KR20160003919A - Cosmetic composition for whitening or improving the facial color containing herb extracts - Google Patents

Abstract

The present invention relates to a composition for whitening or improving facial color. The composition comprising Dioscorea japonica Thunb. root, Ledebouriella seseloides, Atractylodes macrocephala Koidzumi, Zingiber officinale, and Zizyphus jujuba Miller var. inermis Rehder and a mixed extract or fractions thereof as active components according to the present invention has a whitening effect by controlling melanin synthesis, thereby being used as a cosmetic composition for whitening or improving facial color.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition for whitening or improving the complexion,

The present invention relates to a cosmetic composition for improving whitening or facial color including an extract of a medicinal herb, and more particularly, to a cosmetic composition for improving whitening or facial color, which comprises extracts of one or more selected from the group consisting of yam root, licorice, windblown, The present invention relates to a cosmetic composition for improving whitening or complexion.

Melanin, which determines human skin color, is produced in melanocytes. Specifically, melanin is a black-brown pigment formed by a polymerization oxidation reaction with an enzyme such as tyrosinase existing in melanocytes, using tyrosine as an amino acid present in vivo as a substrate. The melanin thus formed is transferred to the epidermal cell called keratinocyte through the dendrites of melanocytes. Melanin, which has been transferred to keratinocytes, can be removed by keratinocytes falling off the skin when they fall off the epidermis. However, since there is no enzyme that degrades melanin in vivo, the once formed melanin is not decomposed in vivo. Therefore, in order to lighten the skin, it is important to suppress the production of melanin.

Recently, the study of whitening agents as cosmetics has become increasingly necessary as skin blackness is recognized as skin aging due to ultraviolet rays, along with the improvement of living standards in Asian countries, which prefer emotionally white skin. Accordingly, substances exhibiting tyrosinase inhibitory activity such as ascorbic acid, hydroquinone, glutathione, and arbutin have been used in cosmetics and medicines (Patent Documents 1 and 2) 2) Most of them are ineffective or unstable because of their shape. In particular, a compound such as hydroquinone exhibits a strong decolorizing action, has a skin sensitization itself, can induce skin allergies and the like, and exhibits adverse effects such as inducing vitiligo by changing normal skin functions. Thus, Its use is limited.

In addition, even if the substance inhibits the activity of tyrosinase as described above, if such a substance acts on keratinocytes, which are keratinocytes, to increase the production of factors promoting melanin biosynthesis, the whitening action is consequently weakened The active inhibitor of tyrosinase is not considered to be a good whitening agent because it can cause harmful effects, and many tyrosinase inhibitors have been developed, but most of them are known to show no excellent whitening effect.

Under these circumstances, the inventors of the present invention conducted studies on substances which are not toxic to naturally occurring natural resources and have excellent skin condition improving effect, and selected from the group consisting of yam root, licorice root, windblown, ginger and jujube Of the present invention exhibit melanin synthesis inhibitory activity, and the cosmetic composition for improving whitening or complexion has been completed.

Korean Patent Registration No. 10-0923141 Korean Patent Registration No. 10-0921947

The object of the present invention is to provide a cosmetic composition for improving whitening or complexion, which comprises, as an active ingredient, at least one extract or a fraction thereof selected from the group consisting of yam root, licorice, windblown, extract, ginger and jujube will be.

In order to solve the above problems, an embodiment of the present invention is characterized by comprising, as an active ingredient, at least one extract or a fraction thereof selected from the group consisting of yam root, licorice, windblown, The present invention provides a cosmetic composition for improving whitening or complexion.

In another embodiment of the present invention, there is provided a cosmetic composition for improving whitening or complexion, which comprises, as an active ingredient, a mixed extract of yam root, licorice, windshield, alfalfa, ginger and jujube or a fraction thereof.

In another embodiment of the present invention, the mixing ratio of yam root, licorice, windblown, alfalfa, ginger and jujube is 15 to 45:15 to 45: 5 to 15: 5 to 15: 5 to 15: To 15 days.

In the present invention, yam root means rootstock of yam (Dioscorea japonica) belonging to Dioscoreaceae. It is also used as a medicament such as goiter, carditis, detoxification, dryness, burn, frog, back pain, Preferably, the dried yam root can be used.

In the present invention, licorice (Glycyrrhiza glabra) means a perennial herb that belongs to leguminosae. Preferably, the root or stem of licorice root can be dried and used. Licorice harmonizes the toxicity of all medicines and makes the medicinal effect appear, regulates the fever and morale of the book, makes good communication of all blood vessels, and strengthens muscles and bones. Pharmacological action is effective for detoxification, hepatitis, urticaria, and eczema. Jinhae, geomung, muscle relaxation, diuretic, anti-inflammatory action and suppress peptic ulcer. Licorice crust is reddish brown or dark brown with vertical wrinkles and occasionally shrubs, buds and scales. The outer skin of the peeled licorice is pale yellow and fibrous.

In the present invention, Lepidoptera (Ledebouriella divaricata) refers to perennial herbaceous plants belonging to the genus Umbelliferae. Preferably, roots or rootstocks of windshields can be used by drying. Windshield is effective for all kinds of winds such as headache, chills, fever, whole body and sore throat. It is used for painful limb pain, tetanus, muscle cramps, paralysis due to paralysis, and paralysis. The pharmacological effects of antipyretic, anti-inflammatory, anti-inflammatory, anti-inflammatory, anti-allergic, anti-ulcer, antibacterial and have been reported. The windshield is cylindrical and the lower part is slightly thinner. The outer surface is light brown, and the upper part of the rootstock has dense wrinkles in the form of rounded nodules, and some of the hairy leaves of brown hair are attached. The roots have many vertical wrinkles and marks of thin roots. There are many fine hairs such as brushes on the head and radial pattern.

In the present invention, the term "flower bud" refers to the root stem of Atractylodes japonica belonging to Compositae. Preferably, the dried product may be dried. It is weak in the function of 脾 胃 (脾胃), news, mala appearance, yellow color of the face is diluted, the diarrhea is good, and the water is stagnant, the whole body is swollen, helps digestion of water when not digested. It can also be used for chest leaks, coughs and clear sputum caused by accumulation of water and wetness in the spleen. It is also used for the vomiting of pregnancy and sweating on the skin due to fragility. do. It is also used for colds and limb pain with gastrointestinal disorders. Pharmacological studies have been reported to increase mouse weight and endurance, increase phagocytosis, and stimulate cellular immune function. In addition, intestinal (intestinal) inhibition and control of excitement, anti-ulcer and liver function protection, immune function hyperactivity, vasodilation, diuretic and hypoglycemic effects, and anti-cancer effects have been reported.

In the present invention, ginger refers to the root of Zingiber officinale, a perennial plant belonging to Zingiberaceae. Preferably, the dried ginger can be used. Ginger treats chills, fever, headache, vomiting, seawater and sputum caused by colds. It also works on abdominal pain and diarrhea caused by food poisoning. It also boils ginger in boiling water and drinks in tea. Pharmacological action to promote gastric secretion, digestive power, cardiac excitement, blood circulation promotion, and bacillary action have been reported.

In the present invention, jujube means the mature fruit of the jujube (Zizyphus jujube) belonging to the Rhamnaceae family. Preferably, the jujube can be dried. Jujube is used for daily diets or for cooking such as rice cakes and short meals. Dried jujube in September, and it has efficacy such as nutrition, tonic, shinhae, analgesia, detoxification in one room, lack of energy, general pain, insomnia, muscle cramps, drug poisoning .

The term "extract" used in the present invention refers to an extract obtained by the extraction treatment of the yam root, licorice, windshield, liquorice, ginger, jujube or mixture thereof, a dilute or concentrated solution of the extract, Extracts of all the formulations which can be formed using the extract itself and the extract, such as a dried product, a controlled preparation or a purified product of the above extract, or a mixture thereof.

The extract of the present invention can be extracted from natural, hybrid, or mutant plants of the respective plants, and can also be extracted from plant tissue cultures.

In the herbal medicine extract of yam root, licorice, windblown, liquorice, ginger, jujube, or mixture thereof, the method for extracting the extract of the present invention is not particularly limited and may be carried out in accordance with a method commonly used in the art can do. Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.

