KR20040025916A - 불임치료를 위한 단일 복용 아로마타제 저해제 - Google Patents

불임치료를 위한 단일 복용 아로마타제 저해제 Download PDF

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Publication number
KR20040025916A
KR20040025916A KR10-2003-7013484A KR20037013484A KR20040025916A KR 20040025916 A KR20040025916 A KR 20040025916A KR 20037013484 A KR20037013484 A KR 20037013484A KR 20040025916 A KR20040025916 A KR 20040025916A
Authority
KR
South Korea
Prior art keywords
inhibitor
aromata
administered
dose
single dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR10-2003-7013484A
Other languages
English (en)
Korean (ko)
Inventor
카스퍼로버트에프
미트왈리모하메드에프엠
Original Assignee
아레스 트레이딩 에스.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아레스 트레이딩 에스.에이. filed Critical 아레스 트레이딩 에스.에이.
Publication of KR20040025916A publication Critical patent/KR20040025916A/ko
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR10-2003-7013484A 2001-04-17 2002-04-17 불임치료를 위한 단일 복용 아로마타제 저해제 Ceased KR20040025916A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28428201P 2001-04-17 2001-04-17
US60/284,282 2001-04-17
PCT/CA2002/000527 WO2002083241A1 (en) 2001-04-17 2002-04-17 Single dose aromatase inhibitor for treating infertility

Publications (1)

Publication Number Publication Date
KR20040025916A true KR20040025916A (ko) 2004-03-26

Family

ID=23089583

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7013484A Ceased KR20040025916A (ko) 2001-04-17 2002-04-17 불임치료를 위한 단일 복용 아로마타제 저해제

Country Status (32)

Country Link
US (1) US8008333B2 (enExample)
EP (1) EP1383578B1 (enExample)
JP (1) JP2004529924A (enExample)
KR (1) KR20040025916A (enExample)
CN (1) CN1551789A (enExample)
AR (1) AR034036A1 (enExample)
AT (1) ATE409066T1 (enExample)
AU (1) AU2002249043B2 (enExample)
BG (1) BG108323A (enExample)
BR (1) BR0208920A (enExample)
CA (1) CA2444980C (enExample)
CY (1) CY1108648T1 (enExample)
CZ (1) CZ20033107A3 (enExample)
DE (1) DE60229047D1 (enExample)
DK (1) DK1383578T3 (enExample)
EA (1) EA011310B1 (enExample)
EE (1) EE200300505A (enExample)
ES (1) ES2311599T3 (enExample)
HR (1) HRP20030839A2 (enExample)
HU (1) HUP0304003A2 (enExample)
IL (1) IL158396A0 (enExample)
MX (1) MXPA03009447A (enExample)
NO (1) NO20034246L (enExample)
NZ (1) NZ552873A (enExample)
PL (1) PL366744A1 (enExample)
PT (1) PT1383578E (enExample)
SI (1) SI1383578T1 (enExample)
SK (1) SK14242003A3 (enExample)
UA (1) UA82648C2 (enExample)
WO (1) WO2002083241A1 (enExample)
YU (1) YU81203A (enExample)
ZA (1) ZA200307516B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1665516A (zh) * 2002-07-02 2005-09-07 法马西亚和厄普乔恩公司 使用依西美坦治疗不孕症
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
US20100105640A1 (en) * 2005-06-28 2010-04-29 Casper Robert F Aromatase Inhibitors for Emergency Contraception
CA2637000A1 (en) * 2006-01-10 2007-07-19 Diobex, Inc. Methods and compositions for treating prostate cancer, benign prostatic hypertrophy, polycystic ovary syndrome and other conditions
BR112012029392A2 (pt) 2010-05-20 2017-07-11 Univ Saskatchewan uso d einibidores de aromatase para a sincronização da ovulação, indução da superovulação ou ovulação dupla e melhora da geminação e fertilidade em um mamífero
US10004723B2 (en) 2013-04-19 2018-06-26 University Of Saskatchewan Aromatase inhibitor-releasing intravaginal device
US20160022644A1 (en) * 2014-07-22 2016-01-28 Tsu-I Catherine Wang Oral Transmucosal Compositions Including Aromatase Inhibitors for Treating Female Infertility

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4845227A (en) * 1984-06-18 1989-07-04 Eli Lilly And Company Aromatase inhibitors from azoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
GB8726505D0 (en) * 1987-11-12 1987-12-16 Ici Plc Naphtho(2 1-b)furan derivatives
DE4330237C2 (de) 1993-09-02 1995-11-30 Schering Ag 1-Methylsubstituierte Androsta-1,4-dien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
CA2250908C (en) * 1996-04-30 2012-03-13 Takeda Chemical Industries, Ltd. Combined use of gnrh agonist and antagonist
DE19622457A1 (de) 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation

Also Published As

Publication number Publication date
SI1383578T1 (sl) 2008-12-31
CA2444980A1 (en) 2002-10-24
BR0208920A (pt) 2004-04-20
ATE409066T1 (de) 2008-10-15
SK14242003A3 (sk) 2004-03-02
JP2004529924A (ja) 2004-09-30
NO20034246D0 (no) 2003-09-23
US20040171660A1 (en) 2004-09-02
DK1383578T3 (da) 2008-11-03
PT1383578E (pt) 2008-10-08
CA2444980C (en) 2010-08-17
PL366744A1 (en) 2005-02-07
AU2002249043B2 (en) 2008-01-10
IL158396A0 (en) 2004-05-12
US8008333B2 (en) 2011-08-30
AR034036A1 (es) 2004-01-21
UA82648C2 (uk) 2008-05-12
CY1108648T1 (el) 2014-04-09
CZ20033107A3 (en) 2004-03-17
YU81203A (sh) 2006-05-25
DE60229047D1 (de) 2008-11-06
EE200300505A (et) 2004-02-16
NZ552873A (en) 2008-05-30
NO20034246L (no) 2003-12-15
CN1551789A (zh) 2004-12-01
MXPA03009447A (es) 2004-05-24
EA011310B1 (ru) 2009-02-27
ZA200307516B (en) 2004-09-27
EA200301128A1 (ru) 2004-04-29
EP1383578B1 (en) 2008-09-24
HUP0304003A2 (hu) 2004-04-28
BG108323A (bg) 2004-12-30
HRP20030839A2 (en) 2005-08-31
EP1383578A1 (en) 2004-01-28
WO2002083241A1 (en) 2002-10-24
ES2311599T3 (es) 2009-02-16

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