KR20040019302A - 멜라노코르틴 수용체 리간드로서의 ｎ-페닐피롤 구아니딘 유도체 - Google Patents

멜라노코르틴 수용체 리간드로서의 ｎ-페닐피롤 구아니딘 유도체 Download PDF

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Publication number
KR20040019302A
KR20040019302A KR10-2003-7016099A KR20037016099A KR20040019302A KR 20040019302 A KR20040019302 A KR 20040019302A KR 20037016099 A KR20037016099 A KR 20037016099A KR 20040019302 A KR20040019302 A KR 20040019302A
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South Korea
Prior art keywords
guanidine
pyrrol
compound
compound according
treatment
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Korean (ko)
Inventor
토르브죄른 룬드스테드트
안나 스코트너
아르네 보맨
페르 안데르손
엘리자베스 세이페르트
빅토르 안드리아노브
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멜라큐어 테라퓨틱스 에이비
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Publication of KR20040019302A publication Critical patent/KR20040019302A/ko
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals

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  • Obesity (AREA)
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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
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  • Child & Adolescent Psychology (AREA)
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KR10-2003-7016099A 2001-08-06 2002-08-06 멜라노코르틴 수용체 리간드로서의 ｎ-페닐피롤 구아니딘 유도체 Withdrawn KR20040019302A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0119172.5A GB0119172D0 (en) 2001-08-06 2001-08-06 Phenyl pyrrole derivatives
GB0119172.5 2001-08-06
PCT/GB2002/003620 WO2003013509A1 (en) 2001-08-06 2002-08-06 N-phenylpyrrole guanidine derivatives as melanocortin reception ligands

Publications (1)

Publication Number Publication Date
KR20040019302A true KR20040019302A (ko) 2004-03-05

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KR10-2003-7016099A Withdrawn KR20040019302A (ko) 2001-08-06 2002-08-06 멜라노코르틴 수용체 리간드로서의 ｎ-페닐피롤 구아니딘 유도체

Country Status (19)

Country Link
US (3) US7186748B2 (https=)
EP (1) EP1414440B1 (https=)
JP (2) JP4450620B2 (https=)
KR (1) KR20040019302A (https=)
AU (1) AU2002313542B2 (https=)
BR (1) BR0210445A (https=)
CA (1) CA2448356C (https=)
CY (1) CY1106424T1 (https=)
DE (1) DE60217503T2 (https=)
DK (1) DK1414440T3 (https=)
ES (1) ES2280555T3 (https=)
GB (1) GB0119172D0 (https=)
IL (1) IL160181A0 (https=)
MX (1) MXPA04001037A (https=)
NO (1) NO20040465L (https=)
NZ (1) NZ529666A (https=)
PT (1) PT1414440E (https=)
SI (1) SI1414440T1 (https=)
WO (1) WO2003013509A1 (https=)

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DK1414440T3 (da) 2007-05-21
CA2448356A1 (en) 2003-02-20
US7186748B2 (en) 2007-03-06
BR0210445A (pt) 2004-08-17
IL160181A0 (en) 2004-07-25
SI1414440T1 (sl) 2007-06-30
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JP2009242414A (ja) 2009-10-22
MXPA04001037A (es) 2004-06-03
DE60217503D1 (de) 2007-02-22
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EP1414440B1 (en) 2007-01-10
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