EA011310B1 - Однократная доза ингибитора ароматазы для лечения бесплодия - Google Patents

Однократная доза ингибитора ароматазы для лечения бесплодия Download PDF

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Publication number
EA011310B1
EA011310B1 EA200301128A EA200301128A EA011310B1 EA 011310 B1 EA011310 B1 EA 011310B1 EA 200301128 A EA200301128 A EA 200301128A EA 200301128 A EA200301128 A EA 200301128A EA 011310 B1 EA011310 B1 EA 011310B1
Authority
EA
Eurasian Patent Office
Prior art keywords
aromatase inhibitor
single dose
administration
female
fsh
Prior art date
Application number
EA200301128A
Other languages
English (en)
Russian (ru)
Other versions
EA200301128A1 (ru
Inventor
Роберт Ф. Каспер
Мохамед Ф.М. Митволли
Original Assignee
Арес Трейдинг С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арес Трейдинг С.А. filed Critical Арес Трейдинг С.А.
Publication of EA200301128A1 publication Critical patent/EA200301128A1/ru
Publication of EA011310B1 publication Critical patent/EA011310B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA200301128A 2001-04-17 2002-04-17 Однократная доза ингибитора ароматазы для лечения бесплодия EA011310B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28428201P 2001-04-17 2001-04-17
PCT/CA2002/000527 WO2002083241A1 (en) 2001-04-17 2002-04-17 Single dose aromatase inhibitor for treating infertility

Publications (2)

Publication Number Publication Date
EA200301128A1 EA200301128A1 (ru) 2004-04-29
EA011310B1 true EA011310B1 (ru) 2009-02-27

Family

ID=23089583

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301128A EA011310B1 (ru) 2001-04-17 2002-04-17 Однократная доза ингибитора ароматазы для лечения бесплодия

Country Status (32)

Country Link
US (1) US8008333B2 (enExample)
EP (1) EP1383578B1 (enExample)
JP (1) JP2004529924A (enExample)
KR (1) KR20040025916A (enExample)
CN (1) CN1551789A (enExample)
AR (1) AR034036A1 (enExample)
AT (1) ATE409066T1 (enExample)
AU (1) AU2002249043B2 (enExample)
BG (1) BG108323A (enExample)
BR (1) BR0208920A (enExample)
CA (1) CA2444980C (enExample)
CY (1) CY1108648T1 (enExample)
CZ (1) CZ20033107A3 (enExample)
DE (1) DE60229047D1 (enExample)
DK (1) DK1383578T3 (enExample)
EA (1) EA011310B1 (enExample)
EE (1) EE200300505A (enExample)
ES (1) ES2311599T3 (enExample)
HR (1) HRP20030839A2 (enExample)
HU (1) HUP0304003A2 (enExample)
IL (1) IL158396A0 (enExample)
MX (1) MXPA03009447A (enExample)
NO (1) NO20034246L (enExample)
NZ (1) NZ552873A (enExample)
PL (1) PL366744A1 (enExample)
PT (1) PT1383578E (enExample)
SI (1) SI1383578T1 (enExample)
SK (1) SK14242003A3 (enExample)
UA (1) UA82648C2 (enExample)
WO (1) WO2002083241A1 (enExample)
YU (1) YU81203A (enExample)
ZA (1) ZA200307516B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1665516A (zh) * 2002-07-02 2005-09-07 法马西亚和厄普乔恩公司 使用依西美坦治疗不孕症
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
US20100105640A1 (en) * 2005-06-28 2010-04-29 Casper Robert F Aromatase Inhibitors for Emergency Contraception
CA2637000A1 (en) * 2006-01-10 2007-07-19 Diobex, Inc. Methods and compositions for treating prostate cancer, benign prostatic hypertrophy, polycystic ovary syndrome and other conditions
BR112012029392A2 (pt) 2010-05-20 2017-07-11 Univ Saskatchewan uso d einibidores de aromatase para a sincronização da ovulação, indução da superovulação ou ovulação dupla e melhora da geminação e fertilidade em um mamífero
US10004723B2 (en) 2013-04-19 2018-06-26 University Of Saskatchewan Aromatase inhibitor-releasing intravaginal device
US20160022644A1 (en) * 2014-07-22 2016-01-28 Tsu-I Catherine Wang Oral Transmucosal Compositions Including Aromatase Inhibitors for Treating Female Infertility

Family Cites Families (9)