In the present invention, the kind of the extraction solvent used to extract the yam root, licorice, windbreak, extract, ginger, jujube or mixture thereof is not particularly limited and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water; C ₁ to C ₄ lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof. Water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in admixture of two or more. In the present invention, water (or distilled water), 1,3-butylene glycol, or a mixed solvent thereof is preferably used as a solvent for extracting herbal medicine roots, licorice root, wind chimes, ginger, jujube or mixtures thereof And more preferably, a solvent in which water (or distilled water): 1,3-butylene glycol is mixed at a weight ratio of about 7: 3 can be used. More preferably, a solvent in which water (or distilled water): 1,3-butylene glycol is mixed at a weight ratio of about 6: 4 can be used. The solvent may be used to prepare a solvent extract by extracting the yam root, licorice, windblown, liquorice, ginger, jujube or a mixture thereof at least once. The solvent extract may be subjected to vacuum distillation or freeze drying or spray drying A dry extract can be prepared. In one specific embodiment of the present invention, a mixture of water (or distilled water) and 1,3-butylene glycol in a weight ratio of 6: 4 is used to make a yam root extract, licorice extract, windshield extract, And extracts of the herbal mixture were respectively prepared (Examples 1 to 7).

In the present invention, the extract obtained by heat extraction or cold extraction is filtered to remove suspended solid particles by filtration, for example, nylon or the like, or filtered using a freezing filtration method or the like, Spray drying and the like.

The term "fraction " as used herein means a product obtained by performing fractionation to separate a specific component or a specific component group from a mixture containing various components.

The fractionation method for obtaining the fraction in the present invention is not particularly limited and may be carried out according to a method commonly used in the art. As a non-limiting example of the above-mentioned fractionation method, there can be mentioned a method of obtaining a fraction from the extract by treating a predetermined solvent with an extract obtained by extracting yam root, licorice, windblown, extract, ginger, jujube or mixture thereof.

The kind of the solvent used for obtaining the fraction in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the fraction solvent include polar solvents such as water and alcohol; And non-polar solvents such as hexane, ethyl acetate, chloroform, and dichloromethane. These may be used alone or in combination of two or more. When alcohols are used in the fraction solvent, C ₁ to C ₄ alcohols can be preferably used.

The yam root extract, licorice extract, windbreak extract, chrysanthemum extract, ginger extract, jujube extract, or mixed extract thereof of the present invention has an effect of effectively inhibiting the production of melanin and specifically decreasing the total amount of synthesized melanin . In addition, since the composition of the present invention is a substance derived from a natural material, it is not toxic and can be used as a cosmetic composition without adverse effect even when it is applied to a human body.

Melanin is a dark brown pigment produced in melanocytes, which determines the skin color of a person and can be expected to brighten the skin by inhibiting melanin pigmentation.

According to a specific embodiment of the present invention, a yamma root extract, a licorice extract, a windbreak extract, an extract, a ginger extract, a jujube extract or a mixed extract thereof is administered to a B-16 mouse melanoma cell It was confirmed that the melanin content of Melanoma cells was reduced in dependence on the treatment concentration of the extract (Example 8), and the extract could be used for whitening or improving the complexion .

In particular, the extract of the mixture or its fractions containing both yam root, licorice, windblown, extract, ginger and jujube of the present invention can be obtained by synergistic or cooperative action between extracts and / It is possible to exhibit a superior skin whitening or anti-color improvement effect as compared with a single extract of a plant, which was first identified in the present invention.

Specifically, the extract of the mixture or the fraction thereof containing all of the yam root, licorice, windblown, liquorice, ginger and jujube of the present invention is superior to the extract of herbal root, licorice, windblown, The total melanin content of melanoma cells by weight was further reduced, resulting in better skin whitening or anti-coloring effect.

In the present invention, the blending ratio of yam root, licorice, windblown, alfalfa, ginger and jujube is preferably 15 to 45:15 to 45: 5 to 15: 5 to 15: 5 to 15: 5 to 15 have.

According to a specific embodiment of the present invention, a mixed extract having a mixing ratio of 30: 30: 10: 10: 10: 10 was prepared from the yam root, licorice, windblown, As a result of the decrease in the total amount of melanoma cells, it was confirmed that the decrease in the total amount of melanoma cells was larger than that of the single extract of yam root, licorice, windshield, alfalfa, ginger or jujube (Example 8).

As used herein, the term "whitening" means any action that inhibits the synthesis of melanin and inhibits or prevents skin deposition of melanin.

As used herein, the term "improvement in complexion" means that skin irritation such as spots on the face, freckles, black spots, etc. is removed or suppressed and the skin tone is brightened, thereby improving the overall color of the face.

The cosmetic composition of the present invention can be used as a cosmetic composition in the form of a solution, a topical ointment, a cream, a foam, a nutritional lotion, a softening lotion, a pack, a soft water, a latex, a makeup base, But are not limited to, those selected from the group consisting of solutions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansing, oils, powdered foundations, emulsion foundations, wax foundations, patches and sprays no.

The cosmetic composition of the present invention may further comprise at least one cosmetically acceptable carrier to be incorporated in a cosmetic composition for general skin. Examples of the cosmetic composition include ordinary ingredients such as oil, water, a surfactant, a moisturizer, a lower alcohol, , A chelating agent, a coloring agent, a preservative, a perfume, and the like may be appropriately compounded, but the present invention is not limited thereto.

The cosmetically acceptable carrier contained in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.

When the formulations of the present invention are ointments, pastes, creams or gels, the carrier component may be an animal oil, a vegetable oil, a wax, a paraffin, a starch, a tracer, a cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc, zinc oxide May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder and the like may be used as a carrier component. In particular, But are not limited to, propellants such as rocaborn, propane / butane or dimethyl ether. These may be used alone or in combination of two or more.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent may be used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil and the like can be used, and particularly fatty acid esters of cottonseed oil, peanut oil, corn oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or sorbitan May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, but are not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a soap, use is made of an alkali metal salt of a fatty acid, a fatty acid hemiester salt, a fatty acid protein hydrolizate, isethionate, a lanolin derivative, an aliphatic alcohol, a vegetable oil, glycerol, But is not limited thereto. These may be used alone or in combination of two or more.

In the cosmetic composition of the present invention, the herbal medicine extract of yam root, licorice, windblown, liquorice, ginger, jujube or mixture thereof may preferably be contained in an amount of 0.0001 to 50% by weight of the total weight of the cosmetic composition, And preferably from 0.0005 to 10% by weight. There is an advantage of exhibiting excellent whitening or anti-color improvement effect within the above range, and there is an advantage that the formulation of the composition is stabilized.

The cosmetic composition of the present invention comprising an extract of rosemary root, licorice root, windblown rouge, ginger, jujube or mixture thereof or a fraction thereof as an active ingredient is excellent in skin whitening effect. Specifically, the composition of the present invention is excellent in the effect of inhibiting the increase of the total amount of melanin.

In addition, since the composition of the present invention is a substance derived from a natural substance, it has no toxicity and does not cause side effects even when it is applied to human body, and thus it is highly utilized as a cosmetic composition.

Hereinafter, the constitution and effects of the present invention will be described in more detail through examples. These embodiments are only for illustrating the present invention, and the scope of the present invention is not limited by these embodiments.

Example  One : Yam root extract  Produce

The yam roots were well dried and then placed in three separate flasks, and 100 g of dry weight was added to the flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a yam root extract.

Example  2: Preparation of licorice extract

The licorice was well dried, and after three folds, the dry weight of 100 g was put into a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a licorice extract.

Example  3: Preparation of windshield extract

After thoroughly drying the windshield, it was cut into three pieces, and 100 g of dry weight was put into a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a windshield extract.

Example  4 : Extract  Produce

After thoroughly drying the extract, the dried weight of 100 g was placed in a flask, and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a crude extract.

Example  5: Preparation of ginger extract

The ginger was well dried and cut into three pieces. 100 g of dry weight was placed in a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare ginger extract.

Example  6: Preparation of Jujube Extract

The jujube was well dried, and after finishing three times, 100 g of dry weight was put into a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The chilled extract was filtered with a filter having a pore size of 0.2 mu m to prepare jujube extract.

Example  7: Preparation of mixed extract of herbal medicines

(Yam root 30g, licorice 30g, wind, 10g, 10g, 10g ginger, 10g jujube) were added to the flask, and the mixture was extracted 1000 g of a solvent (distilled water: 1,3-butylene glycol = 6: 4) was extracted by cooling with ice for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a herbal composition extract.

Example  8: Whitening effect - Confirmation of total melanin reduction effect

The extracts of Examples 1 to 7 were added to a culture solution of mouse melanoma cells (B-16 mouse melanoma cell) to test the whitening effect at the cellular level. For comparison, the negative control group was not treated separately, and the positive control group was added with arbutin.

Specifically, the herbal medicine extracts of Examples 1 to 7 were subjected to experiments such that the final concentration (% by weight) was 0.1% or 1%, and the positive control group, arbutin, was added to the medium to a concentration of 200 μg / 16 melanoma cells and cultured for 3 days.

Cells were then trypsinized, detached from the culture, centrifuged, and extracted with melanin. The removed cells were melted with 1 ml of sodium hydroxide solution (1N concentration), boiled for 10 minutes, melanin was dissolved, and the amount of melanin produced by measuring the absorbance at 400 nanometers (nm) was measured using a spectrophotometer.

The amount of melanin was measured by an absorbance of 10 ⁶ cells per unit cell, and the inhibition rate (%) relative to the total amount of melanin relative to the negative control was calculated. The results are summarized in Table 1 below. The experiment was repeated three times.

Reduction effect of total melanin content of herb extracts sample Melanin total (Absorbance) Inhibition rate (%) Negative control group 0.082 - Arbutin (200 [mu] g / ml) 0.042 48.78  Example 1 (0.1%) 0.071 13.4 Example 1 (1.0%) 0.069 15.9 Example 2 (0.1%) 0.068 17.1 Example 2 (1.0%) 0.067 18.3 Example 3 (0.1%) 0.075 8.5 Example 3 (1.0%) 0.070 14.6  Example 4 (0.1%) 0.069 15.9 Example 4 (1.0%) 0.058 29.3 Example 5 (0.1%) 0.068 17.1 Example 5 (1.0%) 0.066 19.5 Example 6 (0.1%) 0.070 14.6 Example 6 (1.0%) 0.068 17.1 Example 7 (0.1%) 0.051 37.8 Example 7 (1.0%) 0.045 45.1

As can be seen from the results in Table 1, yam root extract, licorice extract, windblown extract, chrysanthemum extract, ginger extract, jujube extract and mixed extracts of these medicinal herbs have an effect of inhibiting melanin synthesis and reducing the total amount of melanin Therefore, it can be used for whitening or improving the complexion.

In addition, in case of Example 7 in which the above-mentioned six herbal medicines were mixed at a ratio of 30: 30: 10: 10: 10: 10 on the basis of weight, the total amount of melanin was more significantly reduced than that of each herbal extract alone, It was confirmed that the concentration of 1% showed a similar effect to that of arbutin, which is a known whitening substance, to a total amount of melanin, which can be used for whitening or improving the complexion.

Manufacturing example  1: Preparation of an essence containing the mixed extract of the present invention

A cosmetic composition of an essence formulation was prepared as shown in the following Table 2 (unit: wt%).

Raw material name Content (% by weight) Cetearyl alcohol
Cetearyl glucoside
Jojoba seed oil
Silica
glycerin
Example 7 Extract
Purified water 2
One
5
0.5
10
5
To 100

Manufacturing example  2: Production of a cream containing the mixed extract of the present invention

A cream form cosmetic composition was prepared as shown in Table 3 below (unit: wt%).

Composition Content (% by weight) Example 7 Extract
Stearic acid
ethanol
Potassium hydroxide
glycerin
Propylene glycol
antiseptic
incense
Purified water 5
15.0
1.0
0.7
5.0
3.0
Suitable amount
Suitable amount
to 100

Claims (7)

Wherein the extract comprises at least one extract or a fraction thereof selected from the group consisting of yam root, licorice, windshield, alfalfa, ginger and jujube as an active ingredient.
The cosmetic composition for improving whitening or facial coloring according to claim 1, which comprises as an active ingredient, a mixed extract of yam root, licorice, windshield, extract, ginger and jujube or a fraction thereof.
The method according to claim 2, wherein the mixing ratio of the yam root, licorice, windblown, alfalfa, ginger and jujube is 15 to 45:15 to 45: 5 to 15: 5 to 15: 5 to 15: 5 to 15 Wherein the cosmetic composition is a cosmetic composition for improving whitening or complexion.
The cosmetic composition for improving whitening or facial color according to claim 3, wherein the mixing ratio of the yam root, licorice, windblown, alfalfa, ginger and jujube is 30: 30: 10: 10: 10: 10 by weight.
The method of claim 1 wherein the extract of yam root, licorice, wind, baekchul, ginger, and at least one member selected from the group consisting of jujube water, a lower alcohol of C ₁ to C _4, 1,3- butylene glycol, And ethyl acetate. The cosmetic composition for improving whitening or complexion of the present invention is characterized in that it is obtained by extracting with at least one solvent selected from the group consisting of ethyl acetate and ethyl acetate.
6. The cosmetic composition according to claim 5, wherein the solvent is water and 1,3-butylene glycol at a weight ratio of 6: 4.
The cosmetic composition for improving whitening or facial coloring according to claim 1, wherein the whitening or facial color improvement is by a decrease in melanoma total amount of melanoma cells.