action of inhibiting or preventing melanin deposition by inhibiting the synthesis of melanin.

As used herein, the term "improving complexion" means that skin blemishes such as spots, freckles, and age spots on the face are removed or produced is suppressed, and the skin tone is brightened, so that the overall color of the face is improved aesthetically.

The cosmetic composition of the present invention is a solution, external ointment, cream, foam, nutrient lotion, flexible lotion, pack, softening water, emulsion, makeup base, essence, soap, liquid detergent, bathing agent, sunscreen cream, sun oil, suspension, emulsion It can be prepared in a formulation selected from the group consisting of liquid, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch, and spray, but is limited thereto. no.

The cosmetic composition of the present invention may additionally include one or more cosmetically acceptable carriers blended in general skin cosmetics, and as common ingredients, for example, oil, water, surfactants, moisturizers, lower alcohols, thickeners , A chelating agent, a colorant, a preservative, a fragrance, and the like may be appropriately blended, but are not limited thereto.

The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.

When the formulation of the present invention is an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc. May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohard It may include a propellant such as locarbon, propane/butane or dimethyl ether, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent may be used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil, and the like may be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used, but are not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a soap, an alkali metal salt of a fatty acid, a fatty acid hemiester salt, a fatty acid protein hydrolyzate, isethionate, a lanolin derivative, an aliphatic alcohol, vegetable oil, glycerol, sugar, etc. are used as a carrier component. It may be, but is not limited thereto. These may be used alone or in combination of two or more.

In the cosmetic composition of the present invention, the herbal extract of yam root, licorice, windbreak, baekchul, ginger, jujube or a mixture thereof may be included in a dry weight, preferably 0.0001 to 50% by weight of the total weight of the cosmetic composition, and more It is preferably contained in 0.0005 to 10% by weight. There is an advantage of showing excellent whitening or complexion improvement effect within the above range, and there is an advantage of stabilizing the formulation of the composition.

The cosmetic composition comprising the extract of yam root, licorice, windbreak, baekchul, ginger, jujube, or a mixture thereof or a fraction thereof as an active ingredient of the present invention has excellent skin whitening effect. Specifically, the composition of the present invention is excellent in the efficacy of inhibiting the increase in the total amount of melanin.

In addition, since the composition of the present invention is a material derived from a natural product, it is not toxic, and even when applied to the human body, it does not cause side effects, so its utilization as a cosmetic composition is high.

Hereinafter, the configuration and effects of the present invention will be described in more detail through examples. These examples are for illustrative purposes only, and the scope of the present invention is not limited by these examples.

Example One : Of yam root extract Produce

After the yam roots were well dried and minced, 100 g of dry weight was put into a flask, and extracted by cold soaking for 3 days with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6:4). The chilled extract was filtered through a filter having a pore size of 0.2 μm to prepare a yam root extract.

Example 2: Preparation of licorice extract

After the licorice was well dried and minced, 100 g of dry weight was placed in a flask, and extracted by cold soaking with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6:4) for 3 days. The cold-precipitated extract was filtered through a filter having a pore size of 0.2 μm to prepare a licorice extract.

Example 3: Preparation of windbreak extract

After the windbreak was well dried and minced, 100 g of dry weight was put into a flask and extracted by cold soaking with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6:4) for 3 days. The cold-precipitated extract was filtered through a filter having a pore size of 0.2 μm to prepare a windbreak extract.

Example 4 : Baekchul extract Produce

After the white extract was well dried and minced, 100 g of dry weight was put into a flask and extracted by cold soaking with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6:4) for 3 days. The cold-precipitated extract was filtered through a filter having a pore size of 0.2 μm to prepare a Baekchul extract.

Example 5: Preparation of ginger extract

After the ginger was well dried and minced, 100 g of dry weight was put in a flask, and extracted by cold soaking with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6:4) for 3 days. Ginger extract was prepared by filtering the chilled extract through a filter having a pore size of 0.2 μm.

Example 6: Preparation of jujube extract

After the jujube was well dried and minced, 100 g of dry weight was put into a flask and extracted by cold soaking with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6:4) for 3 days. The chilled extract was filtered through a filter having a pore size of 0.2 μm to prepare a jujube extract.

Example 7: Preparation of mixed extract of herbal medicine

After drying the yam root, licorice, windbreak, baekchul, ginger and jujube well and mincing them, add 100g of total dry weight (30g yam root, 30g licorice, windbreak, 10g, 10g baekchul, 10g ginger, 10g jujube) into a flask and extract The solvent (distilled water: 1,3-butylene glycol = 6:4) was extracted by cold soaking for 3 days with 1000 g. The cold-precipitated extract was filtered through a filter having a pore size of 0.2 μm to prepare a herbal compound extract.

Example 8: Whitening effect-check the effect of reducing the total amount of melanin

The extracts of Examples 1 to 7 were added to the culture medium of mouse melanoma cells (B-16 mouse melanoma cells) to test the whitening effect at the cellular level. For comparison, no separate treatment was applied to the negative control group, and arbutin was added to the positive control group.

Specifically, for the herbal extracts of Examples 1 to 7, the final concentration (wt%) was 0.1% or 1%, respectively, and arbutin, a positive control, was added to the medium so as to be 200 μg/ml, respectively, and B- 16 melanoma cells were treated and cultured for 3 days.

Thereafter, the cells were treated with trypsin, removed from the culture vessel, centrifuged, and melanin was extracted. The detached cells were boiled for 10 minutes by adding 1 ml of sodium hydroxide solution (1N concentration) to dissolve melanin, and the absorbance was measured at 400 nanometers (nm) using a spectrophotometer to measure the amount of melanin produced.

The amount of melanin was measured by a method expressed in terms of absorbance per unit cell count (10 ⁶ cells), calculated as an inhibition rate (%) relative to the total amount of melanin relative to the negative control group, and the results are summarized in Table 1 below. Also, the experiment was repeated 3 times.

Total melanin reduction effect of herbal extracts sample Total melanin (Absorbance) Inhibition rate (%) Negative control 0.082 - Arbutin (200㎍/ml) 0.042 48.78 Example 1 (0.1%) 0.071 13.4 Example 1 (1.0%) 0.069 15.9 Example 2 (0.1%) 0.068 17.1 Example 2 (1.0%) 0.067 18.3 Example 3 (0.1%) 0.075 8.5 Example 3 (1.0%) 0.070 14.6 Example 4 (0.1%) 0.069 15.9 Example 4 (1.0%) 0.058 29.3 Example 5 (0.1%) 0.068 17.1 Example 5 (1.0%) 0.066 19.5 Example 6 (0.1%) 0.070 14.6 Example 6 (1.0%) 0.068 17.1 Example 7 (0.1%) 0.051 37.8 Example 7 (1.0%) 0.045 45.1

As can be seen from the results of Table 1, yam root extract, licorice extract, windbreak extract, baekchul extract, ginger extract, jujube extract, and mixed extracts of these herbal medicinal herbs inhibit melanin synthesis, thereby reducing the total amount of melanin. As can be seen, it was confirmed that it can be used for whitening or improving complexion.

In addition, in the case of Example 7 extracted by mixing the six herbal medicinal herbs at 30:30:10:10:10:10:10 by weight, there is an effect of further greatly reducing the total amount of melanin compared to each herbal extract alone, and in particular In the case of a concentration of 1%, it was confirmed that it exhibited excellent melanin total reduction efficacy similar to that of arbutin, a previously known whitening substance, and it was found that it can be used for whitening or complexion improvement.

Manufacturing example 1: Preparation of essence containing the mixed extract of the present invention

A cosmetic composition of an essence formulation was prepared as shown in Table 2 below (unit: wt%).

Raw material name Content (% by weight) Cetearyl alcohol
Cetearyl glucoside
Jojoba seed oil
Silica
glycerin
Example 7 extract
Purified water 2
One
5
0.5
10
5
To 100

Manufacturing example 2: Preparation of a cream containing the mixed extract of the present invention

As shown in Table 3 below, a cream-formed cosmetic composition was prepared (unit: wt%).

Composition Content (% by weight) Example 7 extract
Stearic acid
ethanol
Potassium hydroxide
glycerin
Propylene glycol
antiseptic
incense
Purified water 5
15.0
1.0
0.7
5.0
3.0
Appropriate amount
Appropriate amount
to 100

Claims (7)

A cosmetic composition for whitening or improving complexion, comprising a yam root extract or a fraction thereof as an active ingredient.
The cosmetic composition for whitening or improving complexion according to claim 1, comprising a mixed extract of yam root, licorice, windbreak, baekchul, ginger and jujube or a fraction thereof as an active ingredient.
The method of claim 2, wherein the mixing ratio of yam root, licorice, windbreak, baekchul, ginger and jujube is 15 to 45: 15 to 45: 5 to 15: 5 to 15: 5 to 15: 5 to 15 by weight Cosmetic composition for whitening or improving complexion, characterized in that.
The cosmetic composition for whitening or improving complexion according to claim 3, wherein the mixing ratio of the yam root, licorice, windbreak, baekchul, ginger and jujube is 30:30:10:10:10:10:10 by weight.
The method of claim 1, wherein the extract is obtained by extracting yam root with at least one solvent selected from the group consisting of water, C ₁ to C ₄ lower alcohol, 1,3-butylene glycol, and ethyl acetate. Cosmetic composition for whitening or improving complexion, characterized in that.
The cosmetic composition for whitening or improving complexion according to claim 5, wherein the solvent is a mixture of water and 1,3-butylene glycol in a weight ratio of 6:4.
The cosmetic composition of claim 1, wherein the whitening or complexion improvement is due to a decrease in the total amount of melanin in melanoma cells.