* Cited by examiner, † Cited by third party
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US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4845227A (en) * 1984-06-18 1989-07-04 Eli Lilly And Company Aromatase inhibitors from azoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
GB8726505D0 (en) * 1987-11-12 1987-12-16 Ici Plc Naphtho(2 1-b)furan derivatives
DE4330237C2 (de) 1993-09-02 1995-11-30 Schering Ag 1-Methylsubstituierte Androsta-1,4-dien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
CA2250908C (en) * 1996-04-30 2012-03-13 Takeda Chemical Industries, Ltd. Combined use of gnrh agonist and antagonist
DE19622457A1 (de) 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
"The ovulatory cycle and drug therapy - Letrozole Proctocol", INTERNET, 'Online! February 2001 (2001-02), XP002205541, Retrieved from the Internet: <URL:http://www.baby-makers.com/theovulatorycycleanddrugtherapy.html>, retrieved on 2002-07-10!, the whole document *
COOMBES R. C. ET AL.: "AROMATASE INHIBITORS AND THEIR USE IN THE SEQUENTIAL SETTING", ENDROCRINE-RELATED CANCER, JOURNAL OF ENDOCRINOLOGY LTD., BRISTOL, GB, vol. 6, no. 2, June 1999 (1999-06), pages 259-263, XP000986876, ISSN: 1351-0088, abstract *
DATABASE PHARMAPROJECTS 'Online! PJB Publications Ltd., UK; "Exemestane", Database accession no. 4447, XP002209732, the whole document *
DATABASE PHARMAPROJECTS 'Online! PJB Publications Ltd., UK; "Letrozole", Database accession no. 2585, XP002209733, the whole document *
MITWALLY M.F. ET AL: "The use of an aromatase inhibitor for induction of ovulation in cases of clomiphene citrate failure", HUMAN REPRODUCTION (OXFORD), vol. 15, no. Abstract Book 1, June 2000 (2000-06), pages 71-72, XP001094320, 16th Annual Meeting of the European Society of Human Reproduction and Embryology;Bologna, Italy; June 25-28, 2000, ISSN: 0268-1161, the whole document *
MITWALLY M.F.M. AND CASPER R.F.: "Use of aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate", FERTILITY AND STERILITY, vol. 75, no. 2, February 2001 (2001-02), pages 305-309, XP001088751, us, the whole document, page 308, column 2, line 2 - line 14 *
MITWALLY M.F.M. ET AL.: "Aromatase Inhibition Decreases FSH dose Needed During Controlled Ovarian Hyperstimulation: a Controlled Perspective Trial", J. SOC. GYNECOL. INVESTIG., vol. 8, no. 1(Supplement), February 2001 (2001-02), page 85A, XP001084377, cited in the application, the whole document *
Mitwally M.F.M. et al.: 'The Aromatase Inhibitor Letrozole: a Promising Alternative for Clomiphene Citrate for Induction of Ovulation', Abstract No. 0-91 in: Program and Abstracts of the 56th Annual Meeting of the American Society for Reproductive Medicine (ASRM), October 2000, San Diego (CA), USA XP001088806, cited in the application, the whole document *
MITWALLY MOHAMED F. ET AL.: "Aromatase inhibition for ovarian stimulation: future avenues for infertility management", CURRENT OPINION IN OBSTETRICS & GYNECOLOGY. ENGLAND JUN 2002, vol. 14, no. 3, June 2002 (2002-06), pages 255-263, XP001084791, ISSN: 1040-872X, the whole document *
MITWALLY MOHAMED FAROUK M. ET AL.: "Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders(1)", FERTILITY AND STERILITY. UNITED STATES APR, 2002, vol. 77, no. 4, April 2002 (2002-04), pages 776-780, XP001088750, ISSN: 0015-0282, the whole document *
MITWALLY, M.F.M. ET AL.: "Aromatase inhibition: a novel method of ovulation induction in women with polycystic ovary syndrome", REPRODUCTIVE TECHNOLOGIES, vol. 10, no. 5, 2000, pages 244-247, XP001084440, the whole document *
SIOUFI A. ET AL.: "Absolute bioavailability of letrozole in healthy postmenopausal, women", BIOPHARMACEUTICS & DRUG DISPOSITION. ENGLAND, DEC 1997, vol. 18, no. 9, December 1997 (1997-12), pages 779-789, XP002209706, ISSN: 0142-2782, abstract, page 780, paragraph 2, figure 2, table 1, page 787, line 5 -page 788, line 14 *

Also Published As

Publication number Publication date
SI1383578T1 (sl) 2008-12-31
KR20040025916A (ko) 2004-03-26
CA2444980A1 (en) 2002-10-24
BR0208920A (pt) 2004-04-20
ATE409066T1 (de) 2008-10-15
SK14242003A3 (sk) 2004-03-02
JP2004529924A (ja) 2004-09-30
NO20034246D0 (no) 2003-09-23
US20040171660A1 (en) 2004-09-02
DK1383578T3 (da) 2008-11-03
PT1383578E (pt) 2008-10-08
CA2444980C (en) 2010-08-17
PL366744A1 (en) 2005-02-07
AU2002249043B2 (en) 2008-01-10
IL158396A0 (en) 2004-05-12
US8008333B2 (en) 2011-08-30
AR034036A1 (es) 2004-01-21
UA82648C2 (uk) 2008-05-12
CY1108648T1 (el) 2014-04-09
CZ20033107A3 (en) 2004-03-17
YU81203A (sh) 2006-05-25
DE60229047D1 (de) 2008-11-06
EE200300505A (et) 2004-02-16
NZ552873A (en) 2008-05-30
NO20034246L (no) 2003-12-15
CN1551789A (zh) 2004-12-01
MXPA03009447A (es) 2004-05-24
ZA200307516B (en) 2004-09-27
EA200301128A1 (ru) 2004-04-29
EP1383578B1 (en) 2008-09-24
HUP0304003A2 (hu) 2004-04-28
BG108323A (bg) 2004-12-30
HRP20030839A2 (en) 2005-08-31
EP1383578A1 (en) 2004-01-28
WO2002083241A1 (en) 2002-10-24
ES2311599T3 (es) 2009-02-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